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Huifang Xu
Life Science
University of Chinese Academy of Sciences
Shandong
Language: Chinese, English
Protein Engineering
Enzyme
Biocatalysis
Synthetic Biology
Biochemistry
Molecular Biology
Biotechnology
Genetic Engineering
Metabolic Engineering
Bioinformatics
Areas of Focus
- Protein Engineering
- Enzyme and Biocatalysis
- Synthetic Biology
Work Experience
- 2015-07~Present - Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences - Associate Researcher
- 2008-08~2015-03 - Imperial College London, UK - Senior Research Associate
- 2004-10~2007-12 - Imperial College London, UK - Research Associate
- 2002-08~2004-10 - New England Biolabs (Beijing) Ltd. - R&D Director and Production Manager
Academic Background & Achievements
- 1999-09--2002-07 PhD: Institute of Microbiology, Chinese Academy of Sciences
Publications
- ω-transaminase-catalyzed synthesis of (R)-2-(1-aminoethyl)-4-fluorophenol, a chiral intermediate of novel anti-tumor drugs, Huifang Xu, 2024
- Evolving a P450BM3 Peroxygenase for the Production of Indigoid Dyes from Indoles, Huifang Xu, 2022
- Directed Evolution of P450 Fatty Acid Decarboxylases via High-Throughput Screening towards Improved Catalytic Activity, Huifang Xu, 2020
- Establishing an enzyme cascade for one-pot production of α-olefins from low-cost triglycerides and oils without exogenous H2O2 addition, Huifang Xu, 2020
- Biochemical characterization of three new alpha-olefin-producing P450 fatty acid decarboxylases with a halophilic property, Huifang Xu, 2019
- Mutagenesis and redox partners analysis of the P450 fatty acid decarboxylase OleT(JE), Huifang Xu, 2017
- In vitro oxidative decarboxylation of free fatty acids to terminal alkenes by two new P450 peroxygenases, Huifang Xu, 2017
- Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii, Huifang Xu, 2017
- Production of a-alkenes catalyzed by the fused lipase and P450 fatty acid de-carboxylase, Huifang Xu, 2017
- Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor, Huifang Xu, 2016
- Molecular and cellular analysis of a novel mutation in DDR2 causing Spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL), Huifang Xu, 2014
- Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications., Huifang Xu, 2014
- Discoidin Domain Receptors Promote alpha 1 beta 1-and alpha 2 beta 1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation, Huifang Xu, 2012
- Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1, Huifang Xu, 2011
- Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients, Huifang Xu, 2010
- Directed evolution of e-coli alkaline phosphatase towards higher catalytic activity, Huifang Xu, 2003
- Engineering e-coli alkaline phosphatase yields changes of catalytic activity, thermal stability and phosphate inhibition, Huifang Xu, 2002
- 牛消化道正常菌群的研究, Huifang Xu, 1999
- 肉牛粪便正常菌群研究, Huifang Xu, 1999
Awards
- Best Poster Prize (2018): The 18th CLSS-UK Annual Meeting, London UK
- Best Poster Prize (2012): The XXIInd FECTS Meeting, Davos, Swiss
- Conference Attendance Award (2007): ICGEB (International Centre for Genetic Engineering and Biotechnology)
