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Zhangsen Zhou
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Mitochondrial Homeostasis
Endoplasmic Reticulum
Degradation Pathways
Organelle Interaction
Metabolic Diseases
Molecular Mechanisms
Calcium Signaling
Lipid Synthesis
High-Throughput Screening
Proteomics
Areas of Focus
- Molecular mechanisms regulating mitochondrial homeostasis via endoplasmic reticulum degradation pathways
- New mechanisms and modes of multi-level interactions between endoplasmic reticulum and mitochondria
- Functions and regulatory mechanisms of organelle interaction disorders in the pathogenesis of metabolic diseases
Work Experience
- 2016-09 to 2021-05 - University of Michigan - Postdoctoral Researcher
- 2015-07 to 2016-06 - Wuhan University - Assistant Researcher
Academic Background & Achievements
- 2009-09 to 2015-06 Ph.D. in Science: Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
- 2004-09 to 2008-06 Bachelor's in Science: Shandong University
Publications
- Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function., Yoshida, S., X. Wei, G. Zhang, C. L. O'Connor, M. Torres, Z. Zhou, L. Lin, R. Menon, X. Xu, W. Zheng, Y. Xiong, E. Otto, C. A. Tang, R. Hua, R. Verma, H. Mori, Y. Zhang, C. A. Hu, M. Liu, P. Garg, J. B. Hodgin, S. Sun, M. Bitzer & L. Qi*, 2021
- Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes., Zhou, Z.#, M. Torres#, H. Sha, C. J. Halbrook, F. Van den Bergh, R. B. Reinert, T. Yamada, S. Wang, Y. Luo, A. H. Hunter, C. Wang, T. H. Sanderson, M. Liu, A. Taylor, H. Sesaki, C. A. Lyssiotis, J. Wu, S. Kersten, D. A. Beard & L. Qi*, 2020
- Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2., Zhou, Z. S.#, M. X. Li#, J. Liu#, H. Jiao, J. M. Xia, X. J. Shi, H. Zhao, L. Chu, W. Qi, J. Luo & B. L. Song*, 2020
- Inhibition of the sterol regulatory element-binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice., Li, N., Z. S. Zhou, Y. Shen, J. Xu, H. H. Miao, Y. Xiong, F. Xu, B. L. Li, J. Luo & B. L. Song*, 2017
- Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine., Xie, C.#, Z. S. Zhou#, N. Li, Y. Bian, Y. J. Wang, L. J. Wang, B. L. Li* & B. L. Song*, 2012
