2004-09--2007-07 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1999-09--2002-07 Master's: Beijing Normal University
2016-10~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
2009-10~2016-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Associate Researcher
2005-06~2009-10 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher
2004-09~2007-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - PhD
2002-07~2005-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Research Intern
1999-09~2002-07 - Beijing Normal University - Master's
Pudong New Area Science and Technology Progress Award, Second Prize, City Level, 2018
Research
Pharmacology of Metabolic Diseases
Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism., Liver Int., 2024
Arctigenin induces activated HSCs quiescence via AMPK-PPAR�� pathway to ameliorate liver fibrosis in mice., Eur J Pharmacol., 2024
MiR-337-3p improves metabolic associated fatty liver disease through regulation of glycolipid metabolism., iScience., 2023
MiR-552-3p Regulates Multiple Fibrotic and Inflammatory Genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes., Int J Biol Sci., 2023
Identification of 3H-benzo[b] [1,4] diazepine derivatives as PPAR�� agonists by in silico studies and biochemical evaluation., J Biomol Struct Dyn., 2023
MicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage in db/db mice via STAT1/HMGCS1 axis, MOLECULAR BIOMEDICINE, 2022
Kupffer cells play a crucial role in monocrotaline-induced liver injury by producing TNF-alpha, TOXICOLOGY, 2022
Advances of microRNAs in regulating mitochondrial function: new potential application in NAFLD treatment, MOLECULAR BIOLOGY REPORTS, 2022
miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder, JOURNAL OF HEPATOLOGY, 2021
MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice, METABOLISM-CLINICAL AND EXPERIMENTAL, 2021
Role of microRNAs in the process of metformin treating multiple diseases, FRIGID ZONE MEDICINE, 2021
GADD45�� stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation, PHARMACOLOGICAL RESEARCH, 2021
New PCSK9 inhibitor miR-552-3p reduces LDL-C via enhancing LDLR in high fat diet-fed mice, PHARMACOLOGICAL RESEARCH, 2021
热休克蛋白HSP72与非酒精性脂肪性肝病关系的研究进展, 生命科学, 2020
PCSK9与多种代谢相关疾病发生发展关系的研究进展, 中国新药杂志, 2020
Design, synthesis and biological evaluation of vincamine derivatives as potential pancreatic beta-cells protective agents for the treatment of type 2 diabetes mellitus, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020
MiR-629-5p promotes the invasion of lung adenocarcinoma via increasing both tumor cell invasion and endothelial cell permeability, ONCOGENE, 2020
Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice, JOURNAL OF ENDOCRINOLOGY, 2019
Nitazoxanide,an anti-parasitic drug,efficiently ameliorates learning and memory impairments in AD model mice, ACTA PHARMACOLOGICA SINICA, 2019
Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression, CELLULAR AND MOLECULAR LIFE SCIENCES, 2019
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice, ACTA PHARMACOLOGICA SINICA, 2019
(5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice, LIFE SCIENCES, 2019
新型非酒精性脂肪性肝炎小鼠模型的建立, 中国兽医杂志, 2019
ETA as a novel Kv2.1 inhibitor ameliorates beta-cell dysfunction and hyperglycaemia, CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2018
Discovery and structure-activity relationships study of thieno2,3-bpyridine analogues as hepatic gluconeogenesis inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018
TSPA as a novel ATF6 alpha translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018
The dual-inhibitory effect of miR-338-5p on the multidrug resistance and cell growth of hepatocellular carcinoma, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2018
非酒精性脂肪肝病的易感基因及与2型糖尿病相关性的研究进展, 中国药科大学学报, 2018
MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth, PLOS GENETICS, 2017
Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017
Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187, PHYTOCHEMISTRY LETTERS, 2017
DMT efficiently inhibits hepatic gluconeogenesis by regulating the G alpha q signaling pathway, JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2017
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017
The miR-491-3p/Sp3/ABCB1 axis attenuates multidrug resistance of hepatocellular carcinoma, CANCER LETTERS, 2017
Cytosporone derivatives from the endophytic fungus Phomopsis sp. PSU-H188, PHYTOCHEMISTRY LETTERS, 2017
beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123, TETRAHEDRON, 2016
Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening, EUROPEANJOURNALOFMEDICINALCHEMISTRY, 2016
SP6616 as a new Kv2.1 channel inhibitor efficiently promotes ��-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways., Cell Death Dis., 2016
Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha) in Stabilizing the Homodimerization of the Receptor, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015
BBT improves glucose homeostasis by ameliorating beta-cell dysfunction in type 2 diabetic mice, JOURNAL OF ENDOCRINOLOGY, 2015
Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells, ACTA PHARMACOLOGICA SINICA, 2015
基于能量代谢调控机制新型运动模拟剂的发现研究, 2015-01-01
Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways, ACTA PHARMACOLOGICA SINICA, 2014
Identification of novel thiadiazoloacrylamide analogues as inhibitors of dengue-2 virus NS2B/NS3 protease, BIOORGANIC & MEDICINAL CHEMISTRY, 2014
Novel approaches to drug discovery for the treatment of type 2 diabetes, EXPERT OPINION
