Professor | Guangxun Meng | Asia Growth Partners

Name	Guangxun Meng
Contact Information	gxmeng@ips.ac.cn
Language ability	English, Chinese, German
Province	Shanghai

Name

Guangxun Meng

Contact Information

gxmeng@ips.ac.cn

Language ability

English, Chinese, German

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2001-08--2005-05 PhD: Technical University of Munich 1997-09--2000-07 Master's: Shandong Normal University, Shanghai Institute of Cell Biology, Chinese Academy of Sciences (Joint Program) 1993-09--1997-07 Bachelor's: Shandong Normal University
Work Experience	2010/5-Present - Shanghai Institute of Pasteur, Chinese Academy of Sciences - Researcher 2005/5-2010/4 - National Institutes of Health, USA - Postdoctoral Fellow 2000/9-2001/7 - Max Planck Institute for Structural and Molecular Biology, Hamburg, Germany - Visiting Scholar
Awards	Sanofi-Aventis-Excellent Young Talent Award, Chinese Academy of Sciences Shanghai Institute of Life Sciences (2011) National Outstanding Self-Financed International Student Scholarship (2004)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2001-08--2005-05 PhD: Technical University of Munich
1997-09--2000-07 Master's: Shandong Normal University, Shanghai Institute of Cell Biology, Chinese Academy of Sciences (Joint Program)
1993-09--1997-07 Bachelor's: Shandong Normal University

Work Experience

2010/5-Present - Shanghai Institute of Pasteur, Chinese Academy of Sciences - Researcher
2005/5-2010/4 - National Institutes of Health, USA - Postdoctoral Fellow
2000/9-2001/7 - Max Planck Institute for Structural and Molecular Biology, Hamburg, Germany - Visiting Scholar

Awards

Sanofi-Aventis-Excellent Young Talent Award, Chinese Academy of Sciences Shanghai Institute of Life Sciences (2011)
National Outstanding Self-Financed International Student Scholarship (2004)

Areas of Focus	Molecular Mechanisms of Inflammasome Activation and Regulation Role of Inflammasomes in Autoimmune Diseases Role of Inflammasomes in Anti-Infection Mechanisms Pharmacological Regulation of Inflammasomes Development of Vaccine Adjuvants Based on NLR Signaling
Publications	Roles and Mechanisms of NLRP3 in Influenza Viral Infection, Junling Niu, Guangxun Meng, 2023 TRAF6-TAK1-IKKβ pathway mediates TLR2 agonists activating 'one-step' NLRP3 inflammasome in human monocytes, Mengdan Chen, Shi Yu, Yuhui Gao, Jiaxun Li, Xun Wang, Bin Wei, Guangxun Meng, 2023 Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2, Yu, Shi, Zheng, Xu, Zhou, Yanqiu, Gao, Yuhui, Zhou, Bingjie, Zhao, Yapei, Li, Tingting, Li, Yunyi, Mou, Jiabin, Cui, Xiaoxian, Yang, Yuying, Li, Dianfan, Chen, Min, Lavillette, Dimitri, Meng, Guangxun, 2023 cFLIP(S) regulates alternative NLRP3 inflammasome activation in human monocytes, Gao, Yuhui, Yu, Shi, Chen, Mengdan, Wang, Xun, Pan, Lei, Wei, Bin, Meng, Guangxun, 2023 Microbiota-derived acetate enhances host antiviral response via NLRP3, Junling Niu, Mengmeng Cui, Xin Yang, Juan Li, Yuhui Yao, Qiuhong Guo, Ailing Lu, Xiaopeng Qi, Dongming Zhou, Chenhong Zhang, Liping Zhao, Guangxun Meng, 2023 SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation, Shi Yu, Bingjie Zhou, Juan Li, Mengdan Chen, Rong Deng, Gary Wong, Dimitri Lavillette, Guangxun Meng, 2022 Activation of the Nlrp3 Inflammasome Contributes to Shiga Toxin-Induced Hemolytic Uremic Syndrome in a Mouse Model, Song, Liqiong, Xiao, Yuchun, Li, Xianping, Huang, Yuanming, Meng, Guangxun, Ren, Zhihong, 2021 Aim2 Couples With Ube2i for Sumoylation-Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus, Lu, Ailing, Wu, Shuxian, Niu, Junling, Cui, Mengmeng, Chen, Mengdan, Clapp, William L, Barnes, Betsy J, Meng, Guangxun, 2021 AIM2 deficient mice develop severe Systemic Lupus Erthematosus pathogenesis due to elevated type I interferon signaling, Meng, Guangxun, Lu, Ailing, Wu, Shuxian, 2020 Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response, Herv Lecoeur, Eric Prina, Thibault Rosazza, Kossiwa Kokou, Paya NDiaye, Nathalie Aulner, Hugo Varet, Giovanni Bussotti, Yue Xing, Genevive Milon, Robert Weil, Guangxun Meng, Gerald F Spth, 2020

Areas of Focus

Molecular Mechanisms of Inflammasome Activation and Regulation
Role of Inflammasomes in Autoimmune Diseases
Role of Inflammasomes in Anti-Infection Mechanisms
Pharmacological Regulation of Inflammasomes
Development of Vaccine Adjuvants Based on NLR Signaling

Publications

Roles and Mechanisms of NLRP3 in Influenza Viral Infection, Junling Niu, Guangxun Meng, 2023
TRAF6-TAK1-IKKβ pathway mediates TLR2 agonists activating 'one-step' NLRP3 inflammasome in human monocytes, Mengdan Chen, Shi Yu, Yuhui Gao, Jiaxun Li, Xun Wang, Bin Wei, Guangxun Meng, 2023
Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2, Yu, Shi, Zheng, Xu, Zhou, Yanqiu, Gao, Yuhui, Zhou, Bingjie, Zhao, Yapei, Li, Tingting, Li, Yunyi, Mou, Jiabin, Cui, Xiaoxian, Yang, Yuying, Li, Dianfan, Chen, Min, Lavillette, Dimitri, Meng, Guangxun, 2023
cFLIP(S) regulates alternative NLRP3 inflammasome activation in human monocytes, Gao, Yuhui, Yu, Shi, Chen, Mengdan, Wang, Xun, Pan, Lei, Wei, Bin, Meng, Guangxun, 2023
Microbiota-derived acetate enhances host antiviral response via NLRP3, Junling Niu, Mengmeng Cui, Xin Yang, Juan Li, Yuhui Yao, Qiuhong Guo, Ailing Lu, Xiaopeng Qi, Dongming Zhou, Chenhong Zhang, Liping Zhao, Guangxun Meng, 2023
SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation, Shi Yu, Bingjie Zhou, Juan Li, Mengdan Chen, Rong Deng, Gary Wong, Dimitri Lavillette, Guangxun Meng, 2022
Activation of the Nlrp3 Inflammasome Contributes to Shiga Toxin-Induced Hemolytic Uremic Syndrome in a Mouse Model, Song, Liqiong, Xiao, Yuchun, Li, Xianping, Huang, Yuanming, Meng, Guangxun, Ren, Zhihong, 2021
Aim2 Couples With Ube2i for Sumoylation-Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus, Lu, Ailing, Wu, Shuxian, Niu, Junling, Cui, Mengmeng, Chen, Mengdan, Clapp, William L, Barnes, Betsy J, Meng, Guangxun, 2021
AIM2 deficient mice develop severe Systemic Lupus Erthematosus pathogenesis due to elevated type I interferon signaling, Meng, Guangxun, Lu, Ailing, Wu, Shuxian, 2020
Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response, Herv Lecoeur, Eric Prina, Thibault Rosazza, Kossiwa Kokou, Paya NDiaye, Nathalie Aulner, Hugo Varet, Giovanni Bussotti, Yue Xing, Genevive Milon, Robert Weil, Guangxun Meng, Gerald F Spth, 2020

Inflammasome Nlrp3 Molecular Mechanisms Autoimmune Diseases Anti-Infection Pharmacological Regulation Vaccine Adjuvants Nlr Signaling Immune Response Pathogen

Xuebing Li - University of Chinese Academy of Sciences

Guangxun Meng - University of Chinese Academy of Sciences

Lingyun Long - University of Chinese Academy of Sciences

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