Areas of Focus
- Molecular Mechanisms of Inflammasome Activation and Regulation
- Role of Inflammasomes in Autoimmune Diseases
- Role of Inflammasomes in Anti-Infection Mechanisms
- Pharmacological Regulation of Inflammasomes
- Development of Vaccine Adjuvants Based on NLR Signaling
Work Experience
- 2010-05 to present - Shanghai Institute of Pasteur, Chinese Academy of Sciences - Researcher
- 2005-05 to 2010-04 - National Institutes of Health, USA - Postdoctoral Fellow
- 2000-09 to 2001-07 - Max Planck Institute, Hamburg, Germany - Visiting Scholar
Academic Background & Achievements
- 2001-08--2005-05 PhD: Technical University of Munich
- 1997-09--2000-07 Master's: Shandong Normal University, Shanghai Institute of Cell Biology, Chinese Academy of Sciences (Joint Program)
- 1993-09--1997-07 Bachelor's: Shandong Normal University
Publications
- Roles and Mechanisms of NLRP3 in Influenza Viral Infection, Junling Niu, Guangxun Meng, 2023
- TRAF6-TAK1-IKKβ pathway mediates TLR2 agonists activating 'one-step' NLRP3 inflammasome in human monocytes, Mengdan Chen, Shi Yu, Yuhui Gao, Jiaxun Li, Xun Wang, Bin Wei, Guangxun Meng, 2023
- Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2, Yu, Shi, Zheng, Xu, Zhou, Yanqiu, Gao, Yuhui, Zhou, Bingjie, Zhao, Yapei, Li, Tingting, Li, Yunyi, Mou, Jiabin, Cui, Xiaoxian, Yang, Yuying, Li, Dianfan, Chen, Min, Lavillette, Dimitri, Meng, Guangxun, 2023
- cFLIP(S) regulates alternative NLRP3 inflammasome activation in human monocytes, Gao, Yuhui, Yu, Shi, Chen, Mengdan, Wang, Xun, Pan, Lei, Wei, Bin, Meng, Guangxun, 2023
- Microbiota-derived acetate enhances host antiviral response via NLRP3, Junling Niu, Mengmeng Cui, Xin Yang, Juan Li, Yuhui Yao, Qiuhong Guo, Ailing Lu, Xiaopeng Qi, Dongming Zhou, Chenhong Zhang, Liping Zhao, Guangxun Meng, 2023
- SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation, Shi Yu, Bingjie Zhou, Juan Li, Mengdan Chen, Rong Deng, Gary Wong, Dimitri Lavillette, Guangxun Meng, 2022
- Activation of the Nlrp3 Inflammasome Contributes to Shiga Toxin-Induced Hemolytic Uremic Syndrome in a Mouse Model, Song, Liqiong, Xiao, Yuchun, Li, Xianping, Huang, Yuanming, Meng, Guangxun, Ren, Zhihong, 2021
- Aim2 Couples With Ube2i for Sumoylation-Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus, Lu, Ailing, Wu, Shuxian, Niu, Junling, Cui, Mengmeng, Chen, Mengdan, Clapp, William L, Barnes, Betsy J, Meng, Guangxun, 2021
- AIM2 deficient mice develop severe Systemic Lupus Erthematosus pathogenesis due to elevated type I interferon signaling, Meng, Guangxun, Lu, Ailing, Wu, Shuxian, 2020
- Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response, Herv Lecoeur, Eric Prina, Thibault Rosazza, Kossiwa Kokou, Paya NDiaye, Nathalie Aulner, Hugo Varet, Giovanni Bussotti, Yue Xing, Genevive Milon, Robert Weil, Guangxun Meng, Gerald F Spth, 2020
Awards
- Sanofi-Aventis-Excellent Young Talent Award, Chinese Academy of Sciences Shanghai Institute of Life Sciences, 2011
- National Outstanding Self-Financed International Student Scholarship, 2004
