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Lei Tan
Life Science
University of Chinese Academy of Sciences
Guangdong
Language: Chinese, English
Synthetic Biology
Virus Vaccines
Codon Expansion
Stem Cells
Polysaccharide Markers
Tumor Cells
Disease Models
Tumor Therapy
Cell Proliferation
Differentiation Control
Areas of Focus
- Synthetic Biology for Virus Vaccines
- Synthetic Biology for Stem Cells
- Polysaccharide Markers in Tumor Cells
Work Experience
- 2019-10 to Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Associate Researcher
- 2012-06 to 2019-06 - Weill Cornell Medical College, New York, USA - Postdoctoral Researcher
- 2010-11 to 2012-06 - Moffitt Cancer Center, Tampa, Florida, USA - Postdoctoral Researcher
Academic Background & Achievements
- 2002-09 to 2010-01 PhD: Peking University
- 1998-09 to 2002-07 Bachelor's: Peking University
Publications
- Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors, Li, Hongda, SaucedoCuevas, Laura, Yuan, Ling, Ross, Danica, Johansen, Anide, Sands, Daniel, Stanley, Valentina, GuemezGamboa, Alicia, Gregor, Anne, Evans, Todd, Chen, Shuibing, Tan, Lei, Molina, Henrik, Sheets, Nicholas, Shiryaev, Sergey A, Terskikh, Alexey, V, Gladfelter, Amy S, Shresta, Sujan, Xu, Zhiheng, Gleeson, Joseph G., 2019
- Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells, Lei Tan, Lauretta A Lacko, Ting Zhou, Delia Tomoiaga, Romulo Hurtado, Tuo Zhang, Ana Sevilla, Aaron Zhong, Christopher E Mason, Scott Noggle, Todd Evans, Heidi Stuhlmann, Robert E Schwartz, Shuibing Chen, 2019
- Derivation and characterization of a UCP1 reporter human ES cell line, Mukherjee, Suranjit, Zhang, Tuo, Lacko, Lauretta A, Tan, Lei, Xiang, Jenny Zhaoying, Butler, Jason M, Chen, Shuibing, 2018
- A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival, Ting Zhou, Tae Wan Kim, Chi Nok Chong, Lei Tan, Sadaf Amin, Zohreh Sadat Badieyan, Suranjit Mukherjee, Zaniar Ghazizadeh, Hui Zeng, Min Guo, Miguel Crespo, Tuo Zhang, Reyn Kenyon, Christopher L Robinson, Effie Apostolou, Hui Wang, Jenny Zhaoying Xiang, Todd Evans, Lorenz Studer, Shuibing Chen, 2018
- High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain, Zhou, Ting, Tan, Lei, Cederquist, Gustav Y, Fan, Yujie, Hartley, Brigham J, Mukherjee, Suranjit, Tomishima, Mark, Brennand, Kristen J, Zhang, Qisheng, Schwartz, Robert E, Evans, Todd, Studer, Lorenz, Chen, Shuibing, 2017
- An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery, Zeng, Hui, Guo, Min, Zhou, Ting, Tan, Lei, Chong, Chi Nok, Zhang, Tuo, Dong, Xue, Xiang, Jenny Zhaoying, Yu, Albert S, Yue, Lixia, Qi, Qibin, Evans, Todd, Graumann, Johannes, Chen, Shuibing, 2016
- Holoclone Forming Cells from Pancreatic Cancer Cells Enrich Tumor Initiating Cells and Represent a Novel Model for Study of Cancer Stem Cells, Tan, Lei, Sui, Xin, Deng, Hongkui, Ding, Mingxiao, 2011
- Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus, Ren, Xiaofeng, Glende, Jorg, AlFalah, Marwan, de Vries, Victor, SchwegmannWessels, Christel, Qu, Xiuxia, Tan, Lei, Tschernig, Thomas, Deng, Hongkui, Naim, Hassan Y, Herrler, Georg, 2006
- Nestin(neg)CD24(low/-) population from fetal Nestin-EGFP transgenic mice enriches the pancreatic endocrine progenitor cells, Wang, XJ, Hu, JJ, Zhao, DX, Wang, GW, Tan, L, Du, LY, Yang, J, Hou, LL, Zhang, H, Yu, YS, Zhang, H, Deng, HK, Ding, MX, 2005
- Highly infectious SARS-CoV pseudotyped virus reveals the cell tropism and its correlation with receptor expression, Nie, YC, Wang, PG, Shi, XL, Wang, GW, Chen, J, Zheng, AH, Wang, W, Wang, Z, Qu, XX, Luo, M, Tan, L, Song, XJ, Yin, XL, Chen, JG, Ding, MX, Deng, HK, 2004
- Expression cloning of functional receptor used by SARS coronavirus, Wang, PG, Chen, J, Zheng, AH, Nie, YC, Shi, XL, Wang, W, Wang, GW, Luo, M, Liu, HJ, Tan, L, Song, XJ, Wang, Z, Yin, XL, Qu, XX, Wang, XJ, Qing, TT, Ding, MX, Deng, HK, 2004
