Professor | Shengdian Wang | Asia Growth Partners

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Name	Shengdian Wang
Contact Information	sdwang@ibp.ac.cn
Language ability	English, Chinese
Province	Beijing

Upload Avatar (500 x 500)

Name

Shengdian Wang

Contact Information

sdwang@ibp.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2004-03--2005-02 Assistant Researcher: Johns Hopkins University School of Medicine 1998-10--2004-02 Postdoctoral/Assistant Researcher: Mayo Clinic Medical School 1995-09--1998-06 PhD: Chinese Academy of Medical Sciences & Peking Union Medical College
Work Experience	2005-03~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2004-03--2005-02 Assistant Researcher: Johns Hopkins University School of Medicine
1998-10--2004-02 Postdoctoral/Assistant Researcher: Mayo Clinic Medical School
1995-09--1998-06 PhD: Chinese Academy of Medical Sciences & Peking Union Medical College

Work Experience

2005-03~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher

Areas of Focus	Anti-tumor T cell immunity and immunotherapy Regulation of T cell activation Tumor microenvironment and T cell immune suppression Mechanisms of memory CD8+ T cell differentiation
Publications	Glucocorticoid-induced expansion of classical monocytes contributes to bone loss, Liu, Pei, Gao, Youshui, Luo, Pengbo, Yu, Hongping, Guo, Shang, Liu, Fuyun, Gao, Junjie, Xu, Jianzhong, Wang, Shengdian, Zhang, Changqing, 2022 Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development, Jianli He, Xun Shangguan, Wei Zhou, Ying Cao, Quan Zheng, Jun Tu, Gaolei Hu, Zi Liang, Cen Jiang, Liufu Deng, Shengdian Wang, Wen Yang, Yong Zuo, Jiao Ma, Rong Cai, Yalan Chen, Qiuju Fan, Baijun Dong, Wei Xue, Hongsheng Tan, Yitao Qi, Jianmin Gu, Bing Su, Y Eugene Chin, Guoqiang Chen, Qi Wang, Tianshi Wang, Jinke Cheng, 2021 Neutrophil-to-lymphocyte ratio, a critical predictor for assessment of disease severity in patients with COVID-19, Liu, Lei, Zheng, Yaqiong, Cai, Liping, Wu, Wanlei, Tang, Shi, Ding, Yinjuan, Liu, Wanbing, Kou, Guomei, Xiong, Zhou, Wang, Shengdian, Zheng, Shangen, 2021 T Cells Expanded from PD-1(+) Peripheral Blood Lymphocytes Share More Clones with Paired Tumor-Infiltrating Lymphocytes, Li, Tiepeng, Zhao, Lingdi, Yang, Yonghao, Wang, Yao, Zhang, Yong, Guo, Jindong, Chen, Guangyu, Qin, Peng, Xu, Benling, Ma, Baozhen, Zhang, Fang, Shang, Yiman, Li, Qingjun, Zhang, Kai, Yuan, Dongfeng, Feng, Chaojie, Ma, Yan, Liu, Zhiyong, Tian, Zhichao, Li, Hongle, Wang, Shengdian, Gao, Quanli, 2021 Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy, Ying Li, Yanni Cong, Mingming Jia, Qianqian He, Haiqing Zhong, Yun Zhao, Hang Li, Meining Yan, Jia You, Jia Liu, Lieping Chen, Haiying Hang, Shengdian Wang, 2021 A novel workflow for cancer blood biomarker identification, Wang, Xiang, Qiu, Zhiqiang, Ji, Xiangwen, Ning, Weihai, An, Yihua, Wang, Shengdian, Zhang, Hongwei, 2020 The Prognostic Value of EMT in Glioma and its Role in the Glioma Immune Microenvironment, Ning, Weihai, Qiu, Zhiqiang, Ji, Xiangwen, Wang, Xiang, An, Yihua, Wang, Shengdian, Zhang, Hongwei, 2020 A Virus-Infected, Reprogrammed Somatic Cell-Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer, Lu, Shuangshuang, Zhang, Zhe, Du, Pan, Chard, Louisa S, Yan, Wenli, El Khouri, Margueritte, Wang, Zhizhong, Zhang, Zhongxian, Chu, Yongchao, Gao, Dongling, Zhang, Qinxian, Zhang, Lirong, Nagano, Ai, Wang, Jun, Chelala, Claude, Liu, Jing, Chen, Jiekai, Liu, Pentao, Dong, Yunshu, Wang, Shengdian, Li, Xiaozhu, Dong, Jianzeng, Lemoine, Nick R, Pei, Duanqing, Wang, Yaohe, 2020 A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients, Liu, Lei, Liu, Wanbing, Zheng, Yaqiong, Jiang, Xiaojing, Kou, Guomei, Ding, Jinya, Wang, Qiongshu, Huang, Qianchuan, Ding, Yinjuan, Ni, Wenxu, Wu, Wanlei, Tang, Shi, Tan, Li, Hu, Zhenhong, Xu, Weitian, Zhang, Yong, Zhang, Bo, Tang, Zhongzhi, Zhang, Xinhua, Li, Honghua, Rao, Zhiguo, Jiang, Hui, Ren, Xingfeng, Wang, Shengdian, Zheng, Shangen, 2020 First-in-class immune-modulating small molecule Icaritin in advanced hepatocellular carcinoma: preliminary results of safety, durable survival and immune biomarkers, Fan, Ying, Li, Shu, Ding, Xiaoyan, Yue, Jian, Jiang, Jun, Zhao, Hong, Hao, Rui, Qiu, Weiliang, Liu, Kezhen, Li, Ying, Wang, Shengdian, Zheng, Limin, Ye, Bin, Meng, Kun, Xu, Binghe, 2019 S-15 in combination of Akt inhibitor promotes the expansion of CD45RA(-)CCR7(+) tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1(+)Tim-3(+) cells as well as regulatory T cells, Xu, Benling, Yuan, Long, Chen, Guangyu, Li, Tiepeng, Zhou, Jinxue, Zhang, Chengjuan, Qin, Peng, Muthana, Musleh M, Wang, Shengdian, Du, Xuexiang, Gao, Quanli, 2019 NKG2A is a NK cell exhaustion checkpoint for HCV persistence, Chao Zhang, Xiaomei Wang, Shuran Li, Trix Twelkmeyer, Weihong Wang, Shengyuan Zhang, Shufeng Wang, Jizheng Chen, Xia Jin, Yuzhang Wu, Xinwen Chen, Shengdian Wang, Junqi Niu, Hairong Chen, Hong Tang, 2019 Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent (vol 8, 2017), Wang, Pengju, Li, Xiaozhu, Wang, Jiwei, Gao, Dongling, Li, Yuenan, Li, Haoze, Chu, Yongchao, Zhang, Zhongxian, Liu, Hongtao, Jiang, Guozhong, Cheng, Zhenguo, Wang, Shengdian, Dong, Jianzeng, Feng, Baisui, Chard, Louisa S, Lemoine, Nicholas R, Wang, Yaohe, 2018 Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis, Wang, Conghui, Cheng, Yuqiang, Zhang, Xiuping, Li, Nan, Zhang, Lin, Wang, Shengdian, Tong, Xuemei, Xu, Ying, Chen, Guoqiang, Cheng, Shuqun, Fan, Xuemei, Liu, Junling, 2018 CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages, Li, Dongling, Hu, Minling, Liu, Ying, Ye, Peiying, Du, Peishuang, Li, ChiShan, Cheng, Liang, Liu, Ping, Jiang, Jing, Su, Lishan, Wang, Shengdian, Zheng, Pan, Liu, Yang, 2018 S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity, Zhang, Jinhua, Song, Kun, Wang, Jun, Li, Yanan, Liu, Shuangqing, Dai, Chengliang, Chen, Lieping, Wang, Shengdian, Qin, Zhihai, 2018 Arthritis of large joints shown as a rare clinical feature of cytokine release syndrome after chimeric antigen receptor T cell therapy A case report, Wang, LiXin, Chen, Xiaoping, Jia, Mingming, Wang, Shengdian, Shen, Jianliang, 2018 B7-DC (PD-L2) costimulation of CD4(+) T-helper 1 response via RGMb, Nie, Xinxin, Chen, Wenni, Zhu, Ying, Huang, Baozhu, Yu, Weiwei, Wu, Zhanshuai, Guo, Sizheng, Zhu, Yiping, Luo, Liqun, Wang, Shengdian, Chen, Lieping, 2018 The Efficacy of Oncolytic Adenovirus Is Mediated by T-cell Responses against Virus and Tumor in Syrian Hamster Model, Li, Xiaozhu, Wang, Pengju, Li, Hang, Du, Xuexiang, Liu, Mingyue, Huang, Qibin, Wang, Yaohe, Wang, Shengdian, 2017 Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent, Pengju Wang, Xiaozhu Li, Jiwei Wang, Dongling Gao, Yuenan Li, Haoze Li, Yongchao Chu, Zhongxian Zhang, Hongtao Liu, Guozhong Jiang, Zhenguo Cheng, Shengdian Wang, Jianzeng Dong, Baisui Feng, Louisa S Chard, Nicholas R Lemoine, Yaohe Wang, 2017 Genomic sequencing identifies a few mutations driving the independent origin of primary liver tumors in a chronic hepatitis murine model, Yang, Zuyu, Jia, Mingming, Liu, Guojing, Hao, Huaining, Chen, Li, Li, Guanghao, Liu, Sixue, Li, Yawei, Wu, ChungI, Lu, Xuemei, Wang, Shengdian, 2017 Expression of the galectin-9-Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma, Liu, Zengjin, Han, Huamin, He, Xin, Li, Shouwei, Wu, Chenxing, Yu, Chunjiang, Wang, Shengdian, 2016 A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy, Yan, Zhongyi, Wu, Yahong, Du, Jiangfeng, Li, Guodong, Wang, Shengdian, Cao, Wenpeng, Zhou, Xiuman, Wu, Chunjing, Zhang, Dan, Jing, Xueli, Li, Yifan, Wang, Hongfei, Gao, Yanfeng, Qi, Yuanming, 2016 Antibody Therapies in Cancer, Wang, Shengdian, Jia, Mingming, Zhang, S., 2016 Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype, Xu, Meng, Liu, Mingyue, Du, Xuexiang, Li, Sirui, Li, Hang, Li, Xiaozhu, Li, Ying, Wang, Yang, Qin, Zhihai, Fu, YangXin, Wang, Shengdian, 2015 CD163+CD14+macrophages, a potential immune biomarker for malignant pleural effusion, Wang, Fei, Yang, Li, Gao

Areas of Focus

Anti-tumor T cell immunity and immunotherapy
Regulation of T cell activation
Tumor microenvironment and T cell immune suppression
Mechanisms of memory CD8+ T cell differentiation

Publications

Glucocorticoid-induced expansion of classical monocytes contributes to bone loss, Liu, Pei, Gao, Youshui, Luo, Pengbo, Yu, Hongping, Guo, Shang, Liu, Fuyun, Gao, Junjie, Xu, Jianzhong, Wang, Shengdian, Zhang, Changqing, 2022
Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development, Jianli He, Xun Shangguan, Wei Zhou, Ying Cao, Quan Zheng, Jun Tu, Gaolei Hu, Zi Liang, Cen Jiang, Liufu Deng, Shengdian Wang, Wen Yang, Yong Zuo, Jiao Ma, Rong Cai, Yalan Chen, Qiuju Fan, Baijun Dong, Wei Xue, Hongsheng Tan, Yitao Qi, Jianmin Gu, Bing Su, Y Eugene Chin, Guoqiang Chen, Qi Wang, Tianshi Wang, Jinke Cheng, 2021
Neutrophil-to-lymphocyte ratio, a critical predictor for assessment of disease severity in patients with COVID-19, Liu, Lei, Zheng, Yaqiong, Cai, Liping, Wu, Wanlei, Tang, Shi, Ding, Yinjuan, Liu, Wanbing, Kou, Guomei, Xiong, Zhou, Wang, Shengdian, Zheng, Shangen, 2021
T Cells Expanded from PD-1(+) Peripheral Blood Lymphocytes Share More Clones with Paired Tumor-Infiltrating Lymphocytes, Li, Tiepeng, Zhao, Lingdi, Yang, Yonghao, Wang, Yao, Zhang, Yong, Guo, Jindong, Chen, Guangyu, Qin, Peng, Xu, Benling, Ma, Baozhen, Zhang, Fang, Shang, Yiman, Li, Qingjun, Zhang, Kai, Yuan, Dongfeng, Feng, Chaojie, Ma, Yan, Liu, Zhiyong, Tian, Zhichao, Li, Hongle, Wang, Shengdian, Gao, Quanli, 2021
Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy, Ying Li, Yanni Cong, Mingming Jia, Qianqian He, Haiqing Zhong, Yun Zhao, Hang Li, Meining Yan, Jia You, Jia Liu, Lieping Chen, Haiying Hang, Shengdian Wang, 2021
A novel workflow for cancer blood biomarker identification, Wang, Xiang, Qiu, Zhiqiang, Ji, Xiangwen, Ning, Weihai, An, Yihua, Wang, Shengdian, Zhang, Hongwei, 2020
The Prognostic Value of EMT in Glioma and its Role in the Glioma Immune Microenvironment, Ning, Weihai, Qiu, Zhiqiang, Ji, Xiangwen, Wang, Xiang, An, Yihua, Wang, Shengdian, Zhang, Hongwei, 2020
A Virus-Infected, Reprogrammed Somatic Cell-Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer, Lu, Shuangshuang, Zhang, Zhe, Du, Pan, Chard, Louisa S, Yan, Wenli, El Khouri, Margueritte, Wang, Zhizhong, Zhang, Zhongxian, Chu, Yongchao, Gao, Dongling, Zhang, Qinxian, Zhang, Lirong, Nagano, Ai, Wang, Jun, Chelala, Claude, Liu, Jing, Chen, Jiekai, Liu, Pentao, Dong, Yunshu, Wang, Shengdian, Li, Xiaozhu, Dong, Jianzeng, Lemoine, Nick R, Pei, Duanqing, Wang, Yaohe, 2020
A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients, Liu, Lei, Liu, Wanbing, Zheng, Yaqiong, Jiang, Xiaojing, Kou, Guomei, Ding, Jinya, Wang, Qiongshu, Huang, Qianchuan, Ding, Yinjuan, Ni, Wenxu, Wu, Wanlei, Tang, Shi, Tan, Li, Hu, Zhenhong, Xu, Weitian, Zhang, Yong, Zhang, Bo, Tang, Zhongzhi, Zhang, Xinhua, Li, Honghua, Rao, Zhiguo, Jiang, Hui, Ren, Xingfeng, Wang, Shengdian, Zheng, Shangen, 2020
First-in-class immune-modulating small molecule Icaritin in advanced hepatocellular carcinoma: preliminary results of safety, durable survival and immune biomarkers, Fan, Ying, Li, Shu, Ding, Xiaoyan, Yue, Jian, Jiang, Jun, Zhao, Hong, Hao, Rui, Qiu, Weiliang, Liu, Kezhen, Li, Ying, Wang, Shengdian, Zheng, Limin, Ye, Bin, Meng, Kun, Xu, Binghe, 2019
S-15 in combination of Akt inhibitor promotes the expansion of CD45RA(-)CCR7(+) tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1(+)Tim-3(+) cells as well as regulatory T cells, Xu, Benling, Yuan, Long, Chen, Guangyu, Li, Tiepeng, Zhou, Jinxue, Zhang, Chengjuan, Qin, Peng, Muthana, Musleh M, Wang, Shengdian, Du, Xuexiang, Gao, Quanli, 2019
NKG2A is a NK cell exhaustion checkpoint for HCV persistence, Chao Zhang, Xiaomei Wang, Shuran Li, Trix Twelkmeyer, Weihong Wang, Shengyuan Zhang, Shufeng Wang, Jizheng Chen, Xia Jin, Yuzhang Wu, Xinwen Chen, Shengdian Wang, Junqi Niu, Hairong Chen, Hong Tang, 2019
Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent (vol 8, 2017), Wang, Pengju, Li, Xiaozhu, Wang, Jiwei, Gao, Dongling, Li, Yuenan, Li, Haoze, Chu, Yongchao, Zhang, Zhongxian, Liu, Hongtao, Jiang, Guozhong, Cheng, Zhenguo, Wang, Shengdian, Dong, Jianzeng, Feng, Baisui, Chard, Louisa S, Lemoine, Nicholas R, Wang, Yaohe, 2018
Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis, Wang, Conghui, Cheng, Yuqiang, Zhang, Xiuping, Li, Nan, Zhang, Lin, Wang, Shengdian, Tong, Xuemei, Xu, Ying, Chen, Guoqiang, Cheng, Shuqun, Fan, Xuemei, Liu, Junling, 2018
CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages, Li, Dongling, Hu, Minling, Liu, Ying, Ye, Peiying, Du, Peishuang, Li, ChiShan, Cheng, Liang, Liu, Ping, Jiang, Jing, Su, Lishan, Wang, Shengdian, Zheng, Pan, Liu, Yang, 2018
S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity, Zhang, Jinhua, Song, Kun, Wang, Jun, Li, Yanan, Liu, Shuangqing, Dai, Chengliang, Chen, Lieping, Wang, Shengdian, Qin, Zhihai, 2018
Arthritis of large joints shown as a rare clinical feature of cytokine release syndrome after chimeric antigen receptor T cell therapy A case report, Wang, LiXin, Chen, Xiaoping, Jia, Mingming, Wang, Shengdian, Shen, Jianliang, 2018
B7-DC (PD-L2) costimulation of CD4(+) T-helper 1 response via RGMb, Nie, Xinxin, Chen, Wenni, Zhu, Ying, Huang, Baozhu, Yu, Weiwei, Wu, Zhanshuai, Guo, Sizheng, Zhu, Yiping, Luo, Liqun, Wang, Shengdian, Chen, Lieping, 2018
The Efficacy of Oncolytic Adenovirus Is Mediated by T-cell Responses against Virus and Tumor in Syrian Hamster Model, Li, Xiaozhu, Wang, Pengju, Li, Hang, Du, Xuexiang, Liu, Mingyue, Huang, Qibin, Wang, Yaohe, Wang, Shengdian, 2017
Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent, Pengju Wang, Xiaozhu Li, Jiwei Wang, Dongling Gao, Yuenan Li, Haoze Li, Yongchao Chu, Zhongxian Zhang, Hongtao Liu, Guozhong Jiang, Zhenguo Cheng, Shengdian Wang, Jianzeng Dong, Baisui Feng, Louisa S Chard, Nicholas R Lemoine, Yaohe Wang, 2017
Genomic sequencing identifies a few mutations driving the independent origin of primary liver tumors in a chronic hepatitis murine model, Yang, Zuyu, Jia, Mingming, Liu, Guojing, Hao, Huaining, Chen, Li, Li, Guanghao, Liu, Sixue, Li, Yawei, Wu, ChungI, Lu, Xuemei, Wang, Shengdian, 2017
Expression of the galectin-9-Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma, Liu, Zengjin, Han, Huamin, He, Xin, Li, Shouwei, Wu, Chenxing, Yu, Chunjiang, Wang, Shengdian, 2016
A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy, Yan, Zhongyi, Wu, Yahong, Du, Jiangfeng, Li, Guodong, Wang, Shengdian, Cao, Wenpeng, Zhou, Xiuman, Wu, Chunjing, Zhang, Dan, Jing, Xueli, Li, Yifan, Wang, Hongfei, Gao, Yanfeng, Qi, Yuanming, 2016
Antibody Therapies in Cancer, Wang, Shengdian, Jia, Mingming, Zhang, S., 2016
Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype, Xu, Meng, Liu, Mingyue, Du, Xuexiang, Li, Sirui, Li, Hang, Li, Xiaozhu, Li, Ying, Wang, Yang, Qin, Zhihai, Fu, YangXin, Wang, Shengdian, 2015
CD163+CD14+macrophages, a potential immune biomarker for malignant pleural effusion, Wang, Fei, Yang, Li, Gao

T Cell Immunity Immunotherapy Activation Regulation Tumor Microenvironment Suppression Memory Differentiation

Guifen Liu - Tongji University

Guifen Liu - Tongji University

Nengming Xiao - Xiamen University

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