Areas of Focus
- Mechanism of HBV-induced carcinogenesis
- Virus-host interactions and related tumor immune responses
- Molecular mechanisms of inflammation-cancer transformation
Work Experience
- 2014-01~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
- 2009-01~2014-01 - Duke University School of Medicine - Postdoctoral/Research Assistant
- 2004-09~2008-09 - Second Military Medical University - Teacher/Postdoctoral
Academic Background & Achievements
- 1999-09--2004-07 PhD: Second Military Medical University
- 1995-09--1999-07 Bachelor's: Second Military Medical University
Publications
- Epigenetic regulation of HBV-specific tumor-infiltrating T cells in HBV-related HCC, Maojun You, Yanan Gao, Junliang Fu, Runze Xie, Zhenyu Zhu, Zhixian Hong, Lingzhan Meng, Shunda Du, Junliang Liu, FuSheng Wang, Pengyuan Yang, Liang Chen, 2023
- Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis, Wen-Lan Yang, Weinan Qiu, Ting Zhang, Kai Xu, Zi-Juan Gu, Yu Zhou, Heng-Ji Xu, Zhong-Zhou Yang, Bin Shen, Yong-Liang Zhao, Qi Zhou, Ying Yang, Wei Li, Peng-Yuan Yang, Yun-Gui Yang, 2023
- Establishment of an inducible cell line for Hepatitis B virus genotype C2 and its pharmacological responses to interferons, Jiang, Shaodong, Wang, Xin, Chen, Kaili, Yang, Pengyuan, 2022
- Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B, Yanan Gao, Maojun You, Junliang Fu, Meijie Tian, Xinyue Zhong, Chengzhi Du, Zhixian Hong, Zhenyu Zhu, Junliang Liu, Geoffrey J Markowitz, FuSheng Wang, Pengyuan Yang, 2022
- Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19, You, Maojun, Chen, Liang, Zhang, Dawei, Zhao, Peng, Chen, Zhu, Qin, EnQiang, Gao, Yanan, Davis, Mark M, Yang, Pengyuan, 2021
- N-6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA, Weinan Qiu, Qingyang Zhang, Rui Zhang, Yangxu Lu, Xin Wang, Huabin Tian, Ying Yang, Zijuan Gu, Yanan Gao, Xin Yang, Guanshen Cui, Baofa Sun, Yanan Peng, Hongyu Deng, Hua Peng, Angang Yang, YunGui Yang, Pengyuan Yang, 2021
- Hepatitis B-Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation, Zhang, Changlu, Gao, Yanan, Du, Chengzhi, Markowitz, Geoffrey J, Fu, Jing, Zhang, Zhenxing, Liu, Chunliang, Qin, Wenhao, Wang, Hongyang, Wang, Fan, Yang, Pengyuan, 2021
- 3D landscape of Hepatitis B virus interactions with human chromatins, Yang, Bo, Li, Boyuan, Jia, Liyang, Jiang, Yongpeng, Wang, Xin, Jiang, Shaodong, Du, Shunda, Ji, Xiong, Yang, Pengyuan, 2020
- Targeting Histone Deacetylase 6 Reprograms Interleukin-17-Producing Helper T Cell Pathogenicity and Facilitates Immunotherapies for Hepatocellular Carcinoma, Qiu, Weinan, Wang, Bin, Gao, Yanan, Tian, Yuan, Tian, Meijie, Chen, Yuanying, Xu, Li, Yao, TsoPang, Li, Peng, Yang, Pengyuan, 2020
- HBV induced hepatocellular carcinoma and related potential immunotherapy, Jia, Liyang, Gao, Yanan, He, Yaowu, Hooper, John D, Yang, Pengyuan, 2020
- CCL22 signaling contributes to sorafenib resistance in hepatitis B virus-associated hepatocellular carcinoma, Gao, Yanan, Fan, Xing, Li, Nan, Du, Chengzhi, Yang, Bin, Qin, Wenhao, Fu, Jing, Markowitz, Geoffrey J, Wang, Hongyang, Ma, Jianli, Cheng, Shuqun, Yang, Pengyuan, 2020
- An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma, Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth T S Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony W H Chan, Joanna H Tong, YueSun Cheung, Paul B S Lai, Hector K S Wang, ShunWa Tsang, KingLau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, KaFai To, Joseph J Y Sung, Grace L H Wong, Vincent W S Wong, Alfred S L Cheng, 2018
- Epigenetic Activation of Wnt/beta-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis, Tian, Yuan, Mok, Myth T S, Yang, Pengyuan, Cheng, Alfred S L, 2016
- EF1A1/HSC70 Cooperatively Suppress Brain Endothelial Cell Apoptosis via Regulating JNK Activity, Liu, Ying, Jiang, Shu, Yang, PengYuan, Zhang, YueFan, Li, TieJun, Rui, YaoCheng, 2016
- EGF promotes mammalian cell growth by suppressing cellular senescence, Alexander, Peter B, Yuan, Lifeng, Yang, Pengyuan, Sun, Tao, Chen, Rui, Xiang, Handan, Chen, Jiekai, Wu, Haoyu, Radiloff, Daniel R, Wang, XiaoFan, 2015
- 天然免疫识别及其调控的分子机制研究, 曹雪涛, 安华章, 于益芝, 刘星光, 徐胜, 刘书逊, 韩超峰, 蒋应明, 杨鹏远, 侯晋, 2015
- Microenvironmental regulation of cancer metastasis by miRNAs, Zhang, Yun, Yang, Pengyuan, Wang, XiaoFan, 2014
- The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma, Yang, Pengyuan, Markowitz, Geoffrey J, Wang, XiaoFan, 2014
- A PK2/Bv8/PROK2 Antagonist Suppresses Tumorigenic Processes by Inhibiting Angiogenesis in Glioma and Blocking Myeloid Cell Infiltration in Pancreatic Cancer, Curtis, Valerie F, Wang, Hui, Yang, Pengyuan, McLendon, Roger E, Li, Xiaohan, Zhou, QunYong, Wang, XiaoFan, 2013
- miR-126 and miR-126*repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis, Zhang, Yun, Yang, Pengyuan, Sun, Tao, Li, Dong, Xu, Xin, Rui, Yaocheng, Li, Chaoran, Chong, Mengyang, Ibrahim, Toni, Mercatali, Laura, Amadori, Dino, Lu, Xincheng, Xie, Dong, Li, QiJing, Wang, XiaoFan, 2013
- TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma, Yang Pengyuan, Li Qi-Jing, Feng Yuxiong, Zhang Yun, Markowitz Geoffrey J., Ning Shanglei, Deng Yuezhen, Zhao Jiangsha, Jiang Shan, Yuan Yunfei, Wang Hong-Yang, Cheng Shu-Qun, Xie Dong, Wang Xiao-Fan, 2012
Awards
- Chinese Academy of Sciences University Life Sciences College Quality Course (2019)
