Professor | Xiaolong Zhou | Asia Growth Partners

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Name	Xiaolong Zhou
Contact Information	xlzhou@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Xiaolong Zhou

Contact Information

xlzhou@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2004-09--2009-05 PhD: Shanghai Institute of Life Sciences, Chinese Academy of Sciences 2000-09--2004-06 Bachelor's: Anhui Normal University
Work Experience	2019-05~2024-04 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Research Group Leader 2017-11~2024-04 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher 2009-06~2017-10 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher
Awards	Shanghai Youth Science and Technology Star, First Prize, Provincial Level, 2016 Sanofi-Youth Talent Award, First Prize, Institute Level, 2012 CAS Lu Jiaxi Youth Talent Award, First Prize, Academy Level, 2011

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2004-09--2009-05 PhD: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
2000-09--2004-06 Bachelor's: Anhui Normal University

Work Experience

2019-05~2024-04 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Research Group Leader
2017-11~2024-04 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Researcher
2009-06~2017-10 - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher

Awards

Shanghai Youth Science and Technology Star, First Prize, Provincial Level, 2016
Sanofi-Youth Talent Award, First Prize, Institute Level, 2012
CAS Lu Jiaxi Youth Talent Award, First Prize, Academy Level, 2011

Areas of Focus	RNA Metabolism and Mitochondrial Diseases
Publications	Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023 Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023 Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022 Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022 Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022 RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022 Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022 Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021 The development of multiple synthetase complex(MSC), 生命科学, 2021 Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021 The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021 Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6, NUCLEIC ACIDS RESEARCH, 2021 Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA-LIFE SCIENCES, 2021 Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020 Molecular basis for t 6 A modification in human mitochondria, NUCLEIC ACIDS RESEARCH, 2020 Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA(Lys), SCIENCE CHINA-LIFE SCIENCES, 2020 Aminoacyl-tRNA synthetase in neuropathy, 生命科学, 2020 The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, NUCLEIC ACIDS RESEARCH, 2019 Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex, NUCLEIC ACIDS RESEARCH, 2019 Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, NUCLEIC ACIDS RESEARCH, 2018 A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities, NUCLEIC ACIDS RESEARCH, 2018 A natural non-Watson-Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations, NUCLEIC ACIDS RESEARCH, 2018 Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism, HUMAN MUTATION, 2017 Translational Quality Control by Bacterial Threonyl-tRNA Synthetases, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016 A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016 C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeu, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016 Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015 Degenerate Connective Polypeptide 1 (CP1) Domain from Human Mitochondrial Leucyl-tRNA Synthetase, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015 A minimalist mitochondrial threonyl-tRNA synthetase exhibits tRNA-isoacceptor specificity during proofreading, NUCLEIC ACIDS RESEARCH, 2014 Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode, NUCLEIC ACIDS RESEARCH, 2014

Areas of Focus

RNA Metabolism and Mitochondrial Diseases

Publications

Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023
Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023
Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022
Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022
Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022
RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022
Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022
Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021
The development of multiple synthetase complex(MSC), 生命科学, 2021
Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021
The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021
Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6, NUCLEIC ACIDS RESEARCH, 2021
Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA-LIFE SCIENCES, 2021
Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020
Molecular basis for t 6 A modification in human mitochondria, NUCLEIC ACIDS RESEARCH, 2020
Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA(Lys), SCIENCE CHINA-LIFE SCIENCES, 2020
Aminoacyl-tRNA synthetase in neuropathy, 生命科学, 2020
The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, NUCLEIC ACIDS RESEARCH, 2019
Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex, NUCLEIC ACIDS RESEARCH, 2019
Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria, NUCLEIC ACIDS RESEARCH, 2018
A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities, NUCLEIC ACIDS RESEARCH, 2018
A natural non-Watson-Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations, NUCLEIC ACIDS RESEARCH, 2018
Mutations in KARS cause early-onset hearing loss and leukoencephalopathy: Potential pathogenic mechanism, HUMAN MUTATION, 2017
Translational Quality Control by Bacterial Threonyl-tRNA Synthetases, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016
A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016
C-terminal Domain of Leucyl-tRNA Synthetase from Pathogenic Candida albicans Recognizes both tRNASer and tRNALeu, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016
Identification of Lethal Mutations in Yeast Threonyl-tRNA Synthetase Revealing Critical Residues in Its Human Homolog, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015
Degenerate Connective Polypeptide 1 (CP1) Domain from Human Mitochondrial Leucyl-tRNA Synthetase, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015
A minimalist mitochondrial threonyl-tRNA synthetase exhibits tRNA-isoacceptor specificity during proofreading, NUCLEIC ACIDS RESEARCH, 2014
Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode, NUCLEIC ACIDS RESEARCH, 2014

Rna Metabolism Mitochondria Diseases Biochemistry Cell Biology Genetics Molecular Biology Research Innovation

Jing Xie - Tongji University

Jianfeng Chang - Tongji University

Wen Chen - Tongji University

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