Areas of Focus
- Epigenetic regulation mechanisms in mammalian embryonic development
- Single-cell and micro-cell sequencing technologies
Work Experience
- 2022.03 to present - Professor at Tongji University, School of Life Sciences and Technology
- 2019.02 to present - Researcher at Tongji University Affiliated Oriental Hospital, Regenerative Medicine Research Institute
- 2018.08-2022.02 - Distinguished Researcher at Tongji University, School of Life Sciences and Technology/Tongji University Advanced Research Institute
- 2017.11-2018.10 - Visiting Scholar at Weill Cornell Medical College, NY, USA
- 2016.06-2018.07 - Postdoctoral Fellow at Tongji University, School of Life Sciences and Technology
Academic Background & Achievements
- 2011.07 – 2016.06 PhD in Biochemistry and Molecular Biology, National Institute of Biological Sciences, Beijing
- Recipient of the National High-level Talents Special Support Plan
Publications
- Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos, Xiaoyu Liu et al., 2023
- Stage-specific H3K9me3 allocations ensure retrotransposon silencing in human preimplantation embryos, Xiaoyu Liu et al., 2022
- Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation, Xiaoyu Liu et al., 2022
- Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq, Xiaoyu Liu et al., 2022
- Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis, Xiaoyu Liu et al., 2022
- Insights into epigenetic patterns in mammalian early embryos, Xiaoyu Liu et al., 2021
- Advance in the Role of Epigenetic Reprogramming in Somatic Cell Nuclear Transfer-Mediated Embryonic Development, Xiaoyu Liu et al., 2021
- Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos, Xiaoyu Liu et al., 2020
- PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome, Xiaoyu Liu et al., 2020
- Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development, Xiaoyu Liu et al., 2018
- Protein expression landscape of mouse embryos during pre-implantation development, Xiaoyu Liu et al., 2017
- Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos, Xiaoyu Liu et al., 2016
- Identification of key factors releasing cloned embryo arrests by combining embyo biopsy and single-cell sequencing, Xiaoyu Liu et al., 2016
Awards
- 2024 - Third Shanghai Science and Technology Youth 35 Leading Plan
- 2021 - National High-level Talents Special Support Plan, Young Top-notch Talent
- 2020 - Shanghai Science and Technology Rising Star Plan
- 2020 - Shanghai Talent Development Fund
- 2019 - First Prize of Natural Science from the Ministry of Education
- 2016 - Top Ten Advances in China's Life Sciences Field
