Professor | Sheng Wang | Asia Growth Partners

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Name	Sheng Wang
Contact Information	wangsheng@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Sheng Wang

Contact Information

wangsheng@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2007-09 to 2013-09 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences 2005-03 to 2007-07 Dual Bachelor's Degree: Wuhan University 2003-09 to 2007-06 Bachelor's Degree: Huazhong Agricultural University
Work Experience	2020-04 to Present - Chinese Academy of Sciences Center for Excellence in Molecular Cell Science - Researcher 2018-09 to 2020-03 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher 2013-12 to 2018-06 - University of North Carolina at Chapel Hill (USA) - Postdoctoral Researcher
Awards	Tan Jiazhen Life Science Award (2023): Other Top 100 in the First Shanghai High-Value Patent Operation Competition (2022): Provincial Top 10 Emerging Scientists in China (2022): National National Outstanding Youth Award (2022): National WuXi AppTec Life Chemistry Research Award (2022): National Outstanding Young Scientist of the 8th Chinese Academy of Sciences Shanghai Branch (2022): Institutional Excellent Mentor of the Chinese Academy of Sciences (2022): Institutional Shanghai Youth Science and Technology Star (2020): Provincial

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2007-09 to 2013-09 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2005-03 to 2007-07 Dual Bachelor's Degree: Wuhan University
2003-09 to 2007-06 Bachelor's Degree: Huazhong Agricultural University

Work Experience

2020-04 to Present - Chinese Academy of Sciences Center for Excellence in Molecular Cell Science - Researcher
2018-09 to 2020-03 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
2013-12 to 2018-06 - University of North Carolina at Chapel Hill (USA) - Postdoctoral Researcher

Awards

Tan Jiazhen Life Science Award (2023): Other
Top 100 in the First Shanghai High-Value Patent Operation Competition (2022): Provincial
Top 10 Emerging Scientists in China (2022): National
National Outstanding Youth Award (2022): National
WuXi AppTec Life Chemistry Research Award (2022): National
Outstanding Young Scientist of the 8th Chinese Academy of Sciences Shanghai Branch (2022): Institutional
Excellent Mentor of the Chinese Academy of Sciences (2022): Institutional
Shanghai Youth Science and Technology Star (2020): Provincial

Areas of Focus	Neuropsychiatric Drug Pharmacology Drug Design Material Basis of Hallucinations
Publications	Advances in structure-based drug design: The potential for precision therapeutics in psychiatric disorders, Neuron, 2024 Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants, Chemical Reviews, 2024 Flexible scaffold-based cheminformatics approach for polypharmacological drug design, Cell, 2024 Structural insights into constitutive activity of 5-HT6 receptor, Proceedings of the National Academy of Sciences of the United States of America, 2023 Structural insights into sphingosine-1-phosphate receptor activation, Proceedings of the National Academy of Sciences of the United States of America, 2022 The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands, Nature Communications, 2022 Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties, Nature Neuroscience, 2022 Structure-based discovery of nonhallucinogenic psychedelic analogs, Science, 2022 2-Phenylcyclopropylmethylamine Derivatives as Dopamine D-2 Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation, Journal of Medicinal Chemistry, 2021 Haloperidol bound D 2 dopamine receptor structure inspired the discovery of subtype selective ligands, Nature Communications, 2020 Ultra-large library docking for discovering new chemotypes, Nature, 2019 Structural determinants of 5-HT2B receptor activation and biased agonism, Nature Structural & Molecular Biology, 2018 Structure of a nanobody-stabilized active state of the kappa opioid receptor, Cell, 2018 Structure of the D 2 dopamine receptor bound to the atypical antipsychotic drug risperidone, Nature, 2018 D 4 Dopamine Receptor High Resolution Structures Enable the Discovery of Selective Agonists, Science, 2017 Crystal Structure of an LSD-Bound Human Serotonin Receptor, Cell, 2017 Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65, Nature, 2015 New insights into the regulation of Axin function in canonical Wnt signaling pathway, Protein & Cell, 2014 Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function, Cell Reports, 2014 Nature Chem Biol, Nature Chem Biol, 2013 Proc Natl Acad Sci USA, Proc Natl Acad Sci USA, 2011 A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis, Cell Research, 2011

Areas of Focus

Neuropsychiatric Drug Pharmacology
Drug Design
Material Basis of Hallucinations

Publications

Advances in structure-based drug design: The potential for precision therapeutics in psychiatric disorders, Neuron, 2024
Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants, Chemical Reviews, 2024
Flexible scaffold-based cheminformatics approach for polypharmacological drug design, Cell, 2024
Structural insights into constitutive activity of 5-HT6 receptor, Proceedings of the National Academy of Sciences of the United States of America, 2023
Structural insights into sphingosine-1-phosphate receptor activation, Proceedings of the National Academy of Sciences of the United States of America, 2022
The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands, Nature Communications, 2022
Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties, Nature Neuroscience, 2022
Structure-based discovery of nonhallucinogenic psychedelic analogs, Science, 2022
2-Phenylcyclopropylmethylamine Derivatives as Dopamine D-2 Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation, Journal of Medicinal Chemistry, 2021
Haloperidol bound D 2 dopamine receptor structure inspired the discovery of subtype selective ligands, Nature Communications, 2020
Ultra-large library docking for discovering new chemotypes, Nature, 2019
Structural determinants of 5-HT2B receptor activation and biased agonism, Nature Structural & Molecular Biology, 2018
Structure of a nanobody-stabilized active state of the kappa opioid receptor, Cell, 2018
Structure of the D 2 dopamine receptor bound to the atypical antipsychotic drug risperidone, Nature, 2018
D 4 Dopamine Receptor High Resolution Structures Enable the Discovery of Selective Agonists, Science, 2017
Crystal Structure of an LSD-Bound Human Serotonin Receptor, Cell, 2017
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65, Nature, 2015
New insights into the regulation of Axin function in canonical Wnt signaling pathway, Protein & Cell, 2014
Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function, Cell Reports, 2014
Nature Chem Biol, Nature Chem Biol, 2013
Proc Natl Acad Sci USA, Proc Natl Acad Sci USA, 2011
A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis, Cell Research, 2011

Neuropsychiatric Drug Pharmacology Design Hallucinations Material Basis Research Innovation Therapeutics

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Jia Lv - East China Normal University

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