Professor | 陈迁 | 数字化转型顾问

Name	陈迁
Contact Information	chenqian@simm.ac.cn
Language ability	中文, 英语
Province	广东

Name

陈迁

Contact Information

chenqian@simm.ac.cn

Language ability

中文, 英语

Province

广东

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	2003-09--2007-07 博士学位: 中国科学院上海生命科学研究院神经科学研究所 2000-09--2003-06 硕士学位: 中南大学湘雅医学院 1995-09--2000-06 医学学士学位: 中南大学湘雅医学院
Work Experience	2022-01~现在 - 中国科学院上海药物研究所/中科中山药物创新研究院, 研究员/课题组长/博士生导师 2014-04~2022-01 - 美国麻省理工学院麦戈文脑科学研究所, 研究型科学家 2010-08~2014-03 - 美国麻省理工学院麦戈文脑科学研究所, 博士后 2008-05~2010-08 - 美国杜克大学神经生物系, 博士后 2007-07~2008-05 - 中国科学院上海生命科学研究院神经科学研究所, 助理研究员
Awards	美国国家基金（NSF)项目奖 (2020): 一等奖, 国家级神经科学学会（SFN）第六届朱利叶斯·阿克塞尔罗德讲座旅行奖 (2012): 一等奖, 其他第九届九源奖学金 (2008): 三等奖, 市地级中国科学院优秀博士毕业生 (2007): 一等奖, 研究所（学校）宝洁奖 (2007): 一等奖, 市地级

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

2003-09--2007-07 博士学位: 中国科学院上海生命科学研究院神经科学研究所
2000-09--2003-06 硕士学位: 中南大学湘雅医学院
1995-09--2000-06 医学学士学位: 中南大学湘雅医学院

Work Experience

2022-01~现在 - 中国科学院上海药物研究所/中科中山药物创新研究院, 研究员/课题组长/博士生导师
2014-04~2022-01 - 美国麻省理工学院麦戈文脑科学研究所, 研究型科学家
2010-08~2014-03 - 美国麻省理工学院麦戈文脑科学研究所, 博士后
2008-05~2010-08 - 美国杜克大学神经生物系, 博士后
2007-07~2008-05 - 中国科学院上海生命科学研究院神经科学研究所, 助理研究员

Awards

美国国家基金（NSF)项目奖 (2020): 一等奖, 国家级
神经科学学会（SFN）第六届朱利叶斯·阿克塞尔罗德讲座旅行奖 (2012): 一等奖, 其他
第九届九源奖学金 (2008): 三等奖, 市地级
中国科学院优秀博士毕业生 (2007): 一等奖, 研究所（学校）
宝洁奖 (2007): 一等奖, 市地级

Areas of Focus	孤独症大脑神经环路改变孤独症和癫痫病的共病机制孤独症的基因治疗
Publications	Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models, NEURON, 2021 Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells, ANESTHESIA AND ANALGESIA, 2021 An ultra-sensitive step-function opsin for minimally invasive optogenetic stimulation in mice and macaques, Neuron, 2020 Proliferator-Activated Receptor-Gamma Coactivator-1 alpha Haploinsufficiency Promotes Pain Chronification After Burn Injury, ANESTHESIA AND ANALGESIA, 2020 Dysfunction of Cortical GABAergic Neurons Leads to Sensory Hyper-reactivity in a Shank3 Mouse Model of ASD, NATURE NEUROSCIENCE, 2020 A Whole-Brain Cell-Type-Specific Sparse Neuron Labeling Method and Its Application in a Shank3 Autistic Mouse Model, FRONTIERS IN CELLULAR NEUROSCIENCE, 2020 Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice, NATURE NEUROSCIENCE, 2019 Evaluating the pathogenic potential of genes with de novo variants in epileptic encephalopathies, GENETICS IN MEDICINE, 2019 Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism, JOURNAL OF CLINICAL INVESTIGATION, 2017 Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3, MOLECULAR PSYCHIATRY, 2016 A viral strategy for targeting and manipulating interneurons across vertebrate species, NATURE NEUROSCIENCE, 2016 Acute brain slice methods for adult and aging animals: application of targeted patch clampanalysis and optogenetics, Methods in molecular biology (Clifton, N.J.), 2014 Imaging Neural Activity Using Thy1-GCaMP Transgenic Mice, NEURON, 2012 Fluorescent Labeling of Newborn Dentate Granule Cells in GAD67-GFP Transgenic Mice: A Genetic Tool for the Study of Adult Neurogenesis, PLOS ONE, 2010 CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling, JOURNAL OF NEUROSCIENCE, 2010 Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus, JOURNAL OF NEUROCHEMISTRY

Areas of Focus

孤独症大脑神经环路改变
孤独症和癫痫病的共病机制
孤独症的基因治疗

Publications

Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models, NEURON, 2021
Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells, ANESTHESIA AND ANALGESIA, 2021
An ultra-sensitive step-function opsin for minimally invasive optogenetic stimulation in mice and macaques, Neuron, 2020
Proliferator-Activated Receptor-Gamma Coactivator-1 alpha Haploinsufficiency Promotes Pain Chronification After Burn Injury, ANESTHESIA AND ANALGESIA, 2020
Dysfunction of Cortical GABAergic Neurons Leads to Sensory Hyper-reactivity in a Shank3 Mouse Model of ASD, NATURE NEUROSCIENCE, 2020
A Whole-Brain Cell-Type-Specific Sparse Neuron Labeling Method and Its Application in a Shank3 Autistic Mouse Model, FRONTIERS IN CELLULAR NEUROSCIENCE, 2020
Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice, NATURE NEUROSCIENCE, 2019
Evaluating the pathogenic potential of genes with de novo variants in epileptic encephalopathies, GENETICS IN MEDICINE, 2019
Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism, JOURNAL OF CLINICAL INVESTIGATION, 2017
Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3, MOLECULAR PSYCHIATRY, 2016
A viral strategy for targeting and manipulating interneurons across vertebrate species, NATURE NEUROSCIENCE, 2016
Acute brain slice methods for adult and aging animals: application of targeted patch clampanalysis and optogenetics, Methods in molecular biology (Clifton, N.J.), 2014
Imaging Neural Activity Using Thy1-GCaMP Transgenic Mice, NEURON, 2012
Fluorescent Labeling of Newborn Dentate Granule Cells in GAD67-GFP Transgenic Mice: A Genetic Tool for the Study of Adult Neurogenesis, PLOS ONE, 2010
CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling, JOURNAL OF NEUROSCIENCE, 2010
Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus, JOURNAL OF NEUROCHEMISTRY

孤独症神经环路大脑癫痫共病基因治疗神经科学神经发育行为科学遗传学

李翔 - 武汉大学

Area of Focus
表观遗传学 | 大脑 | 认知科学 | 恐惧记忆 | 机制 | 研究 | 神经科学 | 治疗 | 精神疾病 | 药理学

陈治标 - 武汉大学

Area of Focus
脑血管 | 临床研究 | 基础研究 | 大脑 | 疾病 | 病理学 | 治疗 | 神经外科 | 血管 | 神经科学 | 脑肿瘤 | 肿瘤学 | 胶质瘤 | 肿瘤生长 | 癌症治疗

蔡强 - 武汉大学

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