Professor | Likun Wang | Asia Growth Partners

Name	Likun Wang
Contact Information	wanglikun@ibp.ac.cn
Language ability	Chinese, English
Province	Beijing

Name

Likun Wang

Contact Information

wanglikun@ibp.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2005-09 to 2010-06 PhD: Institute of Biophysics, Chinese Academy of Sciences 2001-09 to 2005-06 Bachelor's: Beijing Normal University
Work Experience	2017-07 to Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher 2010-12 to 2017-06 - University of California, San Francisco - Postdoc, Associate Specialist

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2005-09 to 2010-06 PhD: Institute of Biophysics, Chinese Academy of Sciences
2001-09 to 2005-06 Bachelor's: Beijing Normal University

Work Experience

2017-07 to Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
2010-12 to 2017-06 - University of California, San Francisco - Postdoc, Associate Specialist

Areas of Focus	Endoplasmic Reticulum Stress and Unfolded Protein Response
Publications	VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms., Tao Li, Hongyu Zhao, Gaofeng Guo, Shuwei Xia, Likun Wang, 2023 Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production., Yang, Zaili, Huo, Yazhen, Zhou, Shixin, Guo, Jingya, Ma, Xiaotu, Li, Tao, Fan, Congli, Wang, Likun, 2022 内质网应激下的内质网-线粒体互作., 王立堃, 2022 Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress., Yu, Jiaojiao, Li, Tao, Liu, Yu, Wang, Xi, Zhang, Jianchao, Wang, Xie, Shi, Guizhi, Lou, Jizhong, Wang, Likun, Wang, Chihchen, VVang, Lei, 2020 跨细胞蛋白质内稳态调控机制., 田烨, 王立堃, 2018 Targeting ABL-IRE1 alpha Signaling Spares ER- Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes., Morita, Shuhei, Villalta, S Armando, Feldman, Hannah C, Register, Ames C, Rosenthal, Wendy, HoffmannPetersen, Ingeborg T, Mehdizadeh, Morvarid, Ghosh, Rajarshi, Wang, Likun, ColonNegron, Kevin, MezaAcevedo, Rosa, Backes, Bradley J, Maly, Dustin J, Bluestone, Jeffrey A, Papa, Feroz R, 2017 Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes., Morita Shuhei, Villalta S Armando, Feldman Hannah C, Register Ames C, Rosenthal Wendy, HoffmannPetersen Ingeborg T, Mehdizadeh Morvarid, Ghosh Rajarshi, Wang Likun, ColonNegron Kevin, MezaAcevedo Rosa, Backes Bradley J, Maly Dustin J, Bluestone Jeffrey A, Papa Feroz R, 2017 Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands., Feldman Hannah C, Tong Michael, Wang Likun, MezaAcevedo Rosa, Gobillot Theodore A, Lebedev Ivan, Gliedt Micah J, Hari Sanjay B, Mitra Arinjay K, Backes Bradley J, Papa Feroz R, Seeliger Markus A, Maly Dustin J, 2016 Allosteric Inhibition of the IRE1 alpha RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress., Ghosh, Rajarshi, Wang, Likun, Wang, Eric S, Perera, B Gayani K, Igbaria, Aeid, Morita, Shuhei, Prado, Kris, Thamsen, Maike, Caswell, Deborah, Macias, Hector, Weiberth, Kurt F, Gliedt, Micah J, Alavi, Marcel V, Hari, Sanjay B, Mitra, Arinjay K, Bhhatarai, Barun, Schuerer, Stephan C, Snapp, Erik L, Gould, Douglas B, German, Michael S, Backes, Bradley J, Maly, Dustin J, Oakes, Scott A, Papa, Feroz R, 2014 Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors., Wang Likun, 2012 IRE1α Cleaves Select microRNAs during ER Stress to Derepress Translation of Pro-apoptotic Caspase-2., Wang Likun, 2012 Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4., Wang, Xi, Wang, Likun, Wang, Xie, Sun, Fei, Wang, Chihchen, 2012 Divergent allosteric control of the IRE1 alpha endoribonuclease using kinase inhibitors., Wang, Likun, Perera, B Gayani K, Hari, Sanjay B, Bhhatarai, Barun, Backes, Bradley J, Seeliger, Markus A, Schuerer, Stephan C, Oakes, Scott A, Papa, Feroz R, Maly, Dustin J, 2012 ERp44 C160S/C212S mutants regulate IP3R1 channel activity., Pan, Congyan, Zheng, Ji, Wu, Yanyun, Chen, Yingxiao, Wang, Likun, Zhou, Zhansong, Yin, Wenxuan, Ji, Guangju, 2011 Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail., Wang, Likun, Wang, Lei, Vavassori, Stefano, Li, Shengjian, Ke, Huimin, Anelli, Tiziana, Degano, Massimo, Ronzoni, Riccardo, Sitia, Roberto, Sun, Fei, Wang, Chihchen, 2008

Areas of Focus

Endoplasmic Reticulum Stress and Unfolded Protein Response

Publications

VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms., Tao Li, Hongyu Zhao, Gaofeng Guo, Shuwei Xia, Likun Wang, 2023
Cancer cell-intrinsic XBP1 drives immunosuppressive reprogramming of intratumoral myeloid cells by promoting cholesterol production., Yang, Zaili, Huo, Yazhen, Zhou, Shixin, Guo, Jingya, Ma, Xiaotu, Li, Tao, Fan, Congli, Wang, Likun, 2022
内质网应激下的内质网-线粒体互作., 王立堃, 2022
Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress., Yu, Jiaojiao, Li, Tao, Liu, Yu, Wang, Xi, Zhang, Jianchao, Wang, Xie, Shi, Guizhi, Lou, Jizhong, Wang, Likun, Wang, Chihchen, VVang, Lei, 2020
跨细胞蛋白质内稳态调控机制., 田烨, 王立堃, 2018
Targeting ABL-IRE1 alpha Signaling Spares ER- Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes., Morita, Shuhei, Villalta, S Armando, Feldman, Hannah C, Register, Ames C, Rosenthal, Wendy, HoffmannPetersen, Ingeborg T, Mehdizadeh, Morvarid, Ghosh, Rajarshi, Wang, Likun, ColonNegron, Kevin, MezaAcevedo, Rosa, Backes, Bradley J, Maly, Dustin J, Bluestone, Jeffrey A, Papa, Feroz R, 2017
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes., Morita Shuhei, Villalta S Armando, Feldman Hannah C, Register Ames C, Rosenthal Wendy, HoffmannPetersen Ingeborg T, Mehdizadeh Morvarid, Ghosh Rajarshi, Wang Likun, ColonNegron Kevin, MezaAcevedo Rosa, Backes Bradley J, Maly Dustin J, Bluestone Jeffrey A, Papa Feroz R, 2017
Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands., Feldman Hannah C, Tong Michael, Wang Likun, MezaAcevedo Rosa, Gobillot Theodore A, Lebedev Ivan, Gliedt Micah J, Hari Sanjay B, Mitra Arinjay K, Backes Bradley J, Papa Feroz R, Seeliger Markus A, Maly Dustin J, 2016
Allosteric Inhibition of the IRE1 alpha RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress., Ghosh, Rajarshi, Wang, Likun, Wang, Eric S, Perera, B Gayani K, Igbaria, Aeid, Morita, Shuhei, Prado, Kris, Thamsen, Maike, Caswell, Deborah, Macias, Hector, Weiberth, Kurt F, Gliedt, Micah J, Alavi, Marcel V, Hari, Sanjay B, Mitra, Arinjay K, Bhhatarai, Barun, Schuerer, Stephan C, Snapp, Erik L, Gould, Douglas B, German, Michael S, Backes, Bradley J, Maly, Dustin J, Oakes, Scott A, Papa, Feroz R, 2014
Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors., Wang Likun, 2012
IRE1α Cleaves Select microRNAs during ER Stress to Derepress Translation of Pro-apoptotic Caspase-2., Wang Likun, 2012
Structural insights into the peroxidase activity and inactivation of human peroxiredoxin 4., Wang, Xi, Wang, Likun, Wang, Xie, Sun, Fei, Wang, Chihchen, 2012
Divergent allosteric control of the IRE1 alpha endoribonuclease using kinase inhibitors., Wang, Likun, Perera, B Gayani K, Hari, Sanjay B, Bhhatarai, Barun, Backes, Bradley J, Seeliger, Markus A, Schuerer, Stephan C, Oakes, Scott A, Papa, Feroz R, Maly, Dustin J, 2012
ERp44 C160S/C212S mutants regulate IP3R1 channel activity., Pan, Congyan, Zheng, Ji, Wu, Yanyun, Chen, Yingxiao, Wang, Likun, Zhou, Zhansong, Yin, Wenxuan, Ji, Guangju, 2011
Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail., Wang, Likun, Wang, Lei, Vavassori, Stefano, Li, Shengjian, Ke, Huimin, Anelli, Tiziana, Degano, Massimo, Ronzoni, Riccardo, Sitia, Roberto, Sun, Fei, Wang, Chihchen, 2008

Endoplasmic Reticulum Protein Folding Unfolded Protein Response Er Stress Cell Differentiation Apoptosis Neurodegenerative Diseases Diabetes Cancer Gene Mutation

Huiwen Yan - Central South University

Jun Huang - Zhejiang University

Renqing Feng - Peking University

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