Areas of Focus
- Virology
- Structural Biology
Work Experience
- 2014-11 to Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
- 2014-07 to 2014-10 - Institute of Biophysics, Chinese Academy of Sciences - Associate Researcher
- 2009-09 to 2014-06 - University of Chinese Academy of Sciences - Ph.D. Student
- 2005-09 to 2009-06 - Sichuan University - Bachelor's Student
Academic Background & Achievements
- 2009-09 to 2014-06 Ph.D. in Science: University of Chinese Academy of Sciences
- 2005-09 to 2009-06 Bachelor's in Science: Sichuan University
Publications
- Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies, Xiangxi Wang, 2022
- Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron, Xiangxi Wang, 2022
- Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants, Xiangxi Wang, 2022
- A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2, Xiangxi Wang, 2021
- SARS-CoV-2 spike protein interacts with and activates TLR4, Xiangxi Wang, 2021
- Structural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody, Xiangxi Wang, 2021
- Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms, Xiangxi Wang, 2021
- Structure-based development of human antibody cocktails against SARS-CoV-2, Xiangxi Wang, 2021
- Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein, Xiangxi Wang, 2021
- Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial, Xiangxi Wang, 2021
- Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies, Xiangxi Wang, 2021
- Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection, Xiangxi Wang, 2021
- Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2, Xiangxi Wang, 2021
- Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2, Xiangxi Wang, 2021
- Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19, Xiangxi Wang, 2021
- Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10, Xiangxi Wang, 2020
- Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation, Xiangxi Wang, 2020
- Serotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B, Xiangxi Wang, 2020
- Structures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage, Xiangxi Wang, 2020
- Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody, Xiangxi Wang, 2020
- Development of an inactivated vaccine candidate for SARS-CoV-2, Xiangxi Wang, 2020
- Design, Synthesis, and Evaluation of Novel Enterovirus 71 Inhibitors as Therapeutic Drug Leads for the Treatment of Human Hand, Foot, and Mouth Disease, Xiangxi Wang, 2020
- Architecture of the herpesvirus genome-packaging complex and implications for DNA translocation, Xiangxi Wang, 2020
- Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors, Xiangxi Wang, 2019
- Architecture of African swine fever virus and implications for viral assembly, Xiangxi Wang, 2019
- Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71, Xiangxi Wang, 2018
- Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies, Xiangxi Wang, 2018
- Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component, Xiangxi Wang, 2018
- Cryo-EM structure of Type III-A CRISPR effector complex, Xiangxi Wang, 2018
- Cryo-EM structure of a herpesvirus capsid at 3.1 angstrom, Xiangxi Wang, 2018
- Structures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating, Xiangxi Wang, 2018
- Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site, Xiangxi Wang, 2017
- Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability, Xiangxi Wang, 2017
- Structure of human Aichi virus and implications for receptor binding, Xiangxi Wang, 2016
- Structure of Ljungan virus reveals a novel mechanism for picornavirus genome packaging, Xiangxi Wang, 2015
- Hepatitis A virus and the origins of picornaviruses, Xiangxi Wang, 2015
- More powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules, Xiangxi Wang, 2014
- Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71, Xiangxi Wang, 2014
- Picornavirus uncoating intermediate captured in atomic detail, Xiangxi Wang, 2013
- An open conformation determined by a structural switch for 2A protease from coxsackievirus A16, Xiangxi Wang, 2013
- A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71, Xiangxi Wang, 2012
Awards
- Young Top-notch Talent of the Ten Thousand Talents Program (2019): Ministry-level
- Top Ten Scientific Advances in China (2019): Ministry-level
- Top Ten Advances in Life Sciences in China (2018): Ministry-level
- First Youth Support Project of the China Association for Science and Technology (2015): Ministry-level
- Fourth Bei Shizhang Young Biophysicist Award (2015): Ministry-level