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Sheng Wang
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Neuropsychiatric
Drug
Pharmacology
Design
Hallucinations
Material
Basis
Research
Innovation
Therapeutics
Areas of Focus
- Neuropsychiatric Drug Pharmacology
- Drug Design
- Material Basis of Hallucinations
Work Experience
- 2020-04 to Present - Chinese Academy of Sciences Center for Excellence in Molecular Cell Science - Researcher
- 2018-09 to 2020-03 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
- 2013-12 to 2018-06 - University of North Carolina at Chapel Hill (USA) - Postdoctoral Researcher
Academic Background & Achievements
- 2007-09 to 2013-09 PhD: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- 2005-03 to 2007-07 Dual Bachelor's Degree: Wuhan University
- 2003-09 to 2007-06 Bachelor's Degree: Huazhong Agricultural University
Publications
- Advances in structure-based drug design: The potential for precision therapeutics in psychiatric disorders, Neuron, 2024
- Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants, Chemical Reviews, 2024
- Flexible scaffold-based cheminformatics approach for polypharmacological drug design, Cell, 2024
- Structural insights into constitutive activity of 5-HT6 receptor, Proceedings of the National Academy of Sciences of the United States of America, 2023
- Structural insights into sphingosine-1-phosphate receptor activation, Proceedings of the National Academy of Sciences of the United States of America, 2022
- The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands, Nature Communications, 2022
- Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties, Nature Neuroscience, 2022
- Structure-based discovery of nonhallucinogenic psychedelic analogs, Science, 2022
- 2-Phenylcyclopropylmethylamine Derivatives as Dopamine D-2 Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation, Journal of Medicinal Chemistry, 2021
- Haloperidol bound D 2 dopamine receptor structure inspired the discovery of subtype selective ligands, Nature Communications, 2020
- Ultra-large library docking for discovering new chemotypes, Nature, 2019
- Structural determinants of 5-HT2B receptor activation and biased agonism, Nature Structural & Molecular Biology, 2018
- Structure of a nanobody-stabilized active state of the kappa opioid receptor, Cell, 2018
- Structure of the D 2 dopamine receptor bound to the atypical antipsychotic drug risperidone, Nature, 2018
- D 4 Dopamine Receptor High Resolution Structures Enable the Discovery of Selective Agonists, Science, 2017
- Crystal Structure of an LSD-Bound Human Serotonin Receptor, Cell, 2017
- Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65, Nature, 2015
- New insights into the regulation of Axin function in canonical Wnt signaling pathway, Protein & Cell, 2014
- Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function, Cell Reports, 2014
- Nature Chem Biol, Nature Chem Biol, 2013
- Proc Natl Acad Sci USA, Proc Natl Acad Sci USA, 2011
- A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/beta-catenin signaling and colon cancer cell tumorigenesis, Cell Research, 2011
Awards
- Tan Jiazhen Life Science Award (2023): Other
- Top 100 in the First Shanghai High-Value Patent Operation Competition (2022): Provincial
- Top 10 Emerging Scientists in China (2022): National
- National Outstanding Youth Award (2022): National
- WuXi AppTec Life Chemistry Research Award (2022): National
- Outstanding Young Scientist of the 8th Chinese Academy of Sciences Shanghai Branch (2022): Institutional
- Excellent Mentor of the Chinese Academy of Sciences (2022): Institutional
- Shanghai Youth Science and Technology Star (2020): Provincial
