Professor | Dengfeng Zhang | Asia Growth Partners

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Name	Dengfeng Zhang
Contact Information	zhangdengfeng@mail.kiz.ac.cn
Language ability	Chinese, English
Province	Yunnan

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Name

Dengfeng Zhang

Contact Information

zhangdengfeng@mail.kiz.ac.cn

Language ability

Chinese, English

Province

Yunnan

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2010-09 to 2016-01 PhD in Genetics: University of Chinese Academy of Sciences 2006-09 to 2010-06 Bachelor of Science: Huazhong University of Science and Technology
Work Experience	2021-01 to Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Researcher 2018-01 to 2020-12 - Kunming Institute of Zoology, Chinese Academy of Sciences - Associate Researcher 2016-01 to 2017-12 - Kunming Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2010-09 to 2016-01 PhD in Genetics: University of Chinese Academy of Sciences
2006-09 to 2010-06 Bachelor of Science: Huazhong University of Science and Technology

Work Experience

2021-01 to Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Researcher
2018-01 to 2020-12 - Kunming Institute of Zoology, Chinese Academy of Sciences - Associate Researcher
2016-01 to 2017-12 - Kunming Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher

Areas of Focus	Molecular mechanisms of Alzheimer's disease and other complex diseases Genetic, genomic, and molecular epidemiological analysis
Publications	Common and rare variants of EGF increase the genetic risk of Alzheimer's disease as revealed by targeted sequencing of growth factors in Han Chinese., Xiao Li, Min Xu, Rui Bi, LiWen Tan, YongGang Yao, DengFeng Zhang, 2023 Toward a Full Understanding of Causal and Modifiable Risk Factors for Alzheimer’s Disease by Integrative Phenome-wide Association Studies., Zhang, Deng-Feng, Li, Ming, 2023 Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease., Xiao Li, Deng-Feng Zhang, Rui Bi, Li-Wen Tan, Xiaogang Chen, Min Xu, Yong-Gang Yao, 2023 SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy., Guanqin Ma, DengFeng Zhang, QingCui Zou, Xiaochun Xie, Ling Xu, XiaoLi Feng, Xiaohong Li, JianBao Han, Dandan Yu, ZhongHua Deng, Wang Qu, Junyi Long, MingHua Li, YongGang Yao, Jianxiong Zeng, 2022 Exploring the Genetic Association of the ABAT Gene with Alzheimer's Disease., Zheng, Quanzhen, Bi, Rui, Xu, Min, Zhang, DengFeng, Tan, LiWen, Lu, YaPing, Yao, YongGang, 2021 Mapping leprosy-associated coding variants of interleukin genes by targeted sequencing., Zhang, DengFeng, Li, HuiLong, Zheng, Quanzhen, Bi, Rui, Xu, Min, Wang, Dong, Zhu, GuoPing, Li, YuYe, Yao, YongGang, 2021 Editorial: Infection, Inflammation, Cardiovascular Diseases, and Neurodegeneration., Zhang, DengFeng, Bu, XianLe, Aliev, Gjumrakch, Zhu, Feiqi, 2021 Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model., Luo, Rongcan, Su, LingYan, Li, Guiyu, Yang, Jing, Liu, Qianjin, Yang, LuXiu, Zhang, DengFeng, Zhou, Hejiang, Xu, Min, Fan, Yu, Li, Jiali, Yao, YongGang, 2020 Is there an antagonistic pleiotropic effect of a LRRK2 mutation on leprosy and Parkinson's disease?, Zhang, DengFeng, Wang, Dong, Li, YuYe, Yao, YongGang, 2020 KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells., Weidao Zhang, Zhongliang Chen, Dengfeng Zhang, Bo Zhao, Lu Liu, Zhengyuan Xie, Yonggang Yao, Ping Zheng, 2019 EGR1基因与中国汉族人群阿尔茨海默病发病风险的关联研究., 方新宇, 卢卫红, 王慧珍, 倪建良, 张江涛, 蔡军, 李涛, 张登峰, 张晨, 2019 中国汉族FOS基因rs1063169多态性与阿尔茨海默病的关联性研究., 陈艳, 方新宇, 汪也微, 倪建良, 张江涛, 卢卫红, 李涛, 张登峰, 张晨, 2019 Mutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease., Wang, Guihong, Zhang, DengFeng, Jiang, HongYan, Fan, Yu, Ma, Lingyan, Shen, Zonglin, Bi, Rui, Xu, Min, Tan, Liwen, Shan, Baoci, Yao, YongGang, Feng, Tao, 2019 Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese., Zhang, DengFeng, Fan, Yu, Xu, Min, Wang, Guihong, Wang, Dong, Li, Jin, Kong, LiLi, Zhou, Hejiang, Luo, Rongcan, Bi, Rui, Wu, Yong, Li, GuoDong, Li, Ming, Luo, XiongJian, Jiang, HongYan, Tan, Liwen, Zhong, Chunjiu, Fang, Yiru, Zhang, Chen, Sheng, Nengyin, Jiang, Tianzi, Yao, YongGang, 2019 Genetic Analyses of Alzheimer's Disease in China: Achievements and Perspectives., Zhang, DengFeng, Xu, Min, Bi, Rui, Yao, YongGang, 2019 A Comprehensive Analysis of the CaMK2A Gene and Susceptibility to Alzheimer's Disease in the Han Chinese Population., Fang, Xinyu, Tang, Wei, Yang, Fuyin, Lu, Weihong, Cai, Jun, Ni, Jianliang, Zhang, Jiangtao, Tang, Wenxin, Li, Tao, Zhang, DengFeng, Zhang, Chen, 2019 Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese., DengFeng Zhang, Dong Wang, YongGang Yao, Mahadev Malhi, Rui Bi, Yong Wu, Min Xu, XiuFeng Yu, Heng Long, YuYe Li, 2018 Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese., Bi, Rui, Zhang, Wen, Zhang, DengFeng, Xu, Min, Fan, Yu, Hu, QiuXiang, Jiang, HongYan, Tan, Liwen, Li, Tao, Fang, Yiru, Zhang, Chen, Yao, YongGang, 2018 A systematic integrated analysis of brain expression profiles reveals yap1 and other prioritized hub genes as important upstream regulators in alzheimer's disease., Xu M, Zhang DF, Luo R, Wu Y, Zhou H, Kong LL, Bi R, Yao YG, 2018 The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer's Disease., Ni, Hua, Xu, Min, Zhan, GuiLai, Fan, Yu, Zhou, Hejiang, Jiang, HongYan, Lu, WeiHong, Tan, Liwen, Zhang, DengFeng, Yao, YongGang, Zhang, Chen, 2018 Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese., Wang, Dong, Fan, Yu, Malhi, Mahadev, Bi, Rui, Wu, Yong, Xu, Min, Yu, XiuFeng, Long, Heng, Li, YuYe, Zhang, DengFeng, Yao, YongGang, 2018 Increased GSNOR expression during aging impairs cognitive function and decreases S-nitrosation of CaMKIIα., Zhang DF, changchenmoonibpaccn, Wang P, Chang C, Liu LM, Su WT, Zhang C, Liu GH, Yao YG, Yuan ZQ, Yao Q, Qiao XH, Wu KY, Zhang YY, 2017 Rare Genetic Variants of the Transthyretin Gene Are Associated with Alzheimer's Disease in Han Chinese., Xiang, Qun, Bi, Rui, Xu, Min, Zhang, DengFeng, Tan, Liwen, Zhang, Chen, Fang, Yiru, Yao, YongGang, 2017 Fine mapping of the GWAS loci identifies SLC35D1 and IL23R as potential risk genes for leprosy., Li, GuoDong, Wang, Dong, Zhang, DengFeng, Xiang, Qun, Feng, JiaQi, Li, XiaoAn, Li, YuYe, Yao, YongGang, 2016 PLD3 in Alzheimer’s Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses., Zhang DengFeng, Fan Yu, Wang Dong, Bi Rui, Zhang Chen, Fang Yiru, Yao YongGang, 2016 Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile., Zhang, DengFeng, Wang, Dong, Li, Yu Ye, Yao, YongGang, 2016 CFH Variants Affect Structural and Functional Brain Changes and Genetic Risk of Alzheimer's Disease., Zhang, DengFeng, Li, Jin, Wu, Huan, Cui, Yue, Bi, Rui, Zhou, HeJiang, Wang, HuiZhen, Zhang, Chen, Wang, Dong, Kong, QingPeng, Li, Tao, Fang, Yiru, Jiang, Tianzi, Yao, YongGang, ADNI, 2016 Identification of SLC25A37 as a major depressive disorder risk gene., Huo, YongXia, Huang, Liang, Zhang, DengFeng, Yao, YongGang, Fang, YiRu, Zhang, Chen, Luo, XiongJian, 2016 Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China., Xiang, YangLin, Zhang, DengFeng, Wang, Dong, Li, YuYe, Yao, YongGang, 2015 阿尔兹海默病遗传风险相关基因的整合分析., 张登峰, 2015 Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese., Li, Xiao, Zhang, Wen, Zhang, Chen, Yi, Zhenghui, Zhang, DengFeng, Gong, Wei, Tang, Jinsong, Wang, Dong, Lu, Weihong, Chen, Xiaogang, Fang, Yiru, Yao, YongGang, 2015 Genetic variants of complement genes Ficolin-2, Mannose-binding lectin and Complement factor H are associated with leprosy in Han Chinese from Southwest China., Zhang, DengFeng, Huang, XianQiong, Wang, Dong, Li, YuYe, Yao, YongGang, 2013 Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China., Wang, Dong, Feng, JiaQi, Li, YuYe, Zhang, DengFeng, Li, XiaoAn, Li, QingWei, Yao, YongGang, 2012

Areas of Focus

Molecular mechanisms of Alzheimer's disease and other complex diseases
Genetic, genomic, and molecular epidemiological analysis

Publications

Common and rare variants of EGF increase the genetic risk of Alzheimer's disease as revealed by targeted sequencing of growth factors in Han Chinese., Xiao Li, Min Xu, Rui Bi, LiWen Tan, YongGang Yao, DengFeng Zhang, 2023
Toward a Full Understanding of Causal and Modifiable Risk Factors for Alzheimer’s Disease by Integrative Phenome-wide Association Studies., Zhang, Deng-Feng, Li, Ming, 2023
Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease., Xiao Li, Deng-Feng Zhang, Rui Bi, Li-Wen Tan, Xiaogang Chen, Min Xu, Yong-Gang Yao, 2023
SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy., Guanqin Ma, DengFeng Zhang, QingCui Zou, Xiaochun Xie, Ling Xu, XiaoLi Feng, Xiaohong Li, JianBao Han, Dandan Yu, ZhongHua Deng, Wang Qu, Junyi Long, MingHua Li, YongGang Yao, Jianxiong Zeng, 2022
Exploring the Genetic Association of the ABAT Gene with Alzheimer's Disease., Zheng, Quanzhen, Bi, Rui, Xu, Min, Zhang, DengFeng, Tan, LiWen, Lu, YaPing, Yao, YongGang, 2021
Mapping leprosy-associated coding variants of interleukin genes by targeted sequencing., Zhang, DengFeng, Li, HuiLong, Zheng, Quanzhen, Bi, Rui, Xu, Min, Wang, Dong, Zhu, GuoPing, Li, YuYe, Yao, YongGang, 2021
Editorial: Infection, Inflammation, Cardiovascular Diseases, and Neurodegeneration., Zhang, DengFeng, Bu, XianLe, Aliev, Gjumrakch, Zhu, Feiqi, 2021
Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model., Luo, Rongcan, Su, LingYan, Li, Guiyu, Yang, Jing, Liu, Qianjin, Yang, LuXiu, Zhang, DengFeng, Zhou, Hejiang, Xu, Min, Fan, Yu, Li, Jiali, Yao, YongGang, 2020
Is there an antagonistic pleiotropic effect of a LRRK2 mutation on leprosy and Parkinson's disease?, Zhang, DengFeng, Wang, Dong, Li, YuYe, Yao, YongGang, 2020
KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells., Weidao Zhang, Zhongliang Chen, Dengfeng Zhang, Bo Zhao, Lu Liu, Zhengyuan Xie, Yonggang Yao, Ping Zheng, 2019
EGR1基因与中国汉族人群阿尔茨海默病发病风险的关联研究., 方新宇, 卢卫红, 王慧珍, 倪建良, 张江涛, 蔡军, 李涛, 张登峰, 张晨, 2019
中国汉族FOS基因rs1063169多态性与阿尔茨海默病的关联性研究., 陈艳, 方新宇, 汪也微, 倪建良, 张江涛, 卢卫红, 李涛, 张登峰, 张晨, 2019
Mutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease., Wang, Guihong, Zhang, DengFeng, Jiang, HongYan, Fan, Yu, Ma, Lingyan, Shen, Zonglin, Bi, Rui, Xu, Min, Tan, Liwen, Shan, Baoci, Yao, YongGang, Feng, Tao, 2019
Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese., Zhang, DengFeng, Fan, Yu, Xu, Min, Wang, Guihong, Wang, Dong, Li, Jin, Kong, LiLi, Zhou, Hejiang, Luo, Rongcan, Bi, Rui, Wu, Yong, Li, GuoDong, Li, Ming, Luo, XiongJian, Jiang, HongYan, Tan, Liwen, Zhong, Chunjiu, Fang, Yiru, Zhang, Chen, Sheng, Nengyin, Jiang, Tianzi, Yao, YongGang, 2019
Genetic Analyses of Alzheimer's Disease in China: Achievements and Perspectives., Zhang, DengFeng, Xu, Min, Bi, Rui, Yao, YongGang, 2019
A Comprehensive Analysis of the CaMK2A Gene and Susceptibility to Alzheimer's Disease in the Han Chinese Population., Fang, Xinyu, Tang, Wei, Yang, Fuyin, Lu, Weihong, Cai, Jun, Ni, Jianliang, Zhang, Jiangtao, Tang, Wenxin, Li, Tao, Zhang, DengFeng, Zhang, Chen, 2019
Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese., DengFeng Zhang, Dong Wang, YongGang Yao, Mahadev Malhi, Rui Bi, Yong Wu, Min Xu, XiuFeng Yu, Heng Long, YuYe Li, 2018
Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese., Bi, Rui, Zhang, Wen, Zhang, DengFeng, Xu, Min, Fan, Yu, Hu, QiuXiang, Jiang, HongYan, Tan, Liwen, Li, Tao, Fang, Yiru, Zhang, Chen, Yao, YongGang, 2018
A systematic integrated analysis of brain expression profiles reveals yap1 and other prioritized hub genes as important upstream regulators in alzheimer's disease., Xu M, Zhang DF, Luo R, Wu Y, Zhou H, Kong LL, Bi R, Yao YG, 2018
The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer's Disease., Ni, Hua, Xu, Min, Zhan, GuiLai, Fan, Yu, Zhou, Hejiang, Jiang, HongYan, Lu, WeiHong, Tan, Liwen, Zhang, DengFeng, Yao, YongGang, Zhang, Chen, 2018
Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese., Wang, Dong, Fan, Yu, Malhi, Mahadev, Bi, Rui, Wu, Yong, Xu, Min, Yu, XiuFeng, Long, Heng, Li, YuYe, Zhang, DengFeng, Yao, YongGang, 2018
Increased GSNOR expression during aging impairs cognitive function and decreases S-nitrosation of CaMKIIα., Zhang DF, changchenmoonibpaccn, Wang P, Chang C, Liu LM, Su WT, Zhang C, Liu GH, Yao YG, Yuan ZQ, Yao Q, Qiao XH, Wu KY, Zhang YY, 2017
Rare Genetic Variants of the Transthyretin Gene Are Associated with Alzheimer's Disease in Han Chinese., Xiang, Qun, Bi, Rui, Xu, Min, Zhang, DengFeng, Tan, Liwen, Zhang, Chen, Fang, Yiru, Yao, YongGang, 2017
Fine mapping of the GWAS loci identifies SLC35D1 and IL23R as potential risk genes for leprosy., Li, GuoDong, Wang, Dong, Zhang, DengFeng, Xiang, Qun, Feng, JiaQi, Li, XiaoAn, Li, YuYe, Yao, YongGang, 2016
PLD3 in Alzheimer’s Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses., Zhang DengFeng, Fan Yu, Wang Dong, Bi Rui, Zhang Chen, Fang Yiru, Yao YongGang, 2016
Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile., Zhang, DengFeng, Wang, Dong, Li, Yu Ye, Yao, YongGang, 2016
CFH Variants Affect Structural and Functional Brain Changes and Genetic Risk of Alzheimer's Disease., Zhang, DengFeng, Li, Jin, Wu, Huan, Cui, Yue, Bi, Rui, Zhou, HeJiang, Wang, HuiZhen, Zhang, Chen, Wang, Dong, Kong, QingPeng, Li, Tao, Fang, Yiru, Jiang, Tianzi, Yao, YongGang, ADNI, 2016
Identification of SLC25A37 as a major depressive disorder risk gene., Huo, YongXia, Huang, Liang, Zhang, DengFeng, Yao, YongGang, Fang, YiRu, Zhang, Chen, Luo, XiongJian, 2016
Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China., Xiang, YangLin, Zhang, DengFeng, Wang, Dong, Li, YuYe, Yao, YongGang, 2015
阿尔兹海默病遗传风险相关基因的整合分析., 张登峰, 2015
Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese., Li, Xiao, Zhang, Wen, Zhang, Chen, Yi, Zhenghui, Zhang, DengFeng, Gong, Wei, Tang, Jinsong, Wang, Dong, Lu, Weihong, Chen, Xiaogang, Fang, Yiru, Yao, YongGang, 2015
Genetic variants of complement genes Ficolin-2, Mannose-binding lectin and Complement factor H are associated with leprosy in Han Chinese from Southwest China., Zhang, DengFeng, Huang, XianQiong, Wang, Dong, Li, YuYe, Yao, YongGang, 2013
Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China., Wang, Dong, Feng, JiaQi, Li, YuYe, Zhang, DengFeng, Li, XiaoAn, Li, QingWei, Yao, YongGang, 2012

Alzheimer'S Disease Molecular Mechanisms Genetic Analysis Genomic Analysis Molecular Epidemiology Disease Models Cognitive Behavior Neuropathology Gene Therapy Drug Intervention

Yongzhang Luo - Tsinghua University

Xiaohua Cao - East China Normal University

Wei Hong - University of Chinese Academy of Sciences

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