2012-01~Present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Researcher
2005-09~2011-12 - National Institutes of Health, USA - Postdoctoral Research Assistant
2000-09~2005-07 - Peking University - PhD
1996-09~2000-07 - Peking University - Bachelor
Research
Computational Biology - Epigenetic Regulation of Development and Disease
PfSET2 Is Involved in Genome Organization of Var Gene Family in Plasmodium falciparum, 11th Author, 2023
The CTCF/LncRNA-PACERR complex recruits E1A binding protein p300 to induce pro-tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression, 11th Author, 2022
Reorganization of 3D chromatin architecture in doxorubicin-resistant breast cancer cells, 11th Author, 2022
Integrated Chromatin Accessibility and Transcriptome Landscapes of Doxorubicin-Resistant Breast Cancer Cells, 11th Author, 2021
The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum, 11th Author, 2021
Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection, 11th Author, 2020
Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling, 9th Author, 2020
The Nuclear Matrix Protein SAFB Cooperates with Major Satellite RNAs to Stabilize Heterochromatin Architecture Partially through Phase Separation, 0th Author, 2020
Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites, 16th Author, 2020
Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies, 23rd Author, 2020
SH3RF3 promotes breast cancer stem-like properties via JNK activation and PTX3 upregulation, 10th Author, 2020
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, 12th Author, 2020
Establishment and Investigation of a Multiple Gene Expression Signature to Predict Long-Term Survival in Pancreatic Cancer, 11th Author, 2020
Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis, 11th Author, 2019
SMYD2 Drives Mesendodermal Differentiation of Human Embryonic Stem Cells Through Mediating the Transcriptional Activation of Key Mesendodermal Genes, 11th Author, 2019
Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses, 26th Author, 2019
MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes, 7th Author, 2018
Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome., 5th Author, 2018
Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription, 2nd Author, 2017
Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ER/HGF/Met Pathway, 12th Author, 2017
SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing, 9th Author, 2017
Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, 11th Author, 2017
Epigenomic analysis in a cell-based model reveals the roles of H3K9me3 in breast cancer transformation, 11th Author, 2017
USP21 prevents the generation of T-helper-1-like Treg cells, 10th Author, 2016
A positive role for polycomb in transcriptional regulation via H4K20me1, 11th Author, 2016
Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model, 11th Author, 2016
GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer, 12th Author, 2016
Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes, 4th Author, 2016
Foxp1/2/4 regulate endochondral ossification as a suppresser complex, 0th Author, 2015
Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development, 5th Author, 2014
Critical role of histone demethylase Jmjd3 in the regulation of CD4 + T cell differentiation, 8th Author, 2014
Reconstruction of the Gene Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role in Early Development of the Mouse Brain, 5th Author, 2014
Comparison of REST Cistromes across Human Cell Types Reveals Common and Context-Specific Functions, 4th Author, 2014
PARP-1 regulates expression of TGF-β receptors in T cells, 9th Author, 2013
Understanding human diseases with high-throughput quantitative measurement and analysis of molecular signatures, 2nd Author, 2013
c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells, 3rd Author, 2012
The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses, 4th Author, 2012
Genome-Wide Mapping of Nucleosome Occupancy, Histone Modifications, and Gene Expression Using Next-Generation Sequencing Technology, 1st Author, 2012
Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization, 2nd Author, 2012
Chapter Thirteen - Genome-Wide Mapping of Nucleosome Occupancy, Histone Modifications, and Gene Expression Using Next-Generation Sequencing Technology, 1st Author, 2012
Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types, 1st Author, 2011
Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription, 2nd Author, 2011
GATA3 controls Foxp3(+) regulatory T cell fate during inflammation in mice, 13th Author, 2011
Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq, 3rd Author, 2010
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma, 3rd Author, 2010
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells, 2nd Author, 2009
Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103(+) inducible regulatory T cells, 3rd Author, 2009
H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions, 3rd Author, 2009
Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq, 2nd Author, 2009
Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4 + T Cells, 1st Author, 2009
Dynamic Regulation of Nucleosome Positioning in the Human Genome, 7th Author, 2008
High-Resolution Profiling of Histone Methylations in the Human Genome, 7th Author, 2007
Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns, 2nd Author, 2007
Area of Focus
Ai | Omics | Precision Medicine | Bioinformatics | Data Analysis | Genomics | Crispr | Machine Learning | Drug Design | Single-Cell Analysis
