Areas of Focus
- Pathology and Pathophysiology - Nutrition and Metabolic Regulation
- Physiology - Nutrition and Metabolic Regulation
Work Experience
- 2018-01 to present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Researcher, Academic Deputy Director
- 2008-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Director
- 2007-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Executive Deputy Director
- 2006-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Deputy Director
- 2004-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Researcher, Doctoral Supervisor
- 1998-07 to present - Indiana University, Department of Medicine and Molecular Genetics - Assistant Professor, Associate Professor
- 1996-07 to present - Salk Institute, USA - Postdoctoral Fellow
- 1994-07 to present - University of California, San Diego - Postdoctoral Fellow
Academic Background & Achievements
- 1989-09 - Ph.D.: Indiana University
- 1983-09 - Master's: West China University of Medical Sciences
- 1978-09 - Bachelor's: West China University of Medical Sciences
Publications
- Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern, Yan Chen, 2024
- Lactate transported by MCT1 plays an active role in promoting mitochondrial biogenesis and enhancing TCA flux in skeletal muscle, Yan Chen, 2024
- Intermittent protein restriction improves glucose homeostasis in Zucker diabetic fatty rats and single-cell sequencing reveals distinct changes in β cells, Yan Chen, 2023
- Monocarboxylate transporter 1 in the liver modulates high-fat diet-induced obesity and hepatic steatosis in mice, Yan Chen, 2023
- Intermittent Caloric Restriction Promotes Erythroid Development and Ameliorates Phenylhydrazine-Induced Anemia in Mice, Yan Chen, 2022
- Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue, Yan Chen, 2022
- Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation, Yan Chen, 2022
- Intermittent protein restriction protects islet β cells and improves glucose homeostasis in diabetic mice, Yan Chen, 2022
- A cross-sectional study across ten areas in China, Yan Chen, 2022
- Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis, Yan Chen, 2021
- PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα, Yan Chen, 2021
- PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis, Yan Chen, 2021
- Gut Microbiota Composition is Associated with Responses to Peanut Intervention in Multiple Parameters Among Adults with Metabolic Syndrome Risk, Yan Chen, 2021
- Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D, Yan Chen, 2021
- Intermittent administration of a fasting-mimicking diet reduces intestinal inflammation and promotes repair to ameliorate inflammatory bowel disease in mice, Yan Chen, 2021
- PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy, Yan Chen, 2020
- PAQR9 Modulates BAG6-mediated protein quality control of mislocalized membrane proteins, Yan Chen, 2020
- Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers, Yan Chen, 2020
- PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9, Yan Chen, 2019
- Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1, Yan Chen, 2018
- PAQR3 Regulates Endoplasmic Reticulum-to-Golgi Trafficking of COPII Vesicle via Interaction with Sec13/Sec31 Coat Proteins, Yan Chen, 2018
- PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation, Yan Chen, 2018
Awards
- Tan Jiazhen Life Science Award (2011): Ministerial level
- Outstanding Entrepreneurship Award for Overseas Chinese Professionals in Shanghai (2010): Municipal level
- Outstanding Graduate Student Supervisor Award, Chinese Academy of Sciences (2009): Institutional level
- Meiji Dairy Science Award (2006): Other
