Bachelor and Master: Nanjing University, Biochemistry
PhD: SUNY at Buffalo, Anatomy and Cell Biology
Postdoctoral Training: UNC-Chapel Hill, Neuroscience Center
2005-2022 - Johns Hopkins University School of Medicine - Assistant Professor, Associate Professor, Full Professor
2022-Present - Zhejiang University - Qiushi Chair Professor, Director of the Neuroregeneration Translational Center
Research
Central Nervous System Injury, Repair, and Regeneration Maturation and Aging of Neural Cells, Cellular Reprogramming Mechanisms and Treatment of Neurodegenerative Diseases Epigenetic and Cellular Biological Regulation of Neural Development Single-cell Omics, Big Data Analysis, and High-definition Tissue 3D Imaging
Focal loss of actin bundles causes microtubule redistribution and growth cone turning, Zhou F-Q, Waterman-Storer CM, Cohan CS, 2002
NGF-induced axon growth is mediated by localized inactivation of GSK-3β and functions of the microtubule plus end binding protein, APC, Zhou F-Q, Zhou J, Dedhar S, Wu Y-H, Snider WD, 2004
GSK-3β and microtubule assembly in axons, Zhou F-Q, Snider WD, 2005
Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin independent mechanism, Zhou F-Q, Walzer MA, Wu Y-H, Zhou J, Dedhar S, Snider WD, 2006
Essential roles for GSK-3s and GSK-3 primed substrates in neurotrophin-induced and hippocampal axon growth, Kim W-Y, Zhou F-Q, Zhou J, Wang Y-M, Yoshimura T, Kaibuchi K, Woodgett J, Snider WD, 2006
Inactivation of Glycogen Synthase Kinase 3 promotes axonal growth and recovery in the CNS, Dill J, Wang H, Zhou F-Q, Li S, 2008
GSK3 signaling in neural development, Hur E-M, Zhou F-Q, 2010
Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules, Hur E-M, Yang I-H, Kim DH, Byun J, Saijilafu, Xu W-L, Nicovich PR, Cheong R, Levchenko A, Thakor N, Zhou F-Q, 2011
GSK3 controls axon growth via CLASP-mediated regulation of growth cone microtubules, Hur E-M, Saijilafu, Lee BD, Kim SJ, Xu W-L, Zhou F-Q, 2011
Genetic dissection of axon regeneration via in vivo electroporation of mouse adult sensory neurons, Saijilafu, Hur E-M, Zhou F-Q, 2011
Growing the growth cone: remodelling the cytoskeleton to promote axon regeneration, Hur E-M, Saijilafu, Zhou F-Q, 2011
PI3K-GSK3 pathway regulates mammalian axon regeneration by induction of Smad1, Saijilafu, Hur E-M, Liu C-M, Jiao Z-X, Xu W-L, Zhou F-Q, 2013
MicroRNA-138 and Sirt1 form a mutual negative feedback loop to regulate axon regeneration, Liu C-M, Wang R-Y, Saijilafu, Jiao Z, Zhang B-Y, Zhou F-Q, 2013
Minimum information about a spinal cord injury experiment (MIASCI) - a proposed reporting standard for spinal cord injury experiments, Lemmon et al., 2014
MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression, Jiang J, Liu C-M, Zhang B-Y, Wang XW, Zhang M, Saijilafu, Zhang S-R, Hall P, Hu Y-W, Zhou F-Q, 2015
Report on the National Eye Institute Audacious Goals Initiative: Regenerating the Optic Nerve, Goldberg et al., 2016
Coupled activation of primary sensory neurons contributes to chronic pain, Kim YS, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, Saijilafu, Young L, He S, LaVinka PC, Zhou F-Q, Bergles D, Hanani M, Guan Y, Spray DC, Dong X, 2016
NGF-TrkA signaling by sensory nerves coordinates vascularization and ossification of developing endochondral bone, Tomlinson RE, Li Z, Zhang Q, Goh BC, Li Z, Thorek DL, Rajbhandari L, Brushart TM, Minihiello L, Zhou F-Q, Venkatesan A, Clemens TL, 2016
AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons, Gorshkov K, Mehta S, Ramamurthy S, Ronnett GV, Zhou F-Q, Zhang J, 2016
The histone H3K27 demethylase UTX regulates synaptic plasticity and cognitive behaviour in mice, Tang G-B, Zeng Y-Q, Liu P-P, Mi T-W, Zhang S-F, Dai S-K, Tang Q-Y, Yang L, Xu Y-J, Yan H-L, Du H-Z, Teng Z-Q, Zhou F-Q, Liu C-M, 2017
Programmed cell senescence in skeleton during puberty, Li C-J, Chai Y, Wang L, Gao B, Chen H, Gao P, Zhou F-Q, Luo X, Crane JL, Yu B, Cao X, Wan M, 2017
Lin28 signaling supports mammalian PNS and CNS axon regeneration, Wang X-W, Li Q, Liu, C-M, Hall P, Jiang J-J, Liu C-M, Katchis CD, Kang S, Dong BC, Li S, Zhou F-Q, 2018
The telomerase reverse transcriptase (TERT) and p53 regulate mammalian PNS and CNS axon regeneration downstream of c-Myc, Ma J-J, Xu R-J, Ju X, Wang W-H, Luo Z-P, Liu C-M, Yang L, Li B, Chen J-Q, Meng B, Yang H-L, Zhou F-Q, Saijilafu, 2019
The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction, Costa AR, Sousa SC, Pinto-Costa R, Mateus JC, Lopes CDF, Rosa D, Machado D, Pajuelo L, Wang X-W, Zhou F-Q, Pereira AJ, Sampaio P, Rubinstein B, Pinto IM, Lampe M, Aguiar P, Sousa MM, 2020
Knocking out non-muscle myosin IIA/B in retinal ganglion cells promotes long distance optic nerve regeneration, Wang X-W, Yang S-G, Zhang C, Hu M-W, Qian J, Ma J-J, Zhang Y-C, Yang B-B, Weng Y-L, Ming -GL, Kosanam AR, Saijilafu, Zhou F-Q, 2020
Upregulating Lin28a promotes axon regeneration in adult mice with optic nerve and spinal cord injury, Nathan F, Ohtake Y, Wang S, Jiang X, Sami A, Guo H, Zhou F-Q, Li S, 2020
Updates and challenges of axon regeneration in the mammalian central nervous system, Qian C, Zhou F-Q, 2020
Strategies to promote long distance optic nerve regeneration, Yang S-G, Li C, Peng X, Teng Z, Liu C-M, Zhou F-Q, 2020
In Vivo Transdifferentiation for CNS Neuronal Replacement and Functional Recovery, Qian C, Dong BC, Wang X-Y, Zhou F-Q, 2020
N6-methyladenine DNA demethylase ALKBH1 regulates mammalian axon regeneration, Li Q, Qian C, Feng H, Lin T, Zhu Q, Huang Y, Zhou F-Q, 2021
Spatial transcriptomics reveals a role for sensory nerves in preserving cranial suture patency through modulation of BMP/TGFβ signaling, Tower RJ, Li Z, Cheng Y-H, Wang X-W, Rajbhandari L, Zhang Q, Negri S, Uytingco CR, Venkatesan A, Zhou F-Q, Cahan P, James AW, Clemens TL, 2021
Synchronized Cluster Firing, a distinct form of sensory neuron activation, drives Mediates Spontaneous Pain, Zheng Q, Xie W-R, Luckemeyer DD, Lay M, Wang X-W, Dong X, Limjunyawong N, Ye Y, Zhou F-Q, Strong J, Zhang J-M, Dong X, 2022
Reprogramming neurons for regeneration, the fountain of youth, Yang S-G, Wang X-W, Qian C, Zhou F-Q, 2022
LRLoop: Feedback loops as a design principle of cell-cell communications, Xin Y, Lyu P, Jiang J, Zhou F-Q, Wang J, Blackshaw S, Qian J, 2022
scRNA-sequencing reveals subtype-specific transctiptomic perturbations in DRG neurons of Pirt-EGFPf mice in neuropathic pain condition, Zhang C, Hu M-W, Wang X-W, Cui X, Liu J, Huang Q, Cao X, Zhou F-Q, Qian J, He S-Q, Guan Y, 2022
Neuronal histone methyltransferase EZH2 regulates neuronal morphogenesis, synaptic plasticity, and cognitive behavior, Zhang M, Zhang Y, Xu Q, Crawford J, Qian C, Wang G, Pletnikov MV, Qian J, Dong X, Liu C-M, Zhou F-Q, 2023
UCHL1 inhibited by A1 astrocytes facilitates aggregates clearance to promote neural stem cell activation after spinal cord injury, Ding L, Chu W, Xia Y, Shi M, Yuan X, Qiu J, Li T, Luo L, Zhou F-Q, Deng Y-B, 2023
