2004-09--2007-07 PhD: Institute of Microbiology, Chinese Academy of Sciences
2001-09--2004-07 Master's: Hebei Agricultural University
1997-09--2001-06 Bachelor's: Hebei Agricultural University
2022-07~Present - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Researcher
2011-11~2022-06 - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Associate Researcher
2008-02~2011-11 - National Institute for Medical Research, MRC, UK - Career Development Fellowship
Tianjin Most Beautiful Science and Technology Worker (2022): City Level
Tianjin Most Beautiful Female Scientist (2020): City Level
Chinese Preventive Medicine Association Science and Technology Award (2017): National Level
Outstanding Doctoral Dissertation of the Chinese Academy of Sciences (2008): Institute Level
President's Award of the Chinese Academy of Sciences (2006): Institute Level
Research
Antibody and Vaccine Development
Canine interleukin-31 binds directly to OSMR with higher binding affinity than to IL-31RA, 3 Biotech, 2023
Expression, purification, and biological characterization of recombinant human interleukin-31 protein, Biotechnology and Applied Biochemistry, 2023
Development and characterization of a novel mouse anti-canine oncostatin M receptor beta monoclonal antibody, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022
The molecular basis for SARS-CoV-2 binding to dog ACE2, NATURE COMMUNICATIONS, 2021
Avian influenza A(H7N9)virus:from low pathogenic to highly pathogenic, FRONTIERS OF MEDICINE, 2021
犬瘟热病毒融合蛋白的真核细胞表达及鉴定, 今日畜牧兽医, 2020
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2, SCIENCE, 2020
Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses, CELL DISCOVERY, 2019
Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope, CELL REPORTS, 2019
Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses, MBIO, 2018
CASCIRE Surveillance Network and Work on Avian Influenza Viruses, SCIENCE CHINA-LIFE SCIENCES, 2017
CTL immunogenicity of Rv3615c antigen and diagnostic performances of an ESAT-6/CFP-10/Rv3615c antigen cocktail for Mycobacterium tuberculosis infection, TUBERCULOSIS, 2017
Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4, CELL REPORTS, 2017
Role of the B Allele of Influenza A Virus Segment 8 in Setting Mammalian Host Range and Pathogenicity, JOURNAL OF VIROLOGY, 2016
Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions, JOURNAL OF INFECTIOUS DISEASES, 2016
Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice, JOURNAL OF VIROLOGY, 2016
Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody, CELL HOST & MICROBE, 2016
Intra-host dynamics of Ebola virus during 2014, Nature Microbiology, 2016
The NS1 gene from bat-derived influenza-like virus H17N10 can be rescued in influenza A PR8 backbone, JOURNAL OF GENERAL VIROLOGY, 2016
Multivalent S-sialoside protein conjugates block influenza hemagglutinin and neuraminidase, CARBOHYDRATE RESEARCH, 2016
Synthesis of multivalent difluorinated zanamivir analogs as potent antiviral inhibitors, TETRAHEDRON LETTERS, 2016
Distribution of sialic acid receptors and experimental infections with different subtypes of influenza A viruses in Qinghai-Tibet plateau wild pika, VIROLOGY JOURNAL, 2015
Assessment of the Internal Genes of Influenza A (H7N9) Virus Contributing to High Pathogenicity in Mice, JOURNAL OF VIROLOGY, 2015
Changes in the length of the neuraminidase stalk region impacts H7N9 virulence in mice, Journal of Virology, 2015
The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes, SCIENTIFIC REPORTS, 2015
Enhanced human receptor binding by H5 haemagglutinins, VIROLOGY, 2014
H7N9: a low pathogenic avian influenza A virus infecting humans, CURRENT OPINION IN VIROLOGY, 2014
接种疫苗防流感, 科学世界, 2014
Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients, NATURE COMMUNICATIONS, 2014
Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses, Cell Research, 2013
Receptor binding by a ferret-transmissible H5 avian influenza virus, NATURE, 2013
Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6, JOURNAL OF VIROLOGY, 2013
Structure of the Fusion Core and Inhibition of Fusion by a Heptad Repeat Peptide Derived from the S Protein of Middle East Respiratory Syndrome Coronavirus, JOURNAL OF VIROLOGY, 2013
Receptor binding by a ferret-transmissible H5 avian influenza virus, LETTER, 2013
The Lancet, 2013, 2013
Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human, SCIENCE CHINA-LIFE SCIENCES, 2013
Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses, Articles, 2013
A Replicating Modified Vaccinia Tiantan Strain Expressing an Avian-Derived Influenza H5N1 Hemagglutinin Induce Broadly Neutralizing Antibodies and Cross-Clade Protective Immunity in Mice, PLOS ONE, 2013
Origin and Diversity of Novel Avian Influenza A H7N9 Viruses Causing Human Infection: Phylogenetic, Structural, and Coalescent Analyses, LANCET, 2013
Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines (vol 2, pg 997, 2011), PROTEIN & CELL, 2012
Insights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Has an Alpha-Helix Structure in Its Cleavage Site with Inefficient HA1/HA2 Cleavage, JOURNAL OF VIROLOGY, 2012
Insights into avian influenza virus pathogenicity: the hemagglutinin precursor HA0 of H16 subtype has an a-helix structure in its cleavage site with an inefficient HA1/HA2 cleavage, Journal of Virology, 2012
Selection of variant viruses during replication and transmission of H7N1 viruses in chickens and turkeys, VIROLOGY, 2012
Structural vaccinology: Structure-based design of influenza A virus Hemagglutinin (HA) subtype-specific subunit vaccines, Protein and Cell, 2011
Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines, PROTEIN & CELL, 2011
Serological surveillance of influenza a virus infection in swine populations in fujian province, china: no evidence of naturally occurring h5n1 infection in pigs, ZOONOSES AND PUBLIC HEALTH, 2010
Stable non-synonymous substitutions on ns gene (ns1 and ns2 proteins) of qinghai lake h5n1 influenza virus (clade 2.2) after successive passages
Area of Focus
Breast Cancer | Gynecological Tumors | Dna Repair | Regulation Mechanisms | Targeted Therapy | Prevention | Treatment Methods | Research | Cell Models | Animal Models
