Areas of Focus
- DNA Damage Response
- Neurodevelopment and Neurodegeneration
- Aging
- Neuroregeneration
Work Experience
- 2019-02~Present - Chinese Academy of Sciences, Institute of Zoology - Associate Researcher
- 2010-10~2019-02 - Chinese Academy of Sciences, Institute of Zoology - Assistant Researcher
- 2008-09~2010-08 - Forschungszentrum Jülich - Postdoctoral Researcher
- 2005-09~2008-06 - Lanzhou University - PhD
Academic Background & Achievements
- 2005-09--2008-06 PhD: Lanzhou University
Publications
- Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease, Second Author, 2024
- Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration, Fifth Author, 2023
- Restoring carboxypeptidase E rescues BDNF maturation and neurogenesis in aged brains, First Author, 2023
- ER Ca 2+ overload activates the IRE1 signaling and promotes cell survival, Eighth Author, 2023
- Ca2+ maintained by TMCO1 underlies corpus callosum development via ERK signaling, Eleventh Author, 2022
- Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases, Sixth Author, 2022
- Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation, Fourth Author, 2022
- BMP4 Exerts Anti-Neurogenic Effect via Inducing Id3 during Aging, Second Author, 2022
- Miro2 supplies a platform for Parkin translocation to damaged mitochondria, Eleventh Author, 2019
- Epigenetic profiles in polyglutamine disorders, First Author, 2018
- Parkin Regulates Translesion DNA Synthesis in Response to UV Radiation, Fifth Author, 2017
- RBM45 competes with HDAC1 for binding to FUS in response to DNA damage, Fifth Author, 2017
- Ataxin-3 promotes genome integrity by stabilizing Chk1., Second Author, 2017
- Pol O-GlcNAcylation Governs Genome Integrity During Translesion DNA Synthesis, Second Author, 2017
- The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53., First Author, 2016
- Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance, Second Author, 2015
- Transcriptomic Analyses of Neurotoxic Effects in Mouse Brain After Intermittent Neonatal Administration of Thimerosal, Fifth Author, 2014
- Mismatch Repair Protein MSH2 Regulates Translesion DNA Synthesis Following Exposure of Cells to UV Radiation, Sixth Author, 2013
- Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling, Sixth Author, 2008
- Type 1 Diabetes attenuates the modulatory effects of endomorphins on mouse colonic motility, Not mentioned, 2008
- Differential cardiovascular effects of synthetic peptides derived from endomorphin-1 in anesthetized rats, First Author, 2008
- In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: Evidence for the important role of proper spatial disposition of the third aromatic ring, Fourth Author, 2007
- Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: Design, synthesis, and pharmacological characterization, First Author, 2007
- Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1, First Author, 2006
- C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats, Not mentioned, 2006
- Cardiovascular effects of endomorphins in alloxan-induced diabetic rats, Not mentioned, 2005
Awards
- Gansu Province Technology Invention Award (2012): First Prize, Provincial Level
- Gansu Province Science and Technology Progress Award (2012): Second Prize, Provincial Level
- Gansu Province Pharmaceutical Development Award (2010): First Prize, Provincial Level
