Professor | Lan Wang | Asia Growth Partners

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Name	Lan Wang
Contact Information	lwang@sinh.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Lan Wang

Contact Information

lwang@sinh.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2002-09--2007-07 PhD in Biochemistry and Molecular Biology: Shanghai Institute of Health Sciences, Chinese Academy of Sciences 1998-09--2002-07 Bachelor's in Biology: School of Life Sciences, Fudan University
Work Experience	2015-06~Present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher 2013-03~2015-05 - Department of Biochemistry and Molecular Biology, University of Miami - Assistant Professor (tenure track) 2007-12~2013-03 - Memorial Sloan Kettering Cancer Center - Postdoctoral Fellow 2002-09~2007-07 - Shanghai Institute of Health Sciences, Chinese Academy of Sciences - PhD in Biochemistry and Molecular Biology 1998-09~2002-07 - School of Life Sciences, Fudan University - Bachelor's in Biology

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2002-09--2007-07 PhD in Biochemistry and Molecular Biology: Shanghai Institute of Health Sciences, Chinese Academy of Sciences
1998-09--2002-07 Bachelor's in Biology: School of Life Sciences, Fudan University

Work Experience

2015-06~Present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher
2013-03~2015-05 - Department of Biochemistry and Molecular Biology, University of Miami - Assistant Professor (tenure track)
2007-12~2013-03 - Memorial Sloan Kettering Cancer Center - Postdoctoral Fellow
2002-09~2007-07 - Shanghai Institute of Health Sciences, Chinese Academy of Sciences - PhD in Biochemistry and Molecular Biology
1998-09~2002-07 - School of Life Sciences, Fudan University - Bachelor's in Biology

Areas of Focus	Cell Biology - Regulation Mechanisms of Hematologic Tumors and Hematopoietic Stem Cells Pathology and Pathophysiology - Regulation Mechanisms of Hematologic Tumors and Hematopoietic Stem Cells
Publications	SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis, Not mentioned, 2024 S100a9 deficiency accelerates MDS associated tumor escape via PD-1/PD-L1 overexpression, Not mentioned, 2023 Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B cell lymphoma, Not mentioned, 2023 The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment. Blood, Not mentioned, 2023 ROBO1 deficiency impairs HSPCs homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS, Not mentioned, 2023 Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia, Not mentioned, 2022 Chidamide triggers BTG1-mediated autophagy and reverses the chemotherapy resistance in the relapsed/refractory B cell lymphoma, Not mentioned, 2021 SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS, Not mentioned, 2020 Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis, Not mentioned, 2019 Destabilization of AETFC through C/EBP-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation, Not mentioned, 2019 Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner, Not mentioned, 2017 Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin, Not mentioned, 2016 Wang L, Man N, Sun X-J, et al. Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. Blood. 2015;126(5): 640-650, Not mentioned, 2016 PARP inhibitors: a treatment option for AML?, Not mentioned, 2015 The role of histone acetyltransferase in normal and malignant hematopoiesis, Not mentioned, 2015 Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia, Not mentioned, 2008 Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-κB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner, Not mentioned, 2007 Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo, Not mentioned, 2007 Histone deacetylase inhibitor promotes rituximab-induced apoptosis in non-Hodgkin’s B-lymphoma cells by NF-κB-mediated Bcl-2/Bcl-XL downregulation and c-Myc degradation, Not mentioned, 2007 The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation, Not mentioned Post-translational modifications of Runx1 regulate its activity in the cell, Not mentioned

Areas of Focus

Cell Biology - Regulation Mechanisms of Hematologic Tumors and Hematopoietic Stem Cells
Pathology and Pathophysiology - Regulation Mechanisms of Hematologic Tumors and Hematopoietic Stem Cells

Publications

SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis, Not mentioned, 2024
S100a9 deficiency accelerates MDS associated tumor escape via PD-1/PD-L1 overexpression, Not mentioned, 2023
Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B cell lymphoma, Not mentioned, 2023
The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment. Blood, Not mentioned, 2023
ROBO1 deficiency impairs HSPCs homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS, Not mentioned, 2023
Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia, Not mentioned, 2022
Chidamide triggers BTG1-mediated autophagy and reverses the chemotherapy resistance in the relapsed/refractory B cell lymphoma, Not mentioned, 2021
SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS, Not mentioned, 2020
Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis, Not mentioned, 2019
Destabilization of AETFC through C/EBP-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation, Not mentioned, 2019
Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner, Not mentioned, 2017
Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin, Not mentioned, 2016
Wang L, Man N, Sun X-J, et al. Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. Blood. 2015;126(5): 640-650, Not mentioned, 2016
PARP inhibitors: a treatment option for AML?, Not mentioned, 2015
The role of histone acetyltransferase in normal and malignant hematopoiesis, Not mentioned, 2015
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia, Not mentioned, 2008
Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-κB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner, Not mentioned, 2007
Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo, Not mentioned, 2007
Histone deacetylase inhibitor promotes rituximab-induced apoptosis in non-Hodgkin’s B-lymphoma cells by NF-κB-mediated Bcl-2/Bcl-XL downregulation and c-Myc degradation, Not mentioned, 2007
The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation, Not mentioned
Post-translational modifications of Runx1 regulate its activity in the cell, Not mentioned

Hematologic Tumors Hematopoietic Stem Cells Regulation Mechanisms Cell Biology Pathology Pathophysiology Cancer Research Stem Cell Research Molecular Biology Biochemistry

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

Shui Wang - Shanghai Normal University

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