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周小龙
Life Science
中国科学院大学
上海
Language: 中文, 英文
Rna
代谢
线粒体
疾病
生物化学
细胞生物学
遗传学
分子生物学
研究
创新
Areas of Focus
- RNA代谢与线粒体疾病
Work Experience
- 2019-05~2024-04 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 任职研究组长
- 2017-11~2024-04 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 任职研究员
- 2009-06~2017-10 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 任职助理研究员、副研究员
Academic Background & Achievements
- 2004-09--2009-05 博士学位: 中国科学院上海生命科学研究院
- 2000-09--2004-06 学士学位: 安徽师范大学
Publications
- Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023
- Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023
- Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022
- Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022
- Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022
- RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022
- Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022
- Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021
- 多氨基酰-tRNA合成酶复合物的发生发展, 生命科学, 2021
- Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021
- The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021
- Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6, NUCLEIC ACIDS RESEARCH, 2021
- Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA-LIFE SCIENCES, 2021
- Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020
- Molecular basis for t 6 A modification in human mitochondria, NUCLEIC ACIDS RESEARCH, 2020
- Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA(Lys), SCIENCE CHINA-LIFE SCIENCES, 2020
- 氨基酰-tRNA合成酶与神经系统疾病, 生命科学, 2020
- The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, NUCLEIC ACIDS RESEARCH, 2019
- Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex, NUCLEIC ACIDS RESEARCH, 2019
- Editing activity for eliminating mischarged tRNAs
Awards
- 上海市青年科技启明星, 一等奖, 省级, 2016
- 赛诺菲-中科院上海生命科学研究院优秀青年人才奖, 一等奖, 研究所（学校）, 2012
- 中科院卢嘉锡青年人才奖, 一等奖, 院级, 2011
