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He Zhang
Life Science
Tongji University
Shanghai
Language: Chinese, English
Chromatin
Gene Regulation
Transcription
Cancer
Lncrna
3D Genome Architecture
Stem Cells
Tumor Cells
Autophagy
Targeted Therapy
Areas of Focus
- Epigenetics
- Genomics
- Oncology
Work Experience
- 2009-2012 - Postdoctoral Researcher in Epigenetics, Stanford University School of Medicine
- 2012-present - Various academic roles at Shanghai Jiao Tong University and Tongji University, including Professor and Doctoral Supervisor
Academic Background & Achievements
- 2009 - PhD in Biochemistry and Molecular Biology from Shanghai Jiao Tong University School of Medicine
- Joint PhD training at Stanford University School of Medicine in Epigenetics (2007-2009)
- Published 21 SCI papers as corresponding author, 6 as first author
- Hosted 12 major research projects including national key R&D programs
Publications
- In-depth understanding of higher-order genome architecture in orphan cancer, H Zhang*, 2023
- Chromosomal instabilityassociated MAT1 lncRNA insulates MLL1-guided histone methylation and accelerates tumorigenesis, H Zhang*, 2022
- Interruption of aberrant chromatin looping is required for regenerating RB1 function and suppressing tumorigenesis, H Zhang*, 2022
- Novel biological insights revealed from the investigation of multiscalegenome architecture, H Zhang*, 2022
- Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis, H Zhang*, 2020
- ZNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression, H Zhang*, 2020
- A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3, H Zhang*, 2020
- A cohesin-mediated intrachromosomal loop drives oncogenic ROR lncRNA for accelerating tumorigenesis, H Zhang*, 2019
- Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis, H Zhang*, 2018
- Novel insights into chromosomal conformations in cancer, H Zhang*, 2017
- CANT1 lncRNA triggers efficient therapeutic efficacy by correcting aberrant lncing cascade in malignant uveal melanoma, H Zhang*, 2017
- Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis, H Zhang*, 2015
- Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus, H Zhang*, 2014
- Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming, H Zhang*, 2013
- Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway, H Zhang*, 2012
- Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II, H Zhang*, 2011
- Enhanced therapeutic efficacy by simultaneously targeting two genetic defects in tumors, H Zhang*, 2009
Awards
- National Science and Technology Progress Second Prize (2018, 2015)
- Shanghai Science and Technology Progress First Prize (2017, 2014, 2012)
- Ministry of Education Science and Technology Progress First Prize (2014)
