Areas of Focus
- 孤独症大脑神经环路改变
- 孤独症和癫痫病的共病机制
- 孤独症的基因治疗
Work Experience
- 2022-01~现在 - 中国科学院上海药物研究所/中科中山药物创新研究院, 研究员/课题组长/博士生导师
- 2014-04~2022-01 - 美国麻省理工学院麦戈文脑科学研究所, 研究型科学家
- 2010-08~2014-03 - 美国麻省理工学院麦戈文脑科学研究所, 博士后
- 2008-05~2010-08 - 美国杜克大学神经生物系, 博士后
- 2007-07~2008-05 - 中国科学院上海生命科学研究院神经科学研究所, 助理研究员
Academic Background & Achievements
- 2003-09--2007-07 博士学位: 中国科学院上海生命科学研究院神经科学研究所
- 2000-09--2003-06 硕士学位: 中南大学湘雅医学院
- 1995-09--2000-06 医学学士学位: 中南大学湘雅医学院
Publications
- Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models, NEURON, 2021
- Gut Microbiota Influences Neuropathic Pain Through Modulating Proinflammatory and Anti-inflammatory T Cells, ANESTHESIA AND ANALGESIA, 2021
- An ultra-sensitive step-function opsin for minimally invasive optogenetic stimulation in mice and macaques, Neuron, 2020
- Proliferator-Activated Receptor-Gamma Coactivator-1 alpha Haploinsufficiency Promotes Pain Chronification After Burn Injury, ANESTHESIA AND ANALGESIA, 2020
- Dysfunction of Cortical GABAergic Neurons Leads to Sensory Hyper-reactivity in a Shank3 Mouse Model of ASD, NATURE NEUROSCIENCE, 2020
- A Whole-Brain Cell-Type-Specific Sparse Neuron Labeling Method and Its Application in a Shank3 Autistic Mouse Model, FRONTIERS IN CELLULAR NEUROSCIENCE, 2020
- Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice, NATURE NEUROSCIENCE, 2019
- Evaluating the pathogenic potential of genes with de novo variants in epileptic encephalopathies, GENETICS IN MEDICINE, 2019
- Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism, JOURNAL OF CLINICAL INVESTIGATION, 2017
- Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3, MOLECULAR PSYCHIATRY, 2016
- A viral strategy for targeting and manipulating interneurons across vertebrate species, NATURE NEUROSCIENCE, 2016
- Acute brain slice methods for adult and aging animals: application of targeted patch clampanalysis and optogenetics, Methods in molecular biology (Clifton, N.J.), 2014
- Imaging Neural Activity Using Thy1-GCaMP Transgenic Mice, NEURON, 2012
- Fluorescent Labeling of Newborn Dentate Granule Cells in GAD67-GFP Transgenic Mice: A Genetic Tool for the Study of Adult Neurogenesis, PLOS ONE, 2010
- CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling, JOURNAL OF NEUROSCIENCE, 2010
- Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus, JOURNAL OF NEUROCHEMISTRY
Awards
- 美国国家基金（NSF)项目奖 (2020): 一等奖, 国家级
- 神经科学学会（SFN）第六届朱利叶斯·阿克塞尔罗德讲座旅行奖 (2012): 一等奖, 其他
- 第九届九源奖学金 (2008): 三等奖, 市地级
- 中国科学院优秀博士毕业生 (2007): 一等奖, 研究所（学校）
- 宝洁奖 (2007): 一等奖, 市地级
