Professor | Yan Chen | Asia Growth Partners

Name	Yan Chen
Contact Information	ychen3@sibs.ac.cn
Language ability	English, Chinese
Province	Shanghai

Name

Yan Chen

Contact Information

ychen3@sibs.ac.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1989-09 - Ph.D.: Indiana University 1983-09 - Master's: West China University of Medical Sciences 1978-09 - Bachelor's: West China University of Medical Sciences
Work Experience	2018-01 to present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Researcher, Academic Deputy Director 2008-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Director 2007-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Executive Deputy Director 2006-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Deputy Director 2004-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Researcher, Doctoral Supervisor 1998-07 to present - Indiana University, Department of Medicine and Molecular Genetics - Assistant Professor, Associate Professor 1996-07 to present - Salk Institute, USA - Postdoctoral Fellow 1994-07 to present - University of California, San Diego - Postdoctoral Fellow
Awards	Tan Jiazhen Life Science Award (2011): Ministerial level Outstanding Entrepreneurship Award for Overseas Chinese Professionals in Shanghai (2010): Municipal level Outstanding Graduate Student Supervisor Award, Chinese Academy of Sciences (2009): Institutional level Meiji Dairy Science Award (2006): Other

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1989-09 - Ph.D.: Indiana University
1983-09 - Master's: West China University of Medical Sciences
1978-09 - Bachelor's: West China University of Medical Sciences

Work Experience

2018-01 to present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Researcher, Academic Deputy Director
2008-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Director
2007-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Executive Deputy Director
2006-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Deputy Director
2004-07 to present - Shanghai Institute of Nutrition, Chinese Academy of Sciences - Researcher, Doctoral Supervisor
1998-07 to present - Indiana University, Department of Medicine and Molecular Genetics - Assistant Professor, Associate Professor
1996-07 to present - Salk Institute, USA - Postdoctoral Fellow
1994-07 to present - University of California, San Diego - Postdoctoral Fellow

Awards

Tan Jiazhen Life Science Award (2011): Ministerial level
Outstanding Entrepreneurship Award for Overseas Chinese Professionals in Shanghai (2010): Municipal level
Outstanding Graduate Student Supervisor Award, Chinese Academy of Sciences (2009): Institutional level
Meiji Dairy Science Award (2006): Other

Areas of Focus	Pathology and Pathophysiology - Nutrition and Metabolic Regulation Physiology - Nutrition and Metabolic Regulation
Publications	Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern, Yan Chen, 2024 Lactate transported by MCT1 plays an active role in promoting mitochondrial biogenesis and enhancing TCA flux in skeletal muscle, Yan Chen, 2024 Intermittent protein restriction improves glucose homeostasis in Zucker diabetic fatty rats and single-cell sequencing reveals distinct changes in β cells, Yan Chen, 2023 Monocarboxylate transporter 1 in the liver modulates high-fat diet-induced obesity and hepatic steatosis in mice, Yan Chen, 2023 Intermittent Caloric Restriction Promotes Erythroid Development and Ameliorates Phenylhydrazine-Induced Anemia in Mice, Yan Chen, 2022 Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue, Yan Chen, 2022 Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation, Yan Chen, 2022 Intermittent protein restriction protects islet β cells and improves glucose homeostasis in diabetic mice, Yan Chen, 2022 A cross-sectional study across ten areas in China, Yan Chen, 2022 Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis, Yan Chen, 2021 PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα, Yan Chen, 2021 PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis, Yan Chen, 2021 Gut Microbiota Composition is Associated with Responses to Peanut Intervention in Multiple Parameters Among Adults with Metabolic Syndrome Risk, Yan Chen, 2021 Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D, Yan Chen, 2021 Intermittent administration of a fasting-mimicking diet reduces intestinal inflammation and promotes repair to ameliorate inflammatory bowel disease in mice, Yan Chen, 2021 PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy, Yan Chen, 2020 PAQR9 Modulates BAG6-mediated protein quality control of mislocalized membrane proteins, Yan Chen, 2020 Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers, Yan Chen, 2020 PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9, Yan Chen, 2019 Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1, Yan Chen, 2018 PAQR3 Regulates Endoplasmic Reticulum-to-Golgi Trafficking of COPII Vesicle via Interaction with Sec13/Sec31 Coat Proteins, Yan Chen, 2018 PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation, Yan Chen, 2018

Areas of Focus

Pathology and Pathophysiology - Nutrition and Metabolic Regulation
Physiology - Nutrition and Metabolic Regulation

Publications

Intestinal monocarboxylate transporter 1 mediates lactate transport in the gut and regulates metabolic homeostasis of mouse in a sex-dimorphic pattern, Yan Chen, 2024
Lactate transported by MCT1 plays an active role in promoting mitochondrial biogenesis and enhancing TCA flux in skeletal muscle, Yan Chen, 2024
Intermittent protein restriction improves glucose homeostasis in Zucker diabetic fatty rats and single-cell sequencing reveals distinct changes in β cells, Yan Chen, 2023
Monocarboxylate transporter 1 in the liver modulates high-fat diet-induced obesity and hepatic steatosis in mice, Yan Chen, 2023
Intermittent Caloric Restriction Promotes Erythroid Development and Ameliorates Phenylhydrazine-Induced Anemia in Mice, Yan Chen, 2022
Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue, Yan Chen, 2022
Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation, Yan Chen, 2022
Intermittent protein restriction protects islet β cells and improves glucose homeostasis in diabetic mice, Yan Chen, 2022
A cross-sectional study across ten areas in China, Yan Chen, 2022
Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis, Yan Chen, 2021
PAQR9 regulates hepatic ketogenesis and fatty acid oxidation during fasting by modulating protein stability of PPARα, Yan Chen, 2021
PAQR11 modulates monocyte-to-macrophage differentiation and pathogenesis of rheumatoid arthritis, Yan Chen, 2021
Gut Microbiota Composition is Associated with Responses to Peanut Intervention in Multiple Parameters Among Adults with Metabolic Syndrome Risk, Yan Chen, 2021
Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D, Yan Chen, 2021
Intermittent administration of a fasting-mimicking diet reduces intestinal inflammation and promotes repair to ameliorate inflammatory bowel disease in mice, Yan Chen, 2021
PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy, Yan Chen, 2020
PAQR9 Modulates BAG6-mediated protein quality control of mislocalized membrane proteins, Yan Chen, 2020
Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers, Yan Chen, 2020
PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9, Yan Chen, 2019
Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1, Yan Chen, 2018
PAQR3 Regulates Endoplasmic Reticulum-to-Golgi Trafficking of COPII Vesicle via Interaction with Sec13/Sec31 Coat Proteins, Yan Chen, 2018
PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation, Yan Chen, 2018

Pathology Pathophysiology Nutrition Metabolic Regulation Physiology Metabolism Health Disease Research Biology

Xin Xin Han - Southern University of Science and Technology

Hai Rao - Southern University of Science and Technology

Zhuo Wang - Southern University of Science and Technology

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