Areas of Focus
- Tumor Metabolism
- Tumor Immunology
- Epigenetics
Work Experience
- 2015-2020 - University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Postdoctoral Researcher
- 2020-Present - Tongji University, School of Life Science and Technology, Distinguished Research Fellow
Academic Background & Achievements
- 2010 - Bachelor's Degree: Xiamen University, School of Life Sciences
- 2015 - PhD: Fudan University, Biochemistry and Molecular Biology
- Selected for Shanghai Overseas High-Level Talents, Oriental Scholar Special Professor, Pujiang Talent Plan
- Received support from National Natural Science Foundation, National Key R&D Program, Shanghai Municipal Projects
Publications
- Targeting fibrinogen-like protein 1 enhances immunotherapy in hepatocellular carcinoma, Lin, M., He, J., Zhang, X., Sun, X., Dong, W., Zhang, R., Xu, Y.*, and Lv, L.*, 2023
- TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential, He, J., Lin, M., Zhang, X., Zhang, R., Tian, T., Zhou, Y., Dong, W., Yang, Y., Sun, X., Dai, Y., Xu, Y., Zhang, Z., Xu, M., Lei, Q.Y., Xu, Y.*, and Lv, L.*, 2023
- D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1, Zhang, R., Yang, Y., Dong, W., Lin, M., He, J., Zhang, X., Tian, T., Yang, Y., Chen, K., Lei, Q.Y., Zhang, S.*, Xu, Y.*, and Lv, L.*, 2022
- TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling, Zhang, X., Li, S., He, J., Jin, Y., Zhang, R., Dong, W., Lin, M., Yang, Y., Tian, T., Zhou, Y., Xu, Y., Lei, Q.Y., Zhang, J., Zhang, Q., Xu, Y.*, and Lv, L.*, 2022
- USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2, Chen, L.L., Smith, M.D., Lv, L., Nakagawa, T., Li, Z., Sun, S.C., Brown, N.G., Xiong, Y.*, and Xu, Y.*, 2020
- Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy, Xu, Y., Lv, L., Liu, Y., Smith, M.D., Li, W.C., Tan, X.M., Cheng, M., Li, Z., Bovino, M., Aube, J., Xiong, Y.*, 2019
- Vpr Targets TET2 for Degradation by CRL4(VprBP) E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication, Lv, L., Wang, Q., Xu, Y., Tsao, L.C., Nakagawa, T., Guo, H., Su, L.*, and Xiong, Y.*, 2018
- Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication, Murphy, C.M., Xu, Y., Li, F., Nio, K., Reszka-Blanco, N., Li, X., Wu, Y., Yu, Y., Xiong, Y.*, and Su, L.*, 2016
- Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase, Xu, Y., Li, F., Lv, L., Li, T., Zhou, X., Deng, C.X., Guan, K.L., Lei, Q.Y.*, and Xiong, Y.*, 2014
- Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization, Lv, L., Xu, Y., Zhao, D., Li, F.L., Wang, W., Sasaki, N., Jiang, Y., Zhou, X., Li, T.T., Guan, K.L., Lei, Q.Y.*, and Xiong, Y.*, 2013
