Areas of Focus
- Virus Immunology
- Vaccinology
- Vaccine Immunology
- Immunology
Work Experience
- 2019-01~Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Associate Researcher
- 2018-08~2018-12 - Kunming Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher
- 2015-06~2018-05 - University of Texas Medical Branch - Postdoctoral Researcher
- 2015-01~2015-05 - University of South Alabama - Postdoctoral Researcher
- 2011-07~2014-06 - Kunming Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2008-09--2011-06 Ph.D. in Science: Graduate University of Chinese Academy of Sciences
- 2005-09--2008-06 M.Sc. in Science: Yunnan University
- 2001-09--2005-06 B.Sc. in Science: Weifang University
Publications
- SARS-CoV-2 M-pro inhibitors with antiviral activity in a transgenic mouse model, 4th Author, 2021
- SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, 5th Author, 2021
- A proposal for clinical trials of COVID-19 treatment using homo-harringtonine, 2nd Author, 2021
- Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice, 5th Author, 2021
- Northern pig-tailed macaques (Macaca leonina) infected with SARS-CoV-2 show rapid viral clearance and persistent immune response, 5th Author, 2021
- Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation, 1st Author, 2021
- Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models, 4th Author, 2021
- Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques, 6th Author, 2020
- Polymorphisms in the APOBEC3G gene of Chinese rhesus macaques affect resistance to ubiquitination and degradation mediated by HIV-2 Vif, 11th Author, 2019
- Association of TRIMCyp and TRIM5α from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition, 3rd Author, 2018
- Activation of NF-kappa B induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque, 3rd Author, 2018
- Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection, 2nd Author, 2018
- Activation of NF-κB induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque, 3rd Author, 2018
- Association of TRIMCyp and TRIM5 alpha from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition, 3rd Author, 2018
- Heroin use is associated with lower levels of restriction factors and type I interferon expression and facilitates HIV-1 replication, 2nd Author, 2017
- Loss of immune control in HIV-infected patients: how does mucosal candidiasis occur?, 2nd Author, 2017
- Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor, 1st Author, 2017
- The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques, 2nd Author, 2016
- Sequential dysfunction and progressive depletion of Candida albicans-specific CD4 T cell response in HIV-1 infection, Not mentioned, 2016
- Lipopolysaccharide suppresses human immunodeficiency virus 1 reverse transcription in macrophages, 1st Author, 2016
- Dysfunction and depletion of human antigen specific CD4 T cells by HIV: a mechanism for pathogen-specific immune failure in AIDS, 2nd Author, 2016
- High seroprevalence of toxoplasma gondii and HIV-1 co-infection among drug users in Yunnan province, southwest China, 4th Author, 2016
- Increased expression and dysregulated association of restriction factors and type I interferon in HIV, HCV mono- and co-infected patients, 2nd Author, 2016
- HIV Susceptibility of human antigen-specific CD4 T cells in AIDS pathogenesis and vaccine response, 2nd Author, 2016
- Mitochondrial DNA Haplogroup A Decreases the Risk of Drug Addiction but Conversely Increases the Risk of HIV-1 Infection in Chinese Addicts, 3rd Author, 2016
- Factors associated with needle sharing among people who inject drugs in Yunnan, China: a combined network and regression analysis, 4th Author, 2016
- A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China, 3rd Author, 2015
- The Effect of Exon 7 Deletion during the Evolution of TRIMCyp Fusion Proteins on Viral Restriction, Cytoplasmic Body Formation and Multimerization, 1st Author, 2015
- Independent Birth of a Novel TRIMCyp in Tupaia belangeri with a Divergent Function from Its Paralog TRIM5, 4th Author, 2014
- The primate TRIMCyp fusion genes and mechanism of restricting retroviruses replication, 2nd Author, 2012
- Extensive and complex HIV-1 recombination between B ', C and CRF01_AE among IDUs in south-east Asia, 6th Author, 2012
- Identification of the TRIM5/TRIMCyp heterozygous genotype in Macaca assamensis, 3rd Author, 2011
- 中国静脉吸毒人群TRIM5α基因多态性与HIV-1 易感性研究, 1st Author, 2011
- Human Rights, Ethics, and the Protection of Intravenous Drug Users Are Much Improved in China, 11th Author, 2011
- Comparison of HIV-, HBV-, HCV- and Co-Infection Prevalence between Chinese and Burmese Intravenous Drug Users of the China-Myanmar Border Region, 2nd Author, 2011
- HIV-1 restriction factors and their polymorphisms, 1st Author, 2010
- 恒河猴TRIM5α的组织分布及不同刺激促进PBMC中TRIM5α转录水平的上调, 4th Author, 2009
Awards
- Travel Award of 6th Annual Vaccine Development Center of San Antonio Conference (2017): Other
- Travel Award of 5th Annual Vaccine Development Center of San Antonio Conference (2016): Other
- Zhu Li Yuehua Excellent Doctoral Student Scholarship of Chinese Academy of Sciences (2011): Institute Level
- First Prize of the 10th Yunnan Province Excellent Science and Technology Paper Award (2011): Provincial Level
- Second Prize of the 10th Yunnan Province Excellent Science and Technology Paper Award (2011): Provincial Level
