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贾宁
Medical School
南方科技大学
广东省
Language: 中文, 英语
微生物相互作用
宿主免疫系统
分子机制
Crispr-Cas系统
噬菌体抵抗
质粒入侵
生物化学
分子生物学
微生物学
结构生物学
Areas of Focus
- 微生物与宿主免疫系统相互作用的分子机制
- 基于微生物与宿主免疫系统相互作用分子机制的生物技术工具开发
Work Experience
- 2022.06-至今 副教授，南方科技大学医学院
- 2021.05-2022.05 助理教授，南方科技大学医学院
- 2017-2021 博士后，美国纪念斯隆凯特琳癌症中心，导师：Dinshaw J. Patel教授
Academic Background & Achievements
- 2006-2010 学士：中国海洋大学
- 2010-2016 博士：中国科学技术大学，导师：周丛照、陈宇星教授
- 入选《麻省理工科技评论》“35岁以下科技创新35人”亚太区榜单（2022）
- 美国布拉瓦尼克区域青年科学家化学奖获得者（2020）
Publications
- Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system, Zhang, J.T., Liu, X.Y., Li, Z.L., Wei, X.Y., Song, X.Y., Cui, N., Zhong, J., Li, H., and Jia, N.*, 2024
- Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system, Zhang, J.T., Wei, X. Y., Cui, N., Tian, R., Jia, N.*, 2023
- Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment, Cui, N., Zhang, J.T., Li, Y., Liu, Y., Liu, X.Y., Wang, C., Huang, H.*, and Jia, N.*, 2023
- Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05, Duan, Z., Zhang, X., Zhang, J.T., Li, S, Liu, R., Sun, J., Zhao, Q., Jia, N., Jia, N.*, and Zhu, J.K.*, 2023
- Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase, Cui, N., Zhang, J.T., Li, Z., Liu, X.Y.,Wang, C., Huang, H.*, and Jia, N.*, 2022
- Bacterial origins of cyclic nucleotide-activated antiviral immune signaling, Patel, D.J.*, Yu, Y., and Jia, N., 2022
- Structure-based evolutionary relationship between IscB and Cas9, Jia, N.* & Patel, D. J.*, 2022
- Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins, Jia, N.*, Patel. D. J.*, 2021
- A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity, Meeske A. J., Jia, N., Cassel A.K., Kozlova A., Liao J., Wiedmann M., Patel D. J.*, Marraffini L. A.*, 2020
- Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex, Jia, N.*, Xie, W., De La Cruz, J.M., Eng, E.T., Patel, D.J.*, 2020
- CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA
Awards
- 2024: 入选Journal of Biological Chemistry (JBC)期刊的Editorial Board member
- 2022: 入选《麻省理工科技评论》“35岁以下科技创新35人”亚太区榜单
- 2020: 美国布拉瓦尼克区域青年科学家化学奖
- 2016: 蔡司-斑马鱼科学研究奖
- 2010: 山东省优秀毕业生
- 2007，2009: 国家奖学金
