Areas of Focus
- Molecular mechanisms of pathogenic microorganisms invading host cells
- Design of vaccines based on dominant epitopes
- Design of inhibitors
Work Experience
- 2016-08 to Present - Institute of Microbiology, Chinese Academy of Sciences - Researcher
- 2011-08 to 2016-06 - Institute of Microbiology, Chinese Academy of Sciences - Associate Researcher
- 2008-07 to 2011-08 - Institute of Microbiology, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2004-09 to 2008-07 PhD: Institute of Physics, Chinese Academy of Sciences
Publications
- A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease, JOURNAL OF IMMUNOLOGY, 2023
- Cryo-EM structure of severe fever with thrombocytopenia syndrome virus, NATURE COMMUNICATIONS, 2023
- Near-atomic architecture of Singapore grouper iridovirus and implications for giant virus assembly, NATURE COMMUNICATIONS, 2023
- In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike Protein, ACS CENTRAL SCIENCE, 2023
- Mechanistic insights into DNA binding and cleavage by a compact type I-F CRISPR-Cas system in bacteriophage, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023
- Structure of monkeypox virus DNA polymerase holoenzyme, SCIENCE, 2023
- The mechanism of STING autoinhibition and activation, MOLECULAR CELL, 2023
- Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer, MABS, 2023
- An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB, CELL REPORTS MEDICINE, 2023
- Host range and structural analysis of bat-origin RshSTT182/200 coronavirus binding to human ACE2 and its animal orthologs, EMBO JOURNAL, 2023
- Molecular mechanism of de novo replication by the Ebola virus polymerase, Nature, 2023
- Protective prototype-Beta and Delta-Omicron chimeric RBD-dimer vaccines against SARS-CoV-2, CELL, 2022
- VarEPS: an evaluation and prewarning system of known and virtual variations of SARS-CoV-2 genomes, NUCLEIC ACIDS RESEARCH, 2022
- Structural and inhibitor sensitivity analysis of influenza B-like viral neuraminidases derived from Asiatic toad and spiny eel, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022
- Molecular basis of differential receptor usage for naturally occurring CD55-binding and -nonbinding coxsackievirus B3 strains, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022
- Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1, CELL, 2022
- Molecular Basis of Mink ACE2 Binding to SARS-CoV-2 and Its Mink-Derived Variants, JOURNAL OF VIROLOGY, 2022
- Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2, CELL, 2022
- Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA.1/BA.1.1/BA.2/BA.3, IMMUNITY, 2022
- Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals, NATIONAL SCIENCE REVIEW, 2022
- Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses, NATURE COMMUNICATIONS, 2022
- Structure of the Ebola virus polymerase complex, NATURE, 2022
- Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape, NATURE COMMUNICATIONS, 2022
- Structural basis for a human broadly neutralizing influenza A hemagglutinin stem-specific antibody including H17/18 subtypes, Nature Communications, 2022
- Application of an Integrated Platform for Basic and Applied Research in the Prevention and Control of the COVID-19 Pandemic, 中国科学基金, 2022
- Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous beta 2-Microglobulin, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2021
- Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir, 创新(英文), 2021
- Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin, EMBO JOURNAL, 2021
- The molecular basis for SARS-CoV-2 binding to dog ACE2, NATURE COMMUNICATIONS, 2021
- Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1, CELL REPORTS, 2021
- Structure-based design of 5 '-substituted 1,2,3-triazolylated oseltamivir derivatives as potent influenza neuraminidase inhibitors, RSC ADVANCES, 2021
- Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation, CELL REPORTS, 2021
- 新型冠状病毒结合穿山甲ACE2受体的分子机制, 科学通报, 2021
- Cross-species recognition of SARS-CoV-2 to bat ACE2, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021
- Human group A rotavirus P25 VP8* specifically binds to A-type histo-blood group antigen, VIROLOGY, 2021
- Cell entry by SARS-CoV-2, TRENDS IN BIOCHEMICAL SCIENCES, 2021
- Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch, NATURE IMMUNOLOGY, 2021
- Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants, NATURE COMMUNICATIONS, 2021
- Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2, ISCIENCE, 2021
- Crystal structure of the African swine fever virus core shell protein p15, 生物安全与健康(英文), 2021
- Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species, CELL, 2021
- A broadly protective antibody that targets the flavivirus NS1 protein, SCIENCE, 2021
- Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals, NATURE MICROBIOLOGY, 2021
- Crystal structure of the African swine fever virus core shell protein p15, BIOSAFETY AND HEALTH, 2021
- Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021
- Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease, NATURE COMMUNICATIONS, 2020
- Structural insight into arenavirus replication machinery, NATURE, 2020
- Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species, FRONTIERS IN VETERINARY SCIENCE, 2020
- Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex, CELLULAR &
Awards
- Clarivate Highly Cited Researcher (2023): Other
- World's Top 2% Scientists (2023): Other
- Clarivate Highly Cited Researcher (2022): Other
- Clarivate Highly Cited Researcher (2021): Other
- Chinese Preventive Medicine Association Science and Technology Award (2017): First Prize, Ministerial Level
- Beijing Science and Technology Award (2011): First Prize, Provincial Level
