Upload Avatar (500 x 500)
Ning Jia
Medical School
Southern University of Science and Technology
Guangdong
Language: Chinese, English
Microbial Interactions
Host Immune System
Molecular Mechanisms
Crispr-Cas Systems
Phage Resistance
Plasmid Invasion
Biochemistry
Molecular Biology
Microbiology
Structural Biology
Areas of Focus
- Molecular mechanisms of microbial interactions with the host immune system
- Development of biotechnological tools based on microbial-host immune system interactions
Work Experience
- 2022.06-present Associate Professor, School of Medicine, Southern University of Science and Technology
- 2021.05-2022.05 Assistant Professor, School of Medicine, Southern University of Science and Technology
- 2017-2021 Postdoctoral Researcher, Memorial Sloan Kettering Cancer Center, Supervisor: Prof. Dinshaw J. Patel
Academic Background & Achievements
- 2006-2010 Bachelor: Ocean University of China
- 2010-2016 PhD: University of Science and Technology of China, Supervisors: Prof. Congzhao Zhou/Prof. Yuxing Chen
- Selected for MIT Technology Review's 'Innovators Under 35' Asia-Pacific list (2022)
- Blavatnik Regional Awards for Young Scientists Winner in Chemistry (2020)
Publications
- Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system, Zhang, J.T., Liu, X.Y., Li, Z.L., Wei, X.Y., Song, X.Y., Cui, N., Zhong, J., Li, H., and Jia, N.*, 2024
- Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system, Zhang, J.T., Wei, X. Y., Cui, N., Tian, R., Jia, N.*, 2023
- Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment, Cui, N., Zhang, J.T., Li, Y., Liu, Y., Liu, X.Y., Wang, C., Huang, H.*, and Jia, N.*, 2023
- Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05, Duan, Z., Zhang, X., Zhang, J.T., Li, S, Liu, R., Sun, J., Zhao, Q., Jia, N., Jia, N.*, and Zhu, J.K.*, 2023
- Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase, Cui, N., Zhang, J.T., Li, Z., Liu, X.Y.,Wang, C., Huang, H.*, and Jia, N.*, 2022
- Bacterial origins of cyclic nucleotide-activated antiviral immune signaling, Patel, D.J.*, Yu, Y., and Jia, N., 2022
- Structure-based evolutionary relationship between IscB and Cas9, Jia, N.* & Patel, D. J.*, 2022
- Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins, Jia, N.*, Patel. D. J.*, 2021
- A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity, Meeske A. J., Jia, N., Cassel A.K., Kozlova A., Liao J., Wiedmann M., Patel D. J.*, Marraffini L. A.*, 2020
- Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex, Jia, N.*, Xie, W., De La Cruz, J.M., Eng, E.T., Patel, D.J.*, 2020
- CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity, Jia, N.*, Jones, R., Yang, G., Ouerfelli, O., Patel, D.J.*, 2019
- Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path, Jia, N.*, Jones, R., Sukenick, G., Patel, D.J.*, 2019
- Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity, Jia, N.*, Mo, C.Y., Wang, C., Eng, E.T., Marraffini, L.A., Patel, D.J.*, 2019
- Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection, Jia, N., Unciuleac, M., Xue C., Greene E.C., Patel, D.J.*, Shuman, S.*, 2019
- Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein, Jia, N., Liu, N., Cheng, W., Jiang, Y.L., Sun, H., Chen, L.L., Peng, J., Zhang, Y., Ding, Y.H., Zhang, Z.H., et al., 2016
- The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection, Chen, L.L., Xie, J., Cao, D.D., Jia, N., Li, Y.J., Sun, H., Li, W.F., Hu, B., Chen, Y., Zhou, C.Z., 2018
- Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori, Zhou, K., Jia, N., Hu, C., Jiang, Y.L., Yang, J.P., Chen, Y., Li, S., Li, W.F., Zhou, C.Z., 2014
- Genetic differentiation of Trachurus japonicus from the Northwestern Pacific based on the mitochondrial DNA control region, Song, N., Jia, N., Yanagimoto, T., Lin, L., Gao, T., 2013
- N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease, He, Y.X., Zhang, N.N., Li, W.F., Jia, N., Chen, B.Y., Zhou, K., Zhang, J., Chen, Y., Zhou, C.Z., 2012
Awards
- 2024: Editorial Board member of the Journal of Biological Chemistry
- 2022: Selected for MIT Technology Review's 'Innovators Under 35' Asia-Pacific list
- 2020: Blavatnik Regional Awards for Young Scientists Winner in Chemistry
- 2016: Zeiss-Zebrafish Science Award
- 2010: Shandong Province Outstanding Graduate
- 2007, 2009: National Scholarship
