2019-11 to Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Associate Researcher
2014-11 to 2019-10 - Harvard Medical School - Postdoctoral Researcher
2022: Guangdong Province Outstanding Young Talent
2021: Chinese Academy of Sciences Program
2020: Shenzhen Overseas High-Level Talent
Research
Disease Mechanisms Research Models Diagnostic and Therapeutic Techniques
Clearance of β-amyloid and synapses by the optogenetic depolarization of microglia is complement selective, Lv Z, Chen L, Chen P, Peng H, Rong Y, Hong W, Zhou Q, Li N, Li B, Paolicelli RC, Zhan Y, 2024
Methods for the isolation and analysis of Aβ from postmortem brain, Hong W, Liu W, Desousa AO, Young-Pearse T, Walsh DM, 2023
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/ β-catenin activation, Liu Q, Telezhkin V, Jiang W, Gu Y, Wang Y, Hong W, Tian W, Yarova P, Zhang G, Lee SM, Zhang P, Zhao M, Allen ND, Hirsch E, Penninger J, Song B, 2023
Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics, Wang Z, Jin M, Hong W, Liu W, Reczek D, Lagomarsino VN, Hu Y, Weeden T, Frosch MP, Young-Pearse TL, Pradier L, Selkoe D, Walsh DM, 2023
Mitochondrial dysfunction triggers the pathogenesis of Parkinson's disease in neuronal C/EBPβ transgenic mice, Ahn EH, Lei K, Kang SS, Wang Z, Liu X, Hong W, Wang YT, Edgington-Mitchell LE, Jin L, Ye K, 2021
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins, Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, Young-Pearse TL, Billinton A, Walsh DM, 2020
ImKTx96, a peptide blocker of the Kv1.2 ion channel from the venom of the scorpion Isometrus maculates, Li S, Sunchen S, He D, Qin C, Zuo Z, Shen B, Cao Z, Hong W, Miao L, 2020
A vicious cycle of β amyloid-dependent neuronal hyperactivation, Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A, 2019
Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain, Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM, 2019
PrP-grafted antibodies bind certain amyloid β-protein aggregates, but do not prevent toxicity, Mengel D, Hong W, Corbett GT, Liu W, DeSousa A, Solforosi L, Fang C, Frosch MP, Collinge J, Harris DA, Walsh DM, 2019
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain, Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM, 2018
An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease, Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM, 2018
Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1, Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z, 2018
Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo, Ondrejcak T, Klyubin I, Corbett GT, Fraser G, Hong W, Mably AJ, Gardener M, Hammersley J, Perkinton MS, Billinton A, Walsh DM, Rowan MJ, 2018
Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP, Wang Z, Jackson RJ, Hong W, Taylor WM, Corbett GT, Moreno A, Liu W, Li S, Frosch MP, Slutsky I, Young-Pearse TL, Spires-Jones TL, Walsh DM, 2017
A Tat-conjugated Peptide Nucleic Acid Tat-PNA-DR Inhibits Hepatitis B Virus Replication In Vitro and In Vivo by Targeting LTR Direct Repeats of HBV RNA, Zeng Z, Han S, Hong W, Lang Y, Li F, Liu Y, Li Z, Wu Y, Li W, Zhang X, Cao Z, 2016
A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro, Zeng Z, Zhang Q, Hong W, Xie Y, Liu Y, Li W, Wu Y, Cao Z, 2016
A p7 Ion Channel-derived Peptide Inhibits Hepatitis C Virus Infection in Vitro, Hong W, Lang Y, Li T, Zeng Z, Song Y, Wu Y, Li W, Cao Z, 2015
Dual-pH Sensitive Charge-Reversal Polypeptide Micelles for Tumor-Triggered Targeting Uptake and Nuclear Drug Delivery, Han SS, Li ZY, Zhu JY, Han K, Zeng ZY, Hong W, Li WX, Jia HZ, Liu Y, Zhuo RX, Zhang XZ, 2015
Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1, Hong W, Li T, Song Y, Zhang R, Zeng Z, Han S, Zhang X, Wu Y, Li W, Cao Z, 2014
Sj7170, a unique dual-function peptide with a specific alpha-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom, Song Y, Gong K, Yan H, Hong W, Wang L, Wu Y, Li W, Li W, Cao Z, 2014
Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus, Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z, 2013
The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods, Cao Z, Yu Y, Wu Y, Hao P, Di Z, He Y, Chen Z, Yang W, Shen Z, He X, Sheng J, Xu X, Pan B, Feng J, Yang X, Hong W, Zhao W, Li Z, Huang K, Li T, Kong Y, Liu H, Jiang D, Zhang B, Hu J, Hu Y, Wang B, Dai J, Yuan B, Feng Y, Huang W, Xing X, Zhao G, Li X, Li Y, Li W, 2013
Molecular diversity of Chaerilidae venom peptides reveals the dynamic evolution of scorpion venom components from Buthidae to non-Buthidae, He Y, Zhao R, Di Z, Li Z, Xu X, Hong W, Wu Y, Zhao H, Li W, Cao Z, 2013
Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4alpha in vitro and in vivo, Zhao Z, Hong W, Zeng Z, Wu Y, Hu K, Tian X, Li W, Cao Z, 2012
Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses, Li Q, Zhao Z, Zhou D, Chen Y, Hong W, Cao L, Yang J, Zhang Y, Shi W, Cao Z, Wu Y, Yan H, Li W, 2011
A new natural alpha-helical peptide from the venom of the scorpion Heterometrus petersii kills HCV, Yan R, Zhao Z, He Y, Wu L, Cai D, Hong W, Wu Y, Cao Z, Zheng C, Li W, 2011
Keywords
Protein MisfoldingNeurodegenerative DiseasesAlzheimer'S DiseaseParkinson'S DiseaseProtein AggregationMolecular MechanismsClinical ResourcesBiochemistryCell BiologyTherapeutic Strategies
