Areas of Focus
- Microbial enzyme structure and action mechanism
- Novel functional enzyme molecular design and evolution
- Microbial drug synthesis biotechnology
Work Experience
- 1989-2008 - Jilin University, Molecular Enzymology Engineering, Key Laboratory of the Ministry of Education: Lecturer, Associate Professor, Professor, Director
- 2003 - Visiting Scholar at the National Institutes of Health, National Cancer Institute, USA
- 1994-1996, 1998-2000 - Postdoctoral Fellow and Special Research Fellow at the National Institute of Advanced Industrial Science and Technology (AIST), Japan
- 2009-present - Distinguished Professor at Shanghai Jiao Tong University, Doctoral Supervisor
Academic Background & Achievements
- 1986 - Bachelor's Degree in Molecular Biology from Jilin University
- 1994 - PhD in Medicine from Norman Bethune University of Medical Sciences
- Chief Scientist of the 973 Program, received support and awards such as the Ministry of Education's New Century Talent, the State Council Special Allowance, and the Shanghai Leading Talent
Publications
- A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008, Cui L., Wei X., Wang X., Bai L., Lin S., Feng Y*., 2020
- Structure-guided reshaping of the acyl binding pocket of 'TesAthioesterase enhances octanoic acid production in E. coli, Deng X., Chen L., Hei M., Tian G., Feng Y*., Yang G*., 2020
- Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations, Liu Q., Guo X., Xun G., Li Z., Chong Y., Yang L., Wang H., Zhang F., Luo S., Cui L., Zhao P., Ye X., Xu H., Lu H., Li X., Deng Z., Li K., Feng Y.*, 2021
- Catalytic properties and biological function of a PIWI-RE nuclease from Pseudomonas stutzeri, Huang F, Xu X.Y., Dong H., Li N., Zhong B.Z., Lu H., Liu Q., Feng Y.*, 2022
- Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity, Zheng L., Lu H., Zan B., Li S., Liu H., Liu Z., Huang.J, Liu Y, Jiang F., Liu Q.*, Feng Y., Hong L.*, 2022
- Molecular Evolution of an Aminotransferase Based on Substrate–Enzyme Binding Energy Analysis for Efficient Valienamine Synthesis, Cui L*., Cui, A., Li Q., Yang L., Liu H., Shao W., Feng Y.*, 2022
- Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation, He Y., Li S., Wang J., Yang X., Zhu J., Zhang Q., Cui L., Tan Z., Yan W., Zhang Y., Tang L., Da L*., Feng Y*., 2022
- Algorithm-based Coevolution Network Identification Reveals Key Functional Residues of the α/β Hydrolase Subfamilies, Wu Z., Liu H., Xu L., Chen H., Feng Y*., 2020
- Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability, Sun Z., Liu Q., Qu G., Feng Y*., Reetz M*., 2019
- Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Tan Y., Zhang Y., Han Y., Liu H., Chen H., Ma F., Withers S., Feng Y., Yang G.*, 2019
Awards
- DuPont Pioneer Award for Outstanding Contribution to Enzyme Engineering in China
- Shanghai First Prize for Technological Invention
- Multiple provincial and ministerial level Science and Technology Progress Awards
