Professor | Gang Pei | Asia Growth Partners

Name	Gang Pei
Contact Information	peigang@tongji.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Gang Pei

Contact Information

peigang@tongji.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	1981 Bachelor's Degree: Shenyang Pharmaceutical University 1984 Master's Degree: Shenyang Pharmaceutical University 1991 PhD in Biochemistry and Biophysics: University of North Carolina, USA Elected as a member of the Chinese Academy of Sciences in 1999 Elected as a member of The World Academy of Sciences (TWAS) in 2001
Work Experience	1995-2000 Group Leader supported by the Chinese Academy of Sciences and the Max Planck Society, Germany 2000-2006 Director at the Shanghai Institute for Biological Sciences, Chinese Academy of Sciences 2006-2016 Honorary Professor and then President at Tongji University
Awards	1996 National Science Fund for Distinguished Young Scholars 1997 Qiushi Science and Technology Foundation Award for Outstanding Young Scholars 1999 He Liang He Li Science and Technology Progress Award 2002 Second Class National Natural Science Award 2007 Second Class National Natural Science Award 2010 Tan Kah Kee Life Science Award 2011 Tan Jiazhen Life Science Achievement Award

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

1981 Bachelor's Degree: Shenyang Pharmaceutical University
1984 Master's Degree: Shenyang Pharmaceutical University
1991 PhD in Biochemistry and Biophysics: University of North Carolina, USA
Elected as a member of the Chinese Academy of Sciences in 1999
Elected as a member of The World Academy of Sciences (TWAS) in 2001

Work Experience

1995-2000 Group Leader supported by the Chinese Academy of Sciences and the Max Planck Society, Germany
2000-2006 Director at the Shanghai Institute for Biological Sciences, Chinese Academy of Sciences
2006-2016 Honorary Professor and then President at Tongji University

Awards

1996 National Science Fund for Distinguished Young Scholars
1997 Qiushi Science and Technology Foundation Award for Outstanding Young Scholars
1999 He Liang He Li Science and Technology Progress Award
2002 Second Class National Natural Science Award
2007 Second Class National Natural Science Award
2010 Tan Kah Kee Life Science Award
2011 Tan Jiazhen Life Science Achievement Award

Areas of Focus	Cellular Signal Transduction Translational Research
Publications	Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules, Gao L, Guan W, Wang M, Wang H, Yu J, Liu Q, Qiu B, Yu Y, Ping Y, Bian X, Shen L, Pei G, 2017 Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease, Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, Wang P, Zhao C, Yao J, Xia P, Pei G, 2017 Traditional Chinese nootropic medicine radix polygalae and its active constituent onjisaponin B reduce β-amyloid production and improve cognitive impairments, Li X, Cui J, Yu Y, Li W, Hou Y, Wang X, Qin D, Zhao C, Yao X, Zhao J, Pei G, 2016 Direct conversion of astrocytes into neuronal cells by drug cocktail, Cheng L, Gao L, Guan W, Mao J, HuW, Qiu B, Zhao J, Yu Y, Pei G, 2015 Targeting the b-/g-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease related pathogenesis, Cui J, Wang X, Li X, Wang X, Zhang C, Li W, ZhangY, Gu H, Xie X, Nan F, Zhao J, Pei G, 2015 Direct conversion of normal and Alzheimer's disease human fibroblasts into neuronal cells by small molecules, Hu W, Qiu B, Guan W, Wang Q, Wang M, Li W, Gao L, Shen L, Huang Y, Xie G, Zhao H, Jin Y, Tang B, Yu Y, Zhao J, Pei G, 2015 Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation, Li J, Wei B, Guo A, Liu C, Huang S, Du F, Fan W, Bao C, Pei G, 2013 β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology, Liu X, Zhao X, Zeng X, Bossers K, Swaab DF, Zhao J, Pei G, 2013 Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition, Yue R, Li H, Liu H, Li Y, Wei B, Gao G, Jin Y, Liu T, Wei L, Du J, Pei G, 2012 Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells, Chen T, Shen L, Yu J, Wan H, Guo A, Chen J, Long Y, Zhao J, Pei G, 2011 β-arrestin-1 protein represses diet-induced obesity, Zhuang L, Hu W, Zhang M, Xin S, Jia W, Zhao J, Pei G, 2011 E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation, Chen T, Yuan D, Wei B, Jiang J, Kang J, Ling K, Gu Y, Li J, Xiao L, Pei G, 2010 A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis, Teng L, Zhao J, Wang F, Ma L, Pei G, 2010 β-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression, Yue R, Kang J, Zhao C, Hu W, Tang Y, Liu X, Pei G, 2009 MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis, Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, Li Z, Wu Z, Pei G, 2009 More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells, Huang J, Chen T, Liu X, Jiang J, Li J, Li DS, Liu XS, Li W, Kang J, Pei G, 2009 Deficiency of a β-arrestin2 signal complex contributes to insulin resistance, Luan B, Zhao J, Wu HY, Duan BY, Shu GW, Wang XY, Li DS, Jia WP, Kang JH, Pei G, 2009 An essential function for β-arrestin2 in the inhibitory signaling of natural killer cells, Yu MC, Su LL, Zou L, Zang JW, Pei G, Ge BX, 2008 Rapid xenograft tumor progression in β-arrestin1 transgenic mice due to enhanced tumor angiogenesis, Zou L, Yang R, Chai J, Pei G, 2008 Critical regulation of CD4+ T cell survival and autoimmunity by β-arrestin 1, Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ, Pei G, 2007 Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation, Ni Y, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei G, 2006 Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling, Wang YY, Tang YW, Teng L, Wu YL, Zhao XH, Pei G, 2006 β-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-γB activation, Luan B, Zhang ZN, Wu YL, Kang JH, Pei G, 2005 A nuclear function of β-arrestin1: regulation of histone acetylation and gene transcription, Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Pei G, Ma L, 2005 Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia, Guan JS, Xu ZZ, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L, Zhang X, 2005 Identification of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kB pathways, Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G, 2004 β-Arrestin2 functions as a GPCR-activated regulator of onco-protein Mdm2, Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G, 2003 Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses, Xu NJ, Bao L, Fan HP, Bao GB, Pu L, Lu YJ, Wu CF, Zhang X, Pei G, 2003 Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates, Pu L, Bao GB, Xu NJ, Ma L, Pei G, 2002 β-arrestin2 is critically involved in CXCR4-mediated chemotaxis and this is mediated by its enhancement of p38 MAPK activation, Sun Y, Cheng Z, Ma L, Pei G, 2002

Areas of Focus

Cellular Signal Transduction
Translational Research

Publications

Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules, Gao L, Guan W, Wang M, Wang H, Yu J, Liu Q, Qiu B, Yu Y, Ping Y, Bian X, Shen L, Pei G, 2017
Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease, Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, Wang P, Zhao C, Yao J, Xia P, Pei G, 2017
Traditional Chinese nootropic medicine radix polygalae and its active constituent onjisaponin B reduce β-amyloid production and improve cognitive impairments, Li X, Cui J, Yu Y, Li W, Hou Y, Wang X, Qin D, Zhao C, Yao X, Zhao J, Pei G, 2016
Direct conversion of astrocytes into neuronal cells by drug cocktail, Cheng L, Gao L, Guan W, Mao J, HuW, Qiu B, Zhao J, Yu Y, Pei G, 2015
Targeting the b-/g-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease related pathogenesis, Cui J, Wang X, Li X, Wang X, Zhang C, Li W, ZhangY, Gu H, Xie X, Nan F, Zhao J, Pei G, 2015
Direct conversion of normal and Alzheimer's disease human fibroblasts into neuronal cells by small molecules, Hu W, Qiu B, Guan W, Wang Q, Wang M, Li W, Gao L, Shen L, Huang Y, Xie G, Zhao H, Jin Y, Tang B, Yu Y, Zhao J, Pei G, 2015
Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation, Li J, Wei B, Guo A, Liu C, Huang S, Du F, Fan W, Bao C, Pei G, 2013
β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology, Liu X, Zhao X, Zeng X, Bossers K, Swaab DF, Zhao J, Pei G, 2013
Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition, Yue R, Li H, Liu H, Li Y, Wei B, Gao G, Jin Y, Liu T, Wei L, Du J, Pei G, 2012
Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells, Chen T, Shen L, Yu J, Wan H, Guo A, Chen J, Long Y, Zhao J, Pei G, 2011
β-arrestin-1 protein represses diet-induced obesity, Zhuang L, Hu W, Zhang M, Xin S, Jia W, Zhao J, Pei G, 2011
E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation, Chen T, Yuan D, Wei B, Jiang J, Kang J, Ling K, Gu Y, Li J, Xiao L, Pei G, 2010
A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis, Teng L, Zhao J, Wang F, Ma L, Pei G, 2010
β-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression, Yue R, Kang J, Zhao C, Hu W, Tang Y, Liu X, Pei G, 2009
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis, Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, Li Z, Wu Z, Pei G, 2009
More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells, Huang J, Chen T, Liu X, Jiang J, Li J, Li DS, Liu XS, Li W, Kang J, Pei G, 2009
Deficiency of a β-arrestin2 signal complex contributes to insulin resistance, Luan B, Zhao J, Wu HY, Duan BY, Shu GW, Wang XY, Li DS, Jia WP, Kang JH, Pei G, 2009
An essential function for β-arrestin2 in the inhibitory signaling of natural killer cells, Yu MC, Su LL, Zou L, Zang JW, Pei G, Ge BX, 2008
Rapid xenograft tumor progression in β-arrestin1 transgenic mice due to enhanced tumor angiogenesis, Zou L, Yang R, Chai J, Pei G, 2008
Critical regulation of CD4+ T cell survival and autoimmunity by β-arrestin 1, Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ, Pei G, 2007
Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation, Ni Y, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei G, 2006
Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling, Wang YY, Tang YW, Teng L, Wu YL, Zhao XH, Pei G, 2006
β-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-γB activation, Luan B, Zhang ZN, Wu YL, Kang JH, Pei G, 2005
A nuclear function of β-arrestin1: regulation of histone acetylation and gene transcription, Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Pei G, Ma L, 2005
Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia, Guan JS, Xu ZZ, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L, Zhang X, 2005
Identification of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kB pathways, Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G, 2004
β-Arrestin2 functions as a GPCR-activated regulator of onco-protein Mdm2, Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G, 2003
Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses, Xu NJ, Bao L, Fan HP, Bao GB, Pu L, Lu YJ, Wu CF, Zhang X, Pei G, 2003
Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates, Pu L, Bao GB, Xu NJ, Ma L, Pei G, 2002
β-arrestin2 is critically involved in CXCR4-mediated chemotaxis and this is mediated by its enhancement of p38 MAPK activation, Sun Y, Cheng Z, Ma L, Pei G, 2002

Gpcr P53 Nf-Κb Β-Arrestin 1 Epigenetic Modification Cd4+ T Cells Autoimmunity Alzheimer'S Disease Neurodegenerative Diseases Natural Products

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