Professor | Longlong Si | Asia Growth Partners

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Name	Longlong Si
Contact Information	ll.si@siat.ac.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Longlong Si

Contact Information

ll.si@siat.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2012-09 to 2017-06 PhD: Peking University, School of Pharmaceutical Sciences/National Key Laboratory of Natural and Biomimetic Drugs 2008-09 to 2012-06 Bachelor: Sichuan University, West China School of Pharmacy
Awards	Wyss Technology Development Fellowship (2019): Other China's Top Ten Scientific Advances (2017): National China's University Student of the Year (2017): National International Society for Vaccines Papers of The Year (2016): Other

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2012-09 to 2017-06 PhD: Peking University, School of Pharmaceutical Sciences/National Key Laboratory of Natural and Biomimetic Drugs
2008-09 to 2012-06 Bachelor: Sichuan University, West China School of Pharmacy

Awards

Wyss Technology Development Fellowship (2019): Other
China's Top Ten Scientific Advances (2017): National
China's University Student of the Year (2017): National
International Society for Vaccines Papers of The Year (2016): Other

Areas of Focus	Development and application of new strategies and systems for virus infection and prevention research
Publications	Advancements in organs-on-chips technology for viral disease and anti-viral research, Jing Li, Haiqing Bai, Zihao Wang, Beibei Xu, Kristen N Peters Olson, Chengyao Liu, Yinlei Su, Jiawei Hao, Jinying Shen, Xuetong Xi, Jie Zhen, Rong Yu, Rong Yu, Xin Xie, Wenxia Tian, Fei Yu, Xiaoheng Liu, Lihe Zhang, Demin Zhou, Longlong Si, 2023 Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip, Bai, Haiqing, Si, Longlong, Jiang, Amanda, Belgur, Chaitra, Zhai, Yunhao, Plebani, Roberto, Oh, Crystal Yuri, Rodas, Melissa, Patil, Aditya, Nurani, Atiq, Gilpin, Sarah E, Powers, Rani K, Goyal, Girija, PrantilBaun, Rachelle, Ingber, Donald E, 2022 PROTAC vaccine: A new way to live attenuated vaccines, Li, Zhen, Bai, Haiqing, Xi, Xuetong, Tian, Wenxia, Zhang, John Z H, Zhou, Demin, Si, Longlong, 2022 3D Lung Tissue Models for Studies on SARS-CoV-2 Pathophysiology and Therapeutics, Roberto Plebani, Haiqing Bai, Longlong Si, Jing Li, Chunhe Zhang, Mario Romano, Evgenii Gusev, 2022 Generation of a live attenuated influenza A vaccine by proteolysis targeting, Si, Longlong, Shen, Quan, Li, Jing, Chen, Li, Shen, Jinying, Xiao, Xue, Bai, Haiqing, Feng, Tang, Ye, Adam Yongxin, Li, Le, Zhang, Chunhe, Li, Zhen, Wang, Ping, Oh, Crystal Yuri, Nurani, Atiq, Niu, Siwen, Zhang, Chengxin, Wei, Xiaoqiong, Yuan, Wanqiong, Liao, Hao, Huang, Xiaojie, Wang, Ning, Tian, Wen-xia, Tian, Hongwei, Li, Li, Liu, Xiaoheng, Plebani, Roberto, 2022 Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity, Si, Longlong, Bai, Haiqing, Oh, Crystal Yuri, Jiang, Amanda, Hong, Fan, Zhang, Tian, Ye, Yongxin, Jordan, Tristan X, Logue, James, McGrath, Marisa, Belgur, Chaitra, Calderon, Karina, Nurani, Atiq, Cao, Wuji, Carlson, Kenneth E, PrantilBaun, Rachelle, Gygi, Steven P, Yang, Dong, Jonsson, Colleen B, tenOever, Benjamin R, Frieman, Matthew, Ingber, Donald E, 2022 Biomineral interface with superior cell adhesive and antibacterial properties based on enzyme-triggered digestion of saliva acquired pellicle-inspired polypeptide coatings, Yang, Xiao, Ding, Chunmei, Wu, Mingzhen, Xu, Xinyuan, Ke, Xiang, Xu, Huilin, Li, Juan, Lou, Feng, Zhou, Kai, Jiang, Haolun, Peng, Xu, Wang, Xianlong, Si, Longlong, Li, Jianshu, 2021 A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics, Si, Longlong, Bai, Haiqing, Rodas, Melissa, Cao, Wuji, Oh, Crystal Yuri, Jiang, Amanda, Moller, Rasmus, Hoagland, Daisy, Oishi, Kohei, Horiuchi, Shu, Uhl, Skyler, BlancoMelo, Daniel, Albrecht, Randy A, Liu, WenChun, Jordan, Tristan, NilssonPayant, Benjamin E, Golynker, Ilona, Frere, Justin, Logue, James, Haupt, Robert, McGrath, Marisa, Weston, Stuart, Zhang, Tian, Plebani, Roberto, Soong, Mercy, Nurani, Atiq, Kim, Seong Min, Zhu, Danni Y, Benam, Kambez H, Goyal, Girija, Gilpin, Sarah E, PrantilBaun, Rachelle, Gygi, Steven P, Powers, Rani K, Carlson, Kenneth E, Frieman, Matthew, TenOever, Benjamin R, Ingber, Donald E, 2021 Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip, Si, Longlong, Bai, Haiqing, Oh, Crystal Yuri, Jin, Lei, PrantilBaun, Rachelle, Ingber, Donald E, 2021 Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence, Wu, Zhong, Zhou, Jin, Zhang, Xiaoyang, Zhang, Zhouwei, Xie, Yingtian, Liu, Jie bin, Ho, Zandra, V, Panda, Arpit, Qiu, Xintao, Cejas, Paloma, Canadas, Israel, Akarca, Fahire Goknur, McFarland, James M, Nagaraja, Ankur K, Goss, Louisa B, Kesten, Nikolas, Si, Longlong, Lim, Klothilda, Liu, Yanli, Zhang, Yanxi, Baek, Ji Yeon, Liu, Yang, Patil, Deepa T, Katz, Jonathan P, Hai, Josephine, Bao, Chunyang, Stachler, Matthew, Qi, Jun, Ishizuka, Jeffrey J, Nakagawa, Hiroshi, Rustgi, Anil K, Wong, KwokKin, Meyerson, Matthew, Barbie, David A, Brown, Myles, Long, Henry, Bass, Adam J, 2021 Human Organs-on-Chips for Virology, Tang, Huaqi, Abouleila, Yasmine, Si, Longlong, OrtegaPrieto, Ana Maria, Mummery, Christine L, Ingber, Donald E, Mashaghi, Alireza, 2020 Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes, Si, Longlong, Meng, Kun, Tian, Zhenyu, Sun, Jiaqi, Li, Huiqiang, Zhang, Ziwei, Soloveva, Veronica, Li, Haiwei, Fu, Ge, Xia, Qing, Xiao, Sulong, Zhang, Lihe, Zhou, Demin, 2018 Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives, Xiao, Sulong, Tian, Zhenyu, Wang, Yufei, Si, Longlong, Zhang, Lihe, Zhou, Demin, 2018 Precise and combinatorial PEGylation generates a low-immunogenic and stable form of human growth hormone, Wu, Ling, Chen, Jingxian, Wu, Yiming, Zhang, Bo, Cai, Xiaochun, Zhang, Ziwei, Wang, Yan, Si, LongLong, Xu, Huan, Zheng, YongXiang, Zhang, ChuanLing, Liang, Chenggang, Li, Jing, Zhang, Lihe, Zhang, Qiang, Zhou, Demin, 2017 Design, synthesis and biological evaluation of gentiopicroside derivatives as potential antiviral inhibitors, Wu, Shaoping, Yang, Lili, Sun, Wenji, Si, Longlong, Xiao, Sulong, Wang, Qi, Dechoux, Luc, Thorimbert, Serge, Sollogoub, Matthieu, Zhou, Demin, Zhang, Yongmin, 2017 Inhibition of influenza virus infection by multivalent pentacyclic triterpene-functionalized per-O-methylated cyclodextrin conjugates, Tian, Zhenyu, Si, Longlong, Meng, Kun, Zhou, Xiaoshu, Zhang, Yongmin, Zhou, Demin, Xiao, Sulong, 2017 Synthesis and biological evaluation of novel pentacyclic triterpene α-cyclodextrin conjugates as HCV entry inhibitors, Sulong Xiao, Qi Wang, Longlong Si, Xiaoshu Zhou, Yongmin Zhang, Lihe Zhang, Demin Zhou, 2016 Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect, Xiao, Sulong, Si, Longlong, Tian, Zhenyu, Jiao, Pingxuan, Fan, Zibo, Meng, Kun, Zhou, Xiaoshu, Wang, Han, Xu, Renyang, Han, Xu, Fu, Ge, Zhang, Yongmin, Zhang, Lihe, Zhou, Demin, 2016 Spiromastilactones: A new class of influenza virus inhibitors from deep-sea fungus, Niu, Siwen, Si, Longlong, Liu, Dong, Zhou, Andrew, Zhang, Ziwei, Shao, Zongze, Wang, Shaomeng, Zhang, Lihe, Zhou, Demin, Lin, Wenhan, 2016 Synthesis of Site-Specific Radiolabeled Antibodies for Radioimmunotherapy via Genetic Code Expansion, Wu, Yiming, Zhu, Hua, Zhang, Bo, Liu, Fei, Chen, Jingxian, Wang, Yufei, Wang, Yan, Zhang, Ziwei, Wu, Ling, Si, Longlong, Xu, Huan, Yao, Tianzhuo, Xiao, Sulong, Xia, Qing, Zhang, Lihe, Yang, Zhi, Zhou, Demin, 2016 Generation of influenza A viruses as live but replication-incompetent virus vaccines, Si, Longlong, Xu, Huan, Zhou, Xueying, Zhang, Ziwei, Tian, Zhenyu, Wang, Yan, Wu, Yiming, Zhang, Bo, Niu, Zhenlan, Zhang, Chuanling, Fu, Ge, Xiao, Sulong, Xia, Qing, Zhang, Lihe, Zhou, Demin, 2016 Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis, Ji, Shuai, Li, Ru, Wang, Qi, Miao, Wenjuan, Li, Ziwei, Si, Longlong, Qiao, Xue, Yu, Siwang, Zhou, Demin, Ye, Min, 2015 Broadening the versatility of lentiviral vectors as a tool in nucleic acid research via genetic code expansion, Zheng, Yongxiang, Yu, Fei, Wu, Yiming, Si, Longlong, Xu, Huan, Zhang, Chuanling, Xia, Qing, Xiao, Sulong, Wang, Qi, He, Qiuchen, Chen, Peng, Wang, Jiangyun, Taira, Kazunari, Zhang, Lihe, Zhou, Demin, 2015 Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin, Chen, Xueqing, Si, Longlong, Liu, Dong, Proksch, Peter, Zhang, Lihe, Zhou, Demin, Lin, Wenhan, 2015 Development of next generation of therapeutic IFN-alpha 2b via genetic code expansion, Zhang, Bo, Xu, Huan, Chen, Jingxian, Zheng, Yongxiang, Wu, Yiming, Si, Longlong, Wu, Ling, Zhang, Chuanling, Xia, Gang, Zhang, Lihe, Zhou, Demin

Areas of Focus

Development and application of new strategies and systems for virus infection and prevention research

Publications

Advancements in organs-on-chips technology for viral disease and anti-viral research, Jing Li, Haiqing Bai, Zihao Wang, Beibei Xu, Kristen N Peters Olson, Chengyao Liu, Yinlei Su, Jiawei Hao, Jinying Shen, Xuetong Xi, Jie Zhen, Rong Yu, Rong Yu, Xin Xie, Wenxia Tian, Fei Yu, Xiaoheng Liu, Lihe Zhang, Demin Zhou, Longlong Si, 2023
Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip, Bai, Haiqing, Si, Longlong, Jiang, Amanda, Belgur, Chaitra, Zhai, Yunhao, Plebani, Roberto, Oh, Crystal Yuri, Rodas, Melissa, Patil, Aditya, Nurani, Atiq, Gilpin, Sarah E, Powers, Rani K, Goyal, Girija, PrantilBaun, Rachelle, Ingber, Donald E, 2022
PROTAC vaccine: A new way to live attenuated vaccines, Li, Zhen, Bai, Haiqing, Xi, Xuetong, Tian, Wenxia, Zhang, John Z H, Zhou, Demin, Si, Longlong, 2022
3D Lung Tissue Models for Studies on SARS-CoV-2 Pathophysiology and Therapeutics, Roberto Plebani, Haiqing Bai, Longlong Si, Jing Li, Chunhe Zhang, Mario Romano, Evgenii Gusev, 2022
Generation of a live attenuated influenza A vaccine by proteolysis targeting, Si, Longlong, Shen, Quan, Li, Jing, Chen, Li, Shen, Jinying, Xiao, Xue, Bai, Haiqing, Feng, Tang, Ye, Adam Yongxin, Li, Le, Zhang, Chunhe, Li, Zhen, Wang, Ping, Oh, Crystal Yuri, Nurani, Atiq, Niu, Siwen, Zhang, Chengxin, Wei, Xiaoqiong, Yuan, Wanqiong, Liao, Hao, Huang, Xiaojie, Wang, Ning, Tian, Wen-xia, Tian, Hongwei, Li, Li, Liu, Xiaoheng, Plebani, Roberto, 2022
Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity, Si, Longlong, Bai, Haiqing, Oh, Crystal Yuri, Jiang, Amanda, Hong, Fan, Zhang, Tian, Ye, Yongxin, Jordan, Tristan X, Logue, James, McGrath, Marisa, Belgur, Chaitra, Calderon, Karina, Nurani, Atiq, Cao, Wuji, Carlson, Kenneth E, PrantilBaun, Rachelle, Gygi, Steven P, Yang, Dong, Jonsson, Colleen B, tenOever, Benjamin R, Frieman, Matthew, Ingber, Donald E, 2022
Biomineral interface with superior cell adhesive and antibacterial properties based on enzyme-triggered digestion of saliva acquired pellicle-inspired polypeptide coatings, Yang, Xiao, Ding, Chunmei, Wu, Mingzhen, Xu, Xinyuan, Ke, Xiang, Xu, Huilin, Li, Juan, Lou, Feng, Zhou, Kai, Jiang, Haolun, Peng, Xu, Wang, Xianlong, Si, Longlong, Li, Jianshu, 2021
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics, Si, Longlong, Bai, Haiqing, Rodas, Melissa, Cao, Wuji, Oh, Crystal Yuri, Jiang, Amanda, Moller, Rasmus, Hoagland, Daisy, Oishi, Kohei, Horiuchi, Shu, Uhl, Skyler, BlancoMelo, Daniel, Albrecht, Randy A, Liu, WenChun, Jordan, Tristan, NilssonPayant, Benjamin E, Golynker, Ilona, Frere, Justin, Logue, James, Haupt, Robert, McGrath, Marisa, Weston, Stuart, Zhang, Tian, Plebani, Roberto, Soong, Mercy, Nurani, Atiq, Kim, Seong Min, Zhu, Danni Y, Benam, Kambez H, Goyal, Girija, Gilpin, Sarah E, PrantilBaun, Rachelle, Gygi, Steven P, Powers, Rani K, Carlson, Kenneth E, Frieman, Matthew, TenOever, Benjamin R, Ingber, Donald E, 2021
Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip, Si, Longlong, Bai, Haiqing, Oh, Crystal Yuri, Jin, Lei, PrantilBaun, Rachelle, Ingber, Donald E, 2021
Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence, Wu, Zhong, Zhou, Jin, Zhang, Xiaoyang, Zhang, Zhouwei, Xie, Yingtian, Liu, Jie bin, Ho, Zandra, V, Panda, Arpit, Qiu, Xintao, Cejas, Paloma, Canadas, Israel, Akarca, Fahire Goknur, McFarland, James M, Nagaraja, Ankur K, Goss, Louisa B, Kesten, Nikolas, Si, Longlong, Lim, Klothilda, Liu, Yanli, Zhang, Yanxi, Baek, Ji Yeon, Liu, Yang, Patil, Deepa T, Katz, Jonathan P, Hai, Josephine, Bao, Chunyang, Stachler, Matthew, Qi, Jun, Ishizuka, Jeffrey J, Nakagawa, Hiroshi, Rustgi, Anil K, Wong, KwokKin, Meyerson, Matthew, Barbie, David A, Brown, Myles, Long, Henry, Bass, Adam J, 2021
Human Organs-on-Chips for Virology, Tang, Huaqi, Abouleila, Yasmine, Si, Longlong, OrtegaPrieto, Ana Maria, Mummery, Christine L, Ingber, Donald E, Mashaghi, Alireza, 2020
Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalent in viral envelopes, Si, Longlong, Meng, Kun, Tian, Zhenyu, Sun, Jiaqi, Li, Huiqiang, Zhang, Ziwei, Soloveva, Veronica, Li, Haiwei, Fu, Ge, Xia, Qing, Xiao, Sulong, Zhang, Lihe, Zhou, Demin, 2018
Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives, Xiao, Sulong, Tian, Zhenyu, Wang, Yufei, Si, Longlong, Zhang, Lihe, Zhou, Demin, 2018
Precise and combinatorial PEGylation generates a low-immunogenic and stable form of human growth hormone, Wu, Ling, Chen, Jingxian, Wu, Yiming, Zhang, Bo, Cai, Xiaochun, Zhang, Ziwei, Wang, Yan, Si, LongLong, Xu, Huan, Zheng, YongXiang, Zhang, ChuanLing, Liang, Chenggang, Li, Jing, Zhang, Lihe, Zhang, Qiang, Zhou, Demin, 2017
Design, synthesis and biological evaluation of gentiopicroside derivatives as potential antiviral inhibitors, Wu, Shaoping, Yang, Lili, Sun, Wenji, Si, Longlong, Xiao, Sulong, Wang, Qi, Dechoux, Luc, Thorimbert, Serge, Sollogoub, Matthieu, Zhou, Demin, Zhang, Yongmin, 2017
Inhibition of influenza virus infection by multivalent pentacyclic triterpene-functionalized per-O-methylated cyclodextrin conjugates, Tian, Zhenyu, Si, Longlong, Meng, Kun, Zhou, Xiaoshu, Zhang, Yongmin, Zhou, Demin, Xiao, Sulong, 2017
Synthesis and biological evaluation of novel pentacyclic triterpene α-cyclodextrin conjugates as HCV entry inhibitors, Sulong Xiao, Qi Wang, Longlong Si, Xiaoshu Zhou, Yongmin Zhang, Lihe Zhang, Demin Zhou, 2016
Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect, Xiao, Sulong, Si, Longlong, Tian, Zhenyu, Jiao, Pingxuan, Fan, Zibo, Meng, Kun, Zhou, Xiaoshu, Wang, Han, Xu, Renyang, Han, Xu, Fu, Ge, Zhang, Yongmin, Zhang, Lihe, Zhou, Demin, 2016
Spiromastilactones: A new class of influenza virus inhibitors from deep-sea fungus, Niu, Siwen, Si, Longlong, Liu, Dong, Zhou, Andrew, Zhang, Ziwei, Shao, Zongze, Wang, Shaomeng, Zhang, Lihe, Zhou, Demin, Lin, Wenhan, 2016
Synthesis of Site-Specific Radiolabeled Antibodies for Radioimmunotherapy via Genetic Code Expansion, Wu, Yiming, Zhu, Hua, Zhang, Bo, Liu, Fei, Chen, Jingxian, Wang, Yufei, Wang, Yan, Zhang, Ziwei, Wu, Ling, Si, Longlong, Xu, Huan, Yao, Tianzhuo, Xiao, Sulong, Xia, Qing, Zhang, Lihe, Yang, Zhi, Zhou, Demin, 2016
Generation of influenza A viruses as live but replication-incompetent virus vaccines, Si, Longlong, Xu, Huan, Zhou, Xueying, Zhang, Ziwei, Tian, Zhenyu, Wang, Yan, Wu, Yiming, Zhang, Bo, Niu, Zhenlan, Zhang, Chuanling, Fu, Ge, Xiao, Sulong, Xia, Qing, Zhang, Lihe, Zhou, Demin, 2016
Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis, Ji, Shuai, Li, Ru, Wang, Qi, Miao, Wenjuan, Li, Ziwei, Si, Longlong, Qiao, Xue, Yu, Siwang, Zhou, Demin, Ye, Min, 2015
Broadening the versatility of lentiviral vectors as a tool in nucleic acid research via genetic code expansion, Zheng, Yongxiang, Yu, Fei, Wu, Yiming, Si, Longlong, Xu, Huan, Zhang, Chuanling, Xia, Qing, Xiao, Sulong, Wang, Qi, He, Qiuchen, Chen, Peng, Wang, Jiangyun, Taira, Kazunari, Zhang, Lihe, Zhou, Demin, 2015
Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin, Chen, Xueqing, Si, Longlong, Liu, Dong, Proksch, Peter, Zhang, Lihe, Zhou, Demin, Lin, Wenhan, 2015
Development of next generation of therapeutic IFN-alpha 2b via genetic code expansion, Zhang, Bo, Xu, Huan, Chen, Jingxian, Zheng, Yongxiang, Wu, Yiming, Si, Longlong, Wu, Ling, Zhang, Chuanling, Xia, Gang, Zhang, Lihe, Zhou, Demin

Virus Infection Prevention Synthetic Biology Virus Life Cycle Virus Engineering Medical Applications Vaccines Virus Vectors Stem Cells Organ-On-Chip

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