Professor | Yong Tian | Asia Growth Partners

Name	Yong Tian
Contact Information	ytian@ibp.ac.cn
Language ability	Chinese, English
Province	Beijing

Name

Yong Tian

Contact Information

ytian@ibp.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2002-07 to 2008-12 Postdoctoral: ST JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN, US 1997-09 to 2002-07 PhD: Peking Union Medical College
Awards	2020: First Prize of the Chinese Society for Laboratory Animal Science Science and Technology Award

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2002-07 to 2008-12 Postdoctoral: ST JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN, US
1997-09 to 2002-07 PhD: Peking Union Medical College

Awards

2020: First Prize of the Chinese Society for Laboratory Animal Science Science and Technology Award

Areas of Focus	Gene Editing Technology in Non-coding RNA Research and Animal Model Development Experimental Animal Science
Publications	5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis, Zhu P, Lu T, Chen Z, Liu B, Fan D, Li C, Wu J, He L, Zhu X, Du Y, Tian Y, Fan Z, 2022 Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons, Zhu P, Lu T, Wu J, Fan D, Liu B, Zhu X, Guo H, Du Y, Liu F, Tian Y, Fan Z, 2022 Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine, Xiong Z, Zhu X, Geng J, Xu Y, Wu R, Li C, Fan D, Qin X, Du Y, Tian Y, Fan Z, 2022 Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity, Ye B, Yang L, Liu B, Liu N, Fan D, Li H, Sun L, Du Y, Wang S, Tian Y, Fan Z, 2022 Discovery of potent and versatile CRISPR-Cas9 inhibitors engineered for chemically controllable genome editing, Song G, Zhang F, Tian C, Gao X, Zhu X, Fan D, Tian Y, 2022 N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism, Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y, Yi C, Fan Z, 2021 Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling, Gu Y, Wang Y, He L, Zhang J, Zhu X, Liu N, Wang J, Lu T, He L, Tian Y, Fan Z, 2021 Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA, Liu B, Liu N, Zhu X, Yang L, Ye B, Li H, Zhu P, Lu T, Tian Y, Fan Z, 2021 Global profiling of RNA-binding protein target sites by LACE-seq, Su R, Fan LH, Cao C, Wang L, Du Z, Cai Z, Ouyang YC, Wang Y, Zhou Q, Wu L, Zhang N, Zhu X, Lei WL, Zhao H, Tian Y, He S, Wong CCL, Sun QY, Xue Y, 2021 An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution, Liu B, Ye B, Zhu X, Yang L, Li H, Liu N, Zhu P, Lu T, He L, Tian Y, Fan Z, 2020 The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells, Ye B, Yang L, Qian G, Liu B, Zhu X, Zhu P, Ma J, Xie W, Li H, Lu T, Wang Y, Wang S, Du Y, Wang Z, Jiang J, Li J, Fan D, Meng S, Wu J, Tian Y, Fan Z, 2020 Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer, Wang S, Qu Y, Xia P, Chen Y, Zhu X, Zhang J, Wang G, Tian Y, Ying J, Fan Z, 2020 AcrIIA5 Inhibits a Broad Range of Cas9 Orthologs by Preventing DNA Target Cleavage, Song G, Zhang F, Zhang X, Gao X, Zhu X, Fan D, Tian Y, 2019 Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis, Xiong Z, Xia P, Zhu X, Geng J, Wang S, Ye B, Qin X, Qu Y, He L, Fan D, Du Y, Tian Y, Fan Z, 2020 Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription, Liu B, Yang L, Zhu X, Li H, Zhu P, Wu J, Lu T, He L, Liu N, Meng S, Zhou L, Ye B, Tian Y, Fan Z, 2019 Anti-CRISPRs: The natural inhibitors for CRISPR-Cas systems, Zhang F, Song G, Tian Y, 2019 LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling, Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, Du Y, Ye B, Wang D, He L, Ren W, Wang J, Sun X, Chen R, Tian Y, Fan Z, 2019 IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3, Zhu P, Zhu X, Wu J, He L, Lu T, Wang Y, Liu B, Ye B, Sun L, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y, Fan Z, 2019 LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis, Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y, Fan Z, 2018 Long noncoding RNA lncHand2 promotes liver repopulation via initiating Nkx1-2-induced c-Met signaling, Wang Y, Zhu P, Wang J, Zhu X, Luo J, Meng S, Wu J, Ye B, He L, Du Y, He L, Chen R, Tian Y, Fan Z, 2018 Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution, Gao L, Wu K, Liu Z, Yao X, Yuan S, Tao W, Yi L, Yu G, Hou Z, Fan D, Tian Y, Liu J, Chen ZJ, Liu J, 2018 Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice, Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y, Fan Z, 2018 LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3, Ye B, Liu B, Yang L, Zhu X, Zhang D, Wu W, Zhu P, Wang Y, Wang S, Xia P, Du Y, Meng S, Huang G, Wu J, Chen R, Tian Y, Fan Z, 2018 The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity, Xia P, Wang S, Xiong Z, Zhu X, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y, Fan Z, 2018 IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development, Liu B, Ye B, Zhu X, Huang G, Zhu P, Yang L, Du Y, Wu J, Meng S, Tian Y, Fan Z, 2017 Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression, Liu B, Ye B, Yang L, Zhu X, Huang G, Zhu P, Du Y, Wu J, Qin X, Chen R, Tian Y, Fan Z, 2017 Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity, Xia P, Ye B, Wang S, Zhu X, Du Y, Xiong Z, Tian Y, Fan Z, 2016 The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling, Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, Fan Z, 2015 The endoplasmic reticulum adaptor protein ERAdP initiates NK cell activation via the Ubc13-mediated NF-κB pathway, Chen J, Hao L, Li C, Ye B, Du Y, Zhang H, Long B, Zhu P, Liu B, Yang L, Li P, Tian Y, Fan Z, 2015 Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation, Ye B, Li C, Yang Z, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y, Fan Z, 2014 An efficient genotyping method for genome-modified animals and human cells generated with CRISPR/Cas9 system, Zhu X, Xu Y, Yu S, Lu L, Ding M, Cheng J, Song G, Gao X, Yao L, Fan D, Meng S, Zhang X, Hu S, Tian Y, 2014 SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer, Li G, Ci W, Karmakar S, Chen K, Dhar R, Fan Z, Guo Z, Zhang J, Ke Y, Wang L, Zhuang M, Hu S, Li X, Zhou L, Li X, Calabrese MF, Watson ER, Prasad SM, Rinker-Schaeffer C, Eggener SE, Stricker T, Tian Y, Schulman BA, Liu J, White KP, 2014 Photothermal therapy of cancer cells using novel hollow gold nanoflowers, Han J, Li J, Jia W, Yao L, Li X, Jiang L, Tian Y*, 2014

Areas of Focus

Gene Editing Technology in Non-coding RNA Research and Animal Model Development
Experimental Animal Science

Publications

5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis, Zhu P, Lu T, Chen Z, Liu B, Fan D, Li C, Wu J, He L, Zhu X, Du Y, Tian Y*, Fan Z*, 2022
Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons, Zhu P, Lu T, Wu J, Fan D, Liu B, Zhu X, Guo H, Du Y, Liu F, Tian Y*, Fan Z*, 2022
Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine, Xiong Z, Zhu X, Geng J, Xu Y, Wu R, Li C, Fan D, Qin X, Du Y, Tian Y*, Fan Z*, 2022
Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity, Ye B, Yang L, Liu B, Liu N, Fan D, Li H, Sun L, Du Y, Wang S, Tian Y*, Fan Z*, 2022
Discovery of potent and versatile CRISPR-Cas9 inhibitors engineered for chemically controllable genome editing, Song G, Zhang F, Tian C, Gao X, Zhu X, Fan D, Tian Y*, 2022
N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism, Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y*, Yi C*, Fan Z*, 2021
Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling, Gu Y, Wang Y, He L, Zhang J, Zhu X, Liu N, Wang J, Lu T, He L, Tian Y*, Fan Z*, 2021
Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA, Liu B, Liu N, Zhu X, Yang L, Ye B, Li H, Zhu P, Lu T, Tian Y*, Fan Z*, 2021
Global profiling of RNA-binding protein target sites by LACE-seq, Su R, Fan LH, Cao C, Wang L, Du Z, Cai Z, Ouyang YC, Wang Y, Zhou Q, Wu L, Zhang N, Zhu X, Lei WL, Zhao H, Tian Y, He S, Wong CCL, Sun QY, Xue Y, 2021
An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution, Liu B, Ye B, Zhu X, Yang L, Li H, Liu N, Zhu P, Lu T, He L, Tian Y*, Fan Z*, 2020
The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells, Ye B, Yang L, Qian G, Liu B, Zhu X, Zhu P, Ma J, Xie W, Li H, Lu T, Wang Y, Wang S, Du Y, Wang Z, Jiang J, Li J, Fan D, Meng S, Wu J, Tian Y*, Fan Z*, 2020
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer, Wang S, Qu Y, Xia P, Chen Y, Zhu X, Zhang J, Wang G, Tian Y*, Ying J*, Fan Z*, 2020
AcrIIA5 Inhibits a Broad Range of Cas9 Orthologs by Preventing DNA Target Cleavage, Song G, Zhang F, Zhang X, Gao X, Zhu X, Fan D, Tian Y*, 2019
Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis, Xiong Z, Xia P, Zhu X, Geng J, Wang S, Ye B, Qin X, Qu Y, He L, Fan D, Du Y, Tian Y*, Fan Z*, 2020
Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription, Liu B, Yang L, Zhu X, Li H, Zhu P, Wu J, Lu T, He L, Liu N, Meng S, Zhou L, Ye B, Tian Y*, Fan Z*, 2019
Anti-CRISPRs: The natural inhibitors for CRISPR-Cas systems, Zhang F, Song G, Tian Y*, 2019
LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling, Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, Du Y, Ye B, Wang D, He L, Ren W, Wang J, Sun X, Chen R, Tian Y*, Fan Z*, 2019
IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3, Zhu P, Zhu X, Wu J, He L, Lu T, Wang Y, Liu B, Ye B, Sun L, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y*, Fan Z*, 2019
LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis, Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y*, Fan Z*, 2018
Long noncoding RNA lncHand2 promotes liver repopulation via initiating Nkx1-2-induced c-Met signaling, Wang Y, Zhu P, Wang J, Zhu X, Luo J, Meng S, Wu J, Ye B, He L, Du Y, He L, Chen R, Tian Y*, Fan Z*, 2018
Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution, Gao L, Wu K, Liu Z, Yao X, Yuan S, Tao W, Yi L, Yu G, Hou Z, Fan D, Tian Y, Liu J, Chen ZJ, Liu J, 2018
Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice, Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y*, Fan Z*, 2018
LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3, Ye B, Liu B, Yang L, Zhu X, Zhang D, Wu W, Zhu P, Wang Y, Wang S, Xia P, Du Y, Meng S, Huang G, Wu J, Chen R*, Tian Y*, Fan Z*, 2018
The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity, Xia P, Wang S, Xiong Z, Zhu X, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y*, Fan Z*, 2018
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development, Liu B, Ye B, Zhu X, Huang G, Zhu P, Yang L, Du Y, Wu J, Meng S, Tian Y*, Fan Z*, 2017
Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression, Liu B, Ye B, Yang L, Zhu X, Huang G, Zhu P, Du Y, Wu J, Qin X, Chen R*, Tian Y*, Fan Z*, 2017
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity, Xia P, Ye B, Wang S, Zhu X, Du Y, Xiong Z, Tian Y*, Fan Z*, 2016
The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling, Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, Fan Z, 2015
The endoplasmic reticulum adaptor protein ERAdP initiates NK cell activation via the Ubc13-mediated NF-κB pathway, Chen J, Hao L, Li C, Ye B, Du Y, Zhang H, Long B, Zhu P, Liu B, Yang L, Li P, Tian Y*, Fan Z*, 2015
Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation, Ye B, Li C, Yang Z, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y*, Fan Z*, 2014
An efficient genotyping method for genome-modified animals and human cells generated with CRISPR/Cas9 system, Zhu X, Xu Y, Yu S, Lu L, Ding M, Cheng J, Song G, Gao X, Yao L, Fan D, Meng S, Zhang X, Hu S*, Tian Y*, 2014
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer, Li G, Ci W, Karmakar S, Chen K, Dhar R, Fan Z, Guo Z, Zhang J, Ke Y, Wang L, Zhuang M, Hu S, Li X, Zhou L, Li X, Calabrese MF, Watson ER, Prasad SM, Rinker-Schaeffer C, Eggener SE, Stricker T, Tian Y, Schulman BA, Liu J, White KP, 2014
Photothermal therapy of cancer cells using novel hollow gold nanoflowers, Han J, Li J, Jia W, Yao L, Li X, Jiang L*, Tian Y*, 2014

Gene Editing Non-Coding Rna Animal Models Crispr Genetics Molecular Biology Biochemistry Cell Biology Stem Cells Cancer Research

Zhang Peng - Wuhan University

Yu Chen Xia - Wuhan University

Zheqiong Yang - Wuhan University

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