Professor | Qian Chen | Asia Growth Partners

Name	Qian Chen
Contact Information	chenqian@simm.ac.cn
Language ability	Chinese, English
Province	Guangdong

Name

Qian Chen

Contact Information

chenqian@simm.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2003-09--2007-07 PhD: Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2000-09--2003-06 Master's Degree: Xiangya School of Medicine, Central South University 1995-09--2000-06 Medical Bachelor's Degree: Xiangya School of Medicine, Central South University
Work Experience	2022-01~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences/Zhongshan Institute for Drug Innovation, Researcher/Group Leader/Doctoral Supervisor 2014-04~2022-01 - McGovern Institute for Brain Research, MIT, Research Scientist 2010-08~2014-03 - McGovern Institute for Brain Research, MIT, Postdoctoral Fellow 2008-05~2010-08 - Department of Neurobiology, Duke University, Postdoctoral Fellow 2007-07~2008-05 - Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Assistant Researcher
Awards	NSF Project Award (2020): First Prize, National Level Travel award of the Society for Neuroscience (SFN) 6th Annual Julius Axelrod Lecture (2012): First Prize, Other 9th Jiuyuan Scholarship (2008): Third Prize, Municipal Level Outstanding PhD Graduate of the Chinese Academy of Sciences (2007): First Prize, Institute Level Procter & Gamble Award (2007): First Prize, Municipal Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2003-09--2007-07 PhD: Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
2000-09--2003-06 Master's Degree: Xiangya School of Medicine, Central South University
1995-09--2000-06 Medical Bachelor's Degree: Xiangya School of Medicine, Central South University

Work Experience

2022-01~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences/Zhongshan Institute for Drug Innovation, Researcher/Group Leader/Doctoral Supervisor
2014-04~2022-01 - McGovern Institute for Brain Research, MIT, Research Scientist
2010-08~2014-03 - McGovern Institute for Brain Research, MIT, Postdoctoral Fellow
2008-05~2010-08 - Department of Neurobiology, Duke University, Postdoctoral Fellow
2007-07~2008-05 - Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Assistant Researcher

Awards

NSF Project Award (2020): First Prize, National Level
Travel award of the Society for Neuroscience (SFN) 6th Annual Julius Axelrod Lecture (2012): First Prize, Other
9th Jiuyuan Scholarship (2008): Third Prize, Municipal Level
Outstanding PhD Graduate of the Chinese Academy of Sciences (2007): First Prize, Institute Level
Procter & Gamble Award (2007): First Prize, Municipal Level

Areas of Focus	Changes in brain neural circuits in autism Comorbidity mechanisms of autism and epilepsy Gene therapy for autism
Publications	Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models, NEURON, 2021 Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells, ANESTHESIA AND ANALGESIA, 2021 An ultra-sensitive step-function opsin for minimally invasive optogenetic stimulation in mice and macaques, Neuron, 2020 Proliferator-Activated Receptor-Gamma Coactivator-1 alpha Haploinsufficiency Promotes Pain Chronification After Burn Injury, ANESTHESIA AND ANALGESIA, 2020 Dysfunction of Cortical GABAergic Neurons Leads to Sensory Hyper-reactivity in a Shank3 Mouse Model of ASD, NATURE NEUROSCIENCE, 2020 A Whole-Brain Cell-Type-Specific Sparse Neuron Labeling Method and Its Application in a Shank3 Autistic Mouse Model, FRONTIERS IN CELLULAR NEUROSCIENCE, 2020 Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice, NATURE NEUROSCIENCE, 2019 Evaluating the pathogenic potential of genes with de novo variants in epileptic encephalopathies, GENETICS IN MEDICINE, 2019 Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism, JOURNAL OF CLINICAL INVESTIGATION, 2017 Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3, MOLECULAR PSYCHIATRY, 2016 A viral strategy for targeting and manipulating interneurons across vertebrate species, NATURE NEUROSCIENCE, 2016 Acute brain slice methods for adult and aging animals: application of targeted patch clampanalysis and optogenetics, Methods in molecular biology (Clifton, N.J.), 2014 Imaging Neural Activity Using Thy1-GCaMP Transgenic Mice, NEURON, 2012 Fluorescent Labeling of Newborn Dentate Granule Cells in GAD67-GFP Transgenic Mice: A Genetic Tool for the Study of Adult Neurogenesis, PLOS ONE, 2010 CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling, JOURNAL OF NEUROSCIENCE, 2010 Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus, JOURNAL OF NEUROCHEMISTRY, 2009 Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance, STROKE, 2008 Clathrin-dependent Endocytosis Is Required for TrkB-dependent Akt-mediated Neuronal Protection and Dendritic Growth, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008 Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory, NEUROPHARMACOLOGY, 2008 Recombinant AAV-mediated HSVtk gene transfer with direct intratumoral injections and Tet-On regulation for implanted human breast cancer, BMC CANCER, 2006 Requirement of TORC1 for Late-Phase Long-Term Potentiation in the Hippocampus, PLOS ONE, 2006 Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression, JOURNAL OF NEUROSCIENCE, 2004 Suicide gene therapy of human breast cancer in SCID mice model by the regulation of Tet-On, 中华医学杂志：英文版, 2004 Brain-derived Neurotrophic Factor-Tropomyosin-related Kinase B Signaling Contributes to Activity-dependent Changes in Synaptic Proteins, The Journal of Biological Chemistry, 2004

Areas of Focus

Changes in brain neural circuits in autism
Comorbidity mechanisms of autism and epilepsy
Gene therapy for autism

Publications

Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models, NEURON, 2021
Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells, ANESTHESIA AND ANALGESIA, 2021
An ultra-sensitive step-function opsin for minimally invasive optogenetic stimulation in mice and macaques, Neuron, 2020
Proliferator-Activated Receptor-Gamma Coactivator-1 alpha Haploinsufficiency Promotes Pain Chronification After Burn Injury, ANESTHESIA AND ANALGESIA, 2020
Dysfunction of Cortical GABAergic Neurons Leads to Sensory Hyper-reactivity in a Shank3 Mouse Model of ASD, NATURE NEUROSCIENCE, 2020
A Whole-Brain Cell-Type-Specific Sparse Neuron Labeling Method and Its Application in a Shank3 Autistic Mouse Model, FRONTIERS IN CELLULAR NEUROSCIENCE, 2020
Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice, NATURE NEUROSCIENCE, 2019
Evaluating the pathogenic potential of genes with de novo variants in epileptic encephalopathies, GENETICS IN MEDICINE, 2019
Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism, JOURNAL OF CLINICAL INVESTIGATION, 2017
Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3, MOLECULAR PSYCHIATRY, 2016
A viral strategy for targeting and manipulating interneurons across vertebrate species, NATURE NEUROSCIENCE, 2016
Acute brain slice methods for adult and aging animals: application of targeted patch clampanalysis and optogenetics, Methods in molecular biology (Clifton, N.J.), 2014
Imaging Neural Activity Using Thy1-GCaMP Transgenic Mice, NEURON, 2012
Fluorescent Labeling of Newborn Dentate Granule Cells in GAD67-GFP Transgenic Mice: A Genetic Tool for the Study of Adult Neurogenesis, PLOS ONE, 2010
CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling, JOURNAL OF NEUROSCIENCE, 2010
Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus, JOURNAL OF NEUROCHEMISTRY, 2009
Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance, STROKE, 2008
Clathrin-dependent Endocytosis Is Required for TrkB-dependent Akt-mediated Neuronal Protection and Dendritic Growth, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008
Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory, NEUROPHARMACOLOGY, 2008
Recombinant AAV-mediated HSVtk gene transfer with direct intratumoral injections and Tet-On regulation for implanted human breast cancer, BMC CANCER, 2006
Requirement of TORC1 for Late-Phase Long-Term Potentiation in the Hippocampus, PLOS ONE, 2006
Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression, JOURNAL OF NEUROSCIENCE, 2004
Suicide gene therapy of human breast cancer in SCID mice model by the regulation of Tet-On, 中华医学杂志：英文版, 2004
Brain-derived Neurotrophic Factor-Tropomyosin-related Kinase B Signaling Contributes to Activity-dependent Changes in Synaptic Proteins, The Journal of Biological Chemistry, 2004

Autism Neural Circuits Brain Epilepsy Comorbidity Gene Therapy Neuroscience Neurodevelopment Behavioral Science Genetics

Zikai Zhou - University of Chinese Academy of Sciences

Xiaoyan Ke - Nanjing University

Zhenhua Chen - Wuhan University

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