Professor | Yan Zhao | Asia Growth Partners

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Name	Yan Zhao
Contact Information	zhaoyan@sustech.edu.cn
Language ability	Chinese, English
Province	Guangdong

Upload Avatar (500 x 500)

Name

Yan Zhao

Contact Information

zhaoyan@sustech.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Life Sciences
Academic Background & Achievements	Bachelor and PhD: Peking University Medical School Postdoctoral work at the Institute of Biophysics, Chinese Academy of Sciences and University of Massachusetts Medical School Recipient of the National Science Foundation for Excellent Young Scientists Fund
Work Experience	2020 - Present: Southern University of Science and Technology, Associate Professor

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Life Sciences

Academic Background & Achievements

Bachelor and PhD: Peking University Medical School
Postdoctoral work at the Institute of Biophysics, Chinese Academy of Sciences and University of Massachusetts Medical School
Recipient of the National Science Foundation for Excellent Young Scientists Fund

Work Experience

2020 - Present: Southern University of Science and Technology, Associate Professor

Areas of Focus	Molecular mechanisms and physiological functions of autophagy Autophagy in multicellular organisms Neurodegenerative diseases and potential therapeutic targets Interactions between the endoplasmic reticulum and autophagic precursors Molecular mechanisms of autophagy in neural cells Formation mechanisms of double-membrane vesicles in coronavirus transcription replication
Publications	LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation, Li, M., Hou, Y., Zhou, Y., Yang, Z., Zhao, H., Jian, T., Yu, Q., Zeng, F., Liu, X., Zhang, Z., and Zhao, Y.G., 2024 VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection, Ji, M., Li, M., Sun, L., Zhao, H., Li, Y., Zhou, L., Yang, Z., Zhao, X., Qu, W., Xue, H., Zheng, Z., Li, Y., Deng, H., and Zhao, Y.G., 2022 β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells, Ji, C., Zhao, H., Zhang, H., and Zhao, Y.G., 2021 Role of Wdr45b in maintaining neural autophagy and cognitive function, Ji, C., Zhao, H., Li, D., Sun, H., Hao, J., Chen, R., Wang, X., Zhang, H., and Zhao, Y.G., 2020 The ER-localized protein DFCP1 modulates ER-lipid droplet contact formation, Li, D., Zhao, Y.G., Li, D., Zhao, H., Huang, J., Miao, G., Feng, D., Liu, P., Li, D., and Zhang, H., 2019 The ER contact proteins VAPA/B interact with multiple autophagy proteins to modulate autophagosome biogenesis, Zhao, Y.G., Liu, N., Miao, G., Chen, Y., Zhao, H., and Zhang, H., 2018 The ER-localized transmembrane protein EPG-3/VMP1 regulates SERCA activity to control ER-isolation membrane contacts for autophagosome formation, Zhao, Y.G., Chen, Y., Miao, G., Zhao, H., Qu, W., Li, D., Wang, Z., Liu, N., Li, L., Chen, S., Liu, P., Feng, D., and Zhang, H., 2017 The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis, Zhao, Y.G., Sun, L., Miao, G.Y., Ji, C.C., Zhao, H.Y., Sun, H.Y., Miao, L., Yoshii, S.R., Mizushima, N., Wang X.Q., and Zhang, H., 2015 Role of Epg5 in selective neurodegeneration and Vici syndrome, Zhao, Y.G., Zhao, H.Y., Sun, H.Y., and Zhang, H., 2013 Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration, Zhao, H.Y., Zhao, Y.G., Wang, X.W., Xu, L.J., Miao, L., Feng, D., Chen, Q., Kovács, A.L. Fan, D.S., and Zhang, H., 2013 The p53-induced gene Ei24 is an essential component of the basal autophagy pathway, Zhao, Y.G., Zhao, H.Y., Miao, L., Wang, L., Sun, F., and Zhang, H., 2012

Areas of Focus

Molecular mechanisms and physiological functions of autophagy
Autophagy in multicellular organisms
Neurodegenerative diseases and potential therapeutic targets
Interactions between the endoplasmic reticulum and autophagic precursors
Molecular mechanisms of autophagy in neural cells
Formation mechanisms of double-membrane vesicles in coronavirus transcription replication

Publications

LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation, Li, M., Hou, Y., Zhou, Y., Yang, Z., Zhao, H., Jian, T., Yu, Q., Zeng, F., Liu, X., Zhang, Z., and Zhao, Y.G., 2024
VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection, Ji, M., Li, M., Sun, L., Zhao, H., Li, Y., Zhou, L., Yang, Z., Zhao, X., Qu, W., Xue, H., Zheng, Z., Li, Y., Deng, H., and Zhao, Y.G., 2022
β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells, Ji, C., Zhao, H., Zhang, H., and Zhao, Y.G., 2021
Role of Wdr45b in maintaining neural autophagy and cognitive function, Ji, C., Zhao, H., Li, D., Sun, H., Hao, J., Chen, R., Wang, X., Zhang, H., and Zhao, Y.G., 2020
The ER-localized protein DFCP1 modulates ER-lipid droplet contact formation, Li, D., Zhao, Y.G., Li, D., Zhao, H., Huang, J., Miao, G., Feng, D., Liu, P., Li, D., and Zhang, H., 2019
The ER contact proteins VAPA/B interact with multiple autophagy proteins to modulate autophagosome biogenesis, Zhao, Y.G., Liu, N., Miao, G., Chen, Y., Zhao, H., and Zhang, H., 2018
The ER-localized transmembrane protein EPG-3/VMP1 regulates SERCA activity to control ER-isolation membrane contacts for autophagosome formation, Zhao, Y.G., Chen, Y., Miao, G., Zhao, H., Qu, W., Li, D., Wang, Z., Liu, N., Li, L., Chen, S., Liu, P., Feng, D., and Zhang, H., 2017
The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis, Zhao, Y.G., Sun, L., Miao, G.Y., Ji, C.C., Zhao, H.Y., Sun, H.Y., Miao, L., Yoshii, S.R., Mizushima, N., Wang X.Q., and Zhang, H., 2015
Role of Epg5 in selective neurodegeneration and Vici syndrome, Zhao, Y.G., Zhao, H.Y., Sun, H.Y., and Zhang, H., 2013
Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration, Zhao, H.Y., Zhao, Y.G., Wang, X.W., Xu, L.J., Miao, L., Feng, D., Chen, Q., Kovács, A.L. Fan, D.S., and Zhang, H., 2013
The p53-induced gene Ei24 is an essential component of the basal autophagy pathway, Zhao, Y.G., Zhao, H.Y., Miao, L., Wang, L., Sun, F., and Zhang, H., 2012

Autophagy Cell Stability Molecular Mechanisms Physiological Functions Neurodegenerative Diseases Therapeutic Targets Endoplasmic Reticulum Autophagic Precursors Neural Cells Coronavirus

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