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Pengfei Wang
Life Science
Fudan University
Shanghai
Language: English, Chinese
Antiviral
Therapeutics
Vaccines
Infectious Diseases
Antibodies
Drug Screening
Vaccine Evaluation
Hiv/Aids
Emerging Diseases
Prevention
Areas of Focus
- Antiviral therapeutics and vaccines
Work Experience
- 2015-2019 - Rockefeller University - Postdoctoral Researcher
- 2020-2021 - Columbia University - Associate Researcher Scientist
- 2021-Present - Fudan University - Junior Professor
Academic Background & Achievements
- 2006-2010 Bachelor's Degree: Beijing Normal University
- 2010-2015 Doctoral Degree: Fudan University
- Clarivate Highly Cited Researcher 2023
- World's Top 2% Scientists 2023 (Elsevier/Stanford)
Publications
- Enhanced neutralization of SARS-CoV-2 variant BA.2.86 and XBB sub-lineages by a tetravalent COVID-19 vaccine booster., Wang X, Jiang S, Ma W, Li X, Wei K, Xie F, Zhao C, Zhao X, Wang S, Li C, Qiao R, Cui Y, Chen Y, Li J, Cai G, Liu C, Yu J, Li J, Hu Z, Zhang W, Jiang S, Li M, Zhang Y, Wang P, 2023
- Neutralization of SARS-CoV-2 BQ.1.1, CH.1.1, and XBB.1.5 by Breakthrough Infection Sera from Previous and Recent Waves in China., Wang X, Jiang S, Jiang S, Li X, Ai J, Lin K, Lv S, Zhang S, Li M, Li J, Dai L, Hu Z, Zhang W, Zhang Y, Wang P, 2023
- Limited enhancement of antibody and B-cell responses to prototype booster vaccination following SARS-CoV-2 Delta breakthrough infection., Wang X, He X, Jiang S, Fu Z, Jiang S, Zhao X, Zhao C, Li Y, Li D, Zhang W, Ai J, Zhang Y, Xu C, Wang P, 2023
- Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses., Chen Y, Zhao X, Zhou H, Zhu H, Jiang S, Wang P, 2023
- Neutralization against Omicron subvariants after BA.5/BF.7 breakthrough infection weakened as virus evolution and aging despite repeated prototype-based vaccination., Wang H, Xue Q, Zhang H, Yuan G, Wang X, Sheng K, Li C, Cai J, Sun Y, Zhao J, Lu J, Fang S, Yang Y, Zhang Y, Huang Y, Wang J, Xu JH, Jiang MX, Wang X, Shen L, Liu Y, Liu Q, Zhang Q, Wang S, Wang P, Qiu C, Ai J, Zhang W, 2023
- Structure-based virtual screening of ROCK1 inhibitors for the discovery of Enterovirus-A71 antivirals., Qiao R, Tang W, Li J, Li C, Zhao C, Wang X, Li M, Cui Y, Chen Y, Cai G, Wu Q, Zhao X, Wang P, 2023
- In Vitro Antibody-Dependent Enhancement of SARS-CoV-2 Infection Could Be Abolished by Adding Human IgG., Wang X, Li M, Lu P, Li C, Zhao C, Zhao X, Qiao R, Cui Y, Chen Y, Li J, Cai G, Wang P, 2023
- Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2 and BA.3 sub-lineages., Ai J, Wang X, He X, Zhao X, Zhang Y, Jiang Y, Li M, Cui Y, Chen Y, Qiao R, Li L, Yang L, Li Y, Hu Z, Zhang W, Wang P, 2022
- Neutralization of Omicron BA.4/BA.5 and BA.2.75 by Booster Vaccination or BA.2 Breakthrough Infection Sera., Wang X, Ai J, Li X, Zhao X, Wu J, Zhang H, He X, Zhao C, Qiao R, Li M, Cui Y, Hu Z, Xu C, Zhang W, Wang P, 2022
- Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies., Wang X, Zhao X, Song J, Wu J, Zhu Y, Li M, Cui Y, Chen Y, Yang L, Liu J, Zhu H, Jiang S, Wang P, 2022
- Rock1 is a novel host dependency factor of human enterovirus A71: implication as a drug target., Zhao X, Li C, Chiu MC, Qiao R, Jiang S, Wang P, Zhou J, 2022
- Neutralization of distinct Omicron sublineages by longitudinal vaccination sera., Wang X, Zhao X, Cui Y, Qiao R, Li M, Chen Y, Yang L, Jiang S, Wang P, 2022
- Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7., Wang P, Nair MS, Liu L, Iketani S, Luo Y, Guo Y, Wang M, Yu J, Zhang B, Kwong PD, Graham BS, Mascola JR, Chang JY, Yin MT, Sobieszczyk M, Kyratsous CA, Shapiro L, Sheng Z, Huang Y, Ho DD, 2021
- Increased Resistance of SARS-CoV-2 Variant P.1 to Antibody Neutralization., Wang P, Casner RG, Nair MS, Wang M, Yu J, Cerutti G, Liu L, Kwong PD, Huang Y, Shapiro L, Ho DD, 2021
- Potent Neutralizing Monoclonal Antibodies Directed to Multiple Epitopes on the SARS-CoV-2 Spike., Liu L, Wang P, Nair MS, Yu J, Rapp MA, Wang Q, Luo Y, Sahi V, Figueroa A, Guo XV, Cerutti G, Bimela J, Gorman J, Zhou T, Kwong PD, Sodroski JG, Yin MT, Sheng Z, Huang Y, Shapiro L, Ho DD, 2020
- Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids., Han Y, Duan X, Yang L, Nilsson-Payant BE, Wang P, Duan F, Tang X, Yaron TM, Zhang T, Uhl S, Bram Y, Richardson C, Zhu J, Zhao Z, Redmond D, Houghton S, Nguyen D, Xu D, Wang X, Jessurun J, Borczuk A, Huang Y, Johnson JL, Liu Y, Xiang J, Wang H, Cantley LC, tenOever BR, Ho DD, Pan FC, Evans T, Chen HJ, Schwartz RE, Chen S, 2021
- Quantifying the contribution of Fc-mediated effector functions to the antiviral activity of anti-HIV-1 IgG1 antibodies in vivo., Wang P, Gajjar MR, Yu J, Padte NN, Gettie A, Blanchard JL, Russell-Lodrigue K, Liao LE, Perelson AS, Huang Y, Ho DD, 2020
- A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses., Wang P, Casner RG, Nair MS, Yu J, Guo Y, Wang M, Chan JF, Cerutti G, Iketani S, Liu L, Sheng Z, Chen Z, Yuen KY, Kwong PD, Huang Y, Shapiro L, Ho DD, 2022
- SARS-CoV-2 Neutralizing Antibody Responses Are More Robust in Patients with Severe Disease., Wang P, Liu L, Nair MS, Yin MT, Luo Y, Wang Q, Yuan T, Mori K, Solis AG, Yamashita M, Lawrence J, Purpura LJ, Laracy JC, Yu J, Sodroski JG, Huang Y, Ho DD, 2020
- Anti-HIV Passive Immunization in Animal Models., Wang P, 2018
- Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui., Wang P, Lu P, Qu X, Shen Y, Zeng H, Zhu X, Zhu Y, Li X, Wu H, Xu J, Lu H, Ma Z, Zhu H, 2017
- Two cellular microRNAs, miR-196b and miR-1290, contribute to HIV-1 latency., Wang P, Qu X, Zhou X, Shen Y, Ji H, Fu Z, Deng J, Lu P, Yu W, Lu H, Zhu H, 2015
- Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5′-LTR promoter., Wang P, Qu X, Wang X, Zhu X, Zeng H, Chen H, Zhu H, 2014
- As2O3 synergistically reactivate latent HIV-1 by induction of NF-κB., Wang P, Qu X, Wang X, Liu L, Zhu X, Zeng H, Zhu H, 2013
- Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells., Qu X, Wang P, Ding D, Li L, Wang H, Ma L, Zhou X, Liu S, Lin S, Wang X, Zhang G, Liu S, Liu L, Wang J, Zhang F, Lu D, Zhu H, 2013
- HIV-1 Co-Receptor Usage Based on V3 Loop Sequence Analysis: Preferential Suppression of CXCR4 Virus Post HAART?, Jiao Y, Wang P, Zhang H, Zhang T, Zhang Y, Zhu H, Wu H, 2011
Awards
- Clarivate Highly Cited Researcher 2023
- World's Top 2% Scientists 2023 (Elsevier/Stanford)
