Professor | Pengyuan Yang | Asia Growth Partners

Name	Pengyuan Yang
Contact Information	Pyyang163@163.com
Language ability	Chinese, English
Province	Beijing

Name

Pengyuan Yang

Contact Information

Pyyang163@163.com

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1999-09--2004-07 PhD: Second Military Medical University 1995-09--1999-07 Bachelor's: Second Military Medical University
Work Experience	2014-01~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher 2009-01~2014-01 - Duke University School of Medicine - Postdoctoral/Research Assistant 2004-09~2008-09 - Second Military Medical University - Teacher/Postdoctoral
Awards	Chinese Academy of Sciences University Life Sciences College Quality Course (2019)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1999-09--2004-07 PhD: Second Military Medical University
1995-09--1999-07 Bachelor's: Second Military Medical University

Work Experience

2014-01~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
2009-01~2014-01 - Duke University School of Medicine - Postdoctoral/Research Assistant
2004-09~2008-09 - Second Military Medical University - Teacher/Postdoctoral

Awards

Chinese Academy of Sciences University Life Sciences College Quality Course (2019)

Areas of Focus	Mechanism of HBV-induced carcinogenesis Virus-host interactions and related tumor immune responses Molecular mechanisms of inflammation-cancer transformation
Publications	Epigenetic regulation of HBV-specific tumor-infiltrating T cells in HBV-related HCC, Maojun You, Yanan Gao, Junliang Fu, Runze Xie, Zhenyu Zhu, Zhixian Hong, Lingzhan Meng, Shunda Du, Junliang Liu, FuSheng Wang, Pengyuan Yang, Liang Chen, 2023 Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis, Wen-Lan Yang, Weinan Qiu, Ting Zhang, Kai Xu, Zi-Juan Gu, Yu Zhou, Heng-Ji Xu, Zhong-Zhou Yang, Bin Shen, Yong-Liang Zhao, Qi Zhou, Ying Yang, Wei Li, Peng-Yuan Yang, Yun-Gui Yang, 2023 Establishment of an inducible cell line for Hepatitis B virus genotype C2 and its pharmacological responses to interferons, Jiang, Shaodong, Wang, Xin, Chen, Kaili, Yang, Pengyuan, 2022 Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B, Yanan Gao, Maojun You, Junliang Fu, Meijie Tian, Xinyue Zhong, Chengzhi Du, Zhixian Hong, Zhenyu Zhu, Junliang Liu, Geoffrey J Markowitz, FuSheng Wang, Pengyuan Yang, 2022 Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19, You, Maojun, Chen, Liang, Zhang, Dawei, Zhao, Peng, Chen, Zhu, Qin, EnQiang, Gao, Yanan, Davis, Mark M, Yang, Pengyuan, 2021 N-6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA, Weinan Qiu, Qingyang Zhang, Rui Zhang, Yangxu Lu, Xin Wang, Huabin Tian, Ying Yang, Zijuan Gu, Yanan Gao, Xin Yang, Guanshen Cui, Baofa Sun, Yanan Peng, Hongyu Deng, Hua Peng, Angang Yang, YunGui Yang, Pengyuan Yang, 2021 Hepatitis B-Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation, Zhang, Changlu, Gao, Yanan, Du, Chengzhi, Markowitz, Geoffrey J, Fu, Jing, Zhang, Zhenxing, Liu, Chunliang, Qin, Wenhao, Wang, Hongyang, Wang, Fan, Yang, Pengyuan, 2021 3D landscape of Hepatitis B virus interactions with human chromatins, Yang, Bo, Li, Boyuan, Jia, Liyang, Jiang, Yongpeng, Wang, Xin, Jiang, Shaodong, Du, Shunda, Ji, Xiong, Yang, Pengyuan, 2020 Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma, Qiu, Weinan, Wang, Bin, Gao, Yanan, Tian, Yuan, Tian, Meijie, Chen, Yuanying, Xu, Li, Yao, TsoPang, Li, Peng, Yang, Pengyuan, 2020 HBV induced hepatocellular carcinoma and related potential immunotherapy, Jia, Liyang, Gao, Yanan, He, Yaowu, Hooper, John D, Yang, Pengyuan, 2020 CCL22 signaling contributes to sorafenib resistance in hepatitis B virus-associated hepatocellular carcinoma, Gao, Yanan, Fan, Xing, Li, Nan, Du, Chengzhi, Yang, Bin, Qin, Wenhao, Fu, Jing, Markowitz, Geoffrey J, Wang, Hongyang, Ma, Jianli, Cheng, Shuqun, Yang, Pengyuan, 2020 An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma, Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth T S Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony W H Chan, Joanna H Tong, YueSun Cheung, Paul B S Lai, Hector K S Wang, ShunWa Tsang, KingLau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, KaFai To, Joseph J Y Sung, Grace L H Wong, Vincent W S Wong, Alfred S L Cheng, 2018 Epigenetic Activation of Wnt/beta-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis, Tian, Yuan, Mok, Myth T S, Yang, Pengyuan, Cheng, Alfred S L, 2016 EF1A1/HSC70 Cooperatively Suppress Brain Endothelial Cell Apoptosis via Regulating JNK Activity, Liu, Ying, Jiang, Shu, Yang, PengYuan, Zhang, YueFan, Li, TieJun, Rui, YaoCheng, 2016 EGF promotes mammalian cell growth by suppressing cellular senescence, Alexander, Peter B, Yuan, Lifeng, Yang, Pengyuan, Sun, Tao, Chen, Rui, Xiang, Handan, Chen, Jiekai, Wu, Haoyu, Radiloff, Daniel R, Wang, XiaoFan, 2015 天然免疫识别及其调控的分子机制研究, 曹雪涛, 安华章, 于益芝, 刘星光, 徐胜, 刘书逊, 韩超峰, 蒋应明, 杨鹏远, 侯晋, 2015 Microenvironmental regulation of cancer metastasis by miRNAs, Zhang, Yun, Yang, Pengyuan, Wang, XiaoFan, 2014 The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma, Yang, Pengyuan, Markowitz, Geoffrey J, Wang, XiaoFan, 2014 A PK2/Bv8/PROK2 Antagonist Suppresses Tumorigenic Processes by Inhibiting Angiogenesis in Glioma and Blocking Myeloid Cell Infiltration in Pancreatic Cancer, Curtis, Valerie F, Wang, Hui, Yang, Pengyuan, McLendon, Roger E, Li, Xiaohan, Zhou, QunYong, Wang, XiaoFan, 2013 miR-126 and miR-126*repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis, Zhang, Yun, Yang, Pengyuan, Sun, Tao, Li, Dong, Xu, Xin, Rui, Yaocheng, Li, Chaoran, Chong, Mengyang, Ibrahim, Toni, Mercatali, Laura, Amadori, Dino, Lu, Xincheng, Xie, Dong, Li, QiJing, Wang, XiaoFan, 2013 TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma, Yang Pengyuan, Li Qi-Jing, Feng Yuxiong, Zhang Yun, Markowitz Geoffrey J., Ning Shanglei, Deng Yuezhen, Zhao Jiangsha, Jiang Shan, Yuan Yunfei, Wang Hong-Yang, Cheng Shu-Qun, Xie Dong, Wang Xiao-Fan, 2012

Areas of Focus

Mechanism of HBV-induced carcinogenesis
Virus-host interactions and related tumor immune responses
Molecular mechanisms of inflammation-cancer transformation

Publications

Epigenetic regulation of HBV-specific tumor-infiltrating T cells in HBV-related HCC, Maojun You, Yanan Gao, Junliang Fu, Runze Xie, Zhenyu Zhu, Zhixian Hong, Lingzhan Meng, Shunda Du, Junliang Liu, FuSheng Wang, Pengyuan Yang, Liang Chen, 2023
Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis, Wen-Lan Yang, Weinan Qiu, Ting Zhang, Kai Xu, Zi-Juan Gu, Yu Zhou, Heng-Ji Xu, Zhong-Zhou Yang, Bin Shen, Yong-Liang Zhao, Qi Zhou, Ying Yang, Wei Li, Peng-Yuan Yang, Yun-Gui Yang, 2023
Establishment of an inducible cell line for Hepatitis B virus genotype C2 and its pharmacological responses to interferons, Jiang, Shaodong, Wang, Xin, Chen, Kaili, Yang, Pengyuan, 2022
Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B, Yanan Gao, Maojun You, Junliang Fu, Meijie Tian, Xinyue Zhong, Chengzhi Du, Zhixian Hong, Zhenyu Zhu, Junliang Liu, Geoffrey J Markowitz, FuSheng Wang, Pengyuan Yang, 2022
Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19, You, Maojun, Chen, Liang, Zhang, Dawei, Zhao, Peng, Chen, Zhu, Qin, EnQiang, Gao, Yanan, Davis, Mark M, Yang, Pengyuan, 2021
N-6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA, Weinan Qiu, Qingyang Zhang, Rui Zhang, Yangxu Lu, Xin Wang, Huabin Tian, Ying Yang, Zijuan Gu, Yanan Gao, Xin Yang, Guanshen Cui, Baofa Sun, Yanan Peng, Hongyu Deng, Hua Peng, Angang Yang, YunGui Yang, Pengyuan Yang, 2021
Hepatitis B-Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation, Zhang, Changlu, Gao, Yanan, Du, Chengzhi, Markowitz, Geoffrey J, Fu, Jing, Zhang, Zhenxing, Liu, Chunliang, Qin, Wenhao, Wang, Hongyang, Wang, Fan, Yang, Pengyuan, 2021
3D landscape of Hepatitis B virus interactions with human chromatins, Yang, Bo, Li, Boyuan, Jia, Liyang, Jiang, Yongpeng, Wang, Xin, Jiang, Shaodong, Du, Shunda, Ji, Xiong, Yang, Pengyuan, 2020
Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma, Qiu, Weinan, Wang, Bin, Gao, Yanan, Tian, Yuan, Tian, Meijie, Chen, Yuanying, Xu, Li, Yao, TsoPang, Li, Peng, Yang, Pengyuan, 2020
HBV induced hepatocellular carcinoma and related potential immunotherapy, Jia, Liyang, Gao, Yanan, He, Yaowu, Hooper, John D, Yang, Pengyuan, 2020
CCL22 signaling contributes to sorafenib resistance in hepatitis B virus-associated hepatocellular carcinoma, Gao, Yanan, Fan, Xing, Li, Nan, Du, Chengzhi, Yang, Bin, Qin, Wenhao, Fu, Jing, Markowitz, Geoffrey J, Wang, Hongyang, Ma, Jianli, Cheng, Shuqun, Yang, Pengyuan, 2020
An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma, Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth T S Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony W H Chan, Joanna H Tong, YueSun Cheung, Paul B S Lai, Hector K S Wang, ShunWa Tsang, KingLau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, KaFai To, Joseph J Y Sung, Grace L H Wong, Vincent W S Wong, Alfred S L Cheng, 2018
Epigenetic Activation of Wnt/beta-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis, Tian, Yuan, Mok, Myth T S, Yang, Pengyuan, Cheng, Alfred S L, 2016
EF1A1/HSC70 Cooperatively Suppress Brain Endothelial Cell Apoptosis via Regulating JNK Activity, Liu, Ying, Jiang, Shu, Yang, PengYuan, Zhang, YueFan, Li, TieJun, Rui, YaoCheng, 2016
EGF promotes mammalian cell growth by suppressing cellular senescence, Alexander, Peter B, Yuan, Lifeng, Yang, Pengyuan, Sun, Tao, Chen, Rui, Xiang, Handan, Chen, Jiekai, Wu, Haoyu, Radiloff, Daniel R, Wang, XiaoFan, 2015
天然免疫识别及其调控的分子机制研究, 曹雪涛, 安华章, 于益芝, 刘星光, 徐胜, 刘书逊, 韩超峰, 蒋应明, 杨鹏远, 侯晋, 2015
Microenvironmental regulation of cancer metastasis by miRNAs, Zhang, Yun, Yang, Pengyuan, Wang, XiaoFan, 2014
The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma, Yang, Pengyuan, Markowitz, Geoffrey J, Wang, XiaoFan, 2014
A PK2/Bv8/PROK2 Antagonist Suppresses Tumorigenic Processes by Inhibiting Angiogenesis in Glioma and Blocking Myeloid Cell Infiltration in Pancreatic Cancer, Curtis, Valerie F, Wang, Hui, Yang, Pengyuan, McLendon, Roger E, Li, Xiaohan, Zhou, QunYong, Wang, XiaoFan, 2013
miR-126 and miR-126*repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis, Zhang, Yun, Yang, Pengyuan, Sun, Tao, Li, Dong, Xu, Xin, Rui, Yaocheng, Li, Chaoran, Chong, Mengyang, Ibrahim, Toni, Mercatali, Laura, Amadori, Dino, Lu, Xincheng, Xie, Dong, Li, QiJing, Wang, XiaoFan, 2013
TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma, Yang Pengyuan, Li Qi-Jing, Feng Yuxiong, Zhang Yun, Markowitz Geoffrey J., Ning Shanglei, Deng Yuezhen, Zhao Jiangsha, Jiang Shan, Yuan Yunfei, Wang Hong-Yang, Cheng Shu-Qun, Xie Dong, Wang Xiao-Fan, 2012

Hbv Carcinogenesis Virus-Host Interactions Tumor Immune Responses Inflammation Cancer Molecular Mechanisms Transformation Immune System Virology

Jian Zhang - Southern University of Science and Technology

Wei Gang - Wuhan University

Lan Ke - Wuhan University

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