Professor | 周小龙 | 数字化转型顾问

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Name	周小龙
Contact Information	xlzhou@sibcb.ac.cn
Language ability	中文, 英文
Province	上海

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Name

周小龙

Contact Information

xlzhou@sibcb.ac.cn

Language ability

中文, 英文

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2004-09--2009-05 博士学位: 中国科学院上海生命科学研究院 2000-09--2004-06 学士学位: 安徽师范大学
Work Experience	2019-05~2024-04 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 任职研究组长 2017-11~2024-04 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 任职研究员 2009-06~2017-10 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 任职助理研究员、副研究员
Awards	上海市青年科技启明星, 一等奖, 省级, 2016 赛诺菲-中科院上海生命科学研究院优秀青年人才奖, 一等奖, 研究所（学校）, 2012 中科院卢嘉锡青年人才奖, 一等奖, 院级, 2011

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2004-09--2009-05 博士学位: 中国科学院上海生命科学研究院
2000-09--2004-06 学士学位: 安徽师范大学

Work Experience

2019-05~2024-04 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 任职研究组长
2017-11~2024-04 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 任职研究员
2009-06~2017-10 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 任职助理研究员、副研究员

Awards

上海市青年科技启明星, 一等奖, 省级, 2016
赛诺菲-中科院上海生命科学研究院优秀青年人才奖, 一等奖, 研究所（学校）, 2012
中科院卢嘉锡青年人才奖, 一等奖, 院级, 2011

Areas of Focus	RNA代谢与线粒体疾病
Publications	Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023 Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023 Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022 Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022 Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022 RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022 Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022 Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021 多氨基酰-tRNA合成酶复合物的发生发展, 生命科学, 2021 Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021 The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021 Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6, NUCLEIC ACIDS RESEARCH, 2021 Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA-LIFE SCIENCES, 2021 Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020 Molecular basis for t 6 A modification in human mitochondria, NUCLEIC ACIDS RESEARCH, 2020 Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA(Lys), SCIENCE CHINA-LIFE SCIENCES, 2020 氨基酰-tRNA合成酶与神经系统疾病, 生命科学, 2020 The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, NUCLEIC ACIDS RESEARCH, 2019 Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex, NUCLEIC ACIDS RESEARCH, 2019 Editing activity for eliminating mischarged tRNAs

Areas of Focus

RNA代谢与线粒体疾病

Publications

Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development., J Biol Chem, 2023
Mitochondrial translational defect extends lifespan in C. elegans by activating UPR mt, REDOX BIOLOGY, 2023
Selective degradation of tRNA(Ser)(AGY) is the primary driver for mitochondrial seryl-tRNA synthetase-related disease, NUCLEIC ACIDS RESEARCH, 2022
Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8, NUCLEIC ACIDS RESEARCH, 2022
Elucidating the molecular mechanisms associated with TARS2-related mitochondrial disease, HUMAN MOLECULAR GENETICS, 2022
RNA granule-clustered mitochondrial aminoacyl-tRNA synthetases form multiple complexes with the potential to fine-tune tRNA aminoacylation, NUCLEIC ACIDS RESEARCH, 2022
Commonality and diversity in tRNA substrate recognition in t(6)A biogenesis by eukaryotic KEOPSs, NUCLEIC ACIDS RESEARCH, 2022
Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis, CELL DISCOVERY, 2021
多氨基酰-tRNA合成酶复合物的发生发展, 生命科学, 2021
Modifications of the human tRNA anticodon loop and their associations with genetic diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, 2021
The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases, NUCLEIC ACIDS RESEARCH, 2021
Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6, NUCLEIC ACIDS RESEARCH, 2021
Distinct pathogenic mechanisms of various RARS1 mutations in Pelizaeus-Merzbacher-like disease, SCIENCE CHINA-LIFE SCIENCES, 2021
Nitrosative stress inhibits aminoacylation and editing activities of mitochondrial threonyl-tRNA synthetase by S-nitrosation, NUCLEIC ACIDS RESEARCH, 2020
Molecular basis for t 6 A modification in human mitochondria, NUCLEIC ACIDS RESEARCH, 2020
Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNA(Lys), SCIENCE CHINA-LIFE SCIENCES, 2020
氨基酰-tRNA合成酶与神经系统疾病, 生命科学, 2020
The G3-U70-independent tRNA recognition by human mitochondrial alanyl-tRNA synthetase, NUCLEIC ACIDS RESEARCH, 2019
Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex, NUCLEIC ACIDS RESEARCH, 2019
Editing activity for eliminating mischarged tRNAs

Rna 代谢线粒体疾病生物化学细胞生物学遗传学分子生物学研究创新

谢敬 - 同济大学

常建锋 - 同济大学

陈文 - 同济大学

Area of Focus
干细胞 | 神经学 | 胎儿 | 疾病 | 表观遗传学 | 调控 | 机制 | 研究 | 神经发生 | 认知

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