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Wei Gang
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Computational Biology
Epigenetics
Development
Disease
Regulation
Genomics
Bioinformatics
Chromatin
Gene Expression
Systems Biology
Areas of Focus
- Computational Biology - Epigenetic Regulation of Development and Disease
Work Experience
- 2012-01~Present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Researcher
- 2005-09~2011-12 - National Institutes of Health, USA - Postdoctoral Research Assistant
- 2000-09~2005-07 - Peking University - PhD
- 1996-09~2000-07 - Peking University - Bachelor
Academic Background & Achievements
- 2000-09--2005-07 PhD: Peking University
- 1996-09--2000-07 Bachelor: Peking University
Publications
- PfSET2 Is Involved in Genome Organization of Var Gene Family in Plasmodium falciparum, 11th Author, 2023
- The CTCF/LncRNA-PACERR complex recruits E1A binding protein p300 to induce pro-tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression, 11th Author, 2022
- Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells, 11th Author, 2022
- Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging, 18th Author, 2022
- Global changes in chromatin accessibility and transcription in growth hormone-secreting pituitary adenoma, 11th Author, 2022
- Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity, 11th Author, 2022
- Integrated Chromatin Accessibility and Transcriptome Landscapes of Doxorubicin-Resistant Breast Cancer Cells, 11th Author, 2021
- The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum, 11th Author, 2021
- Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection, 11th Author, 2020
- Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling, 9th Author, 2020
- The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation, 0th Author, 2020
- Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites, 16th Author, 2020
- Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies, 23rd Author, 2020
- SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation, 10th Author, 2020
- Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, 12th Author, 2020
- Establishment and Investigation of a Multiple Gene Expression Signature to Predict Long-Term Survival in Pancreatic Cancer, 11th Author, 2020
- Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis, 11th Author, 2019
- SMYD2 Drives Mesendodermal Differentiation of Human Embryonic Stem Cells Through Mediating the Transcriptional Activation of Key Mesendodermal Genes, 11th Author, 2019
- Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses, 26th Author, 2019
- MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes, 7th Author, 2018
- Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome., 5th Author, 2018
- Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription, 2nd Author, 2017
- Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ER/HGF/Met Pathway, 12th Author, 2017
- SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing, 9th Author, 2017
- Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, 11th Author, 2017
- Epigenomic analysis in a cell-based model reveals the roles of H3K9me3 in breast cancer transformation, 11th Author, 2017
- Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, 11th Author, 2017
- USP21 prevents the generation of T-helper-1-like Treg cells, 10th Author, 2016
- A positive role for polycomb in transcriptional regulation via H4K20me1, 11th Author, 2016
- Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model, 11th Author, 2016
- GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer, 12th Author, 2016
- Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes, 4th Author, 2016
- Foxp1/2/4 regulate endochondral ossification as a suppresser complex, 0th Author, 2015
- Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development, 5th Author, 2014
- Critical role of histone demethylase Jmjd3 in the regulation of CD4 + T cell differentiation, 8th Author, 2014
- Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain, 5th Author, 2014
- Comparison of REST Cistromes across Human Cell Types Reveals Common and Context-Specific Functions, 4th Author, 2014
- PARP-1 regulates expression of TGF-β receptors in T cells, 9th Author, 2013
- Understanding human diseases with high-throughput quantitative measurement and analysis of molecular signatures, 2nd Author, 2013
- c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells, 3rd Author, 2012
- The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses, 4th Author, 2012
- Genome-Wide Mapping of Nucleosome Occupancy, Histone Modifications, and Gene Expression Using Next-Generation Sequencing Technology, 1st Author, 2012
- Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization, 2nd Author, 2012
- Chapter Thirteen - Genome-Wide Mapping of Nucleosome Occupancy, Histone Modifications, and Gene Expression Using Next-Generation Sequencing Technology, 1st Author, 2012
- Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types, 1st Author, 2011
- Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription, 2nd Author, 2011
- GATA3 controls Foxp3(+) regulatory T cell fate during inflammation in mice, 13th Author, 2011
- Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq, 3rd Author, 2010
- The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma, 3rd Author, 2010
- IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells, 2nd Author, 2009
- Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103(+) inducible regulatory T cells, 3rd Author, 2009
- H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions, 3rd Author, 2009
- Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq, 2nd Author, 2009
- Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4 + T Cells, 1st Author, 2009
- Dynamic Regulation of Nucleosome Positioning in the Human Genome, 7th Author, 2008
- High-Resolution Profiling of Histone Methylations in the Human Genome, 7th Author, 2007
- Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns, 2nd Author, 2007
