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Yan Zhao
Life Science
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Autophagy
Cell Stability
Molecular Mechanisms
Physiological Functions
Neurodegenerative Diseases
Therapeutic Targets
Endoplasmic Reticulum
Autophagic Precursors
Neural Cells
Coronavirus
Areas of Focus
- Molecular mechanisms and physiological functions of autophagy
- Autophagy in multicellular organisms
- Neurodegenerative diseases and potential therapeutic targets
- Interactions between the endoplasmic reticulum and autophagic precursors
- Molecular mechanisms of autophagy in neural cells
- Formation mechanisms of double-membrane vesicles in coronavirus transcription replication
Work Experience
- 2020 - Present: Southern University of Science and Technology, Associate Professor
Academic Background & Achievements
- Bachelor and PhD: Peking University Medical School
- Postdoctoral work at the Institute of Biophysics, Chinese Academy of Sciences and University of Massachusetts Medical School
- Recipient of the National Science Foundation for Excellent Young Scientists Fund
Publications
- LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation, Li, M., Hou, Y., Zhou, Y., Yang, Z., Zhao, H., Jian, T., Yu, Q., Zeng, F., Liu, X., Zhang, Z., and Zhao, Y.G., 2024
- VMP1 and TMEM41B are essential for DMV formation during β-coronavirus infection, Ji, M., Li, M., Sun, L., Zhao, H., Li, Y., Zhou, L., Yang, Z., Zhao, X., Qu, W., Xue, H., Zheng, Z., Li, Y., Deng, H., and Zhao, Y.G., 2022
- β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells, Ji, C., Zhao, H., Zhang, H., and Zhao, Y.G., 2021
- Role of Wdr45b in maintaining neural autophagy and cognitive function, Ji, C., Zhao, H., Li, D., Sun, H., Hao, J., Chen, R., Wang, X., Zhang, H., and Zhao, Y.G., 2020
- The ER-localized protein DFCP1 modulates ER-lipid droplet contact formation, Li, D., Zhao, Y.G., Li, D., Zhao, H., Huang, J., Miao, G., Feng, D., Liu, P., Li, D., and Zhang, H., 2019
- The ER contact proteins VAPA/B interact with multiple autophagy proteins to modulate autophagosome biogenesis, Zhao, Y.G., Liu, N., Miao, G., Chen, Y., Zhao, H., and Zhang, H., 2018
- The ER-localized transmembrane protein EPG-3/VMP1 regulates SERCA activity to control ER-isolation membrane contacts for autophagosome formation, Zhao, Y.G., Chen, Y., Miao, G., Zhao, H., Qu, W., Li, D., Wang, Z., Liu, N., Li, L., Chen, S., Liu, P., Feng, D., and Zhang, H., 2017
- The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis, Zhao, Y.G., Sun, L., Miao, G.Y., Ji, C.C., Zhao, H.Y., Sun, H.Y., Miao, L., Yoshii, S.R., Mizushima, N., Wang X.Q., and Zhang, H., 2015
- Role of Epg5 in selective neurodegeneration and Vici syndrome, Zhao, Y.G., Zhao, H.Y., Sun, H.Y., and Zhang, H., 2013
- Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration, Zhao, H.Y., Zhao, Y.G., Wang, X.W., Xu, L.J., Miao, L., Feng, D., Chen, Q., Kovács, A.L. Fan, D.S., and Zhang, H., 2013
- The p53-induced gene Ei24 is an essential component of the basal autophagy pathway, Zhao, Y.G., Zhao, H.Y., Miao, L., Wang, L., Sun, F., and Zhang, H., 2012
