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Lan Wang
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Hematologic Tumors
Hematopoietic Stem Cells
Regulation Mechanisms
Cell Biology
Pathology
Pathophysiology
Cancer Research
Stem Cell Research
Molecular Biology
Biochemistry
Areas of Focus
- Cell Biology - Regulation Mechanisms of Hematologic Tumors and Hematopoietic Stem Cells
- Pathology and Pathophysiology - Regulation Mechanisms of Hematologic Tumors and Hematopoietic Stem Cells
Work Experience
- 2015-06~Present - Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences - Researcher
- 2013-03~2015-05 - Department of Biochemistry and Molecular Biology, University of Miami - Assistant Professor (tenure track)
- 2007-12~2013-03 - Memorial Sloan Kettering Cancer Center - Postdoctoral Fellow
- 2002-09~2007-07 - Shanghai Institute of Health Sciences, Chinese Academy of Sciences - PhD in Biochemistry and Molecular Biology
- 1998-09~2002-07 - School of Life Sciences, Fudan University - Bachelor's in Biology
Academic Background & Achievements
- 2002-09--2007-07 PhD in Biochemistry and Molecular Biology: Shanghai Institute of Health Sciences, Chinese Academy of Sciences
- 1998-09--2002-07 Bachelor's in Biology: School of Life Sciences, Fudan University
Publications
- SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis, Not mentioned, 2024
- S100a9 deficiency accelerates MDS associated tumor escape via PD-1/PD-L1 overexpression, Not mentioned, 2023
- Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B cell lymphoma, Not mentioned, 2023
- The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment. Blood, Not mentioned, 2023
- ROBO1 deficiency impairs HSPCs homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS, Not mentioned, 2023
- Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia, Not mentioned, 2022
- Chidamide triggers BTG1-mediated autophagy and reverses the chemotherapy resistance in the relapsed/refractory B cell lymphoma, Not mentioned, 2021
- SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS, Not mentioned, 2020
- Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis, Not mentioned, 2019
- Destabilization of AETFC through C/EBP-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation, Not mentioned, 2019
- Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner, Not mentioned, 2017
- Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin, Not mentioned, 2016
- Wang L, Man N, Sun X-J, et al. Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. Blood. 2015;126(5): 640-650, Not mentioned, 2016
- PARP inhibitors: a treatment option for AML?, Not mentioned, 2015
- The role of histone acetyltransferase in normal and malignant hematopoiesis, Not mentioned, 2015
- Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia, Not mentioned, 2008
- Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-κB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner, Not mentioned, 2007
- Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo, Not mentioned, 2007
- Histone deacetylase inhibitor promotes rituximab-induced apoptosis in non-Hodgkin’s B-lymphoma cells by NF-κB-mediated Bcl-2/Bcl-XL downregulation and c-Myc degradation, Not mentioned, 2007
- The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation, Not mentioned
- Post-translational modifications of Runx1 regulate its activity in the cell, Not mentioned
