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Xiao Haixia
Life Science
University of Chinese Academy of Sciences
Tianjin
Language: Chinese, English
Antibody
Vaccine
Development
Research
Immunology
Biotechnology
Microbiology
Pathogen
Infection
Prevention
Areas of Focus
- Antibody and Vaccine Development
Work Experience
- 2022-07~Present - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Researcher
- 2011-11~2022-06 - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Associate Researcher
- 2008-02~2011-11 - National Institute for Medical Research, MRC, UK - Career Development Fellowship
Academic Background & Achievements
- 2004-09--2007-07 PhD: Institute of Microbiology, Chinese Academy of Sciences
- 2001-09--2004-07 Master's: Hebei Agricultural University
- 1997-09--2001-06 Bachelor's: Hebei Agricultural University
Publications
- Canine interleukin-31 binds directly to OSMR with higher binding affinity than to IL-31RA, 3 Biotech, 2023
- Expression, purification, and biological characterization of recombinant human interleukin-31 protein, Biotechnology and Applied Biochemistry, 2023
- Development and characterization of a novel mouse anti-canine oncostatin M receptor beta monoclonal antibody, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022
- The molecular basis for SARS-CoV-2 binding to dog ACE2, NATURE COMMUNICATIONS, 2021
- Avian influenza A(H7N9)virus:from low pathogenic to highly pathogenic, FRONTIERS OF MEDICINE, 2021
- 犬瘟热病毒融合蛋白的真核细胞表达及鉴定, 今日畜牧兽医, 2020
- A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2, SCIENCE, 2020
- Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses, CELL DISCOVERY, 2019
- Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin, CELL REPORTS, 2019
- Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope, CELL REPORTS, 2019
- Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses, MBIO, 2018
- CASCIRE Surveillance Network and Work on Avian Influenza Viruses, SCIENCE CHINA-LIFE SCIENCES, 2017
- CTL immunogenicity of Rv3615c antigen and diagnostic performances of an ESAT-6/CFP-10/Rv3615c antigen cocktail for Mycobacterium tuberculosis infection, TUBERCULOSIS, 2017
- Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4, CELL REPORTS, 2017
- Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity, JOURNAL OF VIROLOGY, 2016
- Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions, JOURNAL OF INFECTIOUS DISEASES, 2016
- Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice, JOURNAL OF VIROLOGY, 2016
- Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody, CELL HOST & MICROBE, 2016
- Intra-host dynamics of Ebola virus during 2014, Nature Microbiology, 2016
- The NS1 gene from bat-derived influenza-like virus H17N10 can be rescued in influenza A PR8 backbone, JOURNAL OF GENERAL VIROLOGY, 2016
- Multivalent S-sialoside protein conjugates block influenza hemagglutinin and neuraminidase, CARBOHYDRATE RESEARCH, 2016
- Synthesis of multivalent difluorinated zanamivir analogs as potent antiviral inhibitors, TETRAHEDRON LETTERS, 2016
- Distribution of sialic acid receptors and experimental infections with different subtypes of influenza A viruses in Qinghai-Tibet plateau wild pika, VIROLOGY JOURNAL, 2015
- Assessment of the Internal Genes of Influenza A (H7N9) Virus Contributing to High Pathogenicity in Mice, JOURNAL OF VIROLOGY, 2015
- Changes in the length of the neuraminidase stalk region impacts H7N9 virulence in mice, Journal of Virology, 2015
- The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes, SCIENTIFIC REPORTS, 2015
- Enhanced human receptor binding by H5 haemagglutinins, VIROLOGY, 2014
- H7N9: a low pathogenic avian influenza A virus infecting humans, CURRENT OPINION IN VIROLOGY, 2014
- 接种疫苗防流感, 科学世界, 2014
- Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients, NATURE COMMUNICATIONS, 2014
- Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses, Cell Research, 2013
- Receptor binding by a ferret-transmissible H5 avian influenza virus, NATURE, 2013
- Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6, JOURNAL OF VIROLOGY, 2013
- Structure of the Fusion Core and Inhibition of Fusion by a Heptad Repeat Peptide Derived from the S Protein of Middle East Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 2013
- Receptor binding by a ferret-transmissible H5 avian influenza virus, LETTER, 2013
- The Lancet, 2013, 2013
- Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human, SCIENCE CHINA-LIFE SCIENCES, 2013
- Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses, Articles, 2013
- A Replicating Modified Vaccinia Tiantan Strain Expressing an Avian-Derived Influenza H5N1 Hemagglutinin Induce Broadly Neutralizing Antibodies and Cross-Clade Protective Immunity in Mice, PLOS ONE, 2013
- Origin and Diversity of Novel Avian Influenza A H7N9 Viruses Causing Human Infection: Phylogenetic, Structural, and Coalescent Analyses, LANCET, 2013
- Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines (vol 2, pg 997, 2011), PROTEIN & CELL, 2012
- Insights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Has an Alpha-Helix Structure in Its Cleavage Site with Inefficient HA1/HA2 Cleavage, JOURNAL OF VIROLOGY, 2012
- Insights into avian influenza virus pathogenicity: the hemagglutinin precursor HA0 of H16 subtype has an a-helix structure in its cleavage site with an inefficient HA1/HA2 cleavage, Journal of Virology, 2012
- Selection of variant viruses during replication and transmission of H7N1 viruses in chickens and turkeys, VIROLOGY, 2012
- Structural vaccinology: Structure-based design of influenza A virus Hemagglutinin (HA) subtype-specific subunit vaccines, Protein and Cell, 2011
- Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines, PROTEIN & CELL, 2011
- Serological surveillance of influenza a virus infection in swine populations in fujian province, china: no evidence of naturally occurring h5n1 infection in pigs, ZOONOSES AND PUBLIC HEALTH, 2010
- Stable non-synonymous substitutions on ns gene (ns1 and ns2 proteins) of qinghai lake h5n1 influenza virus (clade 2.2) after successive passages
Awards
- Tianjin Most Beautiful Science and Technology Worker (2022): City Level
- Tianjin Most Beautiful Female Scientist (2020): City Level
- Chinese Preventive Medicine Association Science and Technology Award (2017): National Level
- Outstanding Doctoral Dissertation of the Chinese Academy of Sciences (2008): Institute Level
- President's Award of the Chinese Academy of Sciences (2006): Institute Level
