Upload Avatar (500 x 500)
Hai Rao
Medical School
Southern University of Science and Technology
Guangdong
Language: English, Chinese
Protein Homeostasis
Health
Disease
Ubiquitination
Protein Degradation
Cancer Therapy
Protein Stability
Aging
Neurodegenerative Diseases
Cellular Mechanisms
Areas of Focus
- Protein homeostasis and its impact on health and disease
- Mechanisms of protein degradation induced by ubiquitination and its regulation
- Development of new cancer therapies through protein stability manipulation
- Role of ubiquitination in aging and neurodegenerative diseases
Work Experience
- 1997 - 2002 Postdoctoral Researcher in Biology, California Institute of Technology
- 2002 - 2020 Assistant Professor, Associate Professor, Professor at University of Texas Health Center
- 2020 - Present Professor and Head of the Department of Biochemistry, Southern University of Science and Technology
Academic Background & Achievements
- 1985 - 1989 Bachelor of Chemistry, Wuhan University
- 1989 - 1991 Master of Chemistry, Boston University
- 1991 - 1996 PhD in Biochemistry, State University of New York at Stony Brook and Cold Spring Harbor Laboratory
Publications
- Synthesis and characterization of a 29-amino acid residue DNA-binding peptide derived from a/b-type small acid soluble spore proteins (SASP) of bacteria, Rao, H., Mohr, S.C., Fairhead, H. and Setlow, P., 1992
- The replicon model and eukaryotic chromosomes, Bell, S.P., Marhrens, Y., Rao, H. and Stillman, B., 1993
- Functional conservation of modular elements in yeast chromosomal replicators, Rao, H., Marhrens, Y. and Stillman, B., 1994
- The origin recognition complex (ORC) interacts with a bipartite DNA binding site within yeast replicators, Rao, H. and Stillman, B., 1995
- Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability, Rao, H., Uhlmann, F., Nasmyth, K. and Varshavsky, A., 2001
- Recognition of specific ubiquitin conjugates is important for the proteolytic functions of the UBA domain proteins Dsk2 and Rad23, Rao, H.* and Sastry, A., 2002
- Multiple interactions of Rad23 suggest a mechanism for ubiquitylated substrate delivery important in proteolysis, Kim, I., Mi, K. and Rao, H., 2004
- Analysis of Ub-binding proteins by yeast two-hybrid, Apodaca, J., Ahn, J.M., Kim, I. and Rao, H., 2005
- The Png1-Rad23 complex regulates glycoprotein turnover, Kim, I., Ahn, J., Liu, C., Tanabe, K., Apodaca, J., Suzuki, T. and Rao H., 2006
- What’s Ub chain linkage got to do with it?, Kim, I. and Rao, H., 2006
- Cellular tolerance of prion in yeast requires the unfolded protein response and proteolysis, Apodaca, J., Kim, I. and Rao, H., 2006
- Proteasome inhibition in wild-type yeast Saccharomyces cerevisiae cells, Liu, C., Apodaca, J., Davis, L.E. and Rao, H., 2007
- A genome-wide synthetic dosage lethality screen reveals multiple pathways that require the functioning of Ub-binding proteins Rad23 and Dsk2, Liu, C., van Dyk, D., Li, Y., Andrews, B. and Rao, H., 2009
- Usa1 protein facilitates substrate ubiquitylation through two separate domains, Kim, I., Li, Y., Muniz, P. and Rao, H., 2009
- Rad4 regulates protein turnover at a postubiquitylation step, Li, Y., Yan, J., Kim, I., Liu, C., Huo, K. and Rao, H., 2010
- Degradation of misfolded secretory and membrane proteins and associated diseases, Kim, I., and Rao, H., 2010
- Ubiquitin chain elongation enzyme Ufd2 regulates a subset of Doa10 substrates, Liu, C., van Dyk, D., Xu, P., Choe, V., Pan, H., Peng, J., Andrews, B. and Rao, H., 2010
- Identification of an Htm1 (EDEM)- dependent, Mns1-independent Endoplasmic Reticulum-associated Degradation (ERAD) pathway in Saccharomyces cerevisiae: application of a novel assay for glycoprotein ERAD, Hosomi, A., Tanabe, K., Hiryama, H., Kim, I., Rao, H. and Suzuki, T., 2010
- Genome-wide approaches to systematically identify substrates of the ubiquitin-proteasome pathway, Liu, C., Choe, V. and Rao, H., 2010
- A newly identified Pirh2 substrate SCYL-1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination, Yan, J., Zhang, D., Di, Y., Shi, H., Rao, H. and Huo, K., 2010
- Overexpression of SCYL1-BP1 stabilizes functional p53 suppressing MDM2-mediated ubiquitination, Yan, J., Di, Y., Shi, H., Rao, H. and Huo K., 2010
- The Cdc48 ATPase modulates the interaction between two proteolytic factors Ufd2 and Rad23, Baek, G.H., Kim, I., and Rao, H., 2011
- Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase, Liu, C., van Dyk, D., Choe, V., Yan, J., Majumder, S., Costanzo, M., Bao, B., Boone, C., Huo, K. Winey, M., Fisk, H., Andrews, B. and Rao, H., 2011
- The Cdc48 and its cofactor Vms1 are involved in Cdc13 protein degradation, Baek, G.H., Cheng, H., Kim, I., and Rao, H., 2012
- Cdc48, a swiss army knife of cell biology, Baek, G.H., Cheng, H., Choe, V., Bao, X., Shao, J., Luo, S., and Rao, H., 2013
- XPC promotes MDM2-mediated degradation of the p53 tumor suppressor, Krzeszinski, J., Choe, V., Shao, J., Bao, X., Cheng, H., Luo, S., Huo, K., and Rao, H., 2014
- Unglycosylated prion PrP for ubiquitylation and degradation, Shao, J., Choe, V., Cheng, H., Tsai, C., Weissman, A., Luo , S. Rao, H., 2014
- Down-regulation of Gli transcription factor leads to the inhibition of migration and invasion of ovarian cancer cells via integrin β4-mediated FAK signaling, Chen, Q., Xu, R., Zeng, C., Lu, Q., Huang, D, Shi, C., Yan, R., Zhang, W., Deng, L., Rao, H., Gao, G., Luo, S., 2014
- Heat shock protein 90 beta stabilizes Focal Adhesion Kinase and enhances cell migration and invasion in breast cancer cells, Xiong, X., Wang, Y., Liu, C., Lu, Q., Liu, T. Chen, G., Rao, H., Luo, S., 2014
- Rad25 protein is targeted for degradation by the Ubc4-Ufd4 pathway, Bao, X., Johnson, J., and Rao, H., 2015
- Inhibition of Hedgehog signaling pathway impedes cancer cell proliferation by promotion of autophagy, Tang, X., Deng, L., Chen, Q, Wang, Y., Xu, R., Shi, C., Shao, J., Hu, G., Gao, M., Rao, H., Luo, S., Lu, Q., 2015
- Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy, Klionsky, A. et al., 2016
- The F box protein Rcy1 is involved in the degradation of Histone variant Cse4 and genome maintenance, Cheng, H., Bao, X., and Rao, H, 2016
- Nek2A phosphorylates and stabilizes SuFu: A new strategy of Gli2/Hedgehog signaling regulatory mechanism, Wang Y, Li Y, Hu G, Huang X, Rao H, Xiong X, Luo Z, Lu Q, Luo S., 2016
- Nek2A/SuFu feedback loop regulates Gli- mediated Hedgehog signaling pathway, Zhou F, Huang
Awards
- 2006 Minority Institution Faculty Scholar Award from the American Cancer Society
- 1998-2001 Postdoctoral Award from the American Leukemia Foundation
- 1996 Doctoral Research Award from the State University of New York at Stony Brook
