Professor | Zhangsen Zhou | Asia Growth Partners

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Name	Zhangsen Zhou
Contact Information	zszhou@sibs.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Zhangsen Zhou

Contact Information

zszhou@sibs.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2009-09 to 2015-06 Ph.D. in Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences 2004-09 to 2008-06 Bachelor's in Science: Shandong University
Work Experience	2016-09 to 2021-05 - University of Michigan - Postdoctoral Researcher 2015-07 to 2016-06 - Wuhan University - Assistant Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2009-09 to 2015-06 Ph.D. in Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2004-09 to 2008-06 Bachelor's in Science: Shandong University

Work Experience

2016-09 to 2021-05 - University of Michigan - Postdoctoral Researcher
2015-07 to 2016-06 - Wuhan University - Assistant Researcher

Areas of Focus	Molecular mechanisms regulating mitochondrial homeostasis via endoplasmic reticulum degradation pathways New mechanisms and modes of multi-level interactions between endoplasmic reticulum and mitochondria Functions and regulatory mechanisms of organelle interaction disorders in the pathogenesis of metabolic diseases
Publications	Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function., Yoshida, S., X. Wei, G. Zhang, C. L. O'Connor, M. Torres, Z. Zhou, L. Lin, R. Menon, X. Xu, W. Zheng, Y. Xiong, E. Otto, C. A. Tang, R. Hua, R. Verma, H. Mori, Y. Zhang, C. A. Hu, M. Liu, P. Garg, J. B. Hodgin, S. Sun, M. Bitzer & L. Qi, 2021 Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes., Zhou, Z.#, M. Torres#, H. Sha, C. J. Halbrook, F. Van den Bergh, R. B. Reinert, T. Yamada, S. Wang, Y. Luo, A. H. Hunter, C. Wang, T. H. Sanderson, M. Liu, A. Taylor, H. Sesaki, C. A. Lyssiotis, J. Wu, S. Kersten, D. A. Beard & L. Qi, 2020 Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2., Zhou, Z. S.#, M. X. Li#, J. Liu#, H. Jiao, J. M. Xia, X. J. Shi, H. Zhao, L. Chu, W. Qi, J. Luo & B. L. Song, 2020 Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice., Li, N., Z. S. Zhou, Y. Shen, J. Xu, H. H. Miao, Y. Xiong, F. Xu, B. L. Li, J. Luo & B. L. Song, 2017 Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine., Xie, C.#, Z. S. Zhou#, N. Li, Y. Bian, Y. J. Wang, L. J. Wang, B. L. Li* & B. L. Song*, 2012

Areas of Focus

Molecular mechanisms regulating mitochondrial homeostasis via endoplasmic reticulum degradation pathways
New mechanisms and modes of multi-level interactions between endoplasmic reticulum and mitochondria
Functions and regulatory mechanisms of organelle interaction disorders in the pathogenesis of metabolic diseases

Publications

Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function., Yoshida, S., X. Wei, G. Zhang, C. L. O'Connor, M. Torres, Z. Zhou, L. Lin, R. Menon, X. Xu, W. Zheng, Y. Xiong, E. Otto, C. A. Tang, R. Hua, R. Verma, H. Mori, Y. Zhang, C. A. Hu, M. Liu, P. Garg, J. B. Hodgin, S. Sun, M. Bitzer & L. Qi*, 2021
Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes., Zhou, Z.#, M. Torres#, H. Sha, C. J. Halbrook, F. Van den Bergh, R. B. Reinert, T. Yamada, S. Wang, Y. Luo, A. H. Hunter, C. Wang, T. H. Sanderson, M. Liu, A. Taylor, H. Sesaki, C. A. Lyssiotis, J. Wu, S. Kersten, D. A. Beard & L. Qi*, 2020
Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2., Zhou, Z. S.#, M. X. Li#, J. Liu#, H. Jiao, J. M. Xia, X. J. Shi, H. Zhao, L. Chu, W. Qi, J. Luo & B. L. Song*, 2020
Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice., Li, N., Z. S. Zhou, Y. Shen, J. Xu, H. H. Miao, Y. Xiong, F. Xu, B. L. Li, J. Luo & B. L. Song*, 2017
Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine., Xie, C.#, Z. S. Zhou#, N. Li, Y. Bian, Y. J. Wang, L. J. Wang, B. L. Li* & B. L. Song*, 2012

Mitochondrial Homeostasis Endoplasmic Reticulum Degradation Pathways Organelle Interaction Metabolic Diseases Molecular Mechanisms Calcium Signaling Lipid Synthesis High-Throughput Screening Proteomics

Liangliang Fan - Central South University

Yan Zhao - Southern University of Science and Technology

Jianmiao Liu - Huazhong University of Science and Technology

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