Professor | Hongmei Liu | Asia Growth Partners

Name	Hongmei Liu
Contact Information	liuhongmei@ioz.ac.cn
Language ability	Chinese, English, German
Province	Beijing

Name

Hongmei Liu

Contact Information

liuhongmei@ioz.ac.cn

Language ability

Chinese, English, German

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2005-09--2008-06 PhD: Lanzhou University
Work Experience	2019-02~Present - Chinese Academy of Sciences, Institute of Zoology - Associate Researcher 2010-10~2019-02 - Chinese Academy of Sciences, Institute of Zoology - Assistant Researcher 2008-09~2010-08 - Forschungszentrum Jülich - Postdoctoral Researcher 2005-09~2008-06 - Lanzhou University - PhD
Awards	Gansu Province Technology Invention Award (2012): First Prize, Provincial Level Gansu Province Science and Technology Progress Award (2012): Second Prize, Provincial Level Gansu Province Pharmaceutical Development Award (2010): First Prize, Provincial Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2005-09--2008-06 PhD: Lanzhou University

Work Experience

2019-02~Present - Chinese Academy of Sciences, Institute of Zoology - Associate Researcher
2010-10~2019-02 - Chinese Academy of Sciences, Institute of Zoology - Assistant Researcher
2008-09~2010-08 - Forschungszentrum Jülich - Postdoctoral Researcher
2005-09~2008-06 - Lanzhou University - PhD

Awards

Gansu Province Technology Invention Award (2012): First Prize, Provincial Level
Gansu Province Science and Technology Progress Award (2012): Second Prize, Provincial Level
Gansu Province Pharmaceutical Development Award (2010): First Prize, Provincial Level

Areas of Focus	DNA Damage Response Neurodevelopment and Neurodegeneration Aging Neuroregeneration
Publications	Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease, Second Author, 2024 Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration, Fifth Author, 2023 Restoring carboxypeptidase E rescues BDNF maturation and neurogenesis in aged brains, First Author, 2023 ER Ca 2+ overload activates the IRE1 signaling and promotes cell survival, Eighth Author, 2023 Ca2+ maintained by TMCO1 underlies corpus callosum development via ERK signaling, Eleventh Author, 2022 Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases, Sixth Author, 2022 Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation, Fourth Author, 2022 BMP4 Exerts Anti-Neurogenic Effect via Inducing Id3 during Aging, Second Author, 2022 Miro2 supplies a platform for Parkin translocation to damaged mitochondria, Eleventh Author, 2019 Epigenetic profiles in polyglutamine disorders, First Author, 2018 Parkin Regulates Translesion DNA Synthesis in Response to UV Radiation, Fifth Author, 2017 RBM45 competes with HDAC1 for binding to FUS in response to DNA damage, Fifth Author, 2017 Ataxin-3 promotes genome integrity by stabilizing Chk1., Second Author, 2017 Pol O-GlcNAcylation Governs Genome Integrity During Translesion DNA Synthesis, Second Author, 2017 The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53., First Author, 2016 Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance, Second Author, 2015 Transcriptomic Analyses of Neurotoxic Effects in Mouse Brain After Intermittent Neonatal Administration of Thimerosal, Fifth Author, 2014 Mismatch Repair Protein MSH2 Regulates Translesion DNA Synthesis Following Exposure of Cells to UV Radiation, Sixth Author, 2013 Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling, Sixth Author, 2008 Type 1 Diabetes attenuates the modulatory effects of endomorphins on mouse colonic motility, Not mentioned, 2008 Differential cardiovascular effects of synthetic peptides derived from endomorphin-1 in anesthetized rats, First Author, 2008 In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: Evidence for the important role of proper spatial disposition of the third aromatic ring, Fourth Author, 2007 Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: Design, synthesis, and pharmacological characterization, First Author, 2007 Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1, First Author, 2006 C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats, Not mentioned, 2006 Cardiovascular effects of endomorphins in alloxan-induced diabetic rats, Not mentioned, 2005

Areas of Focus

DNA Damage Response
Neurodevelopment and Neurodegeneration
Aging
Neuroregeneration

Publications

Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease, Second Author, 2024
Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration, Fifth Author, 2023
Restoring carboxypeptidase E rescues BDNF maturation and neurogenesis in aged brains, First Author, 2023
ER Ca 2+ overload activates the IRE1 signaling and promotes cell survival, Eighth Author, 2023
Ca2+ maintained by TMCO1 underlies corpus callosum development via ERK signaling, Eleventh Author, 2022
Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases, Sixth Author, 2022
Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation, Fourth Author, 2022
BMP4 Exerts Anti-Neurogenic Effect via Inducing Id3 during Aging, Second Author, 2022
Miro2 supplies a platform for Parkin translocation to damaged mitochondria, Eleventh Author, 2019
Epigenetic profiles in polyglutamine disorders, First Author, 2018
Parkin Regulates Translesion DNA Synthesis in Response to UV Radiation, Fifth Author, 2017
RBM45 competes with HDAC1 for binding to FUS in response to DNA damage, Fifth Author, 2017
Ataxin-3 promotes genome integrity by stabilizing Chk1., Second Author, 2017
Pol O-GlcNAcylation Governs Genome Integrity During Translesion DNA Synthesis, Second Author, 2017
The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53., First Author, 2016
Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance, Second Author, 2015
Transcriptomic Analyses of Neurotoxic Effects in Mouse Brain After Intermittent Neonatal Administration of Thimerosal, Fifth Author, 2014
Mismatch Repair Protein MSH2 Regulates Translesion DNA Synthesis Following Exposure of Cells to UV Radiation, Sixth Author, 2013
Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling, Sixth Author, 2008
Type 1 Diabetes attenuates the modulatory effects of endomorphins on mouse colonic motility, Not mentioned, 2008
Differential cardiovascular effects of synthetic peptides derived from endomorphin-1 in anesthetized rats, First Author, 2008
In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: Evidence for the important role of proper spatial disposition of the third aromatic ring, Fourth Author, 2007
Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: Design, synthesis, and pharmacological characterization, First Author, 2007
Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1, First Author, 2006
C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats, Not mentioned, 2006
Cardiovascular effects of endomorphins in alloxan-induced diabetic rats, Not mentioned, 2005

Dna Repair Neurogenesis Neurodegenerative Diseases Aging Neuroregeneration Cell Survival Chromatin Remodeling Memory Deficits Hippocampal Neurogenesis Bdnf Maturation

Hai Rao - Southern University of Science and Technology

Yu Fu - University of Chinese Academy of Sciences

Hai-Liang Hu - Southern University of Science and Technology

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