Professor | Chunsheng Han | Asia Growth Partners

Name	Chunsheng Han
Contact Information	hancs@ioz.ac.cn
Language ability	English, Chinese
Province	Beijing

Name

Chunsheng Han

Contact Information

hancs@ioz.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1993-09 to 2000-05 Ph.D. in Biochemistry: University of Missouri 1990-09 to 1993-05 Master's in Reproductive Physiology: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences 1986-09 to 1990-05 Bachelor's in Genetics: Department of Bioengineering, Fudan University
Work Experience	2003-12 to Present - Institute of Zoology, Chinese Academy of Sciences - Researcher 2000-09 to 2013-11 - Lexicon Pharmaceuticals, USA - Senior Bioinformatics Scientist

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1993-09 to 2000-05 Ph.D. in Biochemistry: University of Missouri
1990-09 to 1993-05 Master's in Reproductive Physiology: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
1986-09 to 1990-05 Bachelor's in Genetics: Department of Bioengineering, Fudan University

Work Experience

2003-12 to Present - Institute of Zoology, Chinese Academy of Sciences - Researcher
2000-09 to 2013-11 - Lexicon Pharmaceuticals, USA - Senior Bioinformatics Scientist

Areas of Focus	Spermatogonial Stem Cells (SSCs) proliferation, differentiation, and dedifferentiation Epigenetic regulation mechanisms of spermatogenesis
Publications	In vivo functions of miRNAs in mammalian spermatogenesis, Chen, Jian, Han, Chunsheng, 2023 Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus, Liu, PeiPei, Lu, ShiPing, Li, Xiao, Tang, GangBin, Liu, Xiao, Dai, ShangKun, Jiao, LinFei, Lin, XiWen, Li, XingGuo, Hu, Baoyang, Jiao, Jianwei, Teng, ZhaoQian, Han, ChunSheng, 刘长梅, 2023 A CRISPR/Cas9-based kinome screen identifies ErbB signaling as a new regulator of human naïve pluripotency and totipotency, 李佳宇, 韩春生, 2023 RBFOX2 缺失抑制雄性小鼠的减数分裂起始, 闫琳, 陈建, 宁岩, 韩春生, 2023 Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses, Lu, Cuiling, Qin, Caimeng, Fu, Zheng, Wang, Lina, Yi, Yanxiao, Xin, Mingwei, Zhen, Xiumei, Han, Chunsheng, 2022 MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage, Chen, Jian, Gao, Chenxu, Luo, Mengcheng, Zheng, Chunwei, Lin, Xiwen, Ning, Yan, Ma, Longfei, He, Wei, Xie, Dan, Liu, Kui, Hong, Kai, Han, Chunsheng, 2022 Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis, Ma, Longfei, Xie, Dan, Luo, Mengcheng, Lin, Xiwen, Nie, Hengyu, Chen, Jian, Gao, Chenxu, Duo, Shuguang, Han, Chunsheng, 2022 The male germline-specific protein MAPS is indispensable for pachynema progression and fertility, Li, Miao, Zheng, Jiahuan, Li, Gaopeng, Lin, Zexiong, Li, Dongliang, Liu, Dongteng, Feng, Haiwei, Cao, Dandan, Ng, Ernest H Y, Li, Raymond H W, Han, Chunsheng, Yeung, William S B, Chow, Louise T, Wang, Hengbin, Liu, Kui, 2021 PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications, Dong, Fangfang, Chen, Min, Chen, Min, Jiang, Lin, Shen, Zhiming, Ma, Longfei, Han, Chunsheng, Guo, Xudong, Gao, Fei, 2021 The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis, Chen, Jian, Gao, Chenxu, Lin, Xiwen, Ning, Yan, He, Wei, Zheng, Chunwei, Zhang, Daoqin, Yan, Lin, Jiang, Binjie, Zhao, Yuting, Hossen, Md Alim, Han, Chunsheng, 2021 Reorganized 3D Genome Structures Support Transcriptional Regulation in Mouse Spermatogenesis, Luo, Zhengyu, Wang, Xiaorong, Jiang, Hong, Wang, Ruoyu, Chen, Jian, Chen, Yusheng, Xu, Qianlan, Cao, Jun, Gong, Xiaowen, Wu, Ji, Yang, Yungui, Li, Wenbo, Han, Chunsheng, Cheng, C Yan, Rosenfeld, Michael G, Sun, Fei, Song, Xiaoyuan, 2020 FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice, Gao, Hongying, Zheng, Chunwei, Du, Jian, Wu, Yue, Sun, Yonghui, Han, Chunsheng, Kee, Kehkooi, Rao, Yu, 2020 Non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice, Zheng, Chunwei, Ouyang, YingChun, Jiang, Binjie, Lin, Xiwen, Chen, Jian, Dong, MingZhe, Zhuang, Xinjie, Yuan, Shuiqiao, Sun, QingYuan, Han, Chunsheng, 2019 The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice, Li, Miao, Huang, Tao, Li, MengJing, Zhang, ChuanXin, Yu, XiaoChen, Yin, YingYing, Liu, Chao, Wang, Xin, Feng, HaiWei, Zhang, Tuo, Liu, MoFang, Han, ChunSheng, Lu, Gang, Li, Wei, Ma, JinLong, Chen, ZiJiang, Liu, HongBin, Liu, Kui, 2019 Reprogramming p53-Deficient Germline Stem Cells Into Pluripotent State by Nanog, Feng, Yanmin, Ning, Yan, Lin, Xiwen, Zhang, Daoqin, Liao, Shangying, Zheng, Chunwei, Chen, Jian, Wang, Yang, Ma, Longfei, Xie, Dan, Han, Chunsheng, 2018 The transcription factor SOX30 is a key regulator of mouse spermiogenesis, Zhang, Daoqin, Xie, Dan, Lin, Xiwen, Ma, Longfei, Chen, Jian, Zhang, Daoqi, Wang, Yang, Duo, Shuguang, Feng, Yanmin, Zheng, Chunwei, Jiang, Binjie, Ning, Yan, Han, Chunsheng, 2018 Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression, Chen, Min, Zhang, Lianjun, Cui, Xiuhong, Lin, Xiwen, Li, Yaqiong, Wang, Yaqing, Wang, Yanbo, Qin, Yan, Chen, Dahua, Han, Chunsheng, Zhou, Bin, Huff, Vicki, Gao, Fei, 2017 High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1, Liu, Pinglei, Liu, Kun, Gu, Haifeng, Wang, Weixu, Gong, Jiaqi, Zhu, Yingjie, Zhao, Qian, Cao, Jiani, Han, Chunseng, Gao, Fei, Chen, Quan, Li, Wei, Jiao, Jianwei, Hu, Baoyang, Zhou, Qi, Zhao, Tongbiao, 2017 MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins, Chen, Jian, Cai, Tanxi, Zheng, Chunwei, Lin, Xiwen, Wang, Guojun, Liao, Shangying, Wang, Xiuxia, Gan, Haiyun, Zhang, Daoqin, Hu, Xiangjing, Wang, Si, Li, Zhen, Feng, Yanmin, Yang, Fuquan, Han, Chunsheng, 2017 Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation, Tu, Zhaowei, Bayazit, Mustafa Bilal, Liu, Hongbin, Zhang, Jingjing, Busayavalasa, Kiran, Risal, Sanjiv, Shao, Jingchen, Satyanarayana, Ande, Coppola, Vincenzo, Tessarollo, Lino, Singh, Meenakshi, Zheng, Chunwei, Han, Chunsheng, Chen, Zijiang, Kaldis, Philipp, Gustafsson, JanAke, Liu, Kui, 2017 Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint, Hu, Xiangjing, Shen, Bin, Liao, Shangying, Ning, Yan, Ma, Longfei, Chen, Jian, Lin, Xiwen, Zhang, Daoqin, Li, Zhen, Zheng, Chunwei, Feng, Yanmin, Huang, Xingxu, Han, Chunsheng, 2017 Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis, 尚永丰, 2017 BMP4 Cooperates with Retinoic Acid to Induce the Expression of Differentiation Markers in Cultured Mouse Spermatogonia, Yang, Yongguang, Feng, Yanmin, Feng, Xue, Liao, Shangying, Wang, Xiuxia, Gan, Haiyun, Wang, Lixian, Lin, Xiwen, Han, Chunsheng, 2016 Precision Medicine: What Challenges Are We Facing?, Yu Xue, Eric-Wubbo Lameijer, Kai Ye, Kunlin Zhang, Suhua Chang, Xiaoyue Wang, Jianmin Wu, Ge Gao, Fangqing Zhao, Jian Li, Chunsheng Han, Shuhua Xu, Jingfa Xiao, Xuerui Yang, Xiaomin Ying, Xuegong Zhang, Wei-Hua Chen, Yun Liu, Zhang Zhang, Kun Huang, Jun Yu, 2016 Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis, Wu, Yujian, Hu, Xiangjing, Li, Zhen, Wang, Min, Li, Sisi, Wang, Xiuxia, Lin, Xiwen, Liao, Shangying, Zhang, Zhuqiang, Feng, Xue, Wang, Si, Cui, Xiuhong, Wang, Yanling, Gao, Fei, Hess, Rex A, Han, Chunsheng, 2016 Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells, Lin, Xiwen, Han, Miao, Cheng, Lu, Chen, Jian, Zhang, Zhuqiang, Shen, Ting, Wang, Min, Wen, Bo, Ni, Ting, Han, Chunsheng, 2016 Retinoic Acid Is Sufficient for the In Vitro Induction of Mouse Spermatocytes, Wang, Si, Wang, Xiuxia, Ma, Longfei, Lin, Xiwen, Zhang, Daoqin, Li, Zhen, Wu, Yujian, Zheng, Chunwei, Feng, Xue, Liao, Shangying, Feng, Yanmin, Chen, Jian, Hu, Xiangjing, Wang, Min, Han, Chunsheng, 2016 Mammalian elongation

Areas of Focus

Spermatogonial Stem Cells (SSCs) proliferation, differentiation, and dedifferentiation
Epigenetic regulation mechanisms of spermatogenesis

Publications

In vivo functions of miRNAs in mammalian spermatogenesis, Chen, Jian, Han, Chunsheng, 2023
Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus, Liu, PeiPei, Lu, ShiPing, Li, Xiao, Tang, GangBin, Liu, Xiao, Dai, ShangKun, Jiao, LinFei, Lin, XiWen, Li, XingGuo, Hu, Baoyang, Jiao, Jianwei, Teng, ZhaoQian, Han, ChunSheng, 刘长梅, 2023
A CRISPR/Cas9-based kinome screen identifies ErbB signaling as a new regulator of human naïve pluripotency and totipotency, 李佳宇, 韩春生, 2023
RBFOX2 缺失抑制雄性小鼠的减数分裂起始, 闫琳, 陈建, 宁岩, 韩春生, 2023
Metabolic dysregulation in patients with premature ovarian insufficiency revealed by integrated transcriptomic, methylomic and metabolomic analyses, Lu, Cuiling, Qin, Caimeng, Fu, Zheng, Wang, Lina, Yi, Yanxiao, Xin, Mingwei, Zhen, Xiumei, Han, Chunsheng, 2022
MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage, Chen, Jian, Gao, Chenxu, Luo, Mengcheng, Zheng, Chunwei, Lin, Xiwen, Ning, Yan, Ma, Longfei, He, Wei, Xie, Dan, Liu, Kui, Hong, Kai, Han, Chunsheng, 2022
Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis, Ma, Longfei, Xie, Dan, Luo, Mengcheng, Lin, Xiwen, Nie, Hengyu, Chen, Jian, Gao, Chenxu, Duo, Shuguang, Han, Chunsheng, 2022
The male germline-specific protein MAPS is indispensable for pachynema progression and fertility, Li, Miao, Zheng, Jiahuan, Li, Gaopeng, Lin, Zexiong, Li, Dongliang, Liu, Dongteng, Feng, Haiwei, Cao, Dandan, Ng, Ernest H Y, Li, Raymond H W, Han, Chunsheng, Yeung, William S B, Chow, Louise T, Wang, Hengbin, Liu, Kui, 2021
PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications, Dong, Fangfang, Chen, Min, Chen, Min, Jiang, Lin, Shen, Zhiming, Ma, Longfei, Han, Chunsheng, Guo, Xudong, Gao, Fei, 2021
The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis, Chen, Jian, Gao, Chenxu, Lin, Xiwen, Ning, Yan, He, Wei, Zheng, Chunwei, Zhang, Daoqin, Yan, Lin, Jiang, Binjie, Zhao, Yuting, Hossen, Md Alim, Han, Chunsheng, 2021
Reorganized 3D Genome Structures Support Transcriptional Regulation in Mouse Spermatogenesis, Luo, Zhengyu, Wang, Xiaorong, Jiang, Hong, Wang, Ruoyu, Chen, Jian, Chen, Yusheng, Xu, Qianlan, Cao, Jun, Gong, Xiaowen, Wu, Ji, Yang, Yungui, Li, Wenbo, Han, Chunsheng, Cheng, C Yan, Rosenfeld, Michael G, Sun, Fei, Song, Xiaoyuan, 2020
FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice, Gao, Hongying, Zheng, Chunwei, Du, Jian, Wu, Yue, Sun, Yonghui, Han, Chunsheng, Kee, Kehkooi, Rao, Yu, 2020
Non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice, Zheng, Chunwei, Ouyang, YingChun, Jiang, Binjie, Lin, Xiwen, Chen, Jian, Dong, MingZhe, Zhuang, Xinjie, Yuan, Shuiqiao, Sun, QingYuan, Han, Chunsheng, 2019
The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice, Li, Miao, Huang, Tao, Li, MengJing, Zhang, ChuanXin, Yu, XiaoChen, Yin, YingYing, Liu, Chao, Wang, Xin, Feng, HaiWei, Zhang, Tuo, Liu, MoFang, Han, ChunSheng, Lu, Gang, Li, Wei, Ma, JinLong, Chen, ZiJiang, Liu, HongBin, Liu, Kui, 2019
Reprogramming p53-Deficient Germline Stem Cells Into Pluripotent State by Nanog, Feng, Yanmin, Ning, Yan, Lin, Xiwen, Zhang, Daoqin, Liao, Shangying, Zheng, Chunwei, Chen, Jian, Wang, Yang, Ma, Longfei, Xie, Dan, Han, Chunsheng, 2018
The transcription factor SOX30 is a key regulator of mouse spermiogenesis, Zhang, Daoqin, Xie, Dan, Lin, Xiwen, Ma, Longfei, Chen, Jian, Zhang, Daoqi, Wang, Yang, Duo, Shuguang, Feng, Yanmin, Zheng, Chunwei, Jiang, Binjie, Ning, Yan, Han, Chunsheng, 2018
Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression, Chen, Min, Zhang, Lianjun, Cui, Xiuhong, Lin, Xiwen, Li, Yaqiong, Wang, Yaqing, Wang, Yanbo, Qin, Yan, Chen, Dahua, Han, Chunsheng, Zhou, Bin, Huff, Vicki, Gao, Fei, 2017
High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1, Liu, Pinglei, Liu, Kun, Gu, Haifeng, Wang, Weixu, Gong, Jiaqi, Zhu, Yingjie, Zhao, Qian, Cao, Jiani, Han, Chunseng, Gao, Fei, Chen, Quan, Li, Wei, Jiao, Jianwei, Hu, Baoyang, Zhou, Qi, Zhao, Tongbiao, 2017
MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins, Chen, Jian, Cai, Tanxi, Zheng, Chunwei, Lin, Xiwen, Wang, Guojun, Liao, Shangying, Wang, Xiuxia, Gan, Haiyun, Zhang, Daoqin, Hu, Xiangjing, Wang, Si, Li, Zhen, Feng, Yanmin, Yang, Fuquan, Han, Chunsheng, 2017
Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation, Tu, Zhaowei, Bayazit, Mustafa Bilal, Liu, Hongbin, Zhang, Jingjing, Busayavalasa, Kiran, Risal, Sanjiv, Shao, Jingchen, Satyanarayana, Ande, Coppola, Vincenzo, Tessarollo, Lino, Singh, Meenakshi, Zheng, Chunwei, Han, Chunsheng, Chen, Zijiang, Kaldis, Philipp, Gustafsson, JanAke, Liu, Kui, 2017
Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint, Hu, Xiangjing, Shen, Bin, Liao, Shangying, Ning, Yan, Ma, Longfei, Chen, Jian, Lin, Xiwen, Zhang, Daoqin, Li, Zhen, Zheng, Chunwei, Feng, Yanmin, Huang, Xingxu, Han, Chunsheng, 2017
Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis, 尚永丰, 2017
BMP4 Cooperates with Retinoic Acid to Induce the Expression of Differentiation Markers in Cultured Mouse Spermatogonia, Yang, Yongguang, Feng, Yanmin, Feng, Xue, Liao, Shangying, Wang, Xiuxia, Gan, Haiyun, Wang, Lixian, Lin, Xiwen, Han, Chunsheng, 2016
Precision Medicine: What Challenges Are We Facing?, Yu Xue, Eric-Wubbo Lameijer, Kai Ye, Kunlin Zhang, Suhua Chang, Xiaoyue Wang, Jianmin Wu, Ge Gao, Fangqing Zhao, Jian Li, Chunsheng Han, Shuhua Xu, Jingfa Xiao, Xuerui Yang, Xiaomin Ying, Xuegong Zhang, Wei-Hua Chen, Yun Liu, Zhang Zhang, Kun Huang, Jun Yu, 2016
Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis, Wu, Yujian, Hu, Xiangjing, Li, Zhen, Wang, Min, Li, Sisi, Wang, Xiuxia, Lin, Xiwen, Liao, Shangying, Zhang, Zhuqiang, Feng, Xue, Wang, Si, Cui, Xiuhong, Wang, Yanling, Gao, Fei, Hess, Rex A, Han, Chunsheng, 2016
Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells, Lin, Xiwen, Han, Miao, Cheng, Lu, Chen, Jian, Zhang, Zhuqiang, Shen, Ting, Wang, Min, Wen, Bo, Ni, Ting, Han, Chunsheng, 2016
Retinoic Acid Is Sufficient for the In Vitro Induction of Mouse Spermatocytes, Wang, Si, Wang, Xiuxia, Ma, Longfei, Lin, Xiwen, Zhang, Daoqin, Li, Zhen, Wu, Yujian, Zheng, Chunwei, Feng, Xue, Liao, Shangying, Feng, Yanmin, Chen, Jian, Hu, Xiangjing, Wang, Min, Han, Chunsheng, 2016
Mammalian elongation

Spermatogonial Stem Cells Proliferation Differentiation Dedifferentiation Epigenetics Spermatogenesis Gene Regulation Transcription Factors Infertility Treatment Stem Cell Reprogramming

Chunsheng Han - University of Chinese Academy of Sciences

Zheqiong Yang - Wuhan University

Jianwei Jiao - University of Chinese Academy of Sciences

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