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Xiang Sheng
Life Sciences
University of Chinese Academy of Sciences
Tianjin
Language: Chinese, English
Computational Enzymology
Biocatalysis
Enzyme Conformational Dynamics
Artificial Enzyme Design
Quantum Chemical Cluster Approach
Coenzyme Engineering
Selective Synthesis
Enzyme Mechanism
Enzyme Rational Design
Enzyme Activity
Areas of Focus
- Computational Enzymology
- Biocatalysis
- Enzyme Conformational Dynamics
- Artificial Enzyme Design
Work Experience
- 2021-02~Present - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Researcher, Group Leader
- 2019-01~2020-11 - Stockholm University - Research Scientist
- 2014-08~2018-12 - Stockholm University - Postdoctoral Researcher
Academic Background & Achievements
- 2009-09--2014-06 Ph.D. in Science: Shandong University
- 2005-09--2009-06 Bachelor's in Science: Changchun University of Science and Technology
Publications
- The Quantum Chemical Cluster Approach in Biocatalysis, Xiang Sheng, Himo, Fahmi, 2023
- Coenzyme Engineering of Glucose-6-phosphate Dehydrogenase on a Nicotinamide-Based Biomimic and Its Application as a Glucose Biosensor, Meng, Dongdong, Liu, Meixia, Su, Hao, Song, Haiyan, Chen, Lijie, Li, Qiangzi, Liu, Yanan, Zhu, Zhiguang, Liu, Weidong, Sheng, Xiang, You, Chun, Zhang, Job, 2023
- Creating a new benzaldehyde lyase for atom-economic synthesis of chiral 1,2,4-butanetriol and 2-aminobutane-1,4-diol from formaldehyde, Yu Li, Peiyuan Yao, Shiqing Zhang, Jinhui Feng, Hao Su, Xiangtao Liu, Xiang Sheng, Qiaqing Wu, Dunming Zhu, Yanhe Ma, 2023
- Peroxygenase-Catalyzed Selective Synthesis of Calcitriol Starting from Alfacalcidol, Li, Yuanying, Zhang, Pengpeng, Sun, Zhoutong, Li, Huanhuan, Ge, Ran, Sheng, Xiang, Zhang, Wuyuan, 2022
- Molecular Basis of the Unusual Seven-Membered Methylenedioxy Bridge Formation Catalyzed by Fe (II)/α-KG-Dependent Oxygenase CTB9, Xuanzhong Liu, Zhenbo Yuan, Hao Su, Xiaodong Hou, Zhiwei Deng, Huibin Xu, Baodang Guo, Dejing Yin, Xiang Sheng, Yijian Rao, 2022
- A Biocatalytic Platform for the Synthesis of Enantiopure Propargylic Alcohols and Amines, Sang, Xianke, Tong, Feifei, Zeng, Zhigang, Wu, Minghu, Yuan, Bo, Sun, Zhoutong, Sheng, Xiang, Qu, Ge, Alcalde, Miguel, Hollmann, Frank, Zhang, Wuyuan, 2022
- Biocatalytic Baeyer–Villiger Reactions: Uncovering the Source of Regioselectivity at Each Evolutionary Stage of a Mutant with Scrutiny of Fleeting Chiral Intermediates, Yijie Dong, Tang Li, Shiqing Zhang, Joaquin Sanchis, Heng Yin, Jie Ren, Xiang Sheng, Guangyue Li, Manfred T. Reetz, 2022
- Solvent Dependency in Stereoselective δ-Lactam Formation of Chiral α-Fluoromalonate Derivatives: Stereodivergent Synthesis of Heterocycles with Fluorine Containing Stereocenters Adjacent to Tertiary Stereocenters, Kaiheng Zhang, Xiang Sheng, Luca Deiana, Erik Svensson Grape, A. Ken Inge, Fahmi Himo, Armando Córdova, 2022
- Computational Study of Mechanism and Enantioselectivity of Imine Reductase from Amycolatopsis orientalis, Mario Prejan, Xiang Sheng, Fahmi Himo, 2022
- β-Methyltryptamine Provoking the Crucial Role of Strictosidine Synthase Tyr151-OH for Its Stereoselective Pictet− Spengler Reactions to Tryptoline-type Alkaloids, Haicheng Liu, Santosh Panjikar, Xiang Sheng, Yushi Futamura, Chenghua Zhang, Nana Shao, Hiroyuki Osada, Hongbin Zou, 2022
- A Combined Computational-Experimental Study on the Substrate Binding and Reaction Mechanism of Salicylic Acid Decarboxylase, Chen, Fuqiang, Zhao, Yipei, Zhang, Chenghua, Wang, Wei, Gao, Jian, Li, Qian, Qin, Huimin, Dai, Yujie, Liu, Weidong, Liu, Fufeng, Su, Hao, Sheng, Xiang, 2022
- Unraveling the mechanism of enantio-controlling switches of an alcohol dehydrogenase toward sterically small ketone, Yingying Jiang, Ge Qu, Xiang Sheng, Feifei Tong, Zhoutong Sun, 2022
- Design of a gold clustering site in an engineered apo-ferritin cage, Chenlin Lu, Basudev Maity, Xue Peng, Nozomi Ito, Satoshi Abe, Xiang Sheng, Takafumi Ueno, Diannan Lu, 2022
- Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids, Liu, Na, Wu, Lian, Feng, Jinhui, Sheng, Xiang, Li, Jian, Chen, Xi, Li, Jianjiong, Liu, Weidong, Zhou, Jiahai, Wu, Qiaqing, Zhu, Dunming, 2021
- Metal Ion Promiscuity and Structure of 2,3-Dihydroxybenzoic Acid Decarboxylase of Aspergillus oryzae, Hofer, Gerhard, Sheng, Xiang, Braeuer, Simone, Payer, Stefan E, Plasch, Katharina, Goessler, Walter, Faber, Kurt, Keller, Walter, Himo, Fahmi, Glueck, Silvia M., 2021
- Mechanisms of metal-dependent non-redox decarboxylases from quantum chemical calculations, Sheng, Xiang, Himo, Fahmi, 2021
- Computational Study of Pictet–Spenglerase Strictosidine Synthase: Reaction Mechanism and Origins of Enantioselectivity of Natural and Non-Natural Substrates, Xiang Sheng, Fahmi Himo, 2020
- Mechanism of Biocatalytic Friedel-Crafts Acylation by Acyltransferase from Pseudomonas protegen, Xiang Sheng, Masoud Kazemi, Anna Żądło-Dobrowolska, Wolfgang Kroutil, Fahmi Himo, 2020
- Modeling Enzymatic Enantioselectivity using Quantum Chemical Methodology, Sheng, Xiang, Shalkouhi, Masoud Kazemi, Planas, Ferran, Himo, Fahmi, 2020
- Mechanism of 3-Methylglutaconyl CoA Decarboxylase AibA/AibB: Pericyclic Reaction vs. Direct Decarboxylation, Xiang Sheng, Fahmi Himo, 2020
- Origins of Enantiopreference of Mycobacterium smegmatis Acyl Transferase: A Computational Analysis, Kazemi, Masoud, Sheng, Xiang, Himo, Fahmi, 2019
- Enzymatic Pictet-Spengler Reaction: Computational Study of the Mechanism and Enantioselectivity of Norcoclaurine Synthase, Sheng, Xiang, Himo, Fahmi, 2019
- Computational evidence for the importance of lysine carboxylation in the reaction catalyzed by carboxyl transferase domain of pyruvate carboxylase: a QM/MM study, Sheng, Xiang, Hou, Qianqian, Liu, Yongjun, 2019
- Reaction Mechanism and Substrate Specificity of Iso-orotate Decarboxylase: A Combined Theoretical and Experimental Study, Sheng, Xiang, Pasch, Katharina, Payer, Stefan E, Ertl, Claudia, Hofer, Gerhard, Keller, Walter, Braeuer, Simone, Goessler, Walter, Glueck, Silvia M, Himo, Fahmi, Faber, Kurt, 2018
- Computational Study of Mycobacterium smegmatis Acyl Transferase Reaction Mechanism and Specificity, Kazemi, Masoud, Sheng, Xiang, Kroutil, Wolfgang, Himo, Fahmi, 2018
- A Theoretical Study of the Benzoylformate Decarboxylase Reaction Mechanism, Planas, Ferran, Sheng, Xiang, McLeish, Michael J, Himo, Fahmi, 2018
- Exploring the Catalytic Promiscuity of Phenolic Acid Decarboxylases: Asymmetric, 1,6-Conjugate Addition of Nucleophiles Across 4-Hydroxystyrene, Payer, Stefan E, Sheng, Xiang, Pollak, Hannah, Wuensch, Christiane, Steinkellner, Georg, Himo, Fahmi, Glueck, Silvia M, Faber, Kurt, 2017
- Mechanistic Insights into the Decoupled Desaturation and Epoxidation Catalyzed by Dioxygenase AsqJ Involved in the Biosynthesis of Quinolone Alkaloids, Su, Hao, Sheng, Xiang, Zhu, Wenyou, Ma, Guangcai, Liu, Yongjun, 2017
- Mechanism and Structure of γ-Resorcylate Decarboxylase, Xiang Sheng, Yury Patskovsky, Anna Vladimirova, Jeffrey B Bonanno, Steven C Almo, Fahmi Himo, Frank M Raushel, 2017
- A Combined Experimental-Theoretical Study of the LigW-Catalyzed Decarboxylation of 5-Carboxyvanillate in the Metabolic Pathway for Lignin Degradation, Sheng, Xiang, Zhu, Wen, Huddleston, Jamison, Xiang, Dao Fen, Raushel, Frank M, Richards, Nigel G J, Himo, Fahmi, 2017
- Theoretical Study of Enzyme Promiscuity: Mechanisms of Hydration and Carboxylation Activities of Phenolic Acid Decarboxylase, Sheng, Xiang, Himo, Fahmi, 2017
- Exploring the substrate specificity and catalytic mechanism of imidazolonepropionase (HutI) from Bacillus subtilis, Su, Hao, Sheng, Xiang, Liu, Yongjun, 2016
- Insights into the catalytic mechanism of N-acetylglucosaminidase glycoside hydrolase from Bacillus subtilis: a QM/MM study, Su, Hao, Sheng, Xiang, Liu, Yongjun, 2016
- Theoretical study of the reaction mechanism of phenolic acid decarboxylase, Sheng, Xiang, Lind, Maria E S, Himo, Fahmi, 0201
