Professor | He Zhang | Asia Growth Partners

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Name	He Zhang
Contact Information	zhanghe@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

He Zhang

Contact Information

zhanghe@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2009 - PhD in Biochemistry and Molecular Biology from Shanghai Jiao Tong University School of Medicine Joint PhD training at Stanford University School of Medicine in Epigenetics (2007-2009) Published 21 SCI papers as corresponding author, 6 as first author Hosted 12 major research projects including national key R&D programs
Work Experience	2009-2012 - Postdoctoral Researcher in Epigenetics, Stanford University School of Medicine 2012-present - Various academic roles at Shanghai Jiao Tong University and Tongji University, including Professor and Doctoral Supervisor
Awards	National Science and Technology Progress Second Prize (2018, 2015) Shanghai Science and Technology Progress First Prize (2017, 2014, 2012) Ministry of Education Science and Technology Progress First Prize (2014)

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2009 - PhD in Biochemistry and Molecular Biology from Shanghai Jiao Tong University School of Medicine
Joint PhD training at Stanford University School of Medicine in Epigenetics (2007-2009)
Published 21 SCI papers as corresponding author, 6 as first author
Hosted 12 major research projects including national key R&D programs

Work Experience

2009-2012 - Postdoctoral Researcher in Epigenetics, Stanford University School of Medicine
2012-present - Various academic roles at Shanghai Jiao Tong University and Tongji University, including Professor and Doctoral Supervisor

Awards

National Science and Technology Progress Second Prize (2018, 2015)
Shanghai Science and Technology Progress First Prize (2017, 2014, 2012)
Ministry of Education Science and Technology Progress First Prize (2014)

Areas of Focus	Epigenetics Genomics Oncology
Publications	In-depth understanding of higher-order genome architecture in orphan cancer, H Zhang, 2023 Chromosomal instabilityassociated MAT1 lncRNA insulates MLL1-guided histone methylation and accelerates tumorigenesis, H Zhang, 2022 Interruption of aberrant chromatin looping is required for regenerating RB1 function and suppressing tumorigenesis, H Zhang, 2022 Novel biological insights revealed from the investigation of multiscalegenome architecture, H Zhang, 2022 Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis, H Zhang, 2020 ZNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression, H Zhang, 2020 A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3, H Zhang, 2020 A cohesin-mediated intrachromosomal loop drives oncogenic ROR lncRNA for accelerating tumorigenesis, H Zhang, 2019 Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis, H Zhang, 2018 Novel insights into chromosomal conformations in cancer, H Zhang, 2017 CANT1 lncRNA triggers efficient therapeutic efficacy by correcting aberrant lncing cascade in malignant uveal melanoma, H Zhang, 2017 Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis, H Zhang, 2015 Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus, H Zhang, 2014 Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming, H Zhang, 2013 Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway, H Zhang, 2012 Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II, H Zhang, 2011 Enhanced therapeutic efficacy by simultaneously targeting two genetic defects in tumors, H Zhang*, 2009

Areas of Focus

Epigenetics
Genomics
Oncology

Publications

In-depth understanding of higher-order genome architecture in orphan cancer, H Zhang*, 2023
Chromosomal instabilityassociated MAT1 lncRNA insulates MLL1-guided histone methylation and accelerates tumorigenesis, H Zhang*, 2022
Interruption of aberrant chromatin looping is required for regenerating RB1 function and suppressing tumorigenesis, H Zhang*, 2022
Novel biological insights revealed from the investigation of multiscalegenome architecture, H Zhang*, 2022
Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis, H Zhang*, 2020
ZNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression, H Zhang*, 2020
A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3, H Zhang*, 2020
A cohesin-mediated intrachromosomal loop drives oncogenic ROR lncRNA for accelerating tumorigenesis, H Zhang*, 2019
Dynamic chromosomal tuning of a novel GAU1 lncing driver at chr12p13.32 accelerates tumorigenesis, H Zhang*, 2018
Novel insights into chromosomal conformations in cancer, H Zhang*, 2017
CANT1 lncRNA triggers efficient therapeutic efficacy by correcting aberrant lncing cascade in malignant uveal melanoma, H Zhang*, 2017
Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis, H Zhang*, 2015
Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus, H Zhang*, 2014
Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming, H Zhang*, 2013
Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway, H Zhang*, 2012
Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II, H Zhang*, 2011
Enhanced therapeutic efficacy by simultaneously targeting two genetic defects in tumors, H Zhang*, 2009

Chromatin Gene Regulation Transcription Cancer Lncrna 3D Genome Architecture Stem Cells Tumor Cells Autophagy Targeted Therapy

Songcheng Zhu - Tongji University

Jing Liu - Central South University

Xiongwen Cao - East China Normal University

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