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Xiaolong Zhou
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Rna
Metabolism
Mitochondria
Diseases
Biochemistry
Cell Biology
Genetics
Molecular Biology
Research
Innovation
Areas of Focus
- RNA Metabolism and Mitochondrial Diseases
Work Experience
- 2019-05~2024-04 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Research Group Leader
- 2017-11~2024-04 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
- 2009-06~2017-10 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher
Academic Background & Achievements
- 2004-09--2009-05 PhD: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
- 2000-09--2004-06 Bachelor's: Anhui Normal University
Publications
- Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023
- Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023
- Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022
- Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022
- Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022
- RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022
- Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022
- Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021
- The development of multiple synthetase complex(MSC), 生命科学, 2021
- Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021
- The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021
- Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6, NUCLEIC ACIDS RESEARCH, 2021
- Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA-LIFE SCIENCES, 2021
- Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020
- Molecular basis for t 6 A modification in human mitochondria, NUCLEIC ACIDS RESEARCH, 2020
- Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA(Lys), SCIENCE CHINA-LIFE SCIENCES, 2020
- Aminoacyl-tRNA synthetase in neuropathy, 生命科学, 2020
- The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, NUCLEIC ACIDS RESEARCH, 2019
- Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex, NUCLEIC ACIDS RESEARCH, 2019
- Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, NUCLEIC ACIDS RESEARCH, 2018
- A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities, NUCLEIC ACIDS RESEARCH, 2018
- A natural non-Watson-Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations, NUCLEIC ACIDS RESEARCH, 2018
- Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism, HUMAN MUTATION, 2017
- Translational Quality Control by Bacterial Threonyl-tRNA Synthetases, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016
- A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016
- C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeu, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016
- Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015
- Degenerate Connective Polypeptide 1 (CP1) Domain from Human Mitochondrial Leucyl-tRNA Synthetase, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015
- A minimalist mitochondrial threonyl-tRNA synthetase exhibits tRNA-isoacceptor specificity during proofreading, NUCLEIC ACIDS RESEARCH, 2014
- Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode, NUCLEIC ACIDS RESEARCH, 2014
Awards
- Shanghai Youth Science and Technology Star, First Prize, Provincial Level, 2016
- Sanofi-Youth Talent Award, First Prize, Institute Level, 2012
- CAS Lu Jiaxi Youth Talent Award, First Prize, Academy Level, 2011
