Professor | Yan Feng | Asia Growth Partners

Name	Yan Feng
Contact Information	yfeng2009@sjtu.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Yan Feng

Contact Information

yfeng2009@sjtu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Life Sciences
Academic Background & Achievements	1986 - Bachelor's Degree in Molecular Biology from Jilin University 1994 - PhD in Medicine from Norman Bethune University of Medical Sciences Chief Scientist of the 973 Program, received support and awards such as the Ministry of Education's New Century Talent, the State Council Special Allowance, and the Shanghai Leading Talent
Work Experience	1989-2008 - Jilin University, Molecular Enzymology Engineering, Key Laboratory of the Ministry of Education: Lecturer, Associate Professor, Professor, Director 2003 - Visiting Scholar at the National Institutes of Health, National Cancer Institute, USA 1994-1996, 1998-2000 - Postdoctoral Fellow and Special Research Fellow at the National Institute of Advanced Industrial Science and Technology (AIST), Japan 2009-present - Distinguished Professor at Shanghai Jiao Tong University, Doctoral Supervisor
Awards	DuPont Pioneer Award for Outstanding Contribution to Enzyme Engineering in China Shanghai First Prize for Technological Invention Multiple provincial and ministerial level Science and Technology Progress Awards

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Life Sciences

Academic Background & Achievements

1986 - Bachelor's Degree in Molecular Biology from Jilin University
1994 - PhD in Medicine from Norman Bethune University of Medical Sciences
Chief Scientist of the 973 Program, received support and awards such as the Ministry of Education's New Century Talent, the State Council Special Allowance, and the Shanghai Leading Talent

Work Experience

1989-2008 - Jilin University, Molecular Enzymology Engineering, Key Laboratory of the Ministry of Education: Lecturer, Associate Professor, Professor, Director
2003 - Visiting Scholar at the National Institutes of Health, National Cancer Institute, USA
1994-1996, 1998-2000 - Postdoctoral Fellow and Special Research Fellow at the National Institute of Advanced Industrial Science and Technology (AIST), Japan
2009-present - Distinguished Professor at Shanghai Jiao Tong University, Doctoral Supervisor

Awards

DuPont Pioneer Award for Outstanding Contribution to Enzyme Engineering in China
Shanghai First Prize for Technological Invention
Multiple provincial and ministerial level Science and Technology Progress Awards

Areas of Focus	Microbial enzyme structure and action mechanism Novel functional enzyme molecular design and evolution Microbial drug synthesis biotechnology
Publications	A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008, Cui L., Wei X., Wang X., Bai L., Lin S., Feng Y., 2020 Structure-guided reshaping of the acyl binding pocket of 'TesAthioesterase enhances octanoic acid production in E. coli, Deng X., Chen L., Hei M., Tian G., Feng Y., Yang G., 2020 Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations, Liu Q., Guo X., Xun G., Li Z., Chong Y., Yang L., Wang H., Zhang F., Luo S., Cui L., Zhao P., Ye X., Xu H., Lu H., Li X., Deng Z., Li K., Feng Y., 2021 Catalytic properties and biological function of a PIWI-RE nuclease from Pseudomonas stutzeri, Huang F, Xu X.Y., Dong H., Li N., Zhong B.Z., Lu H., Liu Q., Feng Y., 2022 Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity, Zheng L., Lu H., Zan B., Li S., Liu H., Liu Z., Huang.J, Liu Y, Jiang F., Liu Q., Feng Y., Hong L., 2022 Molecular Evolution of an Aminotransferase Based on Substrate–Enzyme Binding Energy Analysis for Efficient Valienamine Synthesis, Cui L., Cui, A., Li Q., Yang L., Liu H., Shao W., Feng Y., 2022 Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation, He Y., Li S., Wang J., Yang X., Zhu J., Zhang Q., Cui L., Tan Z., Yan W., Zhang Y., Tang L., Da L., Feng Y., 2022 Algorithm-based Coevolution Network Identification Reveals Key Functional Residues of the α/β Hydrolase Subfamilies, Wu Z., Liu H., Xu L., Chen H., Feng Y., 2020 Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability, Sun Z., Liu Q., Qu G., Feng Y., Reetz M., 2019 Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Tan Y., Zhang Y., Han Y., Liu H., Chen H., Ma F., Withers S., Feng Y., Yang G.*, 2019

Areas of Focus

Microbial enzyme structure and action mechanism
Novel functional enzyme molecular design and evolution
Microbial drug synthesis biotechnology

Publications

A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008, Cui L., Wei X., Wang X., Bai L., Lin S., Feng Y*., 2020
Structure-guided reshaping of the acyl binding pocket of 'TesAthioesterase enhances octanoic acid production in E. coli, Deng X., Chen L., Hei M., Tian G., Feng Y*., Yang G*., 2020
Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations, Liu Q., Guo X., Xun G., Li Z., Chong Y., Yang L., Wang H., Zhang F., Luo S., Cui L., Zhao P., Ye X., Xu H., Lu H., Li X., Deng Z., Li K., Feng Y.*, 2021
Catalytic properties and biological function of a PIWI-RE nuclease from Pseudomonas stutzeri, Huang F, Xu X.Y., Dong H., Li N., Zhong B.Z., Lu H., Liu Q., Feng Y.*, 2022
Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity, Zheng L., Lu H., Zan B., Li S., Liu H., Liu Z., Huang.J, Liu Y, Jiang F., Liu Q.*, Feng Y., Hong L.*, 2022
Molecular Evolution of an Aminotransferase Based on Substrate–Enzyme Binding Energy Analysis for Efficient Valienamine Synthesis, Cui L*., Cui, A., Li Q., Yang L., Liu H., Shao W., Feng Y.*, 2022
Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation, He Y., Li S., Wang J., Yang X., Zhu J., Zhang Q., Cui L., Tan Z., Yan W., Zhang Y., Tang L., Da L*., Feng Y*., 2022
Algorithm-based Coevolution Network Identification Reveals Key Functional Residues of the α/β Hydrolase Subfamilies, Wu Z., Liu H., Xu L., Chen H., Feng Y*., 2020
Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability, Sun Z., Liu Q., Qu G., Feng Y*., Reetz M*., 2019
Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Tan Y., Zhang Y., Han Y., Liu H., Chen H., Ma F., Withers S., Feng Y., Yang G.*, 2019

Enzyme Structure Mechanism Microbial Biotechnology Synthesis Drug Design Evolution Molecular

Zhong-Lin Zhang - Shanghai Normal University

Chenguang Liu - Shanghai Jiao Tong University

Mingfei Jin - East China Normal University

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