Professor | Zhizhen Wang | Asia Growth Partners

Name	Zhizhen Wang
Contact Information	chihwang@sun5.ibp.ac.cn
Language ability	Chinese, English, German
Province	Beijing

Name

Zhizhen Wang

Contact Information

chihwang@sun5.ibp.ac.cn

Language ability

Chinese, English, German

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1959-09--1964-07 Bachelor's Degree: University of Science and Technology of China
Work Experience	1998-02~1998-04 - Hong Kong University of Science and Technology - Visiting Professor 1995-05~1995-08 - University of Göttingen, Germany - Visiting Scientist 1991-05~1993-01 - University of Alberta, Canada - Research Associate 1988-08~1991-04 - U.S. Food and Drug Administration - Visiting Scientist 1987-05~1988-07 - City of Hope National Medical Center, USA - Visiting Scientist 1981-02~1982-05 - National Institutes of Health, USA - Fogarty Visiting Scholar 1979-02~1981-02 - German Wool Research Institute - Humboldt Visiting Scholar 1964-07~Present - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher, Researcher, Doctoral Supervisor
Awards	Sixth National Top Ten Women, National Level, 2007 Ho Leung Ho Lee Foundation Science and Technology Progress Award, Other, 2005 Second Prize of National Natural Science Award, National Level, 2002 Third World Academy of Sciences Basic Science (Biology) Award, Other, 2002 First Prize of Chinese Academy of Sciences Natural Science Award, Other, 1999 Second Prize of National Natural Science Award, National Level, 1995

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1959-09--1964-07 Bachelor's Degree: University of Science and Technology of China

Work Experience

1998-02~1998-04 - Hong Kong University of Science and Technology - Visiting Professor
1995-05~1995-08 - University of Göttingen, Germany - Visiting Scientist
1991-05~1993-01 - University of Alberta, Canada - Research Associate
1988-08~1991-04 - U.S. Food and Drug Administration - Visiting Scientist
1987-05~1988-07 - City of Hope National Medical Center, USA - Visiting Scientist
1981-02~1982-05 - National Institutes of Health, USA - Fogarty Visiting Scholar
1979-02~1981-02 - German Wool Research Institute - Humboldt Visiting Scholar
1964-07~Present - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher, Researcher, Doctoral Supervisor

Awards

Sixth National Top Ten Women, National Level, 2007
Ho Leung Ho Lee Foundation Science and Technology Progress Award, Other, 2005
Second Prize of National Natural Science Award, National Level, 2002
Third World Academy of Sciences Basic Science (Biology) Award, Other, 2002
First Prize of Chinese Academy of Sciences Natural Science Award, Other, 1999
Second Prize of National Natural Science Award, National Level, 1995

Areas of Focus	Endoplasmic Reticulum Protein Oxidation and Folding System and its Regulation, and its Connection with Diseases and Aging Mechanism of Protein Oxidation and Folding and the Role of Molecular Chaperones in Protein Quality Control
Publications	Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum, Wang, Lei, Wang, Chihchen, 2023 Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H2O2 release, Cheng, Fang, Ji, Qianzhao, Wang, Lu, Wang, Chihchen, Liu, GuangHui, Wang, Lei, 2023 “后AlphaFold时代”的蛋白质折叠问题, 胡昕炜, 王志珍, 王磊, 2023 SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases, Ping Liu, Xi Wang, Yiwei Sun, Hongyu Zhao, Fang Cheng, Jifeng Wang, Fuquan Yang, Junjie Hu, Hong Zhang, Chihchen Wang, Lei Wang, 2022 Two protein disulfide isomerase subgroups work synergistically in catalyzing oxidative protein folding, Fenggui Fan, Qiao Zhang, Yini Zhang, Guozhong Huang, Xuelian Liang, Chih-Chen Wang, Lei Wang, Dongping Lu, 2022 The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential, Lu Wang, Xi Wang, Xiying Lv, Qiushuo Jin, Hongcai Shang, Chih-chen Wang, Lei Wang, 2022 Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities, and pathophysiological functions, Wang, Lei, Yu, Jiaojiao, Wang, Chihchen, 2021 Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization, Xinxin Chen, Jianchao Zhang, Pulan Liu, Yangyang Wei, Xie Wang, Junyu Xiao, Chihchen Wang, Lei Wang, 2021 Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress, Yu, Jiaojiao, Li, Tao, Liu, Yu, Wang, Xi, Zhang, Jianchao, Wang, Xie, Shi, Guizhi, Lou, Jizhong, Wang, Likun, Wang, Chihchen, VVang, Lei, 2020 AtERO1 and AtERO2 Exhibit Differences in Catalyzing Oxidative Protein Folding in the Endoplasmic Reticulum, Fan, Fenggui, Zhang, Yini, Huang, Guozhong, Zhang, Qiao, Wang, Chihchen, Wang, Lei, Lu, Dongping, 2019 The b ' domain of protein disulfide isomerase cooperates with the a and a ' domains to functionally interact with platelets, Wang, Lu, Zhou, Junsong, Wang, Lei, Wang, Chihchen, Essex, David W., 2019 Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis, Wu, Xun, Zhang, Lihui, Miao, Yutong, Yang, Juan, Wang, Xian, Wang, Chihchen, Feng, Juan, Wang, Lei, 2019 Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes, Xu, Shili, Liu, Yajing, Yang, Kai, Wang, Hanxiao, Shergalis, Andrea, Kyani, Anahita, Bankhead, Armand, III, Tamura, Shuzo, Yang, Suhui, Wang, Xi, Wang, Chihchen, Rehemtulla, Alnawaz, Ljungman, Mats, Neamati, Nouri, 2019 Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1 alpha and protein disulfide isomerase suppresses the progression of cervical cancer, Zhang, Yini, Li, Tao, Zhang, Lihui, Shangguan, Fugen, Shi, Guizhi, Wu, Xun, Cui, Ya, Wang, Xie, Wang, Xi, Liu, Yongzhang, Lu, Bin, Wei, Taotao, Wang, Chihchen, Wang, Lei, 2019 Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7, Fang, Jingqi, Yang, Jiping, Wu, Xun, Zhang, Gangming, Li, Tao, Wang, Xie, Zhang, Hong, Wang, Chihchen, Liu, GuangHui, Wang, Lei, 2018 Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity, Li, Huanhuan, Yang, Kai, Wang, Wenjia, Niu, Yingbo, Li, Jun, Dong, Yuhui, Liu, Yingfang, Wang, Chihchen, Wang, Lei, Liang, Huanhuan, 2018 Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1 alpha, Zhang, Jianchao, Zhu, Qinyu, Wang, Xie, Yu, Jiaojiao, Chen, Xinxin, Wang, Jifeng, Wang, Xi, Xiao, Junyu, Wang, Chihchen, Wang, Lei, 2018 Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention, Yang, Kai, Li, DeFeng, Wang, Xie, Liang, Jinzhao, Sitia, Roberto, Wang, Chihchen, Wang, Xi, 2016 Novel Roles of the Non-catalytic Elements of Yeast Protein-disulfide Isomerase in Its Interplay with Endoplasmic Reticulum Oxidoreductin 1, Niu, Yingbo, Zhang, Lihui, Yu, Jiaojiao, Wang, Chihchen, Wang, Lei, 2016 Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone, Wang, Lei, Wang, Xi, Wang, Chihchen, 2015 未折叠蛋白响应：2014年拉斯克基础医学研究奖解读, 王曦, 王磊, 陈畅, 王志珍, 2014 Different Interaction Modes for Protein-disulfide Isomerase (PDI) as an Efficient Regulator and a Specific Substrate of Endoplasmic Reticulum Oxidoreductin-1 alpha (Ero1 alpha), Zhang, Lihui, Niu, Yingbo, Zhu, Li, Fang, Jingqi, Wang, Xie, Wang, Lei, Wang, Chihchen, 2014 Glutathione Peroxidase 7 Utilizes Hydrogen Peroxide Generated by Ero1 alpha to Promote Oxidative Protein Folding, Wang, Lei, Zhang, Lihui, Niu, Yingbo, Sitia, Roberto, Wang, Chihchen, 2014 A Novel Reaction of Peroxiredoxin 4 towards Substrates in Oxidative Protein Folding, Zhu, Li, Yang, Kai, Wang, Xie, Wang, Xi, Wang, Chihchen, 2014 Compact Conformations of Human Protein Disulfide Isomerase, Yang, Shang, Wang, Xi, Cui, Lei, Ding, Xiang, Niu, Lili, Yang, Fuquan, Wang, Chao, Wang, Chihchen, Lou, Jizhong, 2014 Structural Insights into the Redox-Regulated Dynamic Conformations of Human Protein Disulfide Isomerase, Wang, Chao, Li, Wei, Ren, Jinqi, Fang, Jingqi, Ke, Huimin, Gong, Weimin, Feng

Areas of Focus

Endoplasmic Reticulum Protein Oxidation and Folding System and its Regulation, and its Connection with Diseases and Aging
Mechanism of Protein Oxidation and Folding and the Role of Molecular Chaperones in Protein Quality Control

Publications

Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum, Wang, Lei, Wang, Chihchen, 2023
Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H2O2 release, Cheng, Fang, Ji, Qianzhao, Wang, Lu, Wang, Chihchen, Liu, GuangHui, Wang, Lei, 2023
“后AlphaFold时代”的蛋白质折叠问题, 胡昕炜, 王志珍, 王磊, 2023
SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases, Ping Liu, Xi Wang, Yiwei Sun, Hongyu Zhao, Fang Cheng, Jifeng Wang, Fuquan Yang, Junjie Hu, Hong Zhang, Chihchen Wang, Lei Wang, 2022
Two protein disulfide isomerase subgroups work synergistically in catalyzing oxidative protein folding, Fenggui Fan, Qiao Zhang, Yini Zhang, Guozhong Huang, Xuelian Liang, Chih-Chen Wang, Lei Wang, Dongping Lu, 2022
The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential, Lu Wang, Xi Wang, Xiying Lv, Qiushuo Jin, Hongcai Shang, Chih-chen Wang, Lei Wang, 2022
Protein disulfide isomerase is regulated in multiple ways: Consequences for conformation, activities, and pathophysiological functions, Wang, Lei, Yu, Jiaojiao, Wang, Chihchen, 2021
Proteolytic processing of secretory pathway kinase Fam20C by site-1 protease promotes biomineralization, Xinxin Chen, Jianchao Zhang, Pulan Liu, Yangyang Wei, Xie Wang, Junyu Xiao, Chihchen Wang, Lei Wang, 2021
Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress, Yu, Jiaojiao, Li, Tao, Liu, Yu, Wang, Xi, Zhang, Jianchao, Wang, Xie, Shi, Guizhi, Lou, Jizhong, Wang, Likun, Wang, Chihchen, VVang, Lei, 2020
AtERO1 and AtERO2 Exhibit Differences in Catalyzing Oxidative Protein Folding in the Endoplasmic Reticulum, Fan, Fenggui, Zhang, Yini, Huang, Guozhong, Zhang, Qiao, Wang, Chihchen, Wang, Lei, Lu, Dongping, 2019
The b ' domain of protein disulfide isomerase cooperates with the a and a ' domains to functionally interact with platelets, Wang, Lu, Zhou, Junsong, Wang, Lei, Wang, Chihchen, Essex, David W., 2019
Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis, Wu, Xun, Zhang, Lihui, Miao, Yutong, Yang, Juan, Wang, Xian, Wang, Chihchen, Feng, Juan, Wang, Lei, 2019
Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes, Xu, Shili, Liu, Yajing, Yang, Kai, Wang, Hanxiao, Shergalis, Andrea, Kyani, Anahita, Bankhead, Armand, III, Tamura, Shuzo, Yang, Suhui, Wang, Xi, Wang, Chihchen, Rehemtulla, Alnawaz, Ljungman, Mats, Neamati, Nouri, 2019
Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1 alpha and protein disulfide isomerase suppresses the progression of cervical cancer, Zhang, Yini, Li, Tao, Zhang, Lihui, Shangguan, Fugen, Shi, Guizhi, Wu, Xun, Cui, Ya, Wang, Xie, Wang, Xi, Liu, Yongzhang, Lu, Bin, Wei, Taotao, Wang, Chihchen, Wang, Lei, 2019
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7, Fang, Jingqi, Yang, Jiping, Wu, Xun, Zhang, Gangming, Li, Tao, Wang, Xie, Zhang, Hong, Wang, Chihchen, Liu, GuangHui, Wang, Lei, 2018
Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity, Li, Huanhuan, Yang, Kai, Wang, Wenjia, Niu, Yingbo, Li, Jun, Dong, Yuhui, Liu, Yingfang, Wang, Chihchen, Wang, Lei, Liang, Huanhuan, 2018
Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1 alpha, Zhang, Jianchao, Zhu, Qinyu, Wang, Xie, Yu, Jiaojiao, Chen, Xinxin, Wang, Jifeng, Wang, Xi, Xiao, Junyu, Wang, Chihchen, Wang, Lei, 2018
Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention, Yang, Kai, Li, DeFeng, Wang, Xie, Liang, Jinzhao, Sitia, Roberto, Wang, Chihchen, Wang, Xi, 2016
Novel Roles of the Non-catalytic Elements of Yeast Protein-disulfide Isomerase in Its Interplay with Endoplasmic Reticulum Oxidoreductin 1, Niu, Yingbo, Zhang, Lihui, Yu, Jiaojiao, Wang, Chihchen, Wang, Lei, 2016
Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone, Wang, Lei, Wang, Xi, Wang, Chihchen, 2015
未折叠蛋白响应：2014年拉斯克基础医学研究奖解读, 王曦, 王磊, 陈畅, 王志珍, 2014
Different Interaction Modes for Protein-disulfide Isomerase (PDI) as an Efficient Regulator and a Specific Substrate of Endoplasmic Reticulum Oxidoreductin-1 alpha (Ero1 alpha), Zhang, Lihui, Niu, Yingbo, Zhu, Li, Fang, Jingqi, Wang, Xie, Wang, Lei, Wang, Chihchen, 2014
Glutathione Peroxidase 7 Utilizes Hydrogen Peroxide Generated by Ero1 alpha to Promote Oxidative Protein Folding, Wang, Lei, Zhang, Lihui, Niu, Yingbo, Sitia, Roberto, Wang, Chihchen, 2014
A Novel Reaction of Peroxiredoxin 4 towards Substrates in Oxidative Protein Folding, Zhu, Li, Yang, Kai, Wang, Xie, Wang, Xi, Wang, Chihchen, 2014
Compact Conformations of Human Protein Disulfide Isomerase, Yang, Shang, Wang, Xi, Cui, Lei, Ding, Xiang, Niu, Lili, Yang, Fuquan, Wang, Chao, Wang, Chihchen, Lou, Jizhong, 2014
Structural Insights into the Redox-Regulated Dynamic Conformations of Human Protein Disulfide Isomerase, Wang, Chao, Li, Wei, Ren, Jinqi, Fang, Jingqi, Ke, Huimin, Gong, Weimin, Feng

Protein Oxidation Protein Folding Endoplasmic Reticulum Molecular Chaperones Quality Control Diseases Aging Regulation Mechanism Oxidative Stress

Han Song Deng - Tongji University

Fanglin Sun - Tongji University

Shi Jiejun - Tongji University

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