Professor | Hua Xiang | Asia Growth Partners

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Name	Hua Xiang
Contact Information	xiangh@im.ac.cn
Language ability	Chinese, English
Province	Beijing

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Name

Hua Xiang

Contact Information

xiangh@im.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1994-09 to 1997-06: PhD in Basic Medicine, Peking Union Medical College 1991-09 to 1994-06: Master's in Biology, Beijing Normal University 1987-09 to 1991-06: Bachelor's in Biology, Beijing Normal University
Work Experience	2018-04 to Present: Deputy Director, Institute of Microbiology, Chinese Academy of Sciences 2017-09 to Present: Director, State Key Laboratory, Institute of Microbiology, Chinese Academy of Sciences 2003-12 to 2017-09: Researcher/Doctoral Supervisor/Deputy Director of Center/Deputy Director of Key Laboratory, Institute of Microbiology, Chinese Academy of Sciences 2001-06 to 2003-11: Associate Researcher/Master's Supervisor/Deputy Director of Center, Institute of Microbiology, Chinese Academy of Sciences 1999-06 to 2001-06: Postdoctoral Researcher, University of Medicine & Dentistry of New Jersey 1997-07 to 1999-06: Postdoctoral Researcher, Institute of Microbiology, Chinese Academy of Sciences
Awards	2009: Recipient of the National Science Fund for Distinguished Young Scholars 2006: Awarded 'Outstanding Postdoctoral Fellow' by the Chinese Academy of Sciences

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1994-09 to 1997-06: PhD in Basic Medicine, Peking Union Medical College
1991-09 to 1994-06: Master's in Biology, Beijing Normal University
1987-09 to 1991-06: Bachelor's in Biology, Beijing Normal University

Work Experience

2018-04 to Present: Deputy Director, Institute of Microbiology, Chinese Academy of Sciences
2017-09 to Present: Director, State Key Laboratory, Institute of Microbiology, Chinese Academy of Sciences
2003-12 to 2017-09: Researcher/Doctoral Supervisor/Deputy Director of Center/Deputy Director of Key Laboratory, Institute of Microbiology, Chinese Academy of Sciences
2001-06 to 2003-11: Associate Researcher/Master's Supervisor/Deputy Director of Center, Institute of Microbiology, Chinese Academy of Sciences
1999-06 to 2001-06: Postdoctoral Researcher, University of Medicine & Dentistry of New Jersey
1997-07 to 1999-06: Postdoctoral Researcher, Institute of Microbiology, Chinese Academy of Sciences

Awards

2009: Recipient of the National Science Fund for Distinguished Young Scholars
2006: Awarded 'Outstanding Postdoctoral Fellow' by the Chinese Academy of Sciences

Areas of Focus	Microbial Genetics Microbial Physiology and Metabolism Microbial Bioengineering Molecular Microbiology
Publications	Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems, Li M, Gong L, Cheng F, Yu H, Zhao D, Wang R, Wang T, Zhang S, Zhou J, Shmakov SA, Koonin EV, Xiang H, 2021 Highly integrated adaptive mechanisms in Spiribacter halalkaliphilus, a bacterium abundant in Chinese soda-saline lakes, Xue, Q., D. Zhao, S. Zhang, H. Zhou, Z. Zuo, J. Zhou, M. Li and H. Xiang, 2021 Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux, Lin L, Chen J, Mitra R, Gao Q, Cheng F, Xu T, Zuo Z, Xiang H, Han J, 2021 Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins, Cheng F, Wang R, Yu H, Liu C, Yang J, Xiang H, Li M, 2021 Abundant Taxa and Favorable Pathways in the Microbiome of Soda-Saline Lakes in Inner Mongolia, Zhao D, Zhang S, Xue Q, Chen J, Zhou J, Cheng F, Li M, Zhu Y, Yu H, Hu S, Zheng Y, Liu S, Xiang H, 2020 Native CRISPR-Cas-Mediated Genome Editing Enables Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa, Xu Z, Li M, Li Y, Cao H, Miao L, Xu Z, Higuchi Y, Yamasaki S, Nishino K, Woo PCY, Xiang H, Yan A, 2019 A Halocin Promotes DNA Uptake in Haloferax mediterranei, Chen S, Sun S, Korfanty GA, Liu J, Xiang H, 2019 Unusual Phosphoenolpyruvate (PEP) Synthetase-Like Protein Crucial to Enhancement of Polyhydroxyalkanoate Accumulation in Haloferax mediterranei Revealed by Dissection of PEP-Pyruvate Interconversion Mechanism, Chen J, Mitra R, Zhang S, Zuo Z, Lin L, Zhao D, Xiang H, Han J, 2019 Primed adaptation tolerates extensive structural and size variations of the CRISPR RNA guide in Haloarcula hispanica, Gong L, Li M, Cheng F, Zhao D, Chen Y, Xiang H, 2019 Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference, You L, Ma J, Wang J, Artamonova D, Wang M, Liu L, Xiang H, Severinov K, Zhang X, Wang Y, 2019 Engineering Haloferax mediterranei as an Efficient Platform for High Level Production of Lycopene, Zuo ZQ, Xue Q, Zhou J, Zhao DH, Han J, Xiang H, 2018 The spacer size of I-B CRISPR is modulated by the terminal sequence of the protospacer, Li M, Gong L, Zhao D, Zhou J, Xiang H, 2017 Biodegradation and biocompatibility of haloarchaea-produced poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymers, Han J, Wu L, Liu X, Hou J, Zhao L, Chen J, Zhao D, Xiang H, 2017 Systematic analysis of lysine acetylation in the halophilic archaeon Haloferax mediterranei, Liu J, Wang Q, Jiang X, Yang H, Zhao D, Han J, Luo Y, Xiang H, 2017 DNA motifs determining the accuracy of repeat duplication during CRISPR adaptation in Haloarcula hispanica, Wang R, Li M, Gong L, Hu S, Xiang H, 2016 Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins, Yang H, Wu Z, Liu J, Liu X, Wang L, Cai S, Xiang H, 2015 A patatin-like protein associated with the polyhydroxyalkanoate (PHA) granules of Haloferax mediterranei acts as an efficient depolymerase in degradation of native PHA, Liu G, Hou J, Cai S, Zhao D, Cai L, Han J, Zhou J, Xiang H, 2015 Biosynthesis, characterization and hemostasis potential of tailor-made poly(3-hydroxybutyrate-co-3- hydroxyvalerate) produced by Haloferax mediterranei, Han J, Wu LP, Hou J, Zhao D, Xiang H, 2015 Propionyl coenzyme A (propionyl-CoA) carboxylase in Haloferax mediterranei: Indispensability for propionyl-CoA assimilation and impacts on global metabolism, Hou J, Xiang H, Han J, 2015 A novel DNA-binding protein, PhaR, plays a central role in the regulation of polyhydroxyalkanoate accumulation and granule formation in the haloarchaeon Haloferax mediterranei, Cai S, Cai L, Zhao D, Liu G, Han J, Zhou J, Xiang H, 2015 Haloarcula hispanica CRISPR authenticates PAM of a target sequence to prime discriminative adaptation, Li M, Wang R, Xiang H, 2014 Adaptation of the Haloarcula hispanica CRISPR-Cas system to a purified virus strictly requires a priming process, Li M, Wang R, Zhao D, Xiang H, 2014

Areas of Focus

Microbial Genetics
Microbial Physiology and Metabolism
Microbial Bioengineering
Molecular Microbiology

Publications

Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems, Li M, Gong L, Cheng F, Yu H, Zhao D, Wang R, Wang T, Zhang S, Zhou J, Shmakov SA, Koonin EV, Xiang H, 2021
Highly integrated adaptive mechanisms in Spiribacter halalkaliphilus, a bacterium abundant in Chinese soda-saline lakes, Xue, Q., D. Zhao, S. Zhang, H. Zhou, Z. Zuo, J. Zhou, M. Li and H. Xiang, 2021
Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux, Lin L, Chen J, Mitra R, Gao Q, Cheng F, Xu T, Zuo Z, Xiang H, Han J, 2021
Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins, Cheng F, Wang R, Yu H, Liu C, Yang J, Xiang H, Li M, 2021
Abundant Taxa and Favorable Pathways in the Microbiome of Soda-Saline Lakes in Inner Mongolia, Zhao D, Zhang S, Xue Q, Chen J, Zhou J, Cheng F, Li M, Zhu Y, Yu H, Hu S, Zheng Y, Liu S, Xiang H, 2020
Native CRISPR-Cas-Mediated Genome Editing Enables Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa, Xu Z, Li M, Li Y, Cao H, Miao L, Xu Z, Higuchi Y, Yamasaki S, Nishino K, Woo PCY, Xiang H, Yan A, 2019
A Halocin Promotes DNA Uptake in Haloferax mediterranei, Chen S, Sun S, Korfanty GA, Liu J, Xiang H, 2019
Unusual Phosphoenolpyruvate (PEP) Synthetase-Like Protein Crucial to Enhancement of Polyhydroxyalkanoate Accumulation in Haloferax mediterranei Revealed by Dissection of PEP-Pyruvate Interconversion Mechanism, Chen J, Mitra R, Zhang S, Zuo Z, Lin L, Zhao D, Xiang H, Han J, 2019
Primed adaptation tolerates extensive structural and size variations of the CRISPR RNA guide in Haloarcula hispanica, Gong L, Li M, Cheng F, Zhao D, Chen Y, Xiang H, 2019
Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference, You L, Ma J, Wang J, Artamonova D, Wang M, Liu L, Xiang H, Severinov K, Zhang X, Wang Y, 2019
Engineering Haloferax mediterranei as an Efficient Platform for High Level Production of Lycopene, Zuo ZQ, Xue Q, Zhou J, Zhao DH, Han J, Xiang H, 2018
The spacer size of I-B CRISPR is modulated by the terminal sequence of the protospacer, Li M, Gong L, Zhao D, Zhou J, Xiang H, 2017
Biodegradation and biocompatibility of haloarchaea-produced poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymers, Han J, Wu L, Liu X, Hou J, Zhao L, Chen J, Zhao D, Xiang H, 2017
Systematic analysis of lysine acetylation in the halophilic archaeon Haloferax mediterranei, Liu J, Wang Q, Jiang X, Yang H, Zhao D, Han J, Luo Y, Xiang H, 2017
DNA motifs determining the accuracy of repeat duplication during CRISPR adaptation in Haloarcula hispanica, Wang R, Li M, Gong L, Hu S, Xiang H, 2016
Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins, Yang H, Wu Z, Liu J, Liu X, Wang L, Cai S, Xiang H, 2015
A patatin-like protein associated with the polyhydroxyalkanoate (PHA) granules of Haloferax mediterranei acts as an efficient depolymerase in degradation of native PHA, Liu G, Hou J, Cai S, Zhao D, Cai L, Han J, Zhou J, Xiang H, 2015
Biosynthesis, characterization and hemostasis potential of tailor-made poly(3-hydroxybutyrate-co-3- hydroxyvalerate) produced by Haloferax mediterranei, Han J, Wu LP, Hou J, Zhao D, Xiang H, 2015
Propionyl coenzyme A (propionyl-CoA) carboxylase in Haloferax mediterranei: Indispensability for propionyl-CoA assimilation and impacts on global metabolism, Hou J, Xiang H, Han J, 2015
A novel DNA-binding protein, PhaR, plays a central role in the regulation of polyhydroxyalkanoate accumulation and granule formation in the haloarchaeon Haloferax mediterranei, Cai S, Cai L, Zhao D, Liu G, Han J, Zhou J, Xiang H, 2015
Haloarcula hispanica CRISPR authenticates PAM of a target sequence to prime discriminative adaptation, Li M, Wang R, Xiang H, 2014
Adaptation of the Haloarcula hispanica CRISPR-Cas system to a purified virus strictly requires a priming process, Li M, Wang R, Zhao D, Xiang H, 2014

Microbial Genetics Microbial Physiology Metabolism Bioengineering Molecular Microbiology Extremophiles Crispr-Cas Genetic Editing Biodegradable Plastics Microbial Resources

Hua Xiang - University of Chinese Academy of Sciences

Chenguang Liu - Shanghai Jiao Tong University

Jun Xu - Shanghai Jiao Tong University

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