Areas of Focus
- Epigenetic mechanisms of disease occurrence
- Identification and functional study of novel epigenetic modifications
Work Experience
- 2013.07-2014.11 - Fudan University - Assistant Researcher
- 2015.02-2019.12 - Harvard University, Boston Children's Hospital - Postdoctoral Researcher
- 2020.05-present - Southern University of Science and Technology - Assistant Professor
Academic Background & Achievements
- 2004-2008 Bachelor: Wuhan University
- 2008-2013 PhD: Fudan University Biomedical Research Institute
- Postdoctoral training at Harvard Medical School (2015-2019)
Publications
- The 18S rRNA m6A methyltransferase regulates mouse embryonic stem cell differentiation, Xing, M., Liu, Q., Mao, C., Zeng, H., Zhang, X., Zhao, S., Chen, L., Liu, M., Shen, B., Guo, X., Ma, H., Chen, H., Zhang, J., 2020
- METTL4 is an m6Am methyltransferase that regulates RNA splicing, Chen, H., Gu, L., Orellana, E., Wang, Y., Guo, J., Liu, Q., Gregory, R., Xing, Y., Shi, Y., 2020
- The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for proper mitochondrial function, Chen, H., Shi, Guo, J., Chang, K., Chen, Q., Yao, C., Haigis, M., Shi, Y., 2020
- CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila, Gu, L., Wang, L., Chen, H., Hong, J., Shen, Z., Dhall, A., Lao, T., Wu, H., Shi, Y., 2020
- METTL5, an 18S rRNA-specific m6A methyltransferase, modulates expression of stress response genes, Chen, H., Liu, Q., Yu, D., Natchiar, K., Zhou, C., Hsu, C.-h., Hsu, P.-H., Zhang, X., Klaholz, B., Gregory, R., Shi, Y., 2020
- TET2stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer, Chen, H., Yu, D., Fang, R., Rabidou, K., Wu, D., Hu, D., Shi, Y. G., 2019
- Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer, Wu, D., Hu, D., Chen, H., Shi, G., Fetahu, I. S., Wu, F., Shi, Y. G., 2018
- PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression, Sendinc, E., Valle-Garcia, D., Dhall, A., Chen, H., Henriques, T., Navarrete-Perea, J., Sheng, W., Gygi, S., Adelman, K., Shi, Y., 2019
- N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation, Ma, H., Wang, X., Cai, J., Dai, Q., Natchiar, S. K., Lv, R., Chen, H., He, C., 2019
- Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway, Lee, Y., Chen, M., Lee, J., Zhang, J., Lin, S., Fu, T., Chen, H., Ishikawa, T., Chiang, S., Katon, J., Wei W., Pandolfi P., 2019
Awards
- 2013: Outstanding Graduate - Fudan University
- 2013: Best Presentation Award - Tumor Biology and Translational Medicine Forum
- 2012: National Scholarship - Ministry of Education of China
- 2012: Best Presentation Award - Shanghai Life Science Forum