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Xueli Zhang
Life Science
University of Chinese Academy of Sciences
Tianjin
Language: Chinese, English
Synthetic Biology
Metabolic Engineering
Gene Editing
Cell Factories
Biotechnology
Microbial Engineering
Genetic Engineering
Crispr
Genome Editing
Biomanufacturing
Areas of Focus
- Synthetic Biology
- Applied Synthetic Biology
- Metabolic Engineering
- Gene Editing
Work Experience
- 2007-07~2010-01 - University of Florida, Department of Microbiology and Cell Science - Research Assistant Professor
- 2005-08~2007-07 - University of Florida, Department of Microbiology and Cell Science - Postdoctoral Researcher
- 2000-09~2005-07 - Shanghai Jiao Tong University - Ph.D. Student
- 1996-09~2000-07 - Shanghai Jiao Tong University - Bachelor's Student
Academic Background & Achievements
- 2000-09--2005-07 Ph.D.: Shanghai Jiao Tong University
- 1996-09--2000-07 Bachelor's: Shanghai Jiao Tong University
Publications
- Glycosylase-based base editors for efficient T-to-G and C-to-G editing in mammalian cells, Xueli Zhang, 2024
- Construction of cell factories for production of patchoulol in Saccharomyces cerevisiae, Xueli Zhang, 2023
- Microbial cell factories, Xueli Zhang, 2023
- Sterol transport proteins in yeast: a review, Xueli Zhang, 2023
- Microbial L-malic acid production: History, current progress, and perspectives, Xueli Zhang, 2023
- Construction of cell factories for production of valencene in Saccharomyces cerevisiae, Xueli Zhang, 2023
- Combinatorial metabolic engineering and tolerance evolution of Yarrowia lipolytica for improved β-decalactone synthesis, Xueli Zhang, 2023
- High-throughput base editing KO screening of cellular factors for enhanced GBE, Xueli Zhang, 2023
- Artificial Diploid Escherichia coli by a CRISPR Chromosome-Doubling Technique, Xueli Zhang, 2023
- Metabolic engineering of the acid-tolerant yeast Pichia kudriavzevii for efficient L-malic acid production at low pH, Xueli Zhang, 2023
- Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65, Xueli Zhang, 2023
- HMGN1 enhances CRISPR-directed dual-function A-to-G and C-to-G base editing, Xueli Zhang, 2023
- Obtaining the best igRNAs for bystander-less correction of all ABE-reversible pathogenic SNVs using high-throughput screening, Xueli Zhang, 2023
- Development of CRISPR/Cas9-Based Genome Editing Tools for Polyploid Yeast Cyberlindnera jadinii and Its Application in Engineering Heterologous Steroid-Producing Strains, Xueli Zhang, 2023
- AAV-mediated base-editing therapy ameliorates the disease phenotypes in a mouse model of retinitis pigmentosa, Xueli Zhang, 2023
- Genomic allele-specific base editing with imperfect gRNA, Xueli Zhang, 2023
- Targeted C-to-T and A-to-G dual mutagenesis system for RhtA transporter in vivo evolution, Xueli Zhang, 2023
- Plant biomass degradation by filamentous fungi and production of renewable chemicals: a review, Xueli Zhang, 2022
- Artificial bioconversion of carbon dioxide, Xueli Zhang, 2022
- Construction of cell factories for high production of ginsenoside Rh_(2) in Saccharomyces cerevisiae, Xueli Zhang, 2022
- Application of genome editing technology in industrial microorganisms: current status and perspectives, Xueli Zhang, 2022
- Advances in microbial synthesis of plant natural products, Xueli Zhang, 2022
- Circular Guide RNA for Improved Stability and CRISPR-Cas9 Editing Efficiency in Vitro and in Bacteria, Xueli Zhang, 2022
- Reconstructed glycosylase base editors GBE2.0 with enhanced C-to-G base editing efficiency and purity, Xueli Zhang, 2022
- Engineering Circularized mRNAs for the Production of Spider Silk Proteins, Xueli Zhang, 2022
- Sequence motifs and prediction model of GBE editing outcomes based on target library analysis and machine learning, Xueli Zhang, 2022
- A miniaturized bionic ocean-battery mimicking the structure of marine microbial ecosystems, Xueli Zhang, 2022
- Improving astaxanthin production in Escherichia coli by co-utilizing CrtZ enzymes with different substrate preference, Xueli Zhang, 2022
- A CRISPR-based chromosomal-separation technique for Escherichia coli, Xueli Zhang, 2022
- Metabolic engineering of Saccharomyces cerevisiae for gram-scale diosgenin production, Xueli Zhang, 2022
- Pioneer Factor Improves CRISPR-Based C-To-G and C-To-T Base Editing, Xueli Zhang, 2022
- Automated high-throughput genome editing platform with an AI learning in situ prediction model, Xueli Zhang, 2022
- New xylose transporters support the simultaneous consumption of glucose and xylose in Escherichia coli, Xueli Zhang, 2022
- Enhancing glycosylase base-editor activity by fusion to transactivation modules, Xueli Zhang, 2022
- Engineering of the Translesion DNA Synthesis Pathway Enables Controllable C-to-G and C-to-A Base Editing in Corynebacterium glutamicum, Xueli Zhang, 2022
- Construction of Escherichia coli cell factories, Xueli Zhang, 2021
- Dynamic regulation of ERG20 gene expression in Saccharomyces cerevisiae to improve monoterpene production, Xueli Zhang, 2021
- The origin and evolution of the diosgenin biosynthetic pathway in yam, Xueli Zhang, 2021
- CRISPR-based metabolic pathway engineering, Xueli Zhang, 2021
- Fine-tuning the expression of pathway gene in yeast using a regulatory library formed by fusing a synthetic minimal promoter with different Kozak variants, Xueli Zhang, 2021
- De Novo Biosynthesis of the Oleanane-Type Triterpenoids of Tunicosaponins in Yeast, Xueli Zhang, 2021
- Metabolic engineering of microorganisms for L-alanine production, Xueli Zhang, 2021
- Multiple strategies for metabolic engineering of Escherichia coli for efficient production of glycolate, Xueli Zhang, 2021
- Engineering an efficient H2 utilizing Escherichia coli platform by modulation of endogenous hydrogenases, Xueli Zhang, 2021
- Characterization of JEN family carboxylate transporters from the acid-tolerant yeast Pichia kudriavzevii and their applications in succinic acid production, Xueli Zhang, 2021
- Directed evolution of alditol oxidase for the production of optically pure D-glycerate from glycerol in the engineered Escherichia coli, Xueli Zhang, 2021
- Glycosylase base editors enable C-to-A and C-to-G base changes, Xueli Zhang, 2021
- Construction of cell factories for high production of ginsenoside Rh2 in Saccharomyces cerevisiae, Xueli Zhang, 2021
- Engineering yeast subcellular compartments for increased production of the lipophilic natural products ginsenosides, Xueli Zhang, 2021
- Production of plant volatile terpenoids (rose oil) by yeast cell factories, Xueli Zhang, 2021
- Helicase-AID: A novel molecular device for base editing at random genomic loci, Xueli Zhang
Awards
- Anhui Province Patent Gold Award (2023): First Prize, Provincial Level
- China National Light Industry Council Technology Invention Award (2019): First Prize, National Level
- Anhui Province Science and Technology Award (2016): Second Prize, Provincial Level
- China Patent Excellence Award (2015): First Prize, National Level
- Anhui Province Patent Gold Award (2014): First Prize, Provincial Level
- China Industry-University-Research Cooperation Innovation Achievement Award (2014): First Prize, Provincial Level
