Areas of Focus
- Natural Immunity
- Stem Cells
- Cancer Biology
Work Experience
- 2015-03~Present - University of Chinese Academy of Sciences - Researcher
- 2007-05~Present - Institute of Zoology, Chinese Academy of Sciences - Researcher
- 2006-01~2007-12 - University of Texas Southwestern Medical Center - Lecturer
- 2001-12~2005-12 - University of Texas Southwestern Medical Center - Postdoctoral
- 2000-02~2000-11 - University of Kentucky - Postdoctoral
- 1996-09~1999-07 - Institute of Botany, Chinese Academy of Sciences - PhD
- 1993-09~1996-07 - Shandong Agricultural University - Master's
- 1989-09~1993-07 - Shandong Agricultural University - Bachelor's
Academic Background & Achievements
- 1996-09--1999-07 PhD: Institute of Botany, Chinese Academy of Sciences
- 1993-09--1996-07 Master's: Shandong Agricultural University
- 1989-09--1993-07 Bachelor's: Shandong Agricultural University
Publications
- PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling, NATURE COMMUNICATIONS, 2023
- Ku proteins promote DNA binding and condensation of cyclic GMP-AMP synthase, CELL REPORTS, 2022
- PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation, NATURE COMMUNICATIONS, 2022
- Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay, NATURE COMMUNICATIONS, 2022
- KIZ/GM114 Balances the NF-κB Signaling by Antagonizing the Association of TRAF2/6 With Their Upstream Adaptors, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022
- RNA-Seq analysis of gene expression profile of human macrophages infected by vaccinia virus, 微生物学报, 2021
- ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021
- USP27X negatively regulates antiviral signaling by deubiquitinating RIG-I, PLOS PATHOGENS, 2020
- LC Domain-Mediated Coalescence Is Essential for Otu Enzymatic Activity to Extend Drosophila Lifespan, MOLECULAR CELL, 2019
- 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda, NATURE COMMUNICATIONS, 2019
- Parkin negatively regulates the antiviral signaling pathway by targeting TRAF3 for degradation, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018
- Partial loss of psychiatric risk gene miR-137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a, NATURE NEUROSCIENCE, 2018
- Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
- Membrane Targeting of Inhibitory Smads Through Palmitoylation Controls TGF-β/BMP Signaling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
- Syndecan-4 negatively regulates antiviral signaling by mediating RIG-I deubiquitination via CYLD, NATURE COMMUNICATIONS, 2016
- Identification of miRNomes Reveals ssc-miR-30d-R_1 as a Potential Therapeutic Target for PRRS Viral Infection, SCIENTIFIC REPORTS, 2016
- MAVS Maintains Mitochondrial Homeostasis via Autophagy, CELL DISCOVERY, 2016
- Critical POU Domain Residues Confer Oct4 Uniqueness in Somatic Cell Reprogramming, SCIENTIFIC REPORTS, 2016
- PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation, PUBLIC LIBRARY OF SCIENCE, 2015
- N6-Methyladenine Functions as a Potential Epigenetic Mark in Eukaryotes, BIOESSAYS, 2015
- Stucturally Diverse Sesquiterpenes Produced by a Chinese Tibet Fungus Stereum hirsutum and Their Cytotoxic and Immunosuppressant Activities, ORGANIC LETTERS, 2015
- Cell-surface localization of Pellino antagonizes Toll-mediated innate immune signaling by controlling MyD88 turnover in Drosophila, NATURE COMMUNICATIONS, 2014
- Coordination of Engineered Factors with TET1/2 Promotes Early-Stage Epigenetic Modification during Somatic Cell Reprogramming, STEM CELL REPORTS, 2014
- Genome-Wide Loss of 5-hmC Is a Novel Epigenetic Feature of Huntingtons Disease, HUMAN MOLECULAR GENETICS, 2013
- Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington Disease, JOURNAL OF BIOLOGICAL CHEMISTRY, 2013
- COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production, PLOS PATHOGENS, 2012
- The Fused/Smurf Complex Controls the Fate of Drosophila Germline Stem Cells by Generating a Gradient BMP Response, CELL, 2010
- Murine Gamma-Herpesvirus 68 Hijacks MAVS and IKK beta to Initiate Lytic Replication, PLOS PATHOGENS, 2010
- 光照和温度对豌豆Lhcb2基因表达的影响, 植物学报:英文版, 2000
- 豌豆Lhcb2基因在大肠杆菌中的高效表达及其表达产物与色素的重组, 中国科学(C辑), 2000
- 高等植物光系统II捕光色素蛋白复合体结构与功能研究的新进展, 植物学通报, 2000
- 豌豆Lhcb2 基因的克隆、表达、功能分析及其克隆化蛋白与色素体外重组系统的建立, Cloning, Expression, Functional Analysis of Pea Lhcb2 Gene and Construction of Reconstitution System with its Protein Overexpressed in E. coli and Pigment Vitro, 1999
- 纯化膜蛋白质复合体Cytb6f的新方法, 植物学报:英文版, 1998