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Sheng Yang
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Crispr
Genome Editing
Synthetic Biology
Microbial Engineering
Directed Evolution
Biocatalysts
Metabolic Pathways
Green Chemistry
Bioengineering
Genetic Tools
Areas of Focus
- Microbial Genome Editing
- Directed Evolution
- Synthetic Biology
- Bioengineering
- CRISPR Technology
- Industrial Biocatalysts
- Metabolic Engineering
- Green Chemistry
- Biotechnology
- Genetic Engineering
Work Experience
- 2000 - Present - Shanghai Institute for Biological Sciences, Chinese Academy of Sciences
Academic Background & Achievements
- 1995 - Bachelor's Degree: Zhejiang University, Chemical Engineering
- 2000 - Doctoral Degree: Shanghai Institute of Biochemistry, Chinese Academy of Sciences
- DuPont Young Professor Award
- Novozymes Innovation Award
- State Council Special Government Allowance
- National Outstanding Youth Science Fund
Publications
- Blautia Coccoides is a Newly Identified Bacterium Increased by Leucine Deprivation and has a Novel Function in Improving Metabolic Disorders, Yuguo Niu, Xiaoming Hu, Yali Song, Cunchuan Wang, Peixiang Luo, Shihong Ni, Fuxin Jiao, Ju Qiu, Weihong Jiang, Sheng Yang, Jun Chen, Rui Huang, Haizhou Jiang, Shanghai Chen, Qiwei Zhai, Jia Xiao, Feifan Guo, 2024
- Chromosome Recombination and Modification by LoxP-mediated Evolution in Vibrio natriegens using CRISPR-associated Transposases, Jiaqi Xu, Yijie Sun, Jianping Wu, Sheng Yang, Lirong Yang, 2023
- Discovery and remodeling of Vibrio natriegens as a microbial platform for efficient formic acid biorefinery, Jinzhong Tian, Wangshuying Deng, Ziwen Zhang, Jiaqi Xu, Guiling Yang, Guoping Zhao, Sheng Yang, Weihong Jiang, Yang Gu, 2023
- Efficient Genome Editing in Most Staphylococcus aureus by Using the Restriction-Modification Systems Silent CRISPR-Cas9 Toolkit, Ping Yang, Junjie Yang, Ting Lin, Qi Liu, Yu Yin, Daijie Chen, Sheng Yang, 2023
- Modulated Arabinose Uptake and cAMP Signaling Synergistically Improve Glucose and Arabinose Consumption in Recombinant Yeast, Jinle Liu, Junjie Yang, Lihua Yuan, Chunhua Wu, Yu Jiang, Wei Zhuang, Hanjie Ying, Sheng Yang, 2023
- Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis, Junbin He, Lian Wu, Wanqing Wei, Song Meng, Zhengtao Liu, Xuan Wu, Haixue Pan, Sheng Yang, Yong Liang, Jiahai Zhou, Gongli Tang, 2023
- RNA-guided DNA transposition in Corynebacterium glutamicum and Bacillus subtilis, Siqi Yang, Jiao Zhu, Xiaojie Zhou, Jiao Zhang, Qi Li, Furong Bian, Jidong Zhu, Ting Yan, Xiaoyu Wang, Ying Zhang, Junjie Yang, Yu Jiang, Sheng Yang, 2023
- Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway, Yu Jiang, Xiyuan Li, Fenghui Qian, Bingbing Sun, Xiyuan Wang, Yan Zhang, Deqiang Zhang, Meiyu Geng, Zuoquan Xie, Sheng Yang, 2023
- Host sorbitol and bacterial sorbitol utilization promote C. difficile infection in inflammatory bowel disease, Ziyu Yang, Juanxiu Qin, Lina Zhao, Tianchi Chen, Qian Huang, Ying Jian, Qi Zhao, Sheng Yang, Qi Li, Qian Liu, Michael Otto, Min Li, 2023
- Improving the Editing Efficiency of CRISPR-Cas9 by Reducing the Generation of Escapers Based on the Surviving Mechanism, Qi Li, Mingjun Sun, Lu Lv, Yong Zuo, Suyi Zhang, Ying Zhang, Sheng Yang, 2023
- Pilot-scale fermentation of 300 t/a total solvents from sweet sorghum stalk juice, Zhiqiang Wen, Jun Chen, Yunliu Yang, Ying Zhang, Yu Jiang, Sheng Yang, 2022
- Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a living therapeutic for phenylketonuria, Yu Jiang, Bingbing Sun, Fenghui Qian, Feng Dong, Chongmao Xu, Wuling Zhong, Rui Huang, Qiwei Zhai, Sheng Yang, 2022
- High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption, Wuling Zhong, Hui Wang, Yale Yang, Yali Zhang, Hejin Lai, Yalan Cheng, Huimin Yu, Ning Feng, Rui Huang, Shen Liu, Sheng Yang, Tongyang Hao, Baoyu Zhang, Hao Ying, Fang Zhang, Feifan Guo, Qiwei Zhai, 2022
- Vitreoscilla hemoglobin enhances the catalytic performance of industrial oxidases in vitro, Qingzhuo Wang, Huabao Zheng, Rongsheng Tao, Qi Li, Yu Jiang, Sheng Yang, 2022
- CRISPR-associated transposase system can insert multiple copies of donor DNA into the same target locus, Junjie Yang, Jiawei Yang, Yiwen Zhang, Siqi Yang, Jieze Zhang, Yu Jiang, Sheng Yang, 2021
- Vibrio natriegens as a host for rapid biotechnology, Jiaqi Xu, Sheng Yang, Lirong Yang, 2021
- Recent progress on n-butanol production by lactic acid bacteria, Qi Li, Jieze Zhang, Junjie Yang, Yu Jiang, Sheng Yang, 2021
- Orthogonal CRISPR-associated transposases for parallel and multiplexed chromosomal integration, Siqi Yang, Yiwen Zhang, Jiaqi Xu, Jiao Zhang, Jieze Zhang, Junjie Yang, Yu Jiang, Sheng Yang, 2021
- Programming cells by multicopy chromosomal integration using CRISPR-associated transposases, Yiwen Zhang, Jiawei Yang, Siqi Yang, Jieze Zhang, Jun Chen, Rongsheng Tao, Yu Jiang, Junjie Yang, Sheng Yang, 2021
- A novel global transcriptional perturbation target identified by forward genetics reprograms Vibrio natriegens for improving recombinant protein production, Jiaqi Xu, Junjie Yang, Yu Jiang, Mianbin Wu, Sheng Yang, Lirong Yang, 2021
- Engineering the oleaginous yeast Yarrowia lipolytica for β-farnesene overproduction, Tianqiong Shi, Yawen Li, Li Zhu, Yangyang Tong, Junjie Yang, Yunming Fang, Meng Wang, Jieze Zhang, Yu Jiang, Sheng Yang, 2021
- Strategies for optimizing acetyl-CoA formation from glucose in bacteria, Li Zhu, Jieze Zhang, Jiawei Yang, Yu Jiang, Sheng Yang, 2021
- A modified pCas/pTargetF system for CRISPR-Cas9-assisted genome editing in Escherichia coli, Qi Li, Bingbing Sun, Jun Chen, Yiwen Zhang, Yu Jiang, Sheng Yang, 2021
- Reducing glucoamylase usage for commercial-scale ethanol production from starch using glucoamylase expressing Saccharomyces cerevisiae, Xin Wang, Bei Liao, Zhijun Li, Guangxin Liu, Liuyang Diao, Fenghui Qian, Junjie Yang, Yu Jiang, Shumiao Zhao, Youguo Li, Sheng Yang, 2021
- Vibrio natriegens as a pET compatible expression host complementary to Escherichia coli, Jiaqi Xu, Feng Dong, Meixian Wu, Rongsheng Tao, Junjie Yang, Mianbin Wu, Yu Jiang, Sheng Yang, Lirong Yang, 2021
- New Mutations Involved in Colistin Resistance in Acinetobacter baumannii, Bingbing Sun, Haiyan Liu, Yu Jiang, Lei Shao, Sheng Yang, Daijie Chen, 2020
- Optimization of n-butanol synthesis in Lactobacillus brevis via the functional expression of thl, hbd, crt and te, Qi Li, Meixian Wu, Zhiqiang Wen, Yuan Jiang, Xin Wang, Yawei Zhao, Jinle Liu, Junjie Yang, Yu Jiang, Sheng Yang, 2020
- Downregulation of T7 RNA polymerase transcription enhances pET-based recombinant protein production in Escherichia coli BL21 (DE3) by suppressing autolysis, Xiaoman Sun, Zixu Zhang, Lingru Wang, Jinggang Wang, Yan Liang, Haifeng Yang, Rongsheng Tao, Yu Jiang, Junjie Yang, Sheng Yang, 2020
- De Novo Engineering of Corynebacterium glutamicum for l-Proline Production, Jiao Zhang, Fenghui Qian, Feng Dong, Qingzhuo Wang, Junjie Yang, Yu Jiang, Sheng Yang, 2020
- Multicopy chromosomal integration using CRISPR-associated transposases, Yiwen Zhang, Xiaoman Sun, Qingzhuo Wang, Jiaqi Xu, Feng Dong, Siqi Yang, Jiawei Yang, Zixu Zhang, Yuan Qian, Jun Chen, Jiao Zhang, Yingmiao Liu, Rongsheng Tao, Yu Jiang, Junjie Yang, Sheng Yang, 2020
- Metabolic engineering and adaptive evolution of Clostridium beijerinckii to increase solvents production from corn stover hydrolysate, Jinle Liu, Yu Jiang, Jun Chen, Junjie Yang, Weihong Jiang, Wei Zhuang, Hanjie Ying, Sheng Yang, 2020
- Consolidated bioprocessing for butanol production of cellulolytic Clostridia: development and optimization, Zhiqiang Wen, Qi Li, Jinle Liu, Mingjie Jin, Sheng Yang, 2020
- TargeTron Technology Applicable in Solventogenic Clostridia: Revisiting 12 Years' Advances, Zhiqiang Wen, Minrui Lu, Rodrigo Ledesma-Amaro, Qi Li, Mingjie Jin, Sheng Yang, 2020
- Combined evolutionary engineering and genetic manipulation improve low pH tolerance and butanol production in a synthetic microbial Clostridium community, Zhiqiang Wen, Rodrigo Ledesma-Amaro, Minrui Lu, Yu Jiang, Shuliang Gao, Mingjie Jin, Sheng Yang, 2020
- Metabolic Engineering of Clostridium cellulovorans to Improve Butanol Production by Consolidated Bioprocessing, Zhiqiang Wen,
Awards
- DuPont Young Professor Award
- Novozymes Innovation Award
- State Council Special Government Allowance
- National Outstanding Youth Science Fund
