Areas of Focus
- 微生物酶结构与作用机制
- 新功能酶分子设计与进化
- 微生物药物合成生物学
Work Experience
- 1989-2008年 - 吉林大学分子酶学工程教育部重点实验室：讲师、副教授、教授、主任
- 2003年 - 美国国立健康总署癌症研究所高访学者
- 1994-1996年, 1998-2000年 - 日本国立生命科学和技术研究所博士后和特别研究员
- 2009年至今 - 上海交通大学特聘教授，博士生导师
Academic Background & Achievements
- 1986年 - 吉林大学分子生物学系学士学位
- 1994年 - 白求恩医科大学医学博士学位
- 973计划首席科学家，获得教育部新世纪人才、国务院特殊津贴及上海市领军人才等支持和奖励
Publications
- A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008, Cui L., Wei X., Wang X., Bai L., Lin S., Feng Y*., 2020
- Structure-guided reshaping of the acyl binding pocket of 'TesAthioesterase enhances octanoic acid production in E. coli, Deng X., Chen L., Hei M., Tian G., Feng Y*., Yang G*., 2020
- Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations, Liu Q., Guo X., Xun G., Li Z., Chong Y., Yang L., Wang H., Zhang F., Luo S., Cui L., Zhao P., Ye X., Xu H., Lu H., Li X., Deng Z., Li K., Feng Y.*, 2021
- Catalytic properties and biological function of a PIWI-RE nuclease from Pseudomonas stutzeri, Huang F, Xu X.Y., Dong H., Li N., Zhong B.Z., Lu H., Liu Q., Feng Y.*, 2022
- Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity, Zheng L., Lu H., Zan B., Li S., Liu H., Liu Z., Huang.J, Liu Y, Jiang F., Liu Q.*, Feng Y., Hong L.*, 2022
- Molecular Evolution of an Aminotransferase Based on Substrate–Enzyme Binding Energy Analysis for Efficient Valienamine Synthesis, Cui L*., Cui, A., Li Q., Yang L., Liu H., Shao W., Feng Y.*, 2022
- Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation, He Y., Li S., Wang J., Yang X., Zhu J., Zhang Q., Cui L., Tan Z., Yan W., Zhang Y., Tang L., Da L*., Feng Y*., 2022
- Algorithm-based Coevolution Network Identification Reveals Key Functional Residues of the α/β Hydrolase Subfamilies, Wu Z., Liu H., Xu L., Chen H., Feng Y*., 2020
- Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability, Sun Z., Liu Q., Qu G., Feng Y*., Reetz M*., 2019
- Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Tan Y., Zhang Y., Han Y., Liu H., Chen H., Ma F., Withers S., Feng Y., Yang G.*, 2019
Awards
- 杜邦杰能科中国酶工程杰出贡献奖
- 上海市技术发明一等奖
- 多项省部级科技进步奖
