Areas of Focus
- Changes in brain neural circuits in autism
- Comorbidity mechanisms of autism and epilepsy
- Gene therapy for autism
Work Experience
- 2022-01~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences/Zhongshan Institute for Drug Innovation, Researcher/Group Leader/Doctoral Supervisor
- 2014-04~2022-01 - McGovern Institute for Brain Research, MIT, Research Scientist
- 2010-08~2014-03 - McGovern Institute for Brain Research, MIT, Postdoctoral Fellow
- 2008-05~2010-08 - Department of Neurobiology, Duke University, Postdoctoral Fellow
- 2007-07~2008-05 - Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Assistant Researcher
Academic Background & Achievements
- 2003-09--2007-07 PhD: Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- 2000-09--2003-06 Master's Degree: Xiangya School of Medicine, Central South University
- 1995-09--2000-06 Medical Bachelor's Degree: Xiangya School of Medicine, Central South University
Publications
- Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models, NEURON, 2021
- Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells, ANESTHESIA AND ANALGESIA, 2021
- An ultra-sensitive step-function opsin for minimally invasive optogenetic stimulation in mice and macaques, Neuron, 2020
- Proliferator-Activated Receptor-Gamma Coactivator-1 alpha Haploinsufficiency Promotes Pain Chronification After Burn Injury, ANESTHESIA AND ANALGESIA, 2020
- Dysfunction of Cortical GABAergic Neurons Leads to Sensory Hyper-reactivity in a Shank3 Mouse Model of ASD, NATURE NEUROSCIENCE, 2020
- A Whole-Brain Cell-Type-Specific Sparse Neuron Labeling Method and Its Application in a Shank3 Autistic Mouse Model, FRONTIERS IN CELLULAR NEUROSCIENCE, 2020
- Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice, NATURE NEUROSCIENCE, 2019
- Evaluating the pathogenic potential of genes with de novo variants in epileptic encephalopathies, GENETICS IN MEDICINE, 2019
- Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism, JOURNAL OF CLINICAL INVESTIGATION, 2017
- Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3, MOLECULAR PSYCHIATRY, 2016
- A viral strategy for targeting and manipulating interneurons across vertebrate species, NATURE NEUROSCIENCE, 2016
- Acute brain slice methods for adult and aging animals: application of targeted patch clampanalysis and optogenetics, Methods in molecular biology (Clifton, N.J.), 2014
- Imaging Neural Activity Using Thy1-GCaMP Transgenic Mice, NEURON, 2012
- Fluorescent Labeling of Newborn Dentate Granule Cells in GAD67-GFP Transgenic Mice: A Genetic Tool for the Study of Adult Neurogenesis, PLOS ONE, 2010
- CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling, JOURNAL OF NEUROSCIENCE, 2010
- Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus, JOURNAL OF NEUROCHEMISTRY, 2009
- Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance, STROKE, 2008
- Clathrin-dependent Endocytosis Is Required for TrkB-dependent Akt-mediated Neuronal Protection and Dendritic Growth, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008
- Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory, NEUROPHARMACOLOGY, 2008
- Recombinant AAV-mediated HSVtk gene transfer with direct intratumoral injections and Tet-On regulation for implanted human breast cancer, BMC CANCER, 2006
- Requirement of TORC1 for Late-Phase Long-Term Potentiation in the Hippocampus, PLOS ONE, 2006
- Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression, JOURNAL OF NEUROSCIENCE, 2004
- Suicide gene therapy of human breast cancer in SCID mice model by the regulation of Tet-On, 中华医学杂志：英文版, 2004
- Brain-derived Neurotrophic Factor-Tropomyosin-related Kinase B Signaling Contributes to Activity-dependent Changes in Synaptic Proteins, The Journal of Biological Chemistry, 2004
Awards
- NSF Project Award (2020): First Prize, National Level
- Travel award of the Society for Neuroscience (SFN) 6th Annual Julius Axelrod Lecture (2012): First Prize, Other
- 9th Jiuyuan Scholarship (2008): Third Prize, Municipal Level
- Outstanding PhD Graduate of the Chinese Academy of Sciences (2007): First Prize, Institute Level
- Procter & Gamble Award (2007): First Prize, Municipal Level
