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Daichao Xu
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Cell Death
Inflammation
Human Diseases
Ripk1
Neurodegenerative Diseases
Cancer
Liver Diseases
Type Ii Diabetes
Mechanisms
Intervention
Areas of Focus
- Role of cell death and inflammation in human diseases
- Molecular mechanisms of aging and its role in human diseases
- Biochemical studies of cell survival/death protein RIPK1 and its physiological/pathological functions
- Role of RIPK1/3-dependent cell death in quality control of mammalian embryonic development
- Discovery and mechanism study of small molecule drugs regulating cell death and autophagy
Work Experience
- 2019-11 to Present - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences - Researcher
- 2016-10 to 2019-10 - Harvard University - Postdoctoral Fellow
- 2016-07 to 2016-10 - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2011-09 to 2016-06 PhD in Science: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- 2007-09 to 2011-06 Bachelor of Science: Zhejiang University
Publications
- Biomarkers of aging, Bao, Hainan, Cao, Jiani, Chen, Mengting, Chen, Min, Chen, Wei, Chen, Xiao, Chen, Yanhao, Chen, Yu, Chen, Yutian, Chen, Zhiyang, Chhetri, Jagadish K, Ding, Yingjie, Feng, Junlin, Guo, Jun, Guo, Mengmeng, He, Chuting, Jia, Yujuan, Jiang, Haiping, Jing, Ying, Li, Dingfeng, Li, Jiaming, Li, Jingyi, Liang, Qinhao, Liang, Rui, Liu, Feng, Liu, Xiaoqian, Liu, Zuojun, Luo, Oscar Junhong, Lv, Jianwei, Ma, Jingyi, Mao, Kehang, Nie, Jiawei, Qiao, Xinhua, Sun, Xinpei, Tang, Xiaoqiang, Wang, Jianfang, Wang, Qiaoran, Wang, Siyuan, Wang, Xuan, Wang, Yaning, Wang, Yuhan, Wu, Rimo, Xia, Kai, Xiao, FuHui, Xu, Lingyan, Xu, Yingying, Yan, Haoteng, Yang, Liang, Yang, Ruici, Yang, Yuanxin, Ying, Yilin, Zhang, Le, Zhang, Weiwei, Zhang, Wenwan, Zhang, Xing, Zhang, Zhuo, Zhou, Min, Zhou, Rui, Zhu, Qingchen, Zhu, Zhengmao, Cao, Feng, Cao, Zhongwei, Chan, Piu, Chen, Chang, Chen, Guobing, Chen, HouZao, Chen, Jun, Ci, Weimin, Ding, BiSen, Ding, Qiurong, Gao, Feng, Han, JingDong J, Huang, Kai, Ju, Zhenyu, Kong, Qing, 2023
- UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis, Zhang, Tao, Zhang, Na, Xing, Jing, Zhang, Shuhua, Chen, Yulu, Xu, Daichao, Gu, Jinyang, 2023
- SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation, Lingjie Yan, Tao Zhang, Kai Wang, Zezhao Chen, Yuanxin Yang, Bing Shan, Qi Sun, Mengmeng Zhang, Yichi Zhang, Yedan Zhong, Nan Liu, Jinyang Gu, Daichao Xu, 2022
- Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response, 李婉津, 单冰, 邹呈雨, 汪会兵, 张蒙蒙, Hong Zhu, Masanori Gomi Naito, 许代超, Vica Jean Manuel, Lauren Mifflin, 侯召东, John Ravits, 袁钧瑛, 2022
- RIPK1 regulates starvation resistance by modulating aspartate catabolism, Mei, Xinyu, Guo, Yuan, Xie, Zhangdan, Zhong, Yedan, Wu, Xiaofen, Xu, Daichao, Li, Ying, Liu, Nan, Zhu, ZhengJiang, 2021
- Genetic Regulation of RIPK1 and Necroptosis, Xu, Daichao, Zou, Chengyu, Yuan, Junying, Bonini, NM, Piotrowski, T, 2021
- Modulating TRADD to restore cellular homeostasis and inhibit apoptosis, Xu, Daichao, Zhao, Heng, Jin, Minzhi, Zhu, Hong, Shan, Bing, Geng, Jiefei, Dziedzic, Slawomir A, Amin, Palak, Mifflin, Lauren, Naito, Masanori Gomi, Najafov, Ayaz, Xing, Jing, Yan, Lingjie, Liu, Jianping, Qin, Ying, Hu, Xinqian, Wang, Huibing, Zhang, Mengmeng, Manuel, Vica Jean, Tan, Li, He, Zhuohao, Sun, Zhenyu J, Lee, Virginia M Y, Wagner, Gerhard, Yuan, Junying, 2020
- TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging, Xu, Daichao, Jin, Taijie, Zhu, Hong, Chen, Hongbo, Ofengeim, Dimitry, Zou, Chengyu, Mifflin, Lauren, Pan, Lifeng, Amin, Palak, Li, Wanjin, Shan, Bing, Naito, Masanori Gomi, Meng, Huyan, Li, Ying, Pan, Heling, Aron, Liviu, Adiconis, Xian, Levin, Joshua Z, Yankner, Bruce A, Yuan, Junying, 2018
- Structural insights into the ubiquitin recognition by OPTN (optineurin) and its regulation by TBK1-mediated phosphorylation, Li, Faxiang, Xu, Daichao, Wang, Yingli, Zhou, Zixuan, Liu, Jianping, Hu, Shichen, Gong, Yukang, Yuan, Junying, Pan, Lifeng, 2018
- USP25 regulates Wnt signaling by controlling the stability of tankyrases, Xu, Daichao, Liu, Jianping, Fu, Tao, Shan, Bing, Qian, Lihui, Pan, Lifeng, Yuan, Junying, 2017
- USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1, Xu, Daichao, Shan, Bing, Sun, Huawang, Xiao, Juan, Zhu, Kezhou, Xie, Xingxing, Li, Xingyan, Liang, Wei, Lu, Xiaojuan, Qian, Lihui, Yuan, Junying, 2016
- FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation, Xiao, Juan, Zhang, Tao, Xu, Daichao, Wang, Huibing, Cai, Yu, Jin, Taijie, Liu, Min, Jin, Mingzhi, Wu, Kejia, Yuan, Junying, 2015
- Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system, Xu, Daichao, Shan, Bing, Lee, ByungHoon, Zhu, Kezhou, Zhang, Tao, Sun, Huawang, Liu, Min, Shi, Linyu, Liang, Wei, Qian, Lihui, Xiao, Juan, Wang, Lili, Pan, Lifeng, Finley, Daniel, Yuan, Junying, 2015
- Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon, Xu, Daichao, Zhang, Tao, Xiao, Juan, Zhu, Kezhou, Wei, Ran, Wu, Zheming, Meng, Huyan, Li, Ying, Yuan, Junying, 2015
- G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L, Zhang, Tao, Dong, Kangyun, Liang, Wei, Xu, Daichao, Xia, Hongguang, Geng, Jiefei, Najafov, Ayaz, Liu, Min, Li, Yanxia, Han, Xiaoran, Xiao, Juan, Jin, Zhenzhen, Peng, Ting, Gao, Yang, Cai, Yu, Qi, Chunting, Zhang, Qing, Sun, Anyang, Lipinski, Marta, Zhu, Hong, Xiong, Yue, Pandolfi, Pier Paolo, Li, He, Yu, Qiang, Yuan, Junying, 2015
- Palladium-catalyzed double arylations of terminal olefins in acetic acid, Xu, Daichao, Lu, Chunxin, Chen, Wanzhi, 2012
