Areas of Focus
- Endoplasmic Reticulum Stress and Unfolded Protein Response
Work Experience
- 2017-07 to Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
- 2010-12 to 2017-06 - University of California, San Francisco - Postdoc, Associate Specialist
Academic Background & Achievements
- 2005-09 to 2010-06 PhD: Institute of Biophysics, Chinese Academy of Sciences
- 2001-09 to 2005-06 Bachelor's: Beijing Normal University
Publications
- VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms., Tao Li, Hongyu Zhao, Gaofeng Guo, Shuwei Xia, Likun Wang, 2023
- Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production., Yang, Zaili, Huo, Yazhen, Zhou, Shixin, Guo, Jingya, Ma, Xiaotu, Li, Tao, Fan, Congli, Wang, Likun, 2022
- 内质网应激下的内质网-线粒体互作., 王立堃, 2022
- Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress., Yu, Jiaojiao, Li, Tao, Liu, Yu, Wang, Xi, Zhang, Jianchao, Wang, Xie, Shi, Guizhi, Lou, Jizhong, Wang, Likun, Wang, Chihchen, VVang, Lei, 2020
- 跨细胞蛋白质内稳态调控机制., 田烨, 王立堃, 2018
- Targeting ABL-IRE1 alpha Signaling Spares ER- Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes., Morita, Shuhei, Villalta, S Armando, Feldman, Hannah C, Register, Ames C, Rosenthal, Wendy, HoffmannPetersen, Ingeborg T, Mehdizadeh, Morvarid, Ghosh, Rajarshi, Wang, Likun, ColonNegron, Kevin, MezaAcevedo, Rosa, Backes, Bradley J, Maly, Dustin J, Bluestone, Jeffrey A, Papa, Feroz R, 2017
- Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes., Morita Shuhei, Villalta S Armando, Feldman Hannah C, Register Ames C, Rosenthal Wendy, HoffmannPetersen Ingeborg T, Mehdizadeh Morvarid, Ghosh Rajarshi, Wang Likun, ColonNegron Kevin, MezaAcevedo Rosa, Backes Bradley J, Maly Dustin J, Bluestone Jeffrey A, Papa Feroz R, 2017
- Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands., Feldman Hannah C, Tong Michael, Wang Likun, MezaAcevedo Rosa, Gobillot Theodore A, Lebedev Ivan, Gliedt Micah J, Hari Sanjay B, Mitra Arinjay K, Backes Bradley J, Papa Feroz R, Seeliger Markus A, Maly Dustin J, 2016
- Allosteric Inhibition of the IRE1 alpha RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress., Ghosh, Rajarshi, Wang, Likun, Wang, Eric S, Perera, B Gayani K, Igbaria, Aeid, Morita, Shuhei, Prado, Kris, Thamsen, Maike, Caswell, Deborah, Macias, Hector, Weiberth, Kurt F, Gliedt, Micah J, Alavi, Marcel V, Hari, Sanjay B, Mitra, Arinjay K, Bhhatarai, Barun, Schuerer, Stephan C, Snapp, Erik L, Gould, Douglas B, German, Michael S, Backes, Bradley J, Maly, Dustin J, Oakes, Scott A, Papa, Feroz R, 2014
- Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors., Wang Likun, 2012
- IRE1α Cleaves Select microRNAs during ER Stress to Derepress Translation of Pro-apoptotic Caspase-2., Wang Likun, 2012
- Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4., Wang, Xi, Wang, Likun, Wang, Xie, Sun, Fei, Wang, Chihchen, 2012
- Divergent allosteric control of the IRE1 alpha endoribonuclease using kinase inhibitors., Wang, Likun, Perera, B Gayani K, Hari, Sanjay B, Bhhatarai, Barun, Backes, Bradley J, Seeliger, Markus A, Schuerer, Stephan C, Oakes, Scott A, Papa, Feroz R, Maly, Dustin J, 2012
- ERp44 C160S/C212S mutants regulate IP3R1 channel activity., Pan, Congyan, Zheng, Ji, Wu, Yanyun, Chen, Yingxiao, Wang, Likun, Zhou, Zhansong, Yin, Wenxuan, Ji, Guangju, 2011
- Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail., Wang, Likun, Wang, Lei, Vavassori, Stefano, Li, Shengjian, Ke, Huimin, Anelli, Tiziana, Degano, Massimo, Ronzoni, Riccardo, Sitia, Roberto, Sun, Fei, Wang, Chihchen, 2008
