1998-10 to 2003-12 PhD in Immunology: University of Montreal, Canada
1993-07 to 1998-06 Master's in Biochemistry: McGill University, Canada
1983-09 to 1987-07 Bachelor's in Biology: Shihezi University, Xinjiang
Research
Biomedicine
CD317 Promotes the survival of cancer cells through apoptosis-inducing factor, Xin Li, Guizhong Zhang, Qian Chen, Yingxue Lin, Junxin Li, Qinggguo Ruan, Youhai Chen, Guang Yu, and Xiaochun Wan, 2016
JSI-124 inhibits IgE production in an IgE B cell line, Lulu Cui, Jiacheng Bi, Dehong Yan, Xiufeng Ye, Mingxing Zheng, Guang Yu, Xiaochun Wan, 2017
NK cells alleviate lung inflammation by negatively regulating group 2 innate lymphoid cells, Jiacheng Bi, Lulu Cui, Gang Yu, Xiaolu Yang, Youhai Chen, Xiaochun Wan, 2017
Silencing c-Rel in macrophages dampens Th1 and Th17 immune responses and alleviates experimental autoimmune encephalomyelitis in mice, Hongling Zhang, Jiacheng Bi, Huqiang Yi, Tingting Fan, Qingguo Ruan, Lintao Cai, Youhai H Chen, Xiaochun Wan, 2017
Regulation of NF-κB by PML and PML-RARα, Abrar Ahmed, Xiaochun Wan, Izaskun Mitxitorena, Andrew J. Lindsay, Pier Paolo Pandolfi, Mary W. McCaffrey, Karen Keeshan, Youhai H. Chen, Ruaidhrí J. Carmody, 2017
DcR3 combined with hematological traits serves as a valuable biomarker for the diagnosis of cancer metastasis, Junxin Li, Ni Xie, Jianhui Yuan, Lvyan Liu, Qiming Zhou, Xiaohu Ren, Qian Chen, Guizhong Zhang, Qingguo Ruan, Youhai H. Chen, Xiaochun Wan, 2017
Impaired cytolytic activity of asthma-associated natural killer cells is linked to dysregulated transcriptional program in energy metabolism, Haisi Wu, Jiacheng Bi, Gaohui Wu, Chaoyue Zheng, Zhen Lu, Lulu Cui, Xiaochun Wan, 2018
Vaccination with a DNA vaccine encoding CD317-targeting HBs antigen elicits enhanced immunity in mice, Guizhong Zhang, Xin Li, Lvyan Liu, Junxin Li, Qian Chen, Shiran Huang, Yutao Li, Xiaochun Wan, 2018
CD317 activates EGFR by regulating its association with lipid rafts, Guizhong Zhang, Xin Li, Qian Chen, Junxin Li, Qingguo Ruan, Youhai H. Chen, Xiaolu Yang, Xiaochun Wan, 2019
Lipid metabolic pathways confer immunosuppressive function of myeloid-derived suppressor cells in tumor, Dehong Yan, Adeleye O. Adeshakin, Meichen Xu, Lukman O. Afolabi, Guizhong Zhang, Youhai H Chen, Xiaochun Wan, 2019
Preclinical studies of a death receptor-5 fusion protein that ameliorates acute liver failure and inflammation, Qian Chen, Pu Wang, Qingmei Zhang, Meng Xia, Guizhong Zhang, Junxin Li, Enyun Shen, Youhai H. Chen, Xiaochun Wan, 2019
Rapid isolation of a potent human antibody against H7N9 influenza virus from an infected patient, Li, Junxin; Yang, Yang; Wang, Min; Ren, Xiaohu; Yang, Zheng; Liu, Lvyan; Zhang, Guizhong; Chen, Qian; Yang, Wei; Chen, Youhai H; Wan, Xiaochun, 2019
Genetic Reprogramming For NK cell Cancer Immunotherapy with CRISPR/Cas9, Afolabi, Lukman; Adeshakin, Adeleye; Sani, Musbahu; Bi, Jiacheng; Wan, Xiaochun, 2019
TIPE2 Specifies the Functional Polarization of Myeloid-derived Suppressor Cells during Tumorigenesis, Dehong Yan, Jinghui Wang, Honghong Sun, Ali Zamani, Honglin Zhang, Weihong Chen, Aifa Tang, Qingguo Ruan, Xiaolu Yang, Youhai Chen, Xiaochun Wan, 2019
Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL, Qian Chen, Dehong Yan, Qingmei Zhang, Guizhong Zhang, Meng Xia, Junxin Li, Wugen Zhan, Enyun Shen, Youhai H. Chen, Xiaochun Wan, 2019
IL-33-induced reactive oxygen species are required for optimal metabolic programming in group 2 innate lymphoid cells, Zheng, Chaoyue; Wu, Haisi; Lu, Zhen; Bi, Jiacheng; Wan, Xiaochun, 2020
A Novel Virtual Screening Procedure Identifies Pralatrexate as Inhibitor of SARS-CoV-2 RdRp and It Reduces Viral Replication in vitro, Haiping Zhang, Yang Yang, Junxin Li, Min Wang, Konda Mani Saravanan, Jinli Wei, Justin Tze-Yang, Md. Tofazzal Hossain, Maoxuan Liu, Huiling Zhang, Xiaohu Ren, Yi Pan, Yin Peng, Yi Shi, Xiaochun Wan, Yingxia Liu, Yanjie Wei, 2020
DAMPs released by pyroptotic cells as major contributor and therapeutic target for CAR-T-related toxicities, Tian Deng, Chao Tang, Guizhong Zhang, and Xiaochun Wan, 2021
Regulation of lipid metabolism in MDSCs by targeting fatty acid transport protein 2 enhanced anti-PD-L1 tumor immunotherapy, Adeleye Oluwatosin Adeshakin, Wan Liu, Funmilayo O. Adeshakin, Lukman O. Afolabi, Mengqi Zhang, Guizhong Zhang, Lulu Wang, Zhihuan Li, Lilong Lin, Qin Cao, Dehong Yan, Xiaochun Wan, 2021
Exploiting CRISPR-Cas9 gene editing system for human cancers and Immunotherapy, Afolabi, Lukman; Afolabi, Mariam; Sani, Musbahu; Okunowo, Wahab; Chen, Liang; Yan, Dehong; Zhang, Yaou; Wan, Xiaochun, 2021
Mechanisms for Modulating Anoikis Resistance in Cancer and the Relevance of Metabolic Reprogramming, Funmilayo O. Adeshakin, Adeleye O. Adeshakin, Lukman O. Afolabi, Dehong Yan, Guizhong Zhang, and Xiaochun Wan, 2021
