Professor | 王兰 | 数字化转型顾问

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Name	王兰
Contact Information	lwang@sinh.ac.cn
Language ability	中文, 英语
Province	上海

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Name

王兰

Contact Information

lwang@sinh.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2002-09--2007-07 生物化学与分子生物学博士: 中科院上海生命科学院健康科学研究所 1998-09--2002-07 生物学士: 复旦大学生命科学院
Work Experience	2015-06~现在 - 中国科学院上海营养与健康研究所 - 研究员 2013-03~2015-05 - 美国迈阿密大学生物化学与分子生物学系 - 助理教授（tenure track) 2007-12~2013-03 - 美国纪念斯隆凯特琳癌症中心 - 博士后 2002-09~2007-07 - 中科院上海生命科学院健康科学研究所 - 生物化学与分子生物学博士 1998-09~2002-07 - 复旦大学生命科学院 - 生物学士

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2002-09--2007-07 生物化学与分子生物学博士: 中科院上海生命科学院健康科学研究所
1998-09--2002-07 生物学士: 复旦大学生命科学院

Work Experience

2015-06~现在 - 中国科学院上海营养与健康研究所 - 研究员
2013-03~2015-05 - 美国迈阿密大学生物化学与分子生物学系 - 助理教授（tenure track)
2007-12~2013-03 - 美国纪念斯隆凯特琳癌症中心 - 博士后
2002-09~2007-07 - 中科院上海生命科学院健康科学研究所 - 生物化学与分子生物学博士
1998-09~2002-07 - 复旦大学生命科学院 - 生物学士

Areas of Focus	细胞生物学 - 血液肿瘤和造血干细胞的调控机制病理学与病理生理学 - 血液肿瘤和造血干细胞的调控机制
Publications	SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis, 未提及, 2024 S100a9 deficiency accelerates MDS associated tumor escape via PD-1/PD-L1 overexpression, 未提及, 2023 Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B cell lymphoma, 未提及, 2023 The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment. Blood, 未提及, 2023 ROBO1 deficiency impairs HSPCs homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS, 未提及, 2023 Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia, 未提及, 2022 Chidamide triggers BTG1-mediated autophagy and reverses the chemotherapy resistance in the relapsed/refractory B cell lymphoma, 未提及, 2021 SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS, 未提及, 2020 Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis, 未提及, 2019 Destabilization of AETFC through C/EBP-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation, 未提及, 2019 Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner, 未提及, 2017 Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin, 未提及, 2016 Wang L, Man N, Sun X-J, et al. Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. Blood. 2015;126(5): 640-650, 未提及, 2016 PARP inhibitors: a treatment option for AML?, 未提及, 2015 The role of histone acetyltransferase in normal and malignant hematopoiesis, 未提及, 2015 Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia, 未提及, 2008 Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-κB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner, 未提及, 2007 Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo, 未提及, 2007 Histone deacetylase inhibitor promotes rituximab-induced apoptosis in non-Hodgkin’s B-lymphoma cells by NF-κB-mediated Bcl-2/Bcl-XL downregulation and c-Myc degradation, 未提及, 2007 The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation, 未提及 Post-translational modifications of Runx1 regulate its activity in the cell, 未提及

Areas of Focus

细胞生物学 - 血液肿瘤和造血干细胞的调控机制
病理学与病理生理学 - 血液肿瘤和造血干细胞的调控机制

Publications

SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis, 未提及, 2024
S100a9 deficiency accelerates MDS associated tumor escape via PD-1/PD-L1 overexpression, 未提及, 2023
Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B cell lymphoma, 未提及, 2023
The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment. Blood, 未提及, 2023
ROBO1 deficiency impairs HSPCs homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS, 未提及, 2023
Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia, 未提及, 2022
Chidamide triggers BTG1-mediated autophagy and reverses the chemotherapy resistance in the relapsed/refractory B cell lymphoma, 未提及, 2021
SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS, 未提及, 2020
Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis, 未提及, 2019
Destabilization of AETFC through C/EBP-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation, 未提及, 2019
Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner, 未提及, 2017
Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin, 未提及, 2016
Wang L, Man N, Sun X-J, et al. Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. Blood. 2015;126(5): 640-650, 未提及, 2016
PARP inhibitors: a treatment option for AML?, 未提及, 2015
The role of histone acetyltransferase in normal and malignant hematopoiesis, 未提及, 2015
Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia, 未提及, 2008
Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-κB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner, 未提及, 2007
Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo, 未提及, 2007
Histone deacetylase inhibitor promotes rituximab-induced apoptosis in non-Hodgkin’s B-lymphoma cells by NF-κB-mediated Bcl-2/Bcl-XL downregulation and c-Myc degradation, 未提及, 2007
The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation, 未提及
Post-translational modifications of Runx1 regulate its activity in the cell, 未提及

血液肿瘤造血干细胞调控机制细胞生物学病理学病理生理学癌症研究干细胞研究分子生物学生物化学

谢敬 - 同济大学

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