Professor | Huifang Xu | Asia Growth Partners

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Name	Huifang Xu
Contact Information	xu_hf@qibebt.ac.cn
Language ability	Chinese, English
Province	Shandong

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Name

Huifang Xu

Contact Information

xu_hf@qibebt.ac.cn

Language ability

Chinese, English

Province

Shandong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1999-09--2002-07 PhD: Institute of Microbiology, Chinese Academy of Sciences
Work Experience	2015-07~Present - Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences - Associate Researcher 2008-08~2015-03 - Imperial College London, UK - Senior Research Associate 2004-10~2007-12 - Imperial College London, UK - Research Associate 2002-08~2004-10 - New England Biolabs (Beijing) Ltd. - R&D Director and Production Manager
Awards	Best Poster Prize (2018): The 18th CLSS-UK Annual Meeting, London UK Best Poster Prize (2012): The XXIInd FECTS Meeting, Davos, Swiss Conference Attendance Award (2007): ICGEB (International Centre for Genetic Engineering and Biotechnology)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1999-09--2002-07 PhD: Institute of Microbiology, Chinese Academy of Sciences

Work Experience

2015-07~Present - Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences - Associate Researcher
2008-08~2015-03 - Imperial College London, UK - Senior Research Associate
2004-10~2007-12 - Imperial College London, UK - Research Associate
2002-08~2004-10 - New England Biolabs (Beijing) Ltd. - R&D Director and Production Manager

Awards

Best Poster Prize (2018): The 18th CLSS-UK Annual Meeting, London UK
Best Poster Prize (2012): The XXIInd FECTS Meeting, Davos, Swiss
Conference Attendance Award (2007): ICGEB (International Centre for Genetic Engineering and Biotechnology)

Areas of Focus	Protein Engineering Enzyme and Biocatalysis Synthetic Biology
Publications	ω-transaminase-catalyzed synthesis of (R)-2-(1-aminoethyl)-4-fluorophenol, a chiral intermediate of novel anti-tumor drugs, Huifang Xu, 2024 Evolving a P450BM3 Peroxygenase for the Production of Indigoid Dyes from Indoles, Huifang Xu, 2022 Directed Evolution of P450 Fatty Acid Decarboxylases via High-Throughput Screening towards Improved Catalytic Activity, Huifang Xu, 2020 Establishing an enzyme cascade for one-pot production of α-olefins from low-cost triglycerides and oils without exogenous H2O2 addition, Huifang Xu, 2020 Biochemical characterization of three new alpha-olefin-producing P450 fatty acid decarboxylases with a halophilic property, Huifang Xu, 2019 Mutagenesis and redox partners analysis of the P450 fatty acid decarboxylase OleT(JE), Huifang Xu, 2017 In vitro oxidative decarboxylation of free fatty acids to terminal alkenes by two new P450 peroxygenases, Huifang Xu, 2017 Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii, Huifang Xu, 2017 Production of a-alkenes catalyzed by the fused lipase and P450 fatty acid de-carboxylase, Huifang Xu, 2017 Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor, Huifang Xu, 2016 Molecular and cellular analysis of a novel mutation in DDR2 causing Spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL), Huifang Xu, 2014 Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications., Huifang Xu, 2014 Discoidin Domain Receptors Promote alpha 1 beta 1-and alpha 2 beta 1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation, Huifang Xu, 2012 Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1, Huifang Xu, 2011 Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients, Huifang Xu, 2010 Directed evolution of e-coli alkaline phosphatase towards higher catalytic activity, Huifang Xu, 2003 Engineering e-coli alkaline phosphatase yields changes of catalytic activity, thermal stability and phosphate inhibition, Huifang Xu, 2002 牛消化道正常菌群的研究, Huifang Xu, 1999 肉牛粪便正常菌群研究, Huifang Xu, 1999

Areas of Focus

Protein Engineering
Enzyme and Biocatalysis
Synthetic Biology

Publications

ω-transaminase-catalyzed synthesis of (R)-2-(1-aminoethyl)-4-fluorophenol, a chiral intermediate of novel anti-tumor drugs, Huifang Xu, 2024
Evolving a P450BM3 Peroxygenase for the Production of Indigoid Dyes from Indoles, Huifang Xu, 2022
Directed Evolution of P450 Fatty Acid Decarboxylases via High-Throughput Screening towards Improved Catalytic Activity, Huifang Xu, 2020
Establishing an enzyme cascade for one-pot production of α-olefins from low-cost triglycerides and oils without exogenous H2O2 addition, Huifang Xu, 2020
Biochemical characterization of three new alpha-olefin-producing P450 fatty acid decarboxylases with a halophilic property, Huifang Xu, 2019
Mutagenesis and redox partners analysis of the P450 fatty acid decarboxylase OleT(JE), Huifang Xu, 2017
In vitro oxidative decarboxylation of free fatty acids to terminal alkenes by two new P450 peroxygenases, Huifang Xu, 2017
Complete elucidation of the late steps of bafilomycin biosynthesis in Streptomyces lohii, Huifang Xu, 2017
Production of a-alkenes catalyzed by the fused lipase and P450 fatty acid de-carboxylase, Huifang Xu, 2017
Recombinant Collagen Engineered to Bind to Discoidin Domain Receptor Functions as a Receptor Inhibitor, Huifang Xu, 2016
Molecular and cellular analysis of a novel mutation in DDR2 causing Spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL), Huifang Xu, 2014
Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications., Huifang Xu, 2014
Discoidin Domain Receptors Promote alpha 1 beta 1-and alpha 2 beta 1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation, Huifang Xu, 2012
Collagen binding specificity of the discoidin domain receptors: Binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1, Huifang Xu, 2011
Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients, Huifang Xu, 2010
Directed evolution of e-coli alkaline phosphatase towards higher catalytic activity, Huifang Xu, 2003
Engineering e-coli alkaline phosphatase yields changes of catalytic activity, thermal stability and phosphate inhibition, Huifang Xu, 2002
牛消化道正常菌群的研究, Huifang Xu, 1999
肉牛粪便正常菌群研究, Huifang Xu, 1999

Protein Engineering Enzyme Biocatalysis Synthetic Biology Biochemistry Molecular Biology Biotechnology Genetic Engineering Metabolic Engineering Bioinformatics

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