Professor | Ning Jia | Asia Growth Partners

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Name	Ning Jia
Contact Information	jian@sustech.edu.cn
Language ability	Chinese, English
Province	Guangdong

Upload Avatar (500 x 500)

Name

Ning Jia

Contact Information

jian@sustech.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Southern University of Science and Technology
Faculty	Medical School
Academic Background & Achievements	2006-2010 Bachelor: Ocean University of China 2010-2016 PhD: University of Science and Technology of China, Supervisors: Prof. Congzhao Zhou/Prof. Yuxing Chen Selected for MIT Technology Review's 'Innovators Under 35' Asia-Pacific list (2022) Blavatnik Regional Awards for Young Scientists Winner in Chemistry (2020)
Work Experience	2022.06-present Associate Professor, School of Medicine, Southern University of Science and Technology 2021.05-2022.05 Assistant Professor, School of Medicine, Southern University of Science and Technology 2017-2021 Postdoctoral Researcher, Memorial Sloan Kettering Cancer Center, Supervisor: Prof. Dinshaw J. Patel
Awards	2024: Editorial Board member of the Journal of Biological Chemistry 2022: Selected for MIT Technology Review's 'Innovators Under 35' Asia-Pacific list 2020: Blavatnik Regional Awards for Young Scientists Winner in Chemistry 2016: Zeiss-Zebrafish Science Award 2010: Shandong Province Outstanding Graduate 2007, 2009: National Scholarship

University/Lab Affiliation and Title

Southern University of Science and Technology

Faculty

Medical School

Academic Background & Achievements

2006-2010 Bachelor: Ocean University of China
2010-2016 PhD: University of Science and Technology of China, Supervisors: Prof. Congzhao Zhou/Prof. Yuxing Chen
Selected for MIT Technology Review's 'Innovators Under 35' Asia-Pacific list (2022)
Blavatnik Regional Awards for Young Scientists Winner in Chemistry (2020)

Work Experience

2022.06-present Associate Professor, School of Medicine, Southern University of Science and Technology
2021.05-2022.05 Assistant Professor, School of Medicine, Southern University of Science and Technology
2017-2021 Postdoctoral Researcher, Memorial Sloan Kettering Cancer Center, Supervisor: Prof. Dinshaw J. Patel

Awards

2024: Editorial Board member of the Journal of Biological Chemistry
2022: Selected for MIT Technology Review's 'Innovators Under 35' Asia-Pacific list
2020: Blavatnik Regional Awards for Young Scientists Winner in Chemistry
2016: Zeiss-Zebrafish Science Award
2010: Shandong Province Outstanding Graduate
2007, 2009: National Scholarship

Areas of Focus	Molecular mechanisms of microbial interactions with the host immune system Development of biotechnological tools based on microbial-host immune system interactions
Publications	Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system, Zhang, J.T., Liu, X.Y., Li, Z.L., Wei, X.Y., Song, X.Y., Cui, N., Zhong, J., Li, H., and Jia, N., 2024 Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system, Zhang, J.T., Wei, X. Y., Cui, N., Tian, R., Jia, N., 2023 Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment, Cui, N., Zhang, J.T., Li, Y., Liu, Y., Liu, X.Y., Wang, C., Huang, H., and Jia, N., 2023 Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05, Duan, Z., Zhang, X., Zhang, J.T., Li, S, Liu, R., Sun, J., Zhao, Q., Jia, N., Jia, N., and Zhu, J.K., 2023 Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase, Cui, N., Zhang, J.T., Li, Z., Liu, X.Y.,Wang, C., Huang, H., and Jia, N., 2022 Bacterial origins of cyclic nucleotide-activated antiviral immune signaling, Patel, D.J., Yu, Y., and Jia, N., 2022 Structure-based evolutionary relationship between IscB and Cas9, Jia, N. & Patel, D. J., 2022 Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins, Jia, N., Patel. D. J., 2021 A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity, Meeske A. J., Jia, N., Cassel A.K., Kozlova A., Liao J., Wiedmann M., Patel D. J., Marraffini L. A., 2020 Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex, Jia, N., Xie, W., De La Cruz, J.M., Eng, E.T., Patel, D.J., 2020 CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity, Jia, N., Jones, R., Yang, G., Ouerfelli, O., Patel, D.J., 2019 Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path, Jia, N., Jones, R., Sukenick, G., Patel, D.J., 2019 Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity, Jia, N., Mo, C.Y., Wang, C., Eng, E.T., Marraffini, L.A., Patel, D.J., 2019 Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection, Jia, N., Unciuleac, M., Xue C., Greene E.C., Patel, D.J., Shuman, S.*, 2019 Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein, Jia, N., Liu, N., Cheng, W., Jiang, Y.L., Sun, H., Chen, L.L., Peng, J., Zhang, Y., Ding, Y.H., Zhang, Z.H., et al., 2016 The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection, Chen, L.L., Xie, J., Cao, D.D., Jia, N., Li, Y.J., Sun, H., Li, W.F., Hu, B., Chen, Y., Zhou, C.Z., 2018 Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori, Zhou, K., Jia, N., Hu, C., Jiang, Y.L., Yang, J.P., Chen, Y., Li, S., Li, W.F., Zhou, C.Z., 2014 Genetic differentiation of Trachurus japonicus from the Northwestern Pacific based on the mitochondrial DNA control region, Song, N., Jia, N., Yanagimoto, T., Lin, L., Gao, T., 2013 N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease, He, Y.X., Zhang, N.N., Li, W.F., Jia, N., Chen, B.Y., Zhou, K., Zhang, J., Chen, Y., Zhou, C.Z., 2012

Areas of Focus

Molecular mechanisms of microbial interactions with the host immune system
Development of biotechnological tools based on microbial-host immune system interactions

Publications

Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system, Zhang, J.T., Liu, X.Y., Li, Z.L., Wei, X.Y., Song, X.Y., Cui, N., Zhong, J., Li, H., and Jia, N.*, 2024
Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system, Zhang, J.T., Wei, X. Y., Cui, N., Tian, R., Jia, N.*, 2023
Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment, Cui, N., Zhang, J.T., Li, Y., Liu, Y., Liu, X.Y., Wang, C., Huang, H.*, and Jia, N.*, 2023
Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05, Duan, Z., Zhang, X., Zhang, J.T., Li, S, Liu, R., Sun, J., Zhao, Q., Jia, N., Jia, N.*, and Zhu, J.K.*, 2023
Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase, Cui, N., Zhang, J.T., Li, Z., Liu, X.Y.,Wang, C., Huang, H.*, and Jia, N.*, 2022
Bacterial origins of cyclic nucleotide-activated antiviral immune signaling, Patel, D.J.*, Yu, Y., and Jia, N., 2022
Structure-based evolutionary relationship between IscB and Cas9, Jia, N.* & Patel, D. J.*, 2022
Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins, Jia, N.*, Patel. D. J.*, 2021
A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity, Meeske A. J., Jia, N., Cassel A.K., Kozlova A., Liao J., Wiedmann M., Patel D. J.*, Marraffini L. A.*, 2020
Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex, Jia, N.*, Xie, W., De La Cruz, J.M., Eng, E.T., Patel, D.J.*, 2020
CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity, Jia, N.*, Jones, R., Yang, G., Ouerfelli, O., Patel, D.J.*, 2019
Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path, Jia, N.*, Jones, R., Sukenick, G., Patel, D.J.*, 2019
Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity, Jia, N.*, Mo, C.Y., Wang, C., Eng, E.T., Marraffini, L.A., Patel, D.J.*, 2019
Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection, Jia, N., Unciuleac, M., Xue C., Greene E.C., Patel, D.J.*, Shuman, S.*, 2019
Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein, Jia, N., Liu, N., Cheng, W., Jiang, Y.L., Sun, H., Chen, L.L., Peng, J., Zhang, Y., Ding, Y.H., Zhang, Z.H., et al., 2016
The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection, Chen, L.L., Xie, J., Cao, D.D., Jia, N., Li, Y.J., Sun, H., Li, W.F., Hu, B., Chen, Y., Zhou, C.Z., 2018
Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori, Zhou, K., Jia, N., Hu, C., Jiang, Y.L., Yang, J.P., Chen, Y., Li, S., Li, W.F., Zhou, C.Z., 2014
Genetic differentiation of Trachurus japonicus from the Northwestern Pacific based on the mitochondrial DNA control region, Song, N., Jia, N., Yanagimoto, T., Lin, L., Gao, T., 2013
N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease, He, Y.X., Zhang, N.N., Li, W.F., Jia, N., Chen, B.Y., Zhou, K., Zhang, J., Chen, Y., Zhou, C.Z., 2012

Microbial Interactions Host Immune System Molecular Mechanisms Crispr-Cas Systems Phage Resistance Plasmid Invasion Biochemistry Molecular Biology Microbiology Structural Biology

Jin Tang Dong - Southern University of Science and Technology

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