Areas of Focus
- Embryonic Development and Pluripotent Stem Cells
- Epigenetic Regulation Mechanisms in Early Embryonic Development and Somatic Cell Reprogramming
Work Experience
- 1998-2000 Brown University School of Medicine - Research Assistant, Joint PhD Training
- 2000-2002 Roslin Institute, UK - Postdoctoral Researcher (under Prof. Ian Wilmut)
- 2002-2004 Temple University School of Medicine - Postdoctoral Researcher
- 2004-2005 University of Connecticut - Assistant Professor
- 2005-2013 Beijing Institute of Life Sciences - Researcher, Senior Researcher
- 2013-Present Tongji University College of Life Sciences and Technology - Distinguished Professor, Dean
Academic Background & Achievements
- 1989-1993 Bachelor's Degree: Shandong Agricultural University
- 1993-1996 Master's Degree: China Agricultural University
- 1996-2000 PhD: Institute of Zoology, Chinese Academy of Sciences
- Recipient of the National Science Fund for Distinguished Young Scholars
- Leader of the National 'Ten Thousand Talents Program'
Publications
- Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos, Liu X, Wang C, Liu W, Li J, Li C, Kou X, Chen J, Zhao Y, Gao H, Wang H, Zhang Y, Gao Y, Gao S, 2016
- iPS cells can support full term development of tetraploid blastocyst-complemented embryos, Kang L, Wang J, Zhang Y, Kou Z, Gao S, 2009
- Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation, Yuan W, Wu T, Fu H, Dai C, Wu H, Liu N, Li X, Xu M, Zhang Z, Niu T, Han Z, Chai J, Zhou XJ, Gao S, Zhu B, 2012
- Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming, Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, Kou X, Zhan Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T, Gao S, 2013
- FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development, Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui X, Zhang L, Zhao X, Liu Q, He P, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He Y, Li X, Gao S, Gao Y, He C, 2022
- Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos, Xu R, Li S, Wu Q, Li C, Jiang M, Guo L, Chen M, Yang L, Dong X, Wang H, Wang C, Liu X, Ou X, Gao S, 2022
- N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during maternal-to-zygotic transition, Wu Y, Xu X, Qi M, Chen C, Li M, Yan R, Kou X, Zhao Y, Liu W, Li Y, Liu X, Zhang M, Yi C, Liu H, Xiang J, Wang H, Shen B, Gao Y, Gao S, 2022
- Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells, Le R, Huang Y, Zhang Y, Wang H, Lin J, Dong Y, Li Z, Guo M, Kou X, Zhao Y, Chen M, Zhu Q, Zhao A, Yin J, Sun J, Su Z, Shi K, Gao Y, Chen J, Liu W, Kang L, Wang Y, Li C, Liu X, Gao R, Wang H, Ju Z, Gao S, 2021
- Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development, Wang C, Liu X, Gao Y, Yang L, Li C, Liu W, Chen C, Kou X, Zhao Y, Chen J, Wang Y, Le R, Wang H, Duan T, Zhang Y, Gao S, 2018
- Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos, Gao R, Wang C, Gao Y, Xiu W, Chen J, Kou X, Zhao Y, Liao Y, Bai D, Qiao Z, Yang L, Wang M, Zang R, Liu X, Jia Y, Li Y, Zhang Y, Yin J, Wang H, Wan X, Liu W, Zhang Y, Gao S, 2018
- Allele-specific H3K9me3 and DNA methylation marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryos, Yang H, Bai D, Li Y, Yu Z, Wang C, Sheng Y, Liu W, Gao S, Zhang Y, 2022
- DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State, Yang F, Huang X, Zang R, Chen J, Fidalgo M, Sanchez-Priego C, Yang J, Caichen A, Ma F, Macfarlan T, Wang H, Gao S, Zhou H, Wang J, 2020
- Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer, Yang G, Zhang L, Liu W, Qiao Z, Shen S, Zhu Q, Gao R, Wang M, Wang M, Li C, Liu M, Sun J, Wang L, Liu W, Cui X, Zhao K, Zang R, Chen M, Liang Z, Wang L, Kou X, Zhao Y, Wang H, Wang Y, Gao S, Chen J, Jiang C, 2021
- Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation, Wang C, Chen C, Liu X, Li C, Wu Q, Chen X, Yang L, Kou X, Zhao Y, Wang H, Gao Y, Zhang Y, Gao S, 2022
- Accurate annotation of accessible chromatin in mouse and human primordial germ cells, Li J, Shen S, Chen J, Liu W, Li X, Zhu Q, Wang B, Chen X, Wu L, Wang M, Gu L, Wang H, Yin J, Jiang C, Gao S, 2018
- Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing, Liu W, Liu X, Wang C, Gao Y, Gao R, Kou X, Zhao Y, Li J, Wu Y, Xiu W, Wang S, Yin J, Liu W, Cai T, Wang H, Zhang Y, Gao S, 2016
- Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos, Chen C, Liu W, Guo J, Liu Y, Liu X, Liu J, Dou X, Le R, Huang Y, Li C, Yang L, Kou X, Zhao Y, Wu Y, Chen J, Wang H, Shen B, Gao Y, Gao S, 2021
- Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm, Liu K, Xu X, Bai D, Li
Awards
- 2023 National Innovation Competition Award
- 2022 Shanghai Natural Science Award, First Prize (First Author)
- 2021 Chinese Society for Cell Biology Outstanding Achievement Award
- 2020 National Natural Science Award, Second Prize (First Author)
- 2019 Ministry of Education Science Research Outstanding Achievement Award, Natural Science First Prize (First Author)
- 2015 Tan Jiazhen Life Science Innovation Award
- 2014 National Natural Science Award, Second Prize (Fourth Author)
- 2011 Zhou Guangzhao Foundation Award for Outstanding Young Scientists
- 2009 WuXi AppTec Award for Life Chemistry Research
