Areas of Focus
- Cellular Signal Transduction
- Translational Research
Work Experience
- 1995-2000 Group Leader supported by the Chinese Academy of Sciences and the Max Planck Society, Germany
- 2000-2006 Director at the Shanghai Institute for Biological Sciences, Chinese Academy of Sciences
- 2006-2016 Honorary Professor and then President at Tongji University
Academic Background & Achievements
- 1981 Bachelor's Degree: Shenyang Pharmaceutical University
- 1984 Master's Degree: Shenyang Pharmaceutical University
- 1991 PhD in Biochemistry and Biophysics: University of North Carolina, USA
- Elected as a member of the Chinese Academy of Sciences in 1999
- Elected as a member of The World Academy of Sciences (TWAS) in 2001
Publications
- Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules, Gao L, Guan W, Wang M, Wang H, Yu J, Liu Q, Qiu B, Yu Y, Ping Y, Bian X, Shen L, Pei G, 2017
- Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease, Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, Wang P, Zhao C, Yao J, Xia P, Pei G, 2017
- Traditional Chinese nootropic medicine radix polygalae and its active constituent onjisaponin B reduce β-amyloid production and improve cognitive impairments, Li X, Cui J, Yu Y, Li W, Hou Y, Wang X, Qin D, Zhao C, Yao X, Zhao J, Pei G, 2016
- Direct conversion of astrocytes into neuronal cells by drug cocktail, Cheng L, Gao L, Guan W, Mao J, HuW, Qiu B, Zhao J, Yu Y, Pei G, 2015
- Targeting the b-/g-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease related pathogenesis, Cui J, Wang X, Li X, Wang X, Zhang C, Li W, ZhangY, Gu H, Xie X, Nan F, Zhao J, Pei G, 2015
- Direct conversion of normal and Alzheimer's disease human fibroblasts into neuronal cells by small molecules, Hu W, Qiu B, Guan W, Wang Q, Wang M, Li W, Gao L, Shen L, Huang Y, Xie G, Zhao H, Jin Y, Tang B, Yu Y, Zhao J, Pei G, 2015
- Deficiency of beta-arrestin1 ameliorates collagen-induced arthritis with impaired TH17 cell differentiation, Li J, Wei B, Guo A, Liu C, Huang S, Du F, Fan W, Bao C, Pei G, 2013
- β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology, Liu X, Zhao X, Zeng X, Bossers K, Swaab DF, Zhao J, Pei G, 2013
- Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition, Yue R, Li H, Liu H, Li Y, Wei B, Gao G, Jin Y, Liu T, Wei L, Du J, Pei G, 2012
- Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells, Chen T, Shen L, Yu J, Wan H, Guo A, Chen J, Long Y, Zhao J, Pei G, 2011
- β-arrestin-1 protein represses diet-induced obesity, Zhuang L, Hu W, Zhang M, Xin S, Jia W, Zhao J, Pei G, 2011
- E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation, Chen T, Yuan D, Wei B, Jiang J, Kang J, Ling K, Gu Y, Li J, Xiao L, Pei G, 2010
- A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis, Teng L, Zhao J, Wang F, Ma L, Pei G, 2010
- β-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression, Yue R, Kang J, Zhao C, Hu W, Tang Y, Liu X, Pei G, 2009
- MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis, Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, Li Z, Wu Z, Pei G, 2009
- More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells, Huang J, Chen T, Liu X, Jiang J, Li J, Li DS, Liu XS, Li W, Kang J, Pei G, 2009
- Deficiency of a β-arrestin2 signal complex contributes to insulin resistance, Luan B, Zhao J, Wu HY, Duan BY, Shu GW, Wang XY, Li DS, Jia WP, Kang JH, Pei G, 2009
- An essential function for β-arrestin2 in the inhibitory signaling of natural killer cells, Yu MC, Su LL, Zou L, Zang JW, Pei G, Ge BX, 2008
- Rapid xenograft tumor progression in β-arrestin1 transgenic mice due to enhanced tumor angiogenesis, Zou L, Yang R, Chai J, Pei G, 2008
- Critical regulation of CD4+ T cell survival and autoimmunity by β-arrestin 1, Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ, Pei G, 2007
- Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation, Ni Y, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei G, 2006
- Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling, Wang YY, Tang YW, Teng L, Wu YL, Zhao XH, Pei G, 2006
- β-Arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-γB activation, Luan B, Zhang ZN, Wu YL, Kang JH, Pei G, 2005
- A nuclear function of β-arrestin1: regulation of histone acetylation and gene transcription, Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Pei G, Ma L, 2005
- Interaction with vesicle luminal protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia, Guan JS, Xu ZZ, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L, Zhang X, 2005
- Identification of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kB pathways, Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G, 2004
- β-Arrestin2 functions as a GPCR-activated regulator of onco-protein Mdm2, Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G, 2003
- Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses, Xu NJ, Bao L, Fan HP, Bao GB, Pu L, Lu YJ, Wu CF, Zhang X, Pei G, 2003
- Hippocampal long-term potentiation is reduced by chronic opiate treatment and can be restored by re-exposure to opiates, Pu L, Bao GB, Xu NJ, Ma L, Pei G, 2002
- β-arrestin2 is critically involved in CXCR4-mediated chemotaxis and this is mediated by its enhancement of p38 MAPK activation, Sun Y, Cheng Z, Ma L, Pei G, 2002
Awards
- 1996 National Science Fund for Distinguished Young Scholars
- 1997 Qiushi Science and Technology Foundation Award for Outstanding Young Scholars
- 1999 He Liang He Li Science and Technology Progress Award
- 2002 Second Class National Natural Science Award
- 2007 Second Class National Natural Science Award
- 2010 Tan Kah Kee Life Science Award
- 2011 Tan Jiazhen Life Science Achievement Award
